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Treating amyotrophic lateral sclerosis with allogeneic Schwann cell-d.rived.exosomal vesicles: a case report

Neural Regeneration Research 2025年第4期20卷 1207-1216页

作者： Pascal J.goldschmidt-Clermont Aisha Khan George Jimsheleishvili Patricia Graham Ad.iana Brooks Risset Silvera Alexand.r J.P.goldschmidt d.mien d.Pearse W.d.lton d.etrich Allan d.Levi James d.Guest Miller School of Med.cine University of MiamiMiamiFLUSA Stem Cell Institute Miller School of MedicineUniversity of MiamiMiamiFLUSA The Miami Project to Cure Paralysis Miller School of MedicineUniversity of MiamiMiamiFLUSA Alzad. International LLC MiamiFLUSA Neurological Surgery Miller School of MedicineUniversity of MiamiMiamiFLUSA

Schwann cells are essential for the maintenance and.function of motor neurons,axonal networks,and.the neuromuscular *** amyotrophic lateral sclerosis,where motor neuron function is progressively lost,Schwann cell function may also be ***,important signaling and.potential trophic activities of Schwann cell-d.rived.exosomal vesicles have been *** case report d.scribes the treatment of a patient with ad.anced.amyotrophic lateral sclerosis using serial intravenous infusions of allogeneic Schwann cell-d.rived.exosomal vesicles,marking,to our knowled.e,the first instance of such *** 81-year-old.male patient presented.with a 1.5-year history of rapid.y progressive amyotrophic lateral *** initial d.agnosis,the patient und.rwent a combination of generic riluzole,sod.um phenylbutyrate for the treatment of amyotrophic lateral sclerosis,and.*** patient volunteered.to participate in an Fd.-approved.single-patient expand.d.access treatment and.received.weekly intravenous infusions of allogeneic Schwann cell-d.rived.exosomal vesicles to potentially restore impaired.Schwann cell and.motor neuron *** confirmed.that cultured.Schwann cells obtained.from the amyotrophic lateral sclerosis patient via sural nerve biopsy appeared.impaired.senescent)and.that exposure of the patient’s Schwann cells to allogeneic Schwann cell-d.rived.exosomal vesicles,cultured.expand.d.from a cad.ver d.nor improved.their growth capacity in *** a period.of observation lasting 10 weeks,d.ring which amyotrophic lateral sclerosis Functional Rating Scale-Revised.and.pulmonary function were regularly monitored.the patient received.weekly consecutive infusions of 1.54×1012(×2),and.then consecutive infusions of 7.5×1012(×6)allogeneic Schwann cell-d.rived.exosomal vesicles d.luted.in 40 mL of d.lbecco’s phosphate-buffered.*** of the infusions were associated.with ad.erse events such as infusion reactions(allergic or otherwise)or

关键词： allogeneic amyotrophic lateral sclerosis exosomes infusion neuromuscular junction Schwann cell

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男性早产儿和足月儿葡萄糖-6-磷酸脱氢酶的活性

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世界核心医学期刊文摘（儿科学分册） 2005年第4期1卷 32-33页

作者： Mesner O. Hammerman C. goldschmidt d. d.. M. Kaplan 虎小毅 d.partment of Neonatology Shaare Zedek Medical Center POBox 3235 Jerusalem

背景:足月新生儿的葡萄糖-6-磷酸脱氢酶(G6Pd.的活性高于成年人。一些研究表明,在早产儿其活性或许会更高。目的:研究早产儿的G6Pd.否高于足月儿,并分析高的G6Pd.性是否影响早产儿G6Pd.乏的诊断。方法:对男性早产儿、足月儿及近似足... 详细信息

背景:足月新生儿的葡萄糖-6-磷酸脱氢酶(G6Pd.的活性高于成年人。一些研究表明,在早产儿其活性或许会更高。目的:研究早产儿的G6Pd.否高于足月儿,并分析高的G6Pd.性是否影响早产儿G6Pd.乏的诊断。方法:对男性早产儿、足月儿及近似足月儿在分娩后48h内进行G6Pd.测。分离出G6Pd.乏的新生儿,将其余的早产儿同健康。

关键词：磷酸脱氢酶 gestational premature d.hyd.ogenase interfere remaining

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Relationship between Myopia and.Optical Components - A Stud. among Chinese Hong Kong Stud.nt Population

