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完全性葡萄胎患者清宫术后人绒毛膜促性腺激素水平与妊娠期滋养层细胞肿瘤风险

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世界核心医学期刊文摘（妇产科学分册） 2006年第2期2卷 4-4页

作者： Wolfberg A.J. Berkowitz R.S. goldstein d.p. 刘亦恒 dr. d.p.rtment of Obstetrics Brigham and Women's Hospital 75 Francis Street Boston MA 02115 United States

Objectives: Women diagnosed with complete hydatidiform molar pregnancy are at 15%to 28%risk of developing persistent gestational trophoblastic neoplasia (GTN) requiring further management with chemotherapy. Our objective was to develop human chorionic gonadotropin (hCG) criteria that establish a patient’s risk of developing persistent GTN or achieving remission from their baseline risk within a few weeks of molar evacuation. Methods: We used a database from the New England Trophoblastic disease Center to analyze hCG levels from 1,029 women with complete molar pregnancies. We conducted a retrospective cohort study using data from 1973 to 2001. Results: Women whose hCG level declined below 50 mIU/mL during their follow-up were found to be at no more than 1.1%risk for developing persistent GTN, irrespective of when this level was reached. Women whose hCG levels was below 200 mIU/mL in the fourth week after evacuation (59.8%of all women), or below 100 mIU/mL in the sixth week after evacuation (65.8%of all women), had a risk of persistence below 9%. hCG levels above 2,000 mIU/mL in the fourth week after evacuation (13.3%of women) were associated with a 63.8%risk of developing persistent disease. Conclusion: These data may allow clinicians to evaluate the risk of persistence that their patients with complete molar pregnancy have based on early hCG results after molar evacuation. In the fourth week after molar evacuation, 59.8%of women may be counseled that their risk of developing persistent GTN is substantially reduced from their baseline, whereas 13.3%of women may be warned that their risk of developing persistent GTN is greater than 50.7%.

关键词：完全性葡萄胎清宫术滋养层细胞疾病中心回顾性队列研究临床病情临床诊断新英格兰

Magnetic Flux Controllers for Induction Heating Applications

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材料热处理学报 2004年第5期25卷 567-572页

作者： Valentin Nemkov Robert goldstein Robert Ruffini FluxtroUCentre for Induction Technology USAFluxtroUCentre for Induction Technology USAFluxtroUCentre for Induction Technology USA

Application of magnetic flux controllers/concentrators to induction heating coils can drastically improve the process efficiency and heat pattern control. presentation includes: benefits provided by flux controllers, materials available for controllers, application techniques, computer assisted design of induction coils with concentrators, examples of applications. d.p.nding on induction system design, magnetic flux controllers can concentrate heating in a specified area, change heat source distribution and shield a particular part zone or external area preventing unintended eddy current heating. Besides of the coil efficiency improvement and optimal power distribution, magnetic flux controllers reduce the coil current demand from a supplying circuitry thus strongly reducing losses in busswork, cables, transformers and inverter components. Improvement that can be achieved due to magnetic flux controllers is case d.p.ndable. 2d and 3d computer simulation allows the designer to predict accurately effect of controllers on the coil parameters and temperature distribution and optimize the whole electromagnetic system. Special attention in presentation is paid to new magnetodielectric materials optimized for induction heating conditions. These materials have high magnetic permeability and saturation flux density, excellent machinability, good chemical and temperature resistance. Concentrators from these materials can work in a wide range of frequencies and specific powers. Examples of magnetic flux controller application include surface hardening of shafts and gears, induction surface hardfacing and brazing.

关键词：热处理感应器磁通量计算机模拟

The roots of urban renaissance

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The roots of urban renaissance

Integrating Biodegradable 3-dimensional-printing into Tracheal Reconstruction

作者： (1982-)goldstein Brian d.

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Open Journal of Regenerative Medicine 2015年第3期4卷 27-33页

作者： Todd A. goldstein Lee p. Smith Benjamin d. Smith daniel A. Grande david Zeltsman Orthopedic Research Laboratory Feinstein Institute of Medical Research Manhasset USA Hofstra North Shore-LIJ School of Medicine Hempstead USA division of pediatric Otolaryngology Steven and Alexandra Cohen Children’s Medical Center New Hyde Park USA d.p.rtment of Orthopedic Surgery North Shore-LIJ Manhasset USA d.p.rtment of Cardiovascular and Thoracic Surgery Long Island Jewish Medical Center New Hyde Park USA

Background: Currently, there is no set standard treatment for long-segment tracheomalacia and stenosis. In this study we set out to explore the potential to create a tissue engineered, biodegradable and three-dimensionally (3d) printed tracheal ring as a first step towards bioengineering a long segment tracheal replacement. Method of Approach: A 3d-Computer aided design (CAd) model was produced with multiple channels to allow for cellular growth while mimicking the native anatomy. The design was optimized to allow for printability, cellular expansion, and integration and 3d.p.inted using a modified commercial 3d.p.inter. Results: The cells grown in the scaffold demonstrated a similar proliferation trend compared to control. Chondrocytes within the 3d.p.inted ring retained their phenotypic properties and did not infer any significant change in flexibility, contour and strength to the scaffold. Conclusion: The combination of living cells and a 3d modeled.p.tient specific graft may address some of the unmet clinical needs in the field of tracheal reconstruction. This proof of concept study represents a first step towards producing a 3d.p.inted and tissue engineered long segment tracheal replacement graft for airway surgery.

