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Interaction of IFNL3 with insulin resistance,steatosis and lipid metabolism in chronic hepatitis C virus infection

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World Journal of Gastroenterology 2013年第41期19卷 7055-7061页

作者： Mohammed Eslam David R Booth Jacob George golo ahlenstiel Storr Liver Unit Westmead Millennium Institute and Westmead HospitalUniversity of SydneySydneyNSW 2145Australia Institute for Immunology and Allergy Research Westmead Millennium InstituteUniversity of SydneySydneyNSW 2145Australia

Metabolic changes are inextricably linked to chronic hepatitis C(CHC).Recently polymorphisms in the IFNL3(IL28B)region have been shown to be strongly associated with spontaneous and treatment induced recovery from hepatitis C virus(HCV)***,circumstantial evidence suggests a link between IFNL3single nucleotide polymorphisms and lipid metabolism,steatosis and insulin resistance in *** emerging picture suggests that the responder genotypes of IFNL3polymorphisms are associated with a higher serum lipid profile,and less frequent steatosis and insulin *** review analyzes the current data regarding this interaction and its meaning for HCV pathogenesis and disease progression.

关键词： IFNL3 Chronic hepatitis C Insulin resistance Lipids

Dendritic cells in hepatitis C virus infection:Key players in the IFNL3-genotype response

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World Journal of Gastroenterology 2014年第47期20卷 17830-17838页

作者： Kate S O'Connor Jacob George David Booth golo ahlenstiel Institute for Immunology and Allergy Research Westmead Millennium InstituteUniversity of SydneySydneyNSW 2145Australia Storr Liver Unit Westmead Millennium Institute and Westmead HospitalUniversity of SydneySydneyNSW 2145Australia

Recently,single nucleotide polymorphisms,in the vicinity of the interferon lambda 3(IFNL3)gene have been identified as the strongest predictor of spontaneous and treatment induced clearance of hepatitis C virus(HCV)*** then,increasing evidence has implicated the innate immune response in mediating the IFNL3 genotype *** cells(DCs)are key to the host immune response in HCV infection and their vital role in the IFNL3 genotype effect is *** have identified subclasses of DCs,particularly myeloid DC2s and potentially plasmacytoid DCs as the major producers of IFNL3 in the setting of HCV *** the complexities of dendritic cell biology and the conflicting current available data,this review aims to summarize what is currently known regarding the role of dendritic cells in HCV infection and to placeit into context of what is know about lambda interferons and dendritic cells in general.

关键词： Hepatitis C virus Interferon lambda 3 Dendritic cells Plasmacytoid dendritic cells Myeloid dendritic cells Innate immunity

Pharmacogenetics of anticancer monoclonal antibodies

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Cancer Drug Resistance 2019年第1期2卷 69-81页

作者： Dmitrii Shek Scott ARead golo ahlenstiel Irina Piatkov Blacktown Clinical School Western Sydney UniversityBlacktownNSW 2148Australia Storr Liver Centre The Westmead Institute for Medical ResearchThe University of SydneyWestmeadNSW 2145Australia Blacktown Hospital BlacktownNSW 2148Australia

Pharmacogenetics is the study of therapeutic and adverse responses to drugs based on an individual’s genetic *** antibodies(mAbs)are a rapidly evolving field in cancer therapy,however a number of newly developed and highly effective mAbs(e.g.,anti-CTLA-4 and anti-PD-1)possess pharmacogenomic profiles that remain largely *** the first chemotherapeutic mAb Rituximab was approved in 1997 by the US Food and Drug Administration for cancer treatment,a broad number of other mAbs have been successfully developed and implemented into oncological ***,mAbs are considered as one of the most promising new approaches for cancer *** efficacy of mAb treatment can however be significantly affected by genetic background,where genes responsible for antibody presentation and metabolism,for example,can seriously affect patient *** review will focus on current anticancer mAb treatments,patient genetics that shape their efficacy,and the molecular pathways that bridge the two.