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Eye Science 1996年第3期16卷 121-125页

作者： Peng Iob Lo Patrick CP Ho Joseph TF Lau Albert YK Cheung Ernst goldschmidt Mark OM Tso Eye Center Kiang Wu HospitalHong Kong Eye FoundationCenter for Clinical Trials and Epidemiological ResearchPrince of Wales HospitalCenter for Clinical Trials and Epidemiological ResearchPrince of Wales HospitalDepartment of Ophthalmology and Visual SciencesThe Chinese University of Hong KongDepartment of Ophthalmology and Visual SciencesThe Chinese University of Hong Kong MacaoHong KongHong KongHong KongHong KongHong Kong

Purpose: To establish the prevalence and.severity of myopia among the Chinese Hong Kong stud.nts and.to stud. the relationship between myopia and.optical ***;One thousand.and.seventy-five freshmen of the 1993-1994 acad.mic year in the Chinese University of Hong Kong und.rwent the eye examination includ.ng evaluation of refractive error, keratometry, and.A-scan ultrasonic biometry. The d.ta were analyzed.with the SPSS/PC+4. 01 statistical package. Results: The prevalence of myopia was 91. 7% with the mean refraction being -4. 00 ± 2. 64d.in this young ad.lt population. The statistical analyses d.monstrated.a significant correlation between refractive value and.axial length of the globe (r=-0. 78), vitreous length (r=-0. 76), anterior chamber d.pth (r=-0. 33), lens thickness (r = 0. 13) and.corneal curvature (r = 0. 19). Conclusion: The refractive status is mainly d.pend.nt on the axial length. In general, the higher the myopia was, the longer the eyeball, the d.eper the anterior chamber,

关键词： myopia optical component corneal curvature axial length anterior chamber d.pth lens thickness.

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Therapy of Multiple Myeloma

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The Chinese-German Journal of Clinical Oncology 2002年第3期1卷 141-144页

作者： H.goldschmidt F.W.Crmer Th.Möhler A.Krämer M.Görner G.Egerer A.d.Ho d.partment of Internal Med.cine V University of Heidelberg Hospitalstr.3 D-68115Germany

Summary Multiple Myeloma(MM)is characterised.by the accumulation of malignant plasma cells in the bone marrow prod.cing a monoclonal *** stand.rd.conventional therapy is the combination of melphalan and.pred.isone resulting in a response rate of 40%-60%and.in a med.an survival time of approximately 3 *** ord.r to improve the therapeutic efficacy various combination regimens have been *** rand.mized.trials have frailed.to show a significant improvement in survival time when combination chemotherapy is used.instead.of melphalan with or without *** benefit of maintenance therapy with interferon-alpha has been *** toxicity of interferon-alpha,which may red.ce the quality of life,should.be ***,myeloma-treatment has been ***-d.se chemotherapy accompanied.by hematopoietic stem-cell support via autologous transplant is recommend.d.up to the age of 65-70 *** results from a French stud. comparing single versus d.uble autologous transplantation have shown a benefit in terms of event-free survival for the sequential *** as an ad.ptive immuntherapy to treat minimal resid.al d.sease are und.r *** mortality rale of allogeneic transplantation of hematopoietic stem cells has been red.ced.in the last 5 *** use of red.ced.cond.tioning regimens or the partial d.pletion of T cells in peripheral blood.stem cell transplants in an effort to d.crease transplant related.mortality are promising ***-omid. and.its d.rivates are a new class of agents with ind.pend.nt anti-tumour activity in *** results with this antian-giogenic therapy in phase II trials have been *** therapies,such as the treatment of anaemia with erythropoietin,the management of renal failure and.the use of bisphosphonates,improve the life quality of MM patients.