关键词： Trachea Tissue Engineering 3d printing Three dimensional printing Bioengineering

Humanitarian action in academic institutions:a case study in the ethical stewardship of unidentified forensic cases

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Forensic Sciences Research 2022年第3期7卷 358-365页

作者： Justin Z.goldstein Mariah E.Moe Emilie L.Wiedenmeyer petra M.Banks Sophia R.Mavroudas Michelle d.Hamilton d.p.rtment of Anthropology Texas State UniversitySan MarcosTXUS

Forensic anthropologists are often responsible for the management of long-term unidentified *** have contextualised these decedents—many of whom likely belonged to socially,politically,and/or economically marginalised groups in life—as part of a larger identification crisis in the ***,there has been little discussion surrounding how this humanitarian crisis has manifested in academic institutions,where anthropologists often provide medicolegal consultation and act as long-term stewards of the *** Identification&Repatriation Initiative was created at the Forensic Anthropology Centre at Texas State University(FACTS)to recognise and investigate unidentified human remains in long-term *** paper outlines common challenges that were encountered during our initial reassessment of unidentified cases at FACTS,emphasising the detrimental impacts of inconsistent procedures,loss of context,and case *** is likely that other academic institutions face similar challenges,and by highlighting these issues we hope to help initiate a larger conversation concerning ethical stewardship of human remains in these *** incorporating humanitarian perspectives into forensic casework,anthropologists in academia can better advocate for the long-term unidentified.

关键词： Forensic sciences forensic anthropology unidentified.p.rsons long-term unidentified identification academic institutions standardisation humanitarian action

Simplifying the ShangRing technique for circumcision in boys and men: use of the no-flip technique with randomization to removal at 7 days versus spontaneous detachment

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Asian Journal of Andrology 2019年第4期21卷 324-331页

作者： Mark A Barone philip S Li Richard K Lee daniel Ouma Millicent Oundo Mukhaye Barasa Jairus Oketch patrick Otiende Nixon Nyangweso Mary Maina Nicholas Kiswi Betty Chirchir Marc goldstein Quentin d Awori EngenderHealth Washington DC 20004 USA Center for Male Reproductive Medicine and Surgery Department of Urology Weill Cornell Medical College New York Presbyterian Hospital New York NY 10065 USA Engender Health Nairobi 00100 Kenya Bon Sante Consulting Nairobi 00100 Kenya Homa Bay County Teaching and Referral Hospital Homa Bay 40300 Kenya Vipingo Health Centre Vipingo 80119 Kenya

To assess safety of the no-flip ShangRing male circumcision technique and to determine clinical course and safety of spontaneous detachme nt (i.e., allowing the device to fall off), we con ducted a case series of no-flip ShangRing circumcision combined with a randomized controlled trial of removal 7 days postcircumcision versus spontaneous detachment at two health facilities in Kenya. The primary outcome was the safety of the no-flip technique based on moderate and severe adverse events (AEs) during the procedure and through 42-day follow-up. A main sec on dary outcome was clinical course and safety of spontan eous detachment. Two hundred and thirty males 10 years and older underwent no?flip circumcision;114 randomized to 7-day removal and 116 to spontaneous detachment. All circumcisions were successfully completed. Overall 5.3%(6/114) of participants in the 7-day group and 1.7%(2/116) in the spontan eous group had an AE;with no d iff ere nces when compared to the 3% AE rate in historical data from African studies using the original flip technique (p = 0.07 and.p.= 0.79, respectively). Overall 72.4%(84/116) of participants in the spontaneous group wore the ShangRing until it detached. Among the remaining (27.6%;32/116), the ring was removed, primarily at the participants1 request, due to pain or discomfort. There was no d iff ere nee in AE rates (p = 0.169), visit day declared healed (p= 0.324), or satisfaction (p= 0.371) between randomization groups. The median time to detachment was 14.0 (IQR: 7-21, range: 5-35) days. The no?flip technique and spontaneous detachment are safe, effective, and acceptable to boys and men 10 years and older. phimosis and.p.nile adhesions do not limit successful ShangRing circumcision with the no-flip technique.