关键词： Pharmacogenetics pharmacogenomics immune-checkpoint proteins monoclonal antibodies cancer immunotherapy personalized medicine

In-depth profiling of tumor tissue derived from malignant pleural mesothelioma patients identifies potential biomarkers predicting response to immune-checkpoint inhibitor therapy

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Genes & Diseases 2024年第6期11卷 28-31页

作者： Dmitri Shek Bo Gao Hema Mahajan Adnan Nagrial Matteo S.Carlino Fabio Luciani Scott A.Read golo ahlenstiel Blacktown Clinical School Western Sydney UniversitySydneyNSW 2148Australia Westmead Institute for Medical Research SydneyNsw 2145Australia Blacktown Mt Druitt Hospital SydneyNSW 2148Australia Westmead Hospital SydneyNsw 2145Australia Westmead Clinical School University of SydneySydneyNSW 2145Australia Institute of Clinical Pathology and Medical Research SydneyNSW 2145Australia Melanoma Institute Australia SydneyNSW 2065Australia School of Medical Sciences University of New South WalesSydneyNSW 2052Australia Garvan Institute for Medical Research SydneyNSW 2010Australia

Malignant pleural mesothelioma(MPM)is a rare and aggressive cancer with low survival probability as it is generally diagnosed at later stages.'Using a combination of immune-checkpoint inhibitors(ICls)ipilimumab(IPl)and nivolumab(NivO)as a first-line treatment for unresectable MPM,the CheckMate 743 trial reported higher overall survival and prolonged duration of response compared with traditional chemotherapy.

关键词： pleural chemotherapy immune

Distribution and effects of polymorphic RANTES gene alleles in HIV/HCV coinfection - A prospective cross-sectional study

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World Journal of Gastroenterology 2005年第48期11卷 7631-7638页

作者： golo ahlenstiel Agathe Iwan Jacob Nattermann Karin Bueren Jürgen K Rockstroh Hans H Brackmann Bernd Kupfer Olfert Landt Amnon Peled Tilman Sauerbruch Ulrich Spengler Rainer P Woitas Department of Internal Medicine 1 Institute of Experimental Hematology Institute of Medical Microbiology and Immunology TIB MOLBIOL Synthesis Laboratory Goldyne Savad Institute of Gene Therapy

AIM: Chemokines and their receptors are crucial for immune responses in HCV and HIV infection. RANTES gene polymorphisms lead to altered gene expression and influence the natural course of HIV infection. Therefore,these mutations may also affect the course of HIV/HCV ***: We determined allele frequencies of RANTES-403 (G→A), RANTES-28 (C→G) and RANTESIN1.1 (T→C) polymorphisms using real-time PCR and hybridization probes in patients with HIV (n = 85), HCV (n= 112), HIV/HCV coinfection (n = 121), and 109 healthy controls. Furthermore, HIV and HCV loads as well as CD4+ and CD8+ cell counts were compared between different RANTES ***: Frequencies of RANTES-403 A, RANTES-28 G and RANTES-IN1.1 C alleles were higher in HIV infected patients than in healthy controls (-403: 28.2% vs 15.1%,P = 0.002; -28: 5.4% vs 2.8%, not significant; IN1.1:19.0% vs 11.0%, P = 0.038). In HIV/HCV coinfected patients, these RANTES alleles were less frequent than in patients with HIV infection alone (15.4% P = 0.002;1.7%; P = 0.048; 12.0%; not significant). Frequencies of these alleles were not significantly different between HIV/HCV positive patients, HCV positive patients and healthy ***: All three RANTES polymorphisms showed increased frequencies of the variant allele exclusively in patients with HIV monoinfection. The finding that the frequencies of these alleles remained unaltered in HIV/HCV coinfected patients suggests that HCV coinfection interferes with selection processes associated with these alleles in HIV infection.

关键词： RANTES polymorphism HIV/HCV-coinfectJon HCV

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肝脏是一个免疫器官

肝脏 2008年第1期13卷 55-55页

作者： golo ahlenstiel 齐慧慧（译） Immunology Section LDB NIDDKNational Institutes of Health DHHS Bethesda MDUSA 不详

第163届Falk论坛2008年3月14—15日将在中国杭州举行,现将该论坛有关肝脏病的中文摘要介绍给读者,以供参考。若要索取全文资料,请致电深圳市康哲药业有限公司市扬部"优思弗产品事业部",0755-82416868。

关键词：免疫器官肝脏免疫反应细胞抗原递呈作用抗原物质代谢产物 NKT细胞病原微生物