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MMP-9 deficiency accelerates the progress of periodontitis

Genes & Diseases 2024年第5期11卷 117-121页

作者： Chun-Yan Wan Yixin Yin Xiaoyan li Meng Meng liu Graham goldman li-An Wu Feng Wang Dao-Shu luo Zhuo Chen Wen-An Xu Stephen Chen Mary MacDougall Merry l.lindsey Zhi Chen Shuo Chen Department of Endodontics The Affiliated Hospital of Qingdao UniversitySchool of StomatologyQingdao UniversityQingdaoShandong 266003China Department of Developmental Dentistry School of DentistryThe University of Texas Health Science Center at San AntonioSan AntonioTX 78229USA Oral Implantology Center Jinan Stomatological HospitalJinanShandong 250001China Department of Endodontics School and Hospital of StomatologyCheeloo College of MedicineShandong Key Laboratory of Oral Tissue RegenerationShandong Engineering Laboratory for Dental Materials and Oral Tissue RegenerationShandong UniversityJinanShandong 250012China Department of Pediatric Dentistry School of StomatologyThe Fourth Military Medical UniversityXi’anShaanxi 710032China laboratory of Clinical Applied Anatomy Department of Human AnatomySchool of Basic Medical SciencesFujian Medical UniversityFuzhouFujian 350108China Key laboratory for Oral Biomedical Research of Zhejiang Province Affiliated Hospital of StomatologyMedical CollegeZhejiang UniversityHangzhouZhejiang 310027China Department of Stomatology Nanfang HospitalSouthern Medical UniversityGuangzhouGuangdong 510515China UBC Faculty of Dentistry University of British ColumbiaVancouverBC V6T 1Z3Canada School of Graduate Studies and Research Meharry Medical College and Research BiologistResearch Service Nashville VA Medical CenterNashvilleTN 37208USA State Key laboratory Breeding Base of Basic Science of Stomatology(Hubei-MOST) Key Laboratory for Oral Biomedicine of Ministry of Education(KLOBM)School and Hospital of StomatologyWuhan UniversityWuhanHubei 430079China

Periodontitis is a chronic inflammatory disease caused by periodontopathic bacteria that affects periodontal support tissues.1 If left untreated,it results in loss of periodontal attachment and alveolar bone *** one-half of adults in the United States older than 30 years have periodontal disease.2 Though the disease is initiated by bacterial infection,it activates host defense systems that eventually lead to the degradation of the *** periodontitis,the disease progress involves further production of pro-inflammatory mediators such as cytokines,proteolytic enzymes like matrix metalloproteinases(MMPs),and their inhibitors.

关键词： period eventually untreated

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气管憩室

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中华耳鼻咽喉头颈外科杂志 1958年第5期6卷 429-430页

作者： l.goldman J.G.Wilson

气管砠室在临床上很少被診断,往往只在屍体解剖时才發現。Rokitansky氏是首先正确地描述这种病变的一个,認为这种病变的形成是怖和支气管慢性感

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Genetic and phenological variation of tocochromanol(vitamin E)content in wild(Daucus carota ***)and domesticated carrot(*** ***)

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Horticulture Research 2014年第1期1卷 221-226页

作者： Claire H luby Hiroshi A Maeda Irwin l goldman Department of Horticulture University of Wisconsin-MadisonMadisonWI 53706USA Department of Botany University of Wisconsin-MadisonMadisonWI 53706USA

Carrot roots(Daucus carota ***)produce tocochromanol compounds,collectively known as vitamin ***,little is known about their types and *** we determined the range and variation in types and amounts of tocochromanols in a variety of cultivated carrot accessions throughout carrot postharvest storage and reproductive stages and in wild-type roots(Daucus carota ***).Of eight possible tocochromanol compounds,we detected and quantified α-,and the combined peak for β-and γ-forms of tocopherols and *** variation in amounts of tocochromanol compounds was observed across accessions and over *** increases in a-tocopherol were noted during both reproductive growth and the postharvest *** variation of tocochromanols in carrot root tissue provides useful information for future research seeking to understand the role of these compounds in carrot root tissue or to breed varieties with increased levels of these compounds.

