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Enigma of primary aortoduodenal fistula

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World Journal of Gastroenterology 2009年第25期15卷 3191-3193页

作者： Miklosh Bala Jacob Sosna Liat Appelbaum eran Israeli Avraham I Rivkind Department of General Surgery and Trauma Unit Hadassah-Hebrew University Medical Center Department of Radiology Hadassah-Hebrew University Medical Center Department of Gastroenterology Hadassah-Hebrew University Medical Center

A diagnosis of primary aortoenteric fistula is difficult to make despite a high level of clinical suspicion. It should be considered in any elderly patient who presents with upper gastrointestinal bleeding in the context of a known abdominal aortic aneurysm. We present the case of young man with no history of abdominal aortic aneurysm who presented with massive upper gastrointestinal bleeding. Initial misdiagnosis led to a delay in treatment and the patient succumbing to the illness. This case is unique in that the fistula formed as a result of complex atherosclerotic disease of the abdominal aorta, and not from an aneurysm.

关键词： Aortoduodenal fistula Gastrointestinal hemorrhage Computed tomography Aortography

Clinical pregnancies and livebirths achieved by intracytoplasmic injection of round headed acrosomeless spermatozoa with and without oocyte activation in familial globozoospermia： case report

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Asian Journal of Andrology 2008年第2期10卷 332-336页

作者： Enver K. Dirican Ahmet Isik KubilayVicdan eran Sozen Zekiye Suludere Department of Embryology Private Ankara IVF Center Ankara 06460 Turkey

We report the successful outcome of intracytoplasmic sperm injection （ICSI） treatment in two siblings with familial globozoospermia. After controlled ovarian hyperstimulation and oocyte pick-up, retrieved oocytes were mechanically activated before ICSI and a fertilization rate of 33.3% was achieved in the first case. The second couple underwent ICSI without oocyte activation and a 9.1% fertilization rate was obtained. The transfer of two grade I embryos in the first couple and one grade I embryo in the second couple resulted in clinical pregnancies with healthy livebirths. It was concluded that the main problem of cases with globozoospermia is a low fertilization rate, and even though ICSI and oocyte activation can increase this rate it is not necessarily needed to achieve a pregnancy. （Asian J Androl 2008 Mar; 10： 332-336）

关键词： intracytoplasmic sperm injection spermatozoa acrosome scanning electron microscopy

MeNA, Controlled by Reversible Methylation of Nicotinate, Is an NAD Precursor that Undergoes Long-Distance Transport in Arabidopsis

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Molecular Plant 2018年第10期11卷 1264-1277页

作者： Ranran Wu Fengxia Zhang Lingyun Liu Wei Li eran Pichersky Guodong Wang State Key Laboratory of Plant Genomics and National Center for Plant Gene Research Institute of Genetics and Developmental Biology Chinese Academy ofSciences Beijing 100101 China Department of Molecular Cellular and Developmental Biology University of Michigan 830 North University Street Ann Arbor MI 48109-1048 USA University of Chinese Academy of Sciences Beijing 100039 China These authors contributed equally to this work.

Nicotinamide adenine dinucleotide （NAD） biosynthesis, including synthesis from aspartate via the de novo pathway and from nicotinate （NA） via the Preiss-Handler pathway, is conserved in land plants. Diverse spe-cies of NA conjugates, which are mainly involved in NA detoxification, were also found in all tested land plants. Among these conjugates, MeNA （NA methyl ester） has been widely detected in angiosperm plants, although its physiological function and the underlying mechanism for its production in planta remain largely unknown. Here, we show that MeNA is an NAD precursor undergoing more efficient long-distance trans-port between organs than NA and nicotinamide in Arabidopsis. We found that Arabidopsis has one meth- yltransferase （designated AtNaMT1） capable of catalyzing carboxyl methylation of NA to yield MeNA and one methyl esterase （MES2） predominantly hydrolyzing MeNA back to NA. We further uncovered that the transfer of [^14C]MeNA from the root to leaf was significantly increased in both MES2 knockdown and NaMTl-overexpressing lines, suggesting that both NaMT1 and MES2 fine-tune the long-distance transport of MeNA, which is ultimately utilized for NAD production. Abiotic stress （salt, abscisic acid, and mannitol） treatments, which are known to exacerbate NAD degradation, induce the expression of NaMT1 but sup-press MES2 expression, suggesting that MeNA may play a role in stress adaption. Collectively, our study indicates that reversible methylation of NA controls the biosynthesis of MeNA in Arabidopsis, which pre-sumably functions as a detoxification form of free NA for efficient long-distance transport and eventually NAD production especially under abiotic stress, providing new insights into the relationship between NAD biosynthesis and NA conjugation in plants.

