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Graphene oxide-based hydrogels as a nanocarrier for anticancer drug delivery

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Nano Research 2019年第5期12卷 973-990页

作者： Abdullah A.Ghawanmeh gomaa A.m.ali H.Algarni Shaheen m.Sarkar Kwok Feng Chong Faculty of Industrial Sciences & Technology Universiti Malaysia PahangGambang26300 KuantanMalaysia Chemistry Department Faculty of ScienceAl-Azhar UniversityAssiut71524Egypt Department of Physics Faculty of SciencesKing Khalid UniversityAbha 61413P. O. Box 9004Saudi Arabia Research Center for Advanced materials Science (RCAmS) King Khalid UniversityAbha 61413P. O. Box 9004Saudi Arabia Bernal Institute Department of Chemical SciencesUniversity of LimerickCastletroyV94 LimerickIreland

Graphene oxide (GO) possesses excellent mechanical strength,biocompatibility,colloidal stability,large surface area and high adsorption *** has driven to cancer nanotechnology to defeat cancer therapy obstacles,via integration into three-dimensional (3D) hydrogel network with biocompatible polymers as nanocomposites carrier,and controllable release of anticancer ***,the surface of GO affords π-π stacking and hydrophilic interactions with anticancer ***,modification of GO with various polymers such as natural and synthetic polymers enhances its biodegradability,drug loading,and target *** this review,GO based hydrogels research accomplishments are reviewed on the aspects of crosslinking strategies,preparation methods,the model drug,polymer conjugation and modification with targeting ***,swelling kinetics,drug release profile and biological activity in vivo and in vitro are *** biocompatibility of GO based hydrogels is also discussed from the perspective of its nano-bio *** from that,the clinical potential of GO based hydrogels and its major challenges are addressed in ***,this review concludes with a summary and invigorating future perspectives of GO based hydrogels for anticancer drug *** is anticipated that this review can stimulate a new research gateway to facilitate the development of anticancer drug delivery by harnessing the unique properties of GO based hydrogels,such as large surface area,chemical purity,high loading capacity of drug,chemical stability,and the nature of lipophilic for cell membrane penetration.

关键词： graphe ne oxide cancer nan otechnology hydrogel nanocarrier drug delivery

Experimental Design Technique on Removal of Hydrogen Sulfide using CaO-eggshells Dispersed onto Palm Kernel Shell Activated Carbon：Experiment,Optimization,Equilibrium and Kinetic Studies

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Journal of Wuhan University of Technology(materials Science) 2017年第2期32卷 305-320页

作者： OmAR Abed Habecb RAmESH Kanthasamy gomaa A. m. ali ROSLI bin mohd Yunus Faculty of Chemical & Natural Resources Engineering Universiti Malaysia Pahang Gambang 26300 Kuantan Malaysia Faculty of Industrial Sciences and Technology Universiti Malaysia Pahang Gambang 26300 Kuantan Malaysia Chemistry Department Faculty of Science Al-Azhar University Assiut 71524 Egypt Al-Azhar Center of Nanoscience and Applications (ACNA) Al-Azhar University Assiut 71524 Egypt.

This study presents the use of chicken eggshells waste utilizing palm kernel shell based activated carbon（PKSAC） through the modification of their surface to enhance the adsorption capacity of H2S. Response surface methodology technique was used to optimize the process conditions and they were found to be： 500 mg/L for H2S initial concentration, 540 min for contact time and 1 g for adsorbent mass. The impacts of three arrangement factors（calcination temperature of impregnated activated carbon（IAC）, the calcium solution concentration and contact time of calcination） on the H2S removal efficiency and impregnated AC yield were investigated. Both responses IAC yield（IACY, %） and removal efficiency（RE, %） were maximized to optimize the IAC preparation conditions. The optimum preparation conditions for IACY and RE were found as follows： calcination temperature of IAC of 880 ℃, calcium solution concentration of 49.3% and calcination contact time of 57.6 min, which resulted in 35.8% of IACY and 98.2% RE. In addition, the equilibrium and kinetics of the process were investigated. The adsorbent was characterized using TGA, XRD, FTIR, SEm/EDX, and BET. The maximum monolayer adsorption capacity was found to be 543.47 mg/g. The results recommended that the composite of PKSAC and Ca O could be a useful material for H2S containing wastewater treatment.

