检索结果-南通市图书馆

Bibliometric analysis of microphthalmos and anophthalmos over 20 years:from 2004 to 2023

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

International Journal of Ophthalmology(English edition) 2024年第11期17卷 2120-2128页

作者： Ming-Hui Wang gong-Fei li Ju Zhang Beijing Tongren Eye Center Beijing Tongren HospitalBeijing Ophthalmology and Visual Science Key LabCapital Medical UniversityBeijing 100730China Department of Ophthalmology University of CologneFaculty of Medicine and University Hospital CologneCologne 50937Germany Department of Neurology&Stroke University of TübingenTübingen 72076Germany

AIM:To conduct a bibliometric analysis of studies on microphthalmos and anophthalmos(M/A),explore research hotspots,and provide information on future research interests in this field to benefit clinicians and ***:Totally 751 publications related to M/A from the year 2004 to 2023 were collected from the Web of Science Core Collection *** publications consist of both original and review articles,that are composed in *** contributions of different countries,institutions,journals,and authors were analyzed,and network analysis was conducted by using Microsoft Excel 2021,VOSviewer,and R Studio to visualize research ***:Among all publications included,the highest number of publications came from USA(218,29.03%).China followed with 99 publications(13.18%),and England with 86 publications(11.45%).The publications from the USA had the highest frequency of citations,with 16699 citations,and the highest H-index of *** American Journal of Medical Genetics Part A(43,5.73%)published the largest number of papers,and the University of London had the most publications(41,5.46%).The genetic and molecular mechanisms of M/A were still unclear and the clinical intervention for M/A had gained a lot of attention as an emerging area of ***:Data have been gathered on the yearly count of published materials and citations,as well as the rise in publication trends,the efficiency of regions or countries,authors,journals,and organizations,along with the high-cited publications in M/*** recent trend of research has shifted from genetic mechanisms to different clinical phenotypes and corresponding clinical interventions,which can give direction to future research.

关键词： bibliometric analysis network analysis microphthalmos anophthalmos

In vivo investigation of the role of SfmO2 in saframycin A biosynthesis by structural characterization of the analogue saframycin O

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Science China Chemistry 2012年第1期55卷 90-97页

作者： PENG Chao TANG Yu-Min li Lei DING Wei DENG Wei PU Jin-Yue liU Wen TANG gong-li State Key Laboratory of Bio-organic and Natural Products Chemistry Shanghai Institute of Organic Chemistry Chinese Academy of SciencesShanghai 200032China

Saframycin A(SFM-A),a tetrahydroisoquinoline antibiotic isolated from Streptomyces lavendulae,shows potent anti-proliferation activities against a variety of tumor cell lines,and shares the core structure with ecteinascidin 743(ET-743),the anticancer drug for soft-tissue *** of the SFM-A biosynthetic gene cluster revealed three nonribosomal peptide synthetase genes and a series of genes encoding *** investigate the function of sfmO2 gene,encoding a FAD-dependent monooxygenase/hydroxylase,we constructed the gene replacement mutant(△sfmO2) strain *** TL2007 and the corresponding gene complementation mutant strain *** TL2008.A novel compound,SFM-O,was isolated from the △sfmO2 replacement mutant strain and its structure was characterized by comparison to the HRMS and NMR spectra of *** findings indicated that SfmO2 is responsible for the oxidation of ring A in the biosynthetic pathway of SFM-A,and the new compound SFM-O could be considered as an advanced intermediate in the semisynthesis of ET-743.

关键词： saframycin A biosynthesis SfmO2 oxygenase saframycin O

An Empirical Analysis of the Sustainability of China's Trade Surplus:Based on Unit Root and Cointegration Verification of Endogenous Structural Mutation

在线全文

学校读者我要写书评

暂无评论

当代财经 2013年第S1期 94-102页

作者： XU Tong-sheng YIN gong-li ZHU Yong-jun Jiangxi University of Finance and Economics

On the basis of statistical description of the typical facts of China’s monthly import and export data relations during the period of 1990-2010,and making use of the unit root and cointegration verification techniques of endogenous structural break,this paper conducts an empirical analysis of the sustainability of China’s trade *** results show that between China’s import and export there exists a long-term equilibrium relationship in which changes are found in the intercept items and the slope *** trade surplus has weak *** to the restrain of the long-term balanced relationship between the import and export,the deviation from equilibrium of export will be corrected in the next ***,policies aiming at adjusting the trade balance(external)should take full account of this feature.