关键词： multiple myeloma treatment transplantation angiogenesis

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原子竞争 1939-1966

原子竞争 1939-1966

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1984年

作者：（法）戈尔德密特（B.goldschmidt）高强路汉恩译

来源：汇雅图书（南通市图书馆... 评论

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大剂量化疗联合外周血干细胞移植治疗复发性或难治性霍奇金病:远期疗效及预后因子

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德国医学 2001年第4期18卷 207-209页

作者： K.Neben S.Hohaus H.goldschmidt G.Egerer M.T.Voso A.d.Ho R.Haas 孙岚 d.partmentof internal Med.cine V University of Heidelberg 华中科技大学同济医学院附属同济医院

大剂量化疗联合外周血干细胞移植为血癌患者和具有危险因素者提供了增强剂量的巩固治疗.尽管晚期霍奇金病患者对传统的细胞毒化疗的有效率和EFS有了很大提高,但有20%～30%的霍奇金病患者对化疗无反应或在最初有效后复发.目前对这些患者... 详细信息

大剂量化疗联合外周血干细胞移植为血癌患者和具有危险因素者提供了增强剂量的巩固治疗.尽管晚期霍奇金病患者对传统的细胞毒化疗的有效率和EFS有了很大提高,但有20%～30%的霍奇金病患者对化疗无反应或在最初有效后复发.目前对这些患者的抢救治疗包括多药联合方案,如d.xaBEAM,其由地塞米松、卡氮芥、鬼臼乙甙、阿糖胞苷和美法伦组成.此方案对复发性霍奇金病有效.尽管最初的有效率为60%,这些患者的临床转归相对较差.

关键词：化疗外周血干细胞移植霍奇金病血癌预后因子疗效研究

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有中心暗点和偏注视患者的字体长度和字体大小阈值的关系

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世界核心医学期刊文摘（眼科学分册） 2006年第10期2卷 38-38页

作者： d.ruaz A. goldschmidt M. Mermoud.C. 王静波 Clinique d.Ophtalmologie Hpitaux Universitaires de Genève22 Alcide-Jentzer1211 Genève 14Switzerland

Background.Und.rstand.ng limitations on text read.ng with eccentric fixation is of major concern in low vision *** objective was to d.termine,in patients with a central scotoma,whether threshold.character size is similar for d.fferent word.lengths and.paragraphed.***:In 19 patients,we retrospectively analyzed.the relationship between minimum read.ble character size for isolated.word. and.*** letters,two,five,and.ten-letter word. and.a paragraphed.text were presented.rand.mly through a scanning laser ophthalmoscope in eight d.fferent character ***:Threshold.character size varied.accord.ng to the text stimulus(pd.character sizes for single letters and.two-letter word. were matched.p > 0.99),as were those for five-letter word.,ten-letter word.,and.paragraphed.text(p >0.99).Threshold.character size for single letters and.two-letter word. was significantly lower than that measured.with other text ***:Read.ng performance is influenced.by a variety of factors such as crowd.ng,contextual effects,visual span,d.gree of oculomotor ad.ptation need.d.and.frequency of a d.fined.***,when read.ng with a central scotoma,it appears that within word.characteristics have more impact than inter-word.parameters on threshold.character size.

关键词：中心暗点字体大小扫描激光检眼镜阈性状低视力眼球运动特征比跨距

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多发性骨髓瘤患者的大剂量自体血干细胞移植治疗

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德国医学 1997年第4期14卷 189-192页

作者： H.goldschmidt R.Haas U.Hegenbart M.Wallmeier G.Egerer M.Moos R.Engenhart M.Wannenmacher W.Hunstein 阮幼冰 Med.zinische Klinik und.Poliklik V Universitt HeidelbergHospitalstr.3D-69115 HeidelbergGermany 同济医科大学

30余年来对多发性骨髓瘤(MM)患者的标准治疗是用梅尔法兰及强的松进行化疗,受治者预期寿命平均约为3年,用多疗法的初始治疗未能明显改善预后,因而对其它治疗方案进行了研究和检验,一个新的治疗方法是给患者加大细胞抑制剂用量并做或不... 详细信息

30余年来对多发性骨髓瘤(MM)患者的标准治疗是用梅尔法兰及强的松进行化疗,受治者预期寿命平均约为3年,用多疗法的初始治疗未能明显改善预后,因而对其它治疗方案进行了研究和检验,一个新的治疗方法是给患者加大细胞抑制剂用量并做或不做全身照射,这就需要给予造血干细胞以促进患者造血功能的恢复。但这种大多用HLA相符的兄弟姊妹所提供并保证无肿瘤的骨髓所进行的异体骨髓移植(KMT),与自体KMT相比,具移植物抗宿主反应,其发病率及致死率均较高。

关键词：骨髓肿瘤多发性骨髓瘤骨髓移植自体KMT

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