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Development of a MWDC prototype of the CSR external-target experiment

NUCLEAR SCIENCE AND TECHNIQUES 2024年第10期35卷 1-14页

作者： He, Zhou-Bo Qin, Zhi Ma, Peng Yang, He-Run wei, Xiang-Lun Lu, Chen-Gui Wen, Xiang-Jie Zhang, Xiu-Ling Chen, Tao Li, Zhi-Jie Yang, Yuan-Sheng Zhan, Mei-Qiang Liu, Can-Wen Li, Meng Qiu, Tian-Li gong, yi-wei Huang, Xin-Jie yin, Xiao-Hao He, Zhi-Xuan Zhang, Jun-wei Zou, Hai-Chuan Fu, Sheng-wei Guo, Dong Yan, Jun-wei Cao, Zhe Deng, Zhi Kong, Jie Xiao, Zhi-Gang Hu, Rong-Jiang Duan, Li-Min Chinese Acad Sci Inst Modern Phys Lanzhou 730000 Peoples R China Univ Chinese Acad Sci Sch Nucl Sci & Technol Beijing 100049 Peoples R China Tsinghua Univ Dept Phys Beijing 100084 Peoples R China Univ Sci & Technol China Hefei 230026 Peoples R China Sichuan Univ Inst Nucl Sci & Technol Key Lab Radiat Phys & Technol Minist Educ Chengdu 610064 Peoples R China Lanzhou Univ Sch Nucl Sci & Technol Lanzhou 730000 Peoples R China North China Univ Water Resources & Elect Power Zhengzhou 450000 Peoples R China

The cooling storage ring (CSR) external-target experiment (CEE) is a spectrometer used in construction to study the properties of nuclear matter in high-baryon density regions at the Heavy-Ion Research Facility in Lanzhou (HIRFL). This study presents the design, simulation, manufacturing, and testing of a half-size prototype of a multi-wire drift chamber (MWDC) for the CEE. First, the performance of the MWDC connected to homemade electronics was simulated. The results demonstrated that an energy resolution of 18.5% % for 5.9-keV X-rays and a position resolution of 194 mu m for protons can be achieved by the current design. Because the size of the largest MWDC reached 176 cm x 314 cm, a set of 98 cm x 98 cm prototypes was built using the new techniques. The positioning accuracy of the anode wires in this prototype is better than 20 mu m. After optimization, using commercially available electronics, the prototype can achieved an energy resolution of 19.7% % for a Fe-55 X-ray source. The CEE-MWDC detector and electronics were simultaneously tested. An energy resolution of 22% % was achieved for the Fe-55 source; the track residuals were approximately 330 mu m for the cosmic rays. The results demonstrate that the current design and techniques meet the requirements of the CEE-MWDC array.

关键词： CEE MWDC Garfield plus plus Fe-55 source Position resolution DRIFT CHAMBER HIRFL-CSR

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中等断面隧道长进尺直孔掏槽爆破开挖与超欠挖控制现场试验

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爆破 2024年第2期41卷 32-39页

作者：龚伟毅姚颖康杜宇翔中铁十二局集团第一工程有限公司西安710038 江汉大学精细爆破国家重点实验室武汉430056 江汉大学湖北(武汉)爆炸与爆破技术研究院武汉430056

中等断面隧道受施工范围限制易导致爆破难度大,循环进尺短,超欠挖问题严重,长进尺开挖和超欠挖控制是降本增效的有效途径。基于某中等断面隧道工程设计了长进尺直孔掏槽爆破方案,进行了40个循环的爆破开挖现场试验,结果表明:(1)按照爆... 详细信息