关键词： water treatment hydrogen sulfide response surface methodology optimization activated carbon adsorption isotherm kinetics calcium oxide

Superior supercapacitive performance in porous nanocarbons

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Journal of Energy Chemistry 2016年第4期25卷 734-739页

作者： gomaa A.m.ali Shoriya Aruni Abdul manaf Divyashree A Kwok Feng Chong Gurumurthy Hegde Chemistry Department Faculty of ScienceAl-Azhar University Faculty of Industrial Sciences and Technology Universiti Malaysia Pahang BmS R and D Centre BMS College of Engineering

Porous nanocarbons with average particle size 20–40 nm were developed using biowaste oil palm leaves as a *** pyrolysis was carried out at 700 °C under nitrogen *** porous nanocarbons showed excellent porous nature along with spherical *** supercapacitor fabricated from porous nanocarbons showed superior supercapacitance performance where high specific capacitance of 368 F/g at 0.06 A/g in 5 m KOH were *** also exhibited high stability(96% over 1700cycles) and energy density of 13 Wh/*** resistance values were obtained by fitting the impedance spectra,thus indicating the availability of these materials as supercapacitors *** presented method is cost effective and also in line with waste to wealth approach.

关键词： Porous carbon nanoparticles Supercapacitor Catalyst free Biowaste

Generalized uncertainty principle from the regularized self-energy

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Communications in Theoretical Physics 2025年第1期77卷 92-100页

作者： Kimet Jusufi Ahmed Farag ali Physics Department State University of TetovoIlinden Street nn1200TetovoNorth Macedonia Essex County College 303 University AveNewarkNJ 07102United States America Department of Physics Faculty of ScienceBenha UniversityBenha13518Egypt

We use the Schrödinger–Newton equation to calculate the regularized self-energy of a particle using a regular self-gravitational and electrostatic potential derived in string *** particle mass m is no longer concentrated into a point but is diluted and described by a quantum-corrected smeared energy density resulting in corrections to the energy of the particle,which is interpreted as a regularized *** extend our results and find corrections to the relativistic particles using the Klein–Gordon,Proca and Dirac *** important finding is that we extract a form of the generalized uncertainty principle(GUP)from the corrected *** form of the GUP is shown to depend on the nature of particles;namely,for bosons(spin 0 and spin 1)we obtain a quadratic form of the GUP,while for fermions(spin 1/2)we obtain a linear *** correlation we find between spin and GUP may offer insights for investigating quantum gravity.

关键词： generalized uncertainty principle T-duality regularized self-energy

Hybrid and enhanced electrokinetic system for soil remediation from heavy metals and organic matter

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Journal of Environmental Sciences 2025年第1期147卷 424-450页

作者： Faris m.Hamdi Namuun Ganbat ali Altaee Akshaya K.Samal Ibrar Ibrar John L.Zhou Adel O.Sharif Centre for Green Technology School of Civil and Environmental EngineeringThe University of Technology Sydney15 BroadwayNSW 2007Australia Department of Civil Engineering Jazan UniversityJazan 82822Saudi Arabia Centre for Nano and material Sciences Jain UniversityRamanagaraBangaloreKarnataka 562112India School of mechanical Sciences Faculty of Engineering and Physical SciencesUniversity of SurreyAustralia

The electrokinetic(EK)process has been proposed for soil decontamination from heavy metals and organic *** advantages of the EK process include the low operating energy,suitability for fine-grained soil decontamination,and no need for *** the last three decades,enhanced and hybrid EK systems were developed and tested for improving the efficiency of contaminants removal from *** enhanced-EK processes exhibited excellent efficiency in removing contaminants by controlling the soil pH or the chemical reaction of *** hybrid systems were tested to overcome environmental hurdles or technical drawbacks of decontamination *** of the EK process with phytoremediation,bioremediation,or reactive filtermedia(RFm)improved the remediation process performance by capturing contaminants or facilitating biological agents’movement in the ***,EK process coupling with solar energy was proposed to treat off-grid contaminated soils or reduce the EK energy *** study reviews recent advancements in the enhancement and hybrid EK systems for soil remediation and the type of contaminants targeted by the *** study also covered the impact of operating parameters,imperfect pollution separation,and differences in the physicochemical characteristics and microstructure of soil/sediment on the EK ***,a comparison between various remediation processes was presented to highlight the pros and cons of these technologies.