关键词： sativa cultivated vitamin

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激光医学:最近一些发展

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中国医疗器械杂志 1976年第5期 98-104页

作者： l.goldman

在过去几年内,激光医学获得了显著的进展。其中最大的进展或许是二氧化碳(CO2)激光手术器的发展。迄今二氧化碳(CO2)激光器主要用于防止高度血液损失(肝、烧伤、根治性颈部手术、癌等)的外科手术以及达到“通过把血管密封”减少癌的传... 详细信息

在过去几年内,激光医学获得了显著的进展。其中最大的进展或许是二氧化碳(CO2)激光手术器的发展。迄今二氧化碳(CO2)激光器主要用于防止高度血液损失(肝、烧伤、根治性颈部手术、癌等)的外科手术以及达到“通过把血管密封”减少癌的传布的目的。对于后一种情况需要“控制”更严的试验。

关键词：激光器会议光激射器电子器件声学全息激光医学

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心脏病患者作普外科手术的估价与准备

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国际心血管病杂志 1981年第2期 103-106页

作者： goldman l 诸骏仁

心脏科医生或内科医生常被要求为心脏病人接受普外科手术作出担保。虽然有时可以结论认为某一病人接受该手术的危险性小,但极少能给予保证。因此,术前心脏评价不应以担保手术作为唯一目的,是为了多种目的而对病人作全面评价。首先,应该... 详细信息

心脏科医生或内科医生常被要求为心脏病人接受普外科手术作出担保。虽然有时可以结论认为某一病人接受该手术的危险性小,但极少能给予保证。因此,术前心脏评价不应以担保手术作为唯一目的,是为了多种目的而对病人作全面评价。首先,应该在了解与高危险性有关的特

关键词：手术危险性心脏病患者普外科手术前后病人心肌梗塞冠心病心律失常起搏器心力衰竭估价

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A Pooling Method Developed for Use in Convolutional Neural Networks

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Computer Modeling in Engineering & Sciences 2024年第10期141卷 751-770页

作者： Ìsmail Akgül Departmant of Computer Engineering Faculty of Engineering and ArchitectureErzincan Binali Yıldırım UniversityErzincan24002Turkiye

In convolutional neural networks,pooling methods are used to reduce both the size of the data and the number of parameters after the convolution of the *** methods reduce the computational amount of convolutional neural networks,making the neural network more *** pooling,average pooling,and minimum pooling methods are generally used in convolutional neural ***,these pooling methods are not suitable for all datasets used in neural network *** this study,a new pooling approach to the literature is proposed to increase the efficiency and success rates of convolutional neural *** method,which we call MAM(Maximum Average Minimum)pooling,is more interactive than other traditional maximum pooling,average pooling,and minimum pooling methods and reduces data loss by calculating the more appropriate pixel *** proposed MAM pooling method increases the performance of the neural network by calculating the optimal value during the training of convolutional neural *** determine the success accuracy of the proposed MAM pooling method and compare it with other traditional pooling methods,training was carried out on the leNet-5 model using CIFAR-10,CIFAR-100,and MNIST *** to the results obtained,the proposed MAM pooling method performed better than the maximum pooling,average pooling,and minimum pooling methods in all pool sizes on three different datasets.

关键词： Pooling convolutional neural networks deep learning

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On the functions of astrocyte-mediated neuronal slow inward currents

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Neural Regeneration Research 2024年第12期19卷 2602-2612页

作者： Balázs Pál Department of Physiology Faculty of MedicineUniversity of DebrecenDebrecenHungary

Slow inward currents are known as neuronal excitatory currents mediated by glutamate release and activation of neuronal extra synaptic N-met hyl-D-aspartate receptors with the contribution of *** events are significantly slower than the excitatory postsynaptic *** of slow inward currents are determined by seve ral factors including the mechanisms of astrocytic activation and glutamate release,as well as the diffusion pathways from the release site towards the extra synaptic recepto *** are stimulated by neuronal network activity,which in turn excite neurons,forming an astrocyte-neuron feedback *** as a consequence of brain edema,astrocytic swelling can also induce slow inward currents under pathological *** is a growing body of evidence on the roles of slow inward currents on a single neuron or local network *** events often occur in synchro ny on neurons located in the same astrocytic *** synchronization of neuronal excitability,slow inward currents also set synaptic strength via eliciting timing-dependent synaptic *** addition,slow inward currents are also subject to non-synaptic plasticity triggered by long-la sting stimulation of the excitatory *** note,there might be important regionspecific differences in the roles and actions triggering slow inward *** greater networks,the pathophysiological roles of slow inward currents can be better understood than physiological *** inward currents are identified in the pathophysiological background of autism,as slow inward currents drive early hypersynchrony of the neural *** inward currents are significant contributors to paroxysmal depolarizational shifts/interictal *** events are related to epilepsy,but also found in Alzheimer's disease,Parkinson's disease,and stroke,leading to the decline of cognitive *** with features overlapping with slow inward currents(excitatory,N-methyl-Dasp