中等断面隧道受施工范围限制易导致爆破难度大,循环进尺短,超欠挖问题严重,长进尺开挖和超欠挖控制是降本增效的有效途径。基于某中等断面隧道工程设计了长进尺直孔掏槽爆破方案,进行了40个循环的爆破开挖现场试验,结果表明:(1)按照爆破手册设计中等断面隧道开挖爆破参数,往往大块率高,掌子面不平整,适当增加直孔掏槽孔单孔装药量(现场试验掏槽药量占比由12.8%增至18.1%),可获得较好的爆破效果;(2)在初步设计参数基础上调整了中等断面隧道周边孔单孔装药量,线装药密度最终确定为0.27 kg/m,轮廓成形效果好,半孔率达90%以上,现场40个爆破循环超挖平均值为18.6 cm,分析可知超挖量主要由轮廓线处留置错台造成,在超挖控制方面,除了周边孔参数的合理设计外,应在钻孔施工过程中尽可能减小错台宽度,从而降低超挖;(3)直孔掏槽方案能很好地匹配凿岩台车钻孔施工,实现机械化长进尺爆破开挖,但超欠挖精细控制和爆破施工成本控制是重难点问题,需从钻孔人员操作技术和现场施工管理模式方面进行优化提升。研究成果可为中等断面隧道机械化钻爆施工、长进尺爆破开挖与超欠挖精细控制设计和施工提供参考依据。

关键词：中等断面隧道直孔掏槽长进尺开挖超欠挖控制精细爆破

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Decreased LDHB expression in breast tumor cells causes NK cell activation and promotes tumor progression

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Cancer Biology & Medicine 2024年第6期21卷 513-540页

作者： Zhihong Luo Xiaohua Huang Xinyi Xu Kefeng wei yi Zheng Ke gong Wenhua Li Hubei Key Laboratory of Cell Homeostasis College of Life SciencesWuhan UniversityWuhan 430072China Wuhan University Shenzhen Research Institute Shenzhen 518057China Central Laboratory University of Chinese Academy of Sciences-Shenzhen HospitalShenzhen 518107China Hubei Province Key Laboratory of Allergy and Immunology and Department of Immunology School of Basic Medical SciencesWuhan UniversityWuhan 430071China

Objective: Abnormal metabolism is the underlying reason for breast cancer progression. Decreased lactate dehydrogenase B(LDHB) has been detected in breast cancer but the function of LDHB remains ***: Western blot was used to analyze LDHB expression in breast cancer cells. The impact of LDHB on tumor cell migration and invasion was determined using Transwell assays, wound healing assays, and a mouse lung metastasis model. Subcutaneous tumor formation, a natural killer(NK) cell cytotoxicity assay, and flow cytometry evaluated NK cell activation. Immunofluorescence and quantitative real-time PCR detected NK cell activation markers. Kaplan-Meier analysis evaluated the effect of immune cell infiltration on prognosis. Single-sample gene set enrichment analysis determined NK cell activation scores. A support vector machine predicted the role of LDHB in NK cell ***: In this study we showed that LDHB inhibits the breast cancer cell metastasis and orchestrates metabolic reprogramming within tumor cells. Our results revealed that LDHB-mediated lactic acid clearance in breast cancer cells triggers NK cell activation within the tumor microenvironment. Our findings, which were confirmed in a murine model, demonstrated that LDHB in tumor cells promotes NK cell activation and ultimately results in the eradication of malignant cells. Clinically, our study further validated that LDHB affects immune cell infiltration and function. Specifically, its expression has been linked to enhanced NK cell-mediated cytotoxicity and improved patient survival. Furthermore, we identified LDHB expression in tumors as an important predictor of NK cell activation, with strong predictive ability in some ***: Our results suggest that LDHB is a promising target for activating the tumor immune microenvironment in breast cancer, where LDHB-associated lactic acid clearance leads to increased NK cell activity. This study highlights the critical role of LDHB in regula

关键词： Breast cancer lactate dehydrogenase B lactic acid NK cells tumor immunity

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International law obligations for the disposal of Fukushima nuclear-contaminated water under the principles of nuclear safety

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Chinese Journal of Population,Resources and Environment 2024年第1期22卷 10-19页