关键词： Electrokinetic Soil remediation Reactive filter media Enhanced electrokinetic Contaminants

Optimizing non-invasive vagus nerve stimulation for treatment in stroke

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Neural Regeneration Research 2025年第12期20卷 3388-3399页

作者： Sheharyar S.Baig Samantha Dorney mudasar Aziz Simon m.Bell ali N.ali Li Su Jessica N.Redgrave Arshad majid Sheffield Institute for Translational Neuroscience Department of NeuroscienceUniversity of SheffieldSheffieldUK Doncaster and Bassetlaw Teaching Hospitals NHS Foundation Trust DoncasterUK

Stroke remains a leading cause of long-term disability *** is an unmet need for neuromodulatory therapies that can mitigate against neurovascular injury and potentially promote neurological *** vagus nerve stimulation has been demonstrated to show potential therapeutic effects in both acute and chronic ***,previously published research has only investigated a narrow range of stimulation settings and *** this review,we detail the ongoing studies of transcutaneous vagus nerve stimulation in stroke through systematic searches of registered clinical *** summarize the upcoming clinical trials of transcutaneous vagus nerve stimulation in stroke,highlighting their indications,parameter settings,scope,and *** further explore the challenges and barriers associated with the implementation of transcutaneous vagus nerve stimulation in acute stroke and stroke rehabilitation,focusing on critical aspects such as stimulation settings,target groups,biomarkers,and integration with rehabilitation interventions.

关键词： neuromodulation neuroplasticity rehabilitation stroke vagal nerve stimulation vagus nerve stimulation

An integrated approach for GLOF hazard,vulnerability and risk assessment in the Karakoram mountain Range of northern Pakistan

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Journal of mountain Science 2025年第1期22卷 142-155页

作者： Sajid ULLAH muhammad SHAFIQUE Ghazanfar ali KHATTAK Attaullah SHAH Yaseen ULLAH National Centre of Excellence in Geology University of PeshawarPeshawar 25000Pakistan GIS and Space Application in Geosciences National Centre of GIS and Space Applications(NCGSA)Islamabad 44000Pakistan Karakoram International University Gilgit 15100Pakistan

Climate change and rising temperatures are accelerating the rate of deglaciation in the Hindu Kush Karakoram Himalaya(HKH)ranges,leading to the formation of new glacial lakes and the expansion of existing *** lakes are often vulnerable to failure,posing a significant threat to downstream communities and ***,a comprehensive assessment of Glacier-Lake Outburst Flood(GLOF)hazards and risk assessment is crucial to evaluate flood runout characteristics and identify settlements and infrastructure that are exposed and vulnerable to floods,aiding in the development and implementation of risk reduction *** study aims to simulate a GLOF event induced by the Shisper glacier lake in northern Pakistan,using the HEC-RAS,and to assess its impact on settlements,infrastructure,and agricultural *** the hydrometeorological analysis of the GLOF event,topographic data from unmanned aerial vehicles(UAVs),stream profiles,discharge data,manning's roughness coefficient(n),and land use/land cover(LULC)were analyzed using HEC-RAS and geographic information system(GIS).During the GLOF event on may 7,2022,a maximum water depth of 6.3 m and a maximum velocity of 9.5 m/s were *** on the runout characteristics of this event,vulnerability and risk assessments have been *** physical,social,and environmental vulnerabilities of the at-risk elements were evaluated using the analytical hierarchy process(AHP)and integrated with the hazard data to develop a risk *** study identified the areas,infrastructure and settlements susceptible to GLOF hazard to support the development and implementation of targeted and evidence-based mitigation and adaptation strategies.