关键词： astrocyte cortical spreading depolarization gliotransmission glutamate neural synchronization NMDA receptor paroxysmal depolarizational shift slow inward current

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Effect of radiative loss mechanisms on FIR thermometric parameters of Nd^(3+)-doped lithium tellurite glasses

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Journal of Rare Earths 2024年第7期42卷 1250-1257,I0002页

作者： C.Y.Morassuti A.P.l Silva l.A.O.Nunes S.M.lima l.H.C.Andrade Optical and Photothermal Spectroscopy Group(GEOF) Center for Studies in Natural Resources(CERNA)State University of Mato Grosso do Sul(UEMS)C.P.351DouradosMSBrazil Renato Archer Information Technology Center Dom Pedro I Highway(SP-65)Km 1436-Chácaras Campos dos AmaraisCampinasSPBrazil Institute of Physics of São Carlos University of São PauloSão CarlosSPBrazil

Nd^(3+)-doped tellurite glasses are promising materials for thermometers based on the fluorescence intensity ratio(FIR)***,at high Nd^(3+)concentrations,energy transfer(ET)processes such as optical reabsorption and cross-relaxation can affect the Nd^(3+)emission,which has been little explored in the ***,the present work investigated the use of Nd^(3+)-doped tellurite glass(samples doped with Nd^(3+)at 0.2 mol%,0.5 mol%,2.0 mol%,and 4.0 mol%)in fluorescence thermometers,in the temperature range from 299 to 371 *** results indicate a strong dependence of the FIR parameters on the Nd^(3+)concentration,due to changes in the emission band profiles caused by optical reabsorption of the Nd^(3+)emissions and cross-relaxation processes.A decrease of the relative sensitivity of the ratio^(4)F_(5/2)→^(4)I_(9/2)/^(4)F_(3/2)→^(4)I_(9/2)is observed for samples doped with higher amounts of Nd^(3+).The maximum relative sensitivity at 299 K is 3.00%/K,which is the highest value among the reported Nd^(3+)ions.

关键词： Nd^(3+)-doped tellurite glass Fluorescence intensity ratio Optical thermometry Judd-Ofelt Rare earths

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Quantum vortices get stretched

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Frontiers of physics 2024年第3期19卷 225-227页

作者： Emanuel A.l.Henn São Carlos Institute of Physics University of São Paulo-PO Box 36913560-970São CarlosBrazil

Since its discovery, superfluidity [1,2] remains one of the most remarkable phenomena in quantum physics. The onset of the quantum regime in liquid helium is visually striking, when the fluid flows without dissipation or detaches from a rotating bucket, remaining still upon soft rotations. The same phenomenon is present in the context of ultracold bosonic quantum gases where, most of the time, superfluidity walks hand-in-hand with the transition to Bose−Einstein condensation [3].

关键词： quantum rotating rotation

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Time-inconsistent stochastic linear-quadratic control problem with indefinite control weight costs

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Science China Mathematics 2024年第1期67卷 211-236页

作者： Qi lü Bowen Ma School of Mathematics Sichuan UniversityChengdu 610064China

A time-inconsistent linear-quadratic optimal control problem for stochastic differential equations is *** introduce conditions where the control cost weighting matrix is possibly *** such conditions,we obtain a family of closed-loop equilibrium strategies via multi-person differential *** result extends Yong’s work(2017) in the case of stochastic differential equations,where a unique closed-loop equilibrium strategy can be derived under standard conditions(namely,the control cost weighting matrix is uniformly positive definite,and the other weighting coefficients are positive semidefinite).

关键词： linear-quadratic optimal control problem time-inconsistent cost functional generalized Riccati equation indefinite control weight cost closed-loop equilibrium strategy

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