作者： wei gong Law School Southwest UniversityChongqing 400715China

The disposal of contaminated water from Japan’s Fukushima nuclear power plant is a significant international nuclear safety issue with considerable cross-border *** matter requires compliance not only with the law of the sea but also with the principles of nuclear safety under international *** principles serve as the overarching tenet of international and China’s domestic nuclear laws,applicable to nuclear facilities and *** principle of safety in nuclear activities is fully recognized in international and domestic laws,carrying broad legal binding ***’s discharge of nuclear-contaminated water into the sea violates its obligations under the principle of safety in nuclear activities,including commitments to optimum protection,as low as reasonably practicable,and *** Japanese government and the International Atomic Energy Agency(IAEA)have breached the obligation of optimum protection by restricting the scope of assessments,substituting core concepts,and shielding dissenting *** the absence of clear radiation standards,they have acted unilaterally without fulfilling the obligation as low as reasonably practicable *** discharge of Fukushima nuclear-contaminated water poses an imminent and unpredictable risk to all countries worldwide,including Japanese *** and the IAEA should fulfill their obligations under international law regarding disposal,adhering to the principles of nuclear safety,including optimum protection,the obligation as low as reasonably practicable,and prevention through multilateral ***,the obligation to provide optimum protection should be implemented by re-evaluating the most reliable disposal technologies and methods currently available and comprehensively assessing various *** standard of the obligation as low as reasonably practicable requires that the minimization of negative impacts on human health,livelihoods,and the environment should not b

关键词： Principles of nuclear safety Disposal of nuclear-contaminated water Optimum protection Prevention As low as reasonably achievable

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Constant-roll inflation with non-minimally derivative coupling

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Communications in Theoretical Physics 2024年第9期76卷 55-62页

作者： Jie Liu Yungui gong Zhu yi School of Physics and Electronic Engineering Hainan Normal UniversityHaikou 571158China Department of Physics School of Physical Science and TechnologyNingbo UniversityNingboZhejiang 315211China School of Physics Huazhong University of Science and TechnologyWuhanHubei 430074China Faculty of Arts and Sciences Beijing Normal UniversityZhuhai 519087China Advanced Institute of Natural Sciences Beijing Normal UniversityZhuhai 519087China

We investigate the constant-roll inflation with non-minimally kinetic coupling to the Einstein *** the slow-roll parameterηφ=-φ/(Hφ)being a constant,we calculate the power spectra for scalar and tensor perturbations,and derive the expressions for the scalar spectral tilt n_(s),the tensor spectral tilt n_(T),and the tensor-to-scalar ratio *** find that the expressions for n_(s)are different with different ordering of taking the derivative of the scalar power spectrum with respect to the scale k and the horizon crossing condition c_(sk)=a H in the constant-roll inflation,the consistency relation r=-8n_(T)does not hold if|η_(φ)|is not small,and the duality of the tensorto-scalar ratio between the slow-roll inflation and ultra-slow-roll inflation does not exist in inflationary models with non-minimally derivative *** result offers a fresh perspective on the understanding of the inflationary models with non-minimally derivative coupling and is helpful for the production of scalar induced gravitational waves in the framework of ultra-slowroll inflation with non-minimally derivative coupling.

关键词： inflation constant-roll inflation non-minimally derivative coupling inflation

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Predictive model using four ferroptosis-related genes accurately predicts gastric cancer prognosis

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World Journal of Gastrointestinal Oncology 2024年第5期16卷 2018-2037页

作者： Li Wang wei-Hua gong Department of Emergency The Second Affiliated Hospital of Zhejiang University School of MedicineHangzhou 310000Zhejiang ProvinceChina Department of Surgery The Second Affiliated Hospital Zhejiang University School of MedicineHangzhou 310052Zhejiang ProvinceChina

BACKGROUND Gastric cancer(GC)is a common malignancy of the digestive *** to global 2018 cancer data,GC has the fifth-highest incidence and the thirdhighest fatality rate among malignant *** than 60%of GC are linked to infection with Helicobacter pylori(***),a gram-negative,active,microaerophilic,and helical *** parasite induces GC by producing toxic factors,such as cytotoxin-related gene A,vacuolar cytotoxin A,and outer membrane ***,or iron-dependent programmed cell death,has been linked to GC,although there has been little research on the link between *** infection-related GC and *** To identify coregulated differentially expressed genes among ferroptosis-related genes(FRGs)in GC patients and develop a ferroptosis-related prognostic model with discrimination *** Gene expression profiles of GC patients and those with ***-associated GC were obtained from The Cancer Genome Atlas and Gene Expression Omnibus(GEO)*** FRGs were acquired from the FerrDb database.A ferroptosis-related gene prognostic index(FRGPI)was created using least absolute shrinkage and selection operator–Cox *** predictive ability of the FRGPI was validated in the GEO ***,we verified the expression of the hub genes and the activity of the ferroptosis inducer FIN56 in GC cell lines and *** Four hub genes were identified(NOX4,MTCH1,GABARAPL2,and SLC2A3)and shown to accurately predict GC and ***-associated *** FRGPI based on the hub genes could independently predict GC patient survival;GC patients in the high-risk group had considerably worse overall survival than did those in the low-risk *** FRGPI was a significant predictor of GC prognosis and was strongly correlated with disease ***,the gene expression levels of common immune checkpoint proteins dramatically increased in the highrisk subgroup of the FRGPI *** hub genes were also conf