关键词： GLOF Hazard assessment Glacial lake HEC-RAS Vulnerability and risk Shisper glacier

Complement-dependent neuroinflammation in spinal cord injury:from pathology to therapeutic implications

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Neural Regeneration Research 2025年第5期20卷 1324-1335页

作者： Hassan Saad Bachar El Baba ali Tfaily Firas Kobeissy Juanmarco Gutierrez Gonzalez Daniel Refai Gerald R.Rodts Christian mustroph David Gimbel Jonathan Grossberg Daniel L.Barrow matthew F.Gary ali m.Alawieh Department of Neurosurgery Emory University School of MedicineAtlantaGAUSA Department of Neurology Yale UniversityNew HavenCTUSA Center for Neurotrauma Multiomics&Biomarkers(CNMB)Morehouse School of MedicineAtlantaGAUSA

Spinal cord injury remains a major cause of disability in young adults,and beyond acute decompression and rehabilitation,there are no pharmacological treatments to limit the progression of injury and optimize recovery in this *** the thorough investigation of the complement system in triggering and propagating cerebral neuroinflammation,a similar role for complement in spinal neuroinflammation is a focus of ongoing *** this work,we survey the current literature investigating the role of complement in spinal cord injury including the sources of complement proteins,triggers of complement activation,and role of effector functions in the *** study relevant data demonstrating the different triggers of complement activation after spinal cord injury including direct binding to cellular debris,and or activation via antibody binding to damage-associated molecular *** effector functions of complement have been implicated in spinal cord injury,and we critically evaluate recent studies on the dual role of complement anaphylatoxins in spinal cord injury while emphasizing the lack of pathophysiological understanding of the role of opsonins in spinal cord *** this pathophysiological review,we systematically review the different translational approaches used in preclinical models of spinal cord injury and discuss the challenges for future translation into human *** review emphasizes the need for future studies to dissect the roles of different complement pathways in the pathology of spinal cord injury,to evaluate the phases of involvement of opsonins and anaphylatoxins,and to study the role of complement in white matter degeneration and regeneration using translational strategies to supplement genetic models.

关键词： complement neuroinflammation neuroplasticity regeneration spinal cord injury targeted therapy

Effects of rare-earth Pr3+-Dy3+ doping on structural,magnetic,optical and dielectric properties of Zn2Y hexaferrite

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Journal of Rare Earths 2025年第2期43卷 329-336页

作者： Ibrahim mohammed mohamed E.El Sayed ali Shawabkeh mohammad N.murshed Ibtehaj F.Alshdoukhi Zeinhom m.El-Bahy J.mohammed A.K.Srivastava Department of Physics Lovely Professional University Department of Science Technology Waziri Umaru Federal Polytechnic Birnin Kebbi Physics Department Faculty of Science and ArtsKing Khalid University College of Engineering and Technology American University of the Middle East Department of Basic Sciences College of Science and Health ProfessionsKing Saud Bin Abdulaziz University for Health ScienceKing Abdullah International Medical Research Center Department of Chemistry Faculty of ScienceAl-Azhar University Department of Physics Faculty of ScienceFederal University Dutse

This study was conducted to investigate the properties of Pr3+-Dy3+doped Zn2Y-type hexaferrite for potential technological applications.X-ray diffraction（XRD）,Fourier transform infrared spectroscopy（FTIR） and field-emission scanning electron microscopy（FESEm） were used to analyze structural *** crystallite size in the synthesized samples varies between 57.54 and 68.57 *** vibrational bands at 400 and 600 cm-1,common to all hexaferrites,were confirmed through *** FESEm analysis reveals an agglomeration of magnetic grains and a decrease in the average grain size from 1.24 to1.06 μ*** m-H loops show that,with x values of 0.0,0.1,and 0.2,the saturation magnetization is determined to be 34.76,34.23,and 32.52 emu/g,*** corresponding coercivity values are21.24,30.39,and 33.99 ***-visible spectroscopy using Tauc theory reveals an increase in the optical band gap from 2.32 to 2.50 eV,indicating a tunable energy band structure by incorporating Pr3+-Dy3+*** dielectric constant increases,whereas AC conductivity decreases with increased Pr3+-Dy3+*** obtained results suggest the potential suitability of these materials for various technological applications.

关键词： Dielectric constant magnetic hysteresis Optical band gap Pr3+-Dy3+ Rare earths Zn2Y-type hexaferrite