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山东社会科学 2010年第10期 31-34页

作者：宫承波中国传媒大学电视与新闻学院北京100024

新媒体文化彰显出前所未有的生机和活力,但其目前的生存也存在着诸多悖论。这些悖论主要体现为:对传统文化拓展与冲击的悖论;自由狂欢与侵权、乱世的悖论;草根性与精英化的悖论;全球化与民族性的悖论。

关键词：新媒体文化生存悖论传统文化草根性全球化

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浅论近代日本汉学与对中国的东方学话语

深圳大学学报（人文社会科学版） 2006年第5期23卷 15-22页

作者：泊功东北师范大学研究生院

一直到江户时期汉学始终为日本学术的最高境界。但进入明治时代之后,日本将中国看“成落后”的国家,汉学已不再作为达到“先王之道”的学问,随之汉学渐渐地分成几门客观的、科学的学术领域。一批研究中国经典的学者及爱好汉学的作家,虽... 详细信息

一直到江户时期汉学始终为日本学术的最高境界。但进入明治时代之后,日本将中国看“成落后”的国家,汉学已不再作为达到“先王之道”的学问,随之汉学渐渐地分成几门客观的、科学的学术领域。一批研究中国经典的学者及爱好汉学的作家,虽然一方面对传统中国有憧憬、向往的心情,但另一方面他们一致认为应该用从近代化获得的优势,对中国施加压力,进而改变它。在这一过程中,秉承西方列强,形成了为日本帝国主义获得殖民地提供理论支持的日本式东方学话语。

关键词：近代日本日本汉学近代文学东方学

A novel FOXC2 frameshift mutation found in a Chinese family with Lymphedema-Distichiasis

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A novel FOXC2 frameshift mutation found in a Chinese family ...

IMPROVEMENT IN TENSILE PROPERTIES OF α+β TYPE Ti ALLOYS BY HYDROGEN TREATMENT

中华医学会第十五次全国医学遗传学学术会议暨中国医师协会医学遗传医师分会第一届全国学术会议暨2016年浙江省医学遗传学年会

作者： Ye Zimeng gong bo Yang Zhenglin Shi Yi Sichuan Provincial Key Laboratory for Disease Gene Study Hospital of University of Electronic Science and Tec hnology of China & Sichuan Provincial People’s Hospital

Objective Lymphedema-Distichiasis(LD, OMIM 153400), a rare autosomal dominant disorder, is mainly characterised by lower limbs lymphedema and distichiasis(referred to as double rows of e yelashes at the rim of the eyelids). Congenial distichiasis is the most conspicuous manifestation o f LD. Affected individuals may also suffer from other ocular complications, including corneal irritati on, recurrent conjunctivitis, photophobia, exotropia, ptosis, congenital ectropion, and congenital c ataracts. According to previous studies, the FOXC2 protein is indispensable for the development of the vascular and lymphatic systems, mutations in FOXC2 could lead to LD. The purpose of the present study was to report the clinical features of a Chinese family with LD, and to screen for no vel genetic mutations in FOXC2. Method A three-generation family from China was recruited in this study. All of the 9 family memb ers underwent complete and comprehensive physical examinations. Among them, 3 members we re diagnosed with LD. Genomic DNA was collected from peripheral blood of all the participants. T he entire coding sequence of FOXC2 was amplified by polymerase chain reaction(PCR), followe d by direct DNA sequencing. We validated the absence of the novel mutation in the normal memb ers of the family and in other 300 ethnically matched normal *** A novel frameshift mutation(c.936 dup CGCCGCC;***313 Argfs X464) in exon 3 of FOX C2 was identified in all the affected family members, but not in the normal family members or the 300 ethnically matched controls. Bioinformatic analysis suggested this frameshift mutation resulte d in premature stop codon thus produced truncated FOXC2 protein. Conclusion FOXC2 protein is characterized by a conserved DNA-binding domain known as the f orehead domain(FHD). This frameshift mutation could lead to truncated FOXC2 protein, which m ay subsequently impair the DNA-binding of FHD, and compromise the transcriptional activation a bility of the

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Acta Metallurgica Sinica(English Letters) 1993年第2期6卷 121-124页

作者： gong bo LAI Zuhan Northeast University of Technology,Shenyang,ChinaNIINOMI Mitsuo,KOBA YASHI Toshiro Toyohashi University of Technology,Toyohashi Japan Department of Physics,Northeast University of Technology,Shenyang 110006,China Northeast Univ of Technology Shenyang China