关键词： Ferroptosis Gastric cancer Helicobacter pylori infection Immune checkpoint protein Prognostic model Ferroptosis-related gene prognostic index

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Theoretical study on magnetocaloric effect and its electric-field regulation in CrI_(3)/metal heterostructure

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Science China(Physics,Mechanics & Astronomy) 2024年第2期67卷 134-141页

作者： weiwei He Ziming Tang Qihua gong Min yi Wanlin Guo State Key Laboratory of Mechanics and Control for Aerospace Structures Key Laboratory for Intelligent Nano Materials and Devices of Ministry of EducationInstitute for Frontier ScienceNanjing University of Aeronautics and AstronauticsNanjing 210016China MIIT Key Laboratory of Aerospace Information Materials and Physics College of PhysicsNanjing University of Aeronautics and AstronauticsNanjing 211106China

The extraordinary properties of a heterostructure by stacking atom-thick van der Waals(vdW)magnets have been extensively ***,the magnetocaloric effect(MCE)of heterostructures that are based on monolayer magnets remains to be ***,we deliberate MCE of vd W heterostructure composed of a monolayer CrI_(3)and metal atomic layers(Ag,Hf,Au,and Pb).It is revealed that heterostructure engineering by introducing metal substrate can improve MCE of CrI_(3),particularly boosting relative cooling power to 471.72μJ m^(-2)and adiabatic temperature change to 2.1 K at 5 T for CrI_(3)/*** improved MCE is ascribed to the enhancement of magnetic moment and intralayer exchange coupling in CrI_(3)due to the CrI_(3)/metal heterointerface induced charge *** field is further found to tune MCE of CrI_(3)in heterostructures and could shift the peak temperature by around 10 K in CrI_(3)/Hf,thus manipulating the working temperature window of *** theoretical results could enrich the research on low-dimensional magnetocaloric materials.

关键词： magnetocaloric effect heterostructure metal substrate

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Optical coherence tomography angiography metrics in different stages of diabetic macular edema

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Eye and Vision 2024年第3期10卷 13-20页

作者： Ruyi Han Ruowen gong wei Liu Gezhi Xu Eye Institute and Department of Ophthalmology Eye and ENT Hospital of Fudan University83 Fenyang RoadShanghai200031People’s Republic of China Key Laboratory of Visual Impairment and Restoration Fudan UniversityShanghaiPeople’s Republic of China Key Laboratory of Myopia(Fudan University) Chinese Academy of Medical SciencesNational Health CommissionShanghaiPeople’s Republic of China

Background To investigate the optical coherence tomography angiography(OCTA)characteristics of diabetic macular edema(DME)at different *** This study was a cross-sectional *** diagnosed with DME were *** was classified into early,advanced,and severe *** vessel density(VD)in the superficial vascular plexus(SVP),deep vascular plexus(DVP)and foveal avascular zone(FAZ)parameters,including FAZ area,FAZ perimeter,acircularity index and foveal VD in a 300-μm-wide region around the FAZ(FD-300),were calculated by the AngioVue software.A multivariate generalized estimating equation was used to evaluate the associations between visual acuity and OCTA *** Ninety-two eyes from 74 patients with DME were included in this *** to early(P=0.006)and advanced DME(P=0.003),the acircularity index was higher in severe *** whole and parafoveal VD in the DVP decreased in eyes with severe DME compared to early DME(P=0.018,P=0.005,respectively)and advanced DME(P=0.035,P=0.012,respectively).In the multivariate generalized estimating equation,DME severity,FAZ area and foveal thickness were positively associated with worse visual acuity(P=0.001,P=0.007 and P=0.001,respectively).Conclusion Compared to early and advanced DME,severe DME showed increased irregularity in the FAZ and more extensive vessel damage in the *** severity level of DME,larger FAZ area,and increased foveal thickness could be risk factors for poor visual *** registration The protocol was published in the Chinese Clinical Trial Registry(ChiCTR2000033082).