关键词： trade surplus strong sustainability weak sustainability endogenous mutation exogenous mutation

AtMGT7:An Arabidopsis Gene Encoding a Low-Affinity Magnesium Transporter

在线全文

学校读者我要写书评

暂无评论

Journal of Integrative Plant Biology 2008年第12期50卷 1530-1538页

作者： Dan-Dan Mao lian-Fu Tian Le-gong li Jian Chen Pei-Yi Deng Dong-Ping li Sheng Luan College of life Science Hunan Normal University Changsha 410081 China College of life Sciences Capital Normal University Beijing 100037 China Department of Plant and Microbial Biology University of California Berkeley California 94720 USA

Magnesium （Mg^2＋） is one of the essential cations in all cells. Although the Mg^2＋ transport mechanism has been well- documented in bacteria, less is known about Mg^2＋ transporters in eukaryotes. The AtMGT gene family encoding putative magnesium transport proteins had been described previously. We report here that one of the Arabidopsis MGT family members, the AtMGT7 gene, encodes two mRNAs that have resulted from alternative splicing variants, designated AtMGT7a and AtMGT7b. Interestingly, the two mRNA variants were expressed with different patterns with AtMG77a expressing in all organs, but AtMGT7b appearing only in root and flowers. The AtMGT7a variant functionally complemented a bacterial mutant lacking Mg^2＋ transport capacity, whereas AtMGT7b did not. The 63Ni^2＋ tracer uptake analysis in the bacterial model showed that AtMGT7a mediated low-affinity transport of Mg^2＋. Consistent with the complementation assay result, 63Ni^2＋ tracer uptake analysis revealed that AtMGT7b did not transport Mg^2＋. This study therefore has identified from a higher plant the first low-affinity Mg^2＋ transporter encoded by a gene with alternatively spliced transcripts that produce proteins with distinct functions.

关键词： alternative splicing Arabidopsis AtMGT7 magnesium transporter.

AN EFFICIENT GPU ACCELERATION FORMAT FOR FINITE ELEMENT ANALYSIS

在线全文

学校读者我要写书评

暂无评论

Journal of Electronics(China) 2013年第6期30卷 599-608页

作者： Tian Jin li gong Fei Wu Zeng Guohui College of Electronic and Electrical Engineering Shanghai University of Engineering Science Institute of China Innovation East China Normal University

This paper proposes a new Graphics Processing Unit(GPU)-accelerated storage format to speed up Sparse Matrix Vector Products(SMVPs) for Finite Element Method(FEM) analysis of electromagnetic problems.A new format called Modified Compile Time Optimization(MCTO) format is used to reduce much execution time and design for hastening the iterative solution of FEM equations especially when rows have uneven *** MCTO-applied FEM is about 10 times faster than conventional FEM on a CPU,and faster than other row-major ordering formats on a *** results show that the proposed GPU-accelerated storage format turns out to be an excellent accelerator.

关键词： Finite Element Method (FEM) Graphics Processing Unit (GPU) Parallelizationstrategy Modified Compile Time Optimization (MCTO)

Ocellatuspyrones A‒G,new antibacterial polypropionates from the Chinese mollusk Placobranchus ocellatus

在线全文

学校读者我要写书评

暂无评论

Marine life Science & Technology 2023年第3期5卷 373-386页

作者： Song-Wei li Dan-Dan Yu Ming-Zhi Su li-gong Yao Hong Wang Xueting liu Yue-Wei Guo Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals College of Pharmaceutical ScienceZhejiang University of TechnologyHangzhou 310014China State Key Laboratory of Drug Research Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China State Key Laboratory of Bioreactor Engineering East China University of Science and TechnologyShanghai 200237China Shandong Laboratory of Yantai Drug Discovery Bohai Rim Advanced Research Institute for Drug DiscoveryYantai 264117China