A new process to refine the microstructure of α+βtvpe Ti alloys was developed by using hydrogen as a temporary alloying *** involves hydrogenating the alloys below the hydrogenated β transus temperature about 0-40 K,air cooling to room temperature and then dehydrogenating at 948 ***-6AI-4V and Ti-5AI-2.5Fe alloys treated hy this new process show much refined microstructures,and the yield strength,ultimate strength as well as the elongation increase 8—15,5—13 and 7—14% respectively

关键词： Ti-6Al-4V Ti-5Al-2.5Fe thermochemical processing(TCP) microstructural refinement tensile properties

Metabotropic glutamate receptors(mGluRs)in epileptogenesis:an update on abnormal mGluRs signaling and its therapeutic implications

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Neural Regeneration Research 2024年第2期19卷 360-368页

作者： Leyi Huang Wenjie Xiao Yan Wang Juan Li Jiaoe gong Ewen Tu Lili Long bo Xiao Xiaoxin Yan Lily Wan Department of Anatomy and Neurobiology Central South University Xiangya Medical SchoolChangshaHunan ProvinceChina Department of Neurology Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina Department of Neurology Hunan Children’s HospitalChangshaHunan ProvinceChina Department of Neurology Brain Hospital of Hunan ProvinceChangshaHunan ProvinceChina

Epilepsy is a neurological disorder characterized by high morbidity,high recurrence,and drug *** signaling through the excitatory neurotransmitter glutamate is intricately associated with *** glutamate receptors(mGluRs)are G protein-coupled receptors activated by glutamate and are key regulators of neuronal and synaptic *** mGluR signaling has been associated with various neurological disorders,and numerous studies have shown a close relationship between mGluRs expression/activity and the development of *** this review,we first introduce the three groups of mGluRs and their associated signaling ***,we detail how these receptors influence epilepsy by describing the signaling cascades triggered by their activation and their neuroprotective or detrimental roles in *** addition,strategies for pharmacological manipulation of these receptors during the treatment of epilepsy in experimental studies is also *** hope that this review will provide a foundation for future studies on the development of mGluR-targeted antiepileptic drugs.

关键词： antiepileptic drugs epileptogenesis metabotropic glutamate receptors(mGluRs) signal pathways therapeutic potentials

Cross section determination of^(27)Al(n,2n)^(26)Al reaction induced by 14-MeV neutrons uniting with D-T neutron activation and AMS techniques

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Nuclear Science and Techniques 2024年第6期35卷 78-89页

作者： Xian-Lin Yang Chang-Lin Lan Yu-Ting Wei Yi Zhang gong Jiang bo Xie Yu Liu Hong-Tao Shen Xiao-Jun Sun School of Nuclear Science and Technology Lanzhou UniversityLanzhou 730000China MOE Frontiers Science Center for Rare Isotopes Lanzhou UniversityLanzhou 730000China State Key Laboratory of Environmental Geochemistry Institute of GeochemistryChinese Academy of SciencesGuiyang 550081China Guangxi Key Laboratory of Nuclear Physics and Nuclear Technology Guangxi Normal UniversityGuilin 541004China

Aluminum is the primary structural material in nuclear engineering,and its cross section induced by 14-MeV neutrons is of great *** address the issue of insufficient accuracy for the^(27)Al(n,2n)^(26)Al reaction cross section,the activation method and accelerator mass spectrometry(AMS)technique were used to determine the^(27)Al(n,2n)^(26)Al cross section,which could be used as a D-T plasma ion temperature monitor in fusion *** the China Academy of Engineering Physics,neutron activation was performed using a K-400 neutron generator produced by the T(d,n)4He ***^(26)Al∕^(27)Al isotope ratios were measured using the newly installed GYIG 1 MV AMS at the Institute of Geochemistry,Chinese Academy of *** neutron flux was monitored by measuring the activity of 92mNb produced by the 93Nb(n,2n)92mNb *** measured results were compared with available data in the experimental nuclear reaction database,and the measured values showed a reasonable degree of consistency with partially available literature *** newly acquired cross-sectional data at 12 neutron energy points through systematic measurements clarified the divergence,which has two different growth trends from the existing experimental *** obtained results are also compared with the corresponding evaluated database,and the newly calculated excitation functions with TALYS−1.95 and EMPIRE−3.2 codes,the agreement with CENDL−3.2,TENDL-2021 and EMPIRE−3.2 results are generally acceptable.A substantial improvement in the knowledge of the^(27)Al(n,2n)^(26)Al reaction excitation function was obtained in the present work,which will lay the foundation for the diagnosis of the fusion ion temperature,testing of the nuclear physics model,evaluation of nuclear data,etc.