关键词： Optical coherence tomography angiography Diabetic macular edema Vessel density Acircularity index

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Cross section determination of^(27)Al(n,2n)^(26)Al reaction induced by 14-MeV neutrons uniting with D-T neutron activation and AMS techniques

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Nuclear Science and Techniques 2024年第6期35卷 78-89页

作者： Xian-Lin Yang Chang-Lin Lan Yu-Ting wei yi Zhang gong Jiang Bo Xie Yu Liu Hong-Tao Shen Xiao-Jun Sun School of Nuclear Science and Technology Lanzhou UniversityLanzhou 730000China MOE Frontiers Science Center for Rare Isotopes Lanzhou UniversityLanzhou 730000China State Key Laboratory of Environmental Geochemistry Institute of GeochemistryChinese Academy of SciencesGuiyang 550081China Guangxi Key Laboratory of Nuclear Physics and Nuclear Technology Guangxi Normal UniversityGuilin 541004China

Aluminum is the primary structural material in nuclear engineering,and its cross section induced by 14-MeV neutrons is of great *** address the issue of insufficient accuracy for the^(27)Al(n,2n)^(26)Al reaction cross section,the activation method and accelerator mass spectrometry(AMS)technique were used to determine the^(27)Al(n,2n)^(26)Al cross section,which could be used as a D-T plasma ion temperature monitor in fusion *** the China Academy of Engineering Physics,neutron activation was performed using a K-400 neutron generator produced by the T(d,n)4He ***^(26)Al∕^(27)Al isotope ratios were measured using the newly installed GyiG 1 MV AMS at the Institute of Geochemistry,Chinese Academy of *** neutron flux was monitored by measuring the activity of 92mNb produced by the 93Nb(n,2n)92mNb *** measured results were compared with available data in the experimental nuclear reaction database,and the measured values showed a reasonable degree of consistency with partially available literature *** newly acquired cross-sectional data at 12 neutron energy points through systematic measurements clarified the divergence,which has two different growth trends from the existing experimental *** obtained results are also compared with the corresponding evaluated database,and the newly calculated excitation functions with TALYS−1.95 and EMPIRE−3.2 codes,the agreement with CENDL−3.2,TENDL-2021 and EMPIRE−3.2 results are generally acceptable.A substantial improvement in the knowledge of the^(27)Al(n,2n)^(26)Al reaction excitation function was obtained in the present work,which will lay the foundation for the diagnosis of the fusion ion temperature,testing of the nuclear physics model,evaluation of nuclear data,etc.

关键词： 14-MeV neutron ^(27)Al(n,2n)^(26)Al Cross section AMS

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Passive Ubiquitous Perception System Oriented to Aerospace-Ground Internet of Things Communication

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Journal of Communications and Information Networks 2024年第3期9卷 277-285页

作者： Hong Hong wei gong Qiwei Wang School of Electronic and Optical Engineering Nanjing University of Science and TechnologyNanjing 210094China School of Computer Science and Technology University of Science and Technology of ChinaHefei 230027China

Because the aerospace-ground Internet no longer relies on deploying infrastructure such as base stations,it has the advantage of all-weather full coverage services that traditional terrestrial networks do not ***,the traditional global navigation satellite system does not support communication *** newly developing aerospace network system is still in the construction stage,and there is no applicable solution *** communication technology is an important method to solve the contradiction between the low battery capacity of the Internet of things(IoT)node and the high energy consumption of *** is the development trend of the ***,the current passive technology based on Wi-Fi and other signals cannot achieve arbitrary communication due to the excitation signal acquisition *** solve the above two major problems,this paper proposes a passive system design for aerospace-ground IoT *** system can use the global navigation signal as excitation signal for backscatter *** the global navigation signal has the characteristics of all-weather and full coverage,this design solves the carrier acquisition problem in previous *** addition,this paper also proposes a low-power signal detection technology that can detect navigation signals with high precision on passive *** evaluate system performance through simulation *** experimental results show that the backscatter system based on global navigation satellite signals can realize efficient communication of IoT nodes.

关键词： backscatter passive IoT global navigation satellite system aerospace network

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