Marine invertebrates serve as rich sources of secondary metabolites with intriguing chemical diversities and a wide spectrum of biological ***,marine shell-less sacoglossan mollusks have attracted much attentions due to the fact that mollusks apply complex metabolites as chemical defense agents against to their *** the purpose of discovering bioactive secondary metabolites to develop marine-derived medicines from the South China Sea,we have conducted a chemical study on the photosynthetic mollusk Placobranchus *** a result,seven newγ-pyrone polypropionates,namely(±)-ocellatuspyrone A(1),(±)-ocellatuspyrone B(2),and ocellatuspyrones C−G(5,9−12),along with fve known polypropionates,have been isolated and characterized from the South China Sea photosynthetic mollusk Placobranchus *** spectroscopic analysis,single crystal X-ray difraction analysis,modifed Mosher’s method,ECD comparison,CD exciton chirality method,TDDFT-ECD calculation,and chemical conversion were used to determine the structures and absolute confgurations of the new compounds and the stereochemistry of undefned known compounds 4,6 and *** these isolated polypropionates were evaluated in bioassays for their biological activities,including antibacterial,neuroprotective efect,anti-infammatory,PTP1B inhibitory,and antiviral *** 7,8 and 11 were found for the frst time to show antibacterial activity against fsh pathogenic bacteria Streptococcus parauberis(the main pathogen causing fsh streptococcal infections and acute death)with MIC values of 35.8,34.2,and 37.4μg/mL,respectively,which might be potential novel antibacterial agents for the treatment of fsh infectious diseases.

关键词： Placobranchus ocellatus γ-pyrone polypropionate Photosynthetic mollusk Antibacterial activity

Profiling Drug-Protein Interactions by Micro Column Affinity Purification Combined with Label Free Quantification Proteomics

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Journal of Chemistry 2020年第12期38卷 1681-1685页

作者： li gong Yao Xu Guizhen liu Mengmeng Zheng Xuepei Zhang Ying Hang Jingwu Kang State Key Laboratory of Bioorganic and Natural Products Chemistry Center for Excellence in Molecular SynthesisShanghai Institute of Organic ChemistryChinese Academy of Sciences345 Lingling RoadShanghai 200032China School of Physical Science and Technology ShanghoiTech UniversityHaike Rood 100Shanghai 200120China School of life Science and Technology ShanghaiTech UniversityHaike Road 100Shanghai 200120China

of main observation and conclusion We developed a method for comprehensively profiling drug-protein interactions using micro-column affinity purification(AP)combined with label-free quantitative(LFQ)proteomics as well as the statistical and bioinformatics ***506 was used as the experimental model for proof of *** true interacting proteins were distinguished from the background proteins by their fold changes of FLQ intensities combined with *** 116 FK506 interacting proteins including 5 known target proteins were *** method was validated by using the LFQ intensity of the endogenous known drug targets together with statistical *** demonstrated that the micro-column-based affinity purification in combination with LFQ proteomics provides a highly reproducible and robust approach for profiling drug-protein interactions.

关键词： proof analysis. conclusion

Complete Mitochondrial Genome Analysis of Daphniopsis tibetana(Branchiopoda:Diplostraca):New Insights into the Taxonomy of the Genus and Its Phylogenetic Implications for Branchiopoda

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Ocean University of China 2022年第6期21卷 1622-1632页

作者： liU Bingjian PENG Ying liU Yifan li Jiasheng ZHANG Kun CHEN Jian gong li liU liqin LÜZhenming ZHANG Chi National Engineering Laboratory of Marine Germplasm Resources Exploration and Utilization Zhejiang Ocean UniversityZhoushan 316022China Institute of Fisheries Science Tibet Academy of Agricultural and Animal Husbandry SciencesLhasa 850002China Key Laboratory of Tropical Marine Bio-Resources and Ecology Chinese Academy of SciencesGuangzhou 510301China