关键词： nicotinate methyltransferase esterase long-distance transport NAD

Complement-mediated microvascular injury and thrombosis in the pathogenesis of severe COVID-19: A review

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World Journal of Experimental Medicine 2022年第4期12卷 53-67页

作者： Panagiota Gianni Mark goldin Sam Ngu Stefanos Zafeiropoulos Georgios Geropoulos Dimitrios Giannis Department of Internal Medicine III HematologyOncologyPalliative MedicineRheumatology and Infectious DiseasesUniversity Hospital UlmUlm 89070Germany School of Medicine at Hofstra/Northwell Northwell HealthNew YorkNY 11549United States Feinstein Institutes for Medical Research at Northwell Health Feinstein InstitutesNew YorkNY 11030United States Elmezzi Graduate School of Molecular Medicine Northwell HealthNew YorkNY 11030United States Department of General Surgery University College London HospitalsLondon NW12BUUnited Kingdom North Shore/Long Island Jewish General Surgery Northwell HealthNew YorkNY 11021United States

Coronavirus disease 2019(COVID-19)causes acute microvascular thrombosis in both venous and arterial structures which is highly associated with increased *** mechanisms leading to thromboembolism are still under *** evidence suggests that excessive complement activation with severe amplification of the inflammatory response(cytokine storm)hastens disease progression and initiates complement-dependent cytotoxic tissue damage with resultant prothrombotic *** concept of thromboinflammation,involving overt inflammation and activation of the coagulation cascade causing thrombotic microangiopathy and end-organ damage,has emerged as one of the core components of COVID-19 *** complement system is a major mediator of the innate immune response and inflammation and thus an appealing treatment *** this review,we discuss the role of complement in the development of thrombotic microangiopathy and summarize the current data on complement inhibitors as COVID-19 therapeutics.

关键词： COVID-19 Complement Microvascular injury Thromboembolism Cytokine storm Thrombotic microangiopathy

The Table of Sixty-One Headings as a Tool for Finding the Intervals between the Recurrence of Paired Year Codes in the Jewish Calendar

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Open Journal of Applied Sciences 2020年第4期10卷 169-190页

作者： eran Raviv General History: A Science and Halacha Program Bar Ilan University Ramat-Gan Israel

This paper presents an additional mathematical tool that can be used to analyze the Jewish calendar. The table of sixty-one headings was prepared in France, seven hundred and fifty years ago as a tool for finding the year codes for the 19-year of a particular cycle of Jewish years. This unique table demonstrated that there are only 61 possible arrangements of the year codes in these 19-year cycles. The table can be used to calculate the intervals between the appearances of a pair or any series of particular year codes. These intervals create a closed path.

关键词： Calendar Hebrew Calendar Sixty-One Headings

Factors associated with surgery in patients with intra-abdominal fistulizing Crohn's disease

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World Journal of Gastroenterology 2016年第47期22卷 10380-10387页

作者： Shaul Yaari Ariel Benson Eyal Aviran Naama Lev Cohain Ran Oren Jacob Sosna eran Israeli IBD Unit Institute of Gastroenterology and Liver Diseases Hadassah-Hebrew University Medical Center Department of Radiology and Medical Imaging Hadassah-Hebrew University Medical Center