关键词： 14-MeV neutron ^(27)Al(n,2n)^(26)Al Cross section AMS

深圳有线数字电视整体转换试点工程的验收测试

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广播与电视技术 2006年第6期33卷 32-33,36页

作者：龚波国家广电总局广播电视计量检测中心

本文介绍了深圳有线数字电视整体转换试点工程的验收测试情况,并探讨了深圳市有线数字电视的几个特点。

关键词：数字电视整体转换验收测试

外高桥第二发电有限责任公司生产管理信息系统介绍

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华东电力 2007年第6期35卷 90-91页

作者：龚波外高桥第二发电有限责任公司上海200137

随着外高桥第二发电有限责任公司2×900MW机组的投运,用信息化手段来进行管理的需求越来越强烈.大量的缺陷和工作票需要记录和查询,燃料的到货堆放情况需要了解,到厂煤及入炉煤的化学成分需要掌握,与设备供应商的来往传真需要随时调阅.... 详细信息

随着外高桥第二发电有限责任公司2×900MW机组的投运,用信息化手段来进行管理的需求越来越强烈.大量的缺陷和工作票需要记录和查询,燃料的到货堆放情况需要了解,到厂煤及入炉煤的化学成分需要掌握,与设备供应商的来往传真需要随时调阅.传统的手工台帐或不联网的计算机管理已不能满足生产和管理的需要,信息中心开发了生产管理信息系统,主要包括缺陷记录、工作票记录、化学试验报告、来往传真查询及岛供设备查询等.

关键词：生产管理系统功能软件

Analysis of Four Solvatomorphs of Betulin by TG-DTA-EI/PI-MS System Equipped with the Skimmer-Type Interface

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Natural Products and Bioprospecting 2020年第3期10卷 141-152页

作者： Peng-Hui Yuan Yan-Cai Bi Bin Su De-Zhi Yang Ning-bo gong Li Zhang Yang Lu Guan-Hua Du Beijing City Key Laboratory of Polymorphic Drugs Center of Pharmaceutical PolymorphsInstitute of Materia MedicaChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100050People’s Republic of China Soteria Pharmaceutical Co. LtdLaiwu 271100People’s Republic of China Beijing City Key Laboratory of Drug Target and Screening Research National Center for Pharmaceutical ScreeningInstitute of Materia MedicaChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100050People’s Republic of China

Betulin(BE)has exceedingly become a potential natural product,providing multiple pharmacological and biological activi-ties,including anti-cancer,anti-viral,and anti-inflammatory *** research indicated that the solvatomorphism of BE can easily occur through crystallization with different organic *** property of BE can directly affect its extraction,isolation,and preparation *** this study,a system of thermogravimetry(TG)-differential thermal analysis(DTA)coupled with mass spectrometry(MS)with electron ionization(EI)and photoionization(PI)capability,equipped with the skimmer-type interface(i.e.,skimmer-type interfaced TG-DTA-EI/PI-MS system),as a real-time and onsite analysis technique,was ***,four solvatomorphs of BE,namely,with pyridine and water(A),sec-butanol(B),n,n-dimethylformamide(DMF)(C),and isopropanol(V),were analyzed for the first ***,five kinds of the main volatile gaseous species,including H2O,pyridine,sec-butanol,DMF,and isopropanol,were identified ***,the multi-step desolvation processes of the four solvatomorphs of BE were revealed by this system for the first *** system showed great potential for the rapid and accurate analysis of various solvatomorphs of natural products.

关键词： Betulin Solvatomorphs TG-MS PI method

磷酰胆碱色谱固定相的制备及其在分离生物大分子中的应用

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高等学校化学学报 2008年第11期29卷 2138-2141页

作者：徐黎珍龚波林宁夏大学能源化工重点实验室银川750021

以三氯氧磷、氯化胆碱和甲基丙烯酸-2-羟乙酯(HEMA)为原料合成了含磷酰胆碱的单体2-甲基丙烯酰氧乙基磷酰胆碱(MPC).在硅胶表面嫁接聚合MPC,得到磷酰胆碱两性离子交换色谱填料.研究了该填料对标准蛋白的分离性能及pH对蛋白质保留的影响... 详细信息

以三氯氧磷、氯化胆碱和甲基丙烯酸-2-羟乙酯(HEMA)为原料合成了含磷酰胆碱的单体2-甲基丙烯酰氧乙基磷酰胆碱(MPC).在硅胶表面嫁接聚合MPC,得到磷酰胆碱两性离子交换色谱填料.研究了该填料对标准蛋白的分离性能及pH对蛋白质保留的影响.结果表明,该填料对溶菌酶和牛血清白蛋白的动态吸附容量分别为13.8和18.7 mg/g,其基质磷酰胆碱色谱固定相可同时基线分离两种酸性和两种碱性蛋白.

关键词：磷酰胆碱色谱固定相制备两性离子交换填料蛋白质分离