Daphniopsis tibetana is widely distributed in Xinjiang,Qinghai,Tibet of China,as well as in Russia and India,which is the dominant zooplankton in many high-altitude(4000 m)salt *** can adapt to saline waters,whereas the other species of the superorder Cladocera can only inhabit in ***,the phylogenetic status of *** in Branchiopoda remains unclear primarily because of limited *** this study,complete mitochondrial genome sequences of *** were sequenced and annotated for the first time to obtain a comprehensive understanding of its phylogenetic *** complete mitogenome of *** is 16196 bp in *** contains 37 genes,including two ribosomal RNAs(12S and 16S rRNAs)genes,22 transfer RNA(tRNA)genes,13 protein-coding genes,and one non-coding *** overall base composition is 29.6%A,33.2%T,19.0%G,and 18.2%C with a high AT bias(62.8%).Except for trnS1(GCT),most tRNAs have a typical cloverleaf secondary *** analysis based on maximum likelihood and Bayesian inference generates identical phylogenetic topology and shows the phylogenetic status of ***,which reconfirm the distinction between the genera Daphniopsis and ***,the class Branchiopoda is clustered into three clades(Anostraca,Notostraca,and Diplostraca)with high support *** results provide not only a comprehensive understanding of the characteristics of *** mitogenome and its phylogenetic position in Diplostraca,but also information for future research on the phylogeny of Branchiopoda.

关键词： Daphniopsis tibetana mitogenome phylogenetic analysis Branchiopoda Diplostraca

Comparative mitochondrial genome analysis of Varunidae and its phylogenetic implications

在线全文

学校读者我要写书评

暂无评论

Acta Oceanologica Sinica 2022年第6期41卷 119-131页

作者： Ying Zhang li gong Xinting Lu Zengliang Miao lihua Jiang Bingjian liu liqin liu Pengfei li Xu Zhang Zhenming Lü National Engineering Laboratory of Marine Germplasm Resources Exploration and Utilization Zhejiang Ocean UniversityZhoushan 316022China Marine Science and Technology College Zhejiang Ocean UniversityZhoushan 316022China Guangxi Key Laboratory of Marine Natural Products and Combinatorial Biosynthesis Chemistry Guangxi Beibu Gulf Marine Research CenterGuangxi Academy of SciencesNanning 530007China Key Laboratory of Zoological Systematics and Evolution Institute of ZoologyChinese Academy of SciencesBeijing 100101China

Complete mitochondrial genomes(mitogenomes)can indicate phylogenetic relationships,as well as useful information for gene rearrangement mechanisms and molecular ***,the phylogenetic location of the genus Varuna(Brachyura:Varunidae)has not been well resolved mainly because of limited representatives(only two extant species).Here,we determined a new mitogenome of this genus(Varuna litterata)and added the published mitogenomes to reconstruct the phylogeny of *** 16368-bp mitogenome contains the entire set of 37 genes and a putative control *** characteristics of this newly sequenced mitogenome were described and compared with the other 15 Varunidae *** 16 analyzed mitogenomes have identical gene order and similar molecular *** sliding window and genetic distance analyses demonstrate highly variable nucleotide diversity,with comparatively low variability of COI and COII,and high variability of *** nonsynonymous/synonymous substitution rates(dN/dS ratio)analysis shows that all 13 PCGs are under purifying selection and ATP8 gene evolves under the least selective *** tRNA genes,two rRNAs,one PCG,and the putative control region are found to be rearranged with respect to the pancrustacean ground pattern gene *** duplication/random loss model is adopted to explain the large-scale gene rearrangement events occurring in Varunidae *** analyses show that all Varunidae species are placed into one group,and form a sister clade with ***,the phylogenetic relationships within Varunidae are not completely consistent based on the two different datasets used in this *** findings will contribute to a better understanding of gene rearrangement and molecular evolution in Varunidae mitogenomes,as well as provide insights into the phylogenetic studies of Brachyura.

关键词： varunid crab Varuna litterata mitogenome gene rearrangement tandem duplication/random loss phylogeny