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Atypical pathogens in community acquired pneumonia of Egyptian children

Asian Pacific Journal of Tropical Medicine 2009年第2期2卷 1-8页

作者： Deraz TE El Sahriggy SA Shaheen MA Motawea AA gomaa he Fawzy SH Mohamed AA Pediatric Department Ain Shams Faculty of Medicine Pediatric Department National Research Center Clinical Pathology Department National Research Center Microbiology Department Ain Shams Faculty of Medicine Cairo 11371 Egypt

Objective:Diagnosis of atypical pathogens as an aetiology for community-acquired pneumonia(CAP) in children is a challenge world *** aim of this study was to detect the frequency of atypical pathogens as a cause of community-acquired pneumonia(CAP) in Egyptian ***:From 50 children(with age ranged from 2 months to 12 years) hospitalized for community-acquired pneumonia;respiratory sputum samples were collected by induction or *** samples were subjected to conventional cultures and Polymerase Chain Reaction(PCR) technique DNA extraction for identification of Mycoplasma,Chlamydia pneumoniae and Legionella ***;A definite pathogen was identified in 78%of the studied children;30% typical bacteria,8%Candida albicans and atypical bacteria in 40%of the pneumonic *** pneumoniae was isolated from 26%of the children while Mycoplasma pneumoniae was isolated from 14%, whereas Legionella pneumophilla was not isolated at ***;Atypical pathogens are evident as a potential aetiology for community-acquired pneumonia in(13.3%) of young and(80%) of older Egyptian children.

关键词： Atypical pathogens Community-acquired pneumonia Children Egypt

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Middle East respiratory syndrome coronavirus： a comprehensive review

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Frontiers of Medicine 2016年第2期10卷 120-136页

作者： Mahmoud M. Shehata Mokhtar R. gomaa Mohamed A. Ali Ghazi Kayali Center of Scientific Excellence for Influenza Viruses National Research Centre Giza Egypt Department of Infectious Diseases St. Jude Children's Research Hospital Memphis TN 38105 USA

The Middle East respiratory syndrome eoronavirus was first identified in 2012 and has since then remained uncontrolled. Cases have been mostly reported in the Middle East, however travel-associated cases and outbreaks have also occurred. Nosocomial and zoonotic transmission of the virus appear to he the most important routes. The infection is severe and highly fatal thus necessitating rapid and efficacious interventions. here, we performed a comprehensive review of published literature and summarized the epidemiology of the virus. In addition, we summarized the virological aspects of the infection and reviewed the animal models used as well as vaccination and antiviral tested against it.

关键词： MERS coronavirus review

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Pituitary macroadenoma apoplexy as a rare complication of Bruton tyrosine kinase inhibitor in chronic lymphoid leukaemia

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Chinese Neurosurgical Journal 2023年第4期9卷 320-325页

作者： Aysha gomaa Robert Skelly East Sussex healthcare NHS Trust EastbourneUK East Suffolk and North Essex NHS Foundation Trust ColcchesterUK

Background Pituitary apoplexy is a neurosurgical emergency and is a known yet rare complication of pituitary *** typically present with visual field defects,headache and altered *** are multiple risk factors for this complication and a thorough drug history is essential to exclude iatrogenic causes of *** present an extremely rare case of newly diagnosed pituitary insufficiency unveiled by ibrutinib therapy(a Bruton tyrosine kinase inhibitor).Furthermore,after initial withdrawal of ibrutinib because of the erroneous diagnosis of Syndrome of Inappropriate Antidiuretic Hormone Secretion(SIADH),its re-administration led to the development of classical pituitary apoplexy 4 months after treatment was *** presentation A male patient in his 60s with a background of chronic lymphocytic leukaemia(CLL)on ibrutinib and venetoclax presents with acute confusion and deranged *** is found to be hyponatraemic and is diagnosed with Syndrome of Inappropriate Antidiuretic Hormone Secretion(SIADH)and treated with fluid *** represents again 3 weeks later with hyponatraemia and further investigations reveal pituitary insufficiency and *** was restarted on ibrutinib and venetoclax at the time of *** months later,he presents with sudden retro-orbital headache associated with *** findings include cranial nerve III,IV and XI ***’s visual field examination revealed a left visual field index(VFI)of only 1%while the right was 64%with temporal *** pupils were mid-dilated and poorly reactive to *** pituitary with contrast showed features of pituitary apoplexy and optic nerve *** was urgently referred to the neurosurgical team and underwent an emergency trans-sphenoidal hypophysectomy with circumferential excision of the ***-operative recovery was uneventful with marked improvement in vision *** patient was restarted on ibruti

关键词： Pituitary apoplexy Pituitary macroadenoma Chronic lymphocytic leukaemia Chemotherapy

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