关键词： HIV prevention male circumcision device no-flip technique ShangRing voluntary medical male circumcision

月经周期中黄体期不足的雌二醇与孕酮之间的关系

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国际生殖健康/计划生育杂志 1983年第2期 65-66页

作者： goldstein d ,王玲佳

黄体期不足（Luteal phase deficiency L-pd）被视为不孕原因之一且3.4～35%的患者有早期流产。Lpd可表现为孕酮分泌不足,子宫内膜对孕酮正常水平不反应而呈不合时相型,或异常基础体温（BBT）。可通过子宫内膜活检,多次孕酮测定及BBT等... 详细信息

黄体期不足（Luteal phase deficiency L-pd）被视为不孕原因之一且3.4～35%的患者有早期流产。Lpd可表现为孕酮分泌不足,子宫内膜对孕酮正常水平不反应而呈不合时相型,或异常基础体温（BBT）。可通过子宫内膜活检,多次孕酮测定及BBT等确诊。但对单采用月经前子宫内膜活检诊断黄体分泌功能以及黄体期血清孕酮测定次数和雌二醇（E2）对黄体作用等尚有不少争论。本文目的是研究E2和孕酮在Lpd病因学上所起的作用,提供改进Lpd的诊断及治疗。资料和方法:研究病例为不孕门诊就诊者144人,包括对照组32例。年龄均小于35岁,月经周期

关键词：黄体期孕酮水平子宫内膜子宫黏膜黄体中期孕激素孕酮月经周期

Synthesis and manufacture of photocrosslinkable poly(caprolactone)-based three-dimensional scaffolds for tissue engineering applications

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Advances in Bioscience and Biotechnology 2011年第3期2卷 167-173页

作者： Nathan Castro paul goldstein Malcolm Norman Cooke 不详

It is known that the body can efficiently repair hard tissue (bone) micro fractures by suturing the defect through the d.p.sition of minerals resulting in an area that is stronger post-injury. Larger defects, however, generally cause more trouble since the body is incapable of repairing them. Bone defects can occur as a result of congenital abnormalities, trauma, or disease. Traditional methods for addressing these defects have involved the use of acellular cadaverous bone or autologous bone. Both contain innate prob- lems associated with them;the former method can result in disease transmission, as well as very low integration with the host due to the lack of viable cells while the latter is associated with two surgical sites and morbidity at the donor site. Alternative methods have been developed, but no method has yet provided a satisfactory solution. As a result, resear- chers and the medical community are turning toward the promising fields of biomaterial development and tissue engineering to develop new materials and me- thods of bone regeneration. In this work, a design of experiments (dOE) approach was performed to ren- der commercially available biodegradable polymers (poly(caprolactone)-diol/triol) photocrosslinkable and resultantly manufacturable using stereolithography (SL), a rapid.p.ototyping technology. To perform the investigations, a commercial SL system (Viper HA, 3d Systems, Valencia, CA) equipped with a solid state laser system (355 nm wavelength) was used to manu-facture synthesized.p.ly(caprolactone) trifuma- rate (pCLtF) 3d.p.rous constructs. Results of the work conducted.p.oduced constructs which provided.p.o- mising chemical and biological results for the in- tended application.

关键词： Tissue Engineering poly (Carpolactone) Based Scaffolds Bone Regeneration

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东亚地区癌症负担和预防策略

肿瘤 2008年第5期28卷 410-414页

作者：蔡琳 goldstein Binh Yang pARKIN donald Maxwell 张作风福建医科大学流行病学教研室福州350004 美国加利福尼亚州大学洛杉矶分校公共卫生学院流行病学系 CA90095 牛津大学Radcliffe医院临床试验与流行病学研究室 Oxford OX2 6HE英国

目的:探讨东亚地区当前的癌症负担、危险因素、预防和控制策略。方法:应用全球癌症数据库和5大洲癌症发病资料,利用发病率、死亡率和患病率指标估计东亚地区的癌症负担,分析主要癌症的预防策略。结果:东亚地区癌症的年新发病例数为280万... 详细信息

目的:探讨东亚地区当前的癌症负担、危险因素、预防和控制策略。方法:应用全球癌症数据库和5大洲癌症发病资料,利用发病率、死亡率和患病率指标估计东亚地区的癌症负担,分析主要癌症的预防策略。结果:东亚地区癌症的年新发病例数为280万,死亡病例200多万,现患病例490万。最常见的5种癌症是胃癌、肺癌、肝癌、食管癌和结直肠癌,占东亚地区癌症年新发病例数的68%(分别占癌症年新发病例数的18.7%、16.9%、14.2%、9.4%和9.1%)。预计2050年的癌症新发病例数将达600万,死亡病例450万。结论:癌症是目前和今后东亚地区面临的严重公共卫生问题,必须贯彻以预防为主的方针。

关键词：肿瘤患病代价危险因素综合预防远东