AIM To characterize radiological and clinical factors associated with subsequent surgical intervention in Crohn's disease(CD) patients with intra-abdominal *** From a cohort of 1244 CD patients seen over an eight year period(2006 to 2014), 126 patients were identified as having intra-abdominal fistulae, and included in the study. Baseline patient information was collected from the medical records. Imaging studies were assessed for: anatomic type and number of fistulae; diameter of the inflammatory conglomerate; length of diseased bowel; presence of a stricture with pre-stenotic dilatation; presence of an abscess; lymphadenopathy; and the degree of bowel enhancement. Multivariate analysis for the prediction of abdominal surgery was calculated via Generalized Linear *** In total, there were 193 fistulae in 132 patients, the majority(52%) being entero-enteric. Fifty-nine(47%) patients underwent surgery within one year of the imaging study, of which 36(29%) underwent surgery within one month. Radiologic features that were associated with subsequent surgery included: multiple fistulae(P = 0.009), presence of stricture(P = 0.02), and an entero-vesical fistula(P = 0.01). Evidence of an abscess, lymphadenopathy, or intense bowel enhancement as well as C-reactive protein levels was not associated with an increased rate of surgery. Patients who were treated after the imaging study with combination immunomodulatory and anti-TNF therapy had significantly lower rates of surgery(P = 0.01). In the multivariate analysis, presence of a stricture [RR 4.5(1.23-16.3), P = 0.02] was the only factor that increased surgery *** A bowel stricture is the only factor predicting an increased rate of surgery. Radiological parameters may guide in selecting treatment options in patients with fistulizing CD.

关键词： Crohn’s disease Fistula Cross-sectional imaging Intra-abdominal surgery Magnetic resonance imaging Computed tomography-scan

用ASOM和PDF方程模型模拟湍流射流燃烧

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燃烧科学与技术 2007年第5期13卷 431-436页

作者：王方周力行许春晓 Graham M goldin 清华大学工程力学系 Ansys Inc 10 Cavendish CourtLebanon 03766USA

分别用代数二阶矩(ASOM)湍流燃烧模型和概率密度函数(PDF)输运方程模型模拟了美国Sandia国家实验室测量的甲烷-空气湍流射流燃烧,并将模拟结果与实验结果对比.结果表明,在大多数区域内,两种模型预报的平均温度、平均组分质量分数都与实... 详细信息

分别用代数二阶矩(ASOM)湍流燃烧模型和概率密度函数(PDF)输运方程模型模拟了美国Sandia国家实验室测量的甲烷-空气湍流射流燃烧,并将模拟结果与实验结果对比.结果表明,在大多数区域内,两种模型预报的平均温度、平均组分质量分数都与实验结果符合很好,考虑到ASOM模型的计算量约为PDF方程模拟计算量的1/100,因而认为ASOM模型更适合工程应用.用PDF模拟结果统计的温度和质量分数脉动的自关联,以及反应速率系数脉动和质量分数脉动的互关联,在大多数区域内与对应的时均量的梯度乘积有相似的变化趋势,因此验证了ASOM模型封闭假设的合理性。

关键词：湍流燃烧二阶矩模型标量概率密度函数方程模型

Prior abdominal surgery as a potential risk factor for colonic diverticulosis or diverticulitis

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World Journal of Clinical Cases 2023年第35期11卷 8320-8329页

作者： eran Ariam Vered Richter Anton Bermont Yael Sandler Daniel L Cohen Haim Shirin Department of Gastroenterology Kaplan Medical CenterRehovot 76100Israel The Gonczarowski Family Institute of Gastroenterology and Liver Diseases Shamir Medical CenterZerifin 70300Israel and the Faculty of MedicineTel Aviv UniversityTel AvivIsrael Department of Surgery Division Shamir Medical CenterZerifin 70300Israel

BACKGROUND Abnormal colonic pressure profiles have been associated with an increased risk of colonic diverticulosis.A surgical history is a known risk factor for abdominal adhesions and these may lead to increased intraluminal colonic *** To assess whether previous abdominal surgery is associated with colonic divertic-ulosis or *** We analyzed data from a study of patients undergoing colonoscopy for different indications from 2020 through *** completed a structured question-naire concerning previous abdominal surgeries,dietary and lifestyle exposures including smoking,alcohol use and *** Three hundred and fifty-nine patients were included in the *** mean age was 67.6 and 46%were *** mellitus,hypertension,ischemic heart disease,chronic obstructive pulmonary disease,chronic renal failure,and body mass index were similar in the diverticulosis and control *** overall prevalence of colonic diverticulosis was 25%(91/359)and 48%of the patients had previous abdominal *** expected,the prevalence of diverticulosis increased with *** was no difference in the rate of previous abdominal surgery between patients with or without diverticulosis(49%vs 47%,P=0.78).In regards to specific surgeries,inguinal hernia repair was significantly associated with diverticulosis(52%vs 20%,P=0.001),but not *** contrast,appendectomy was not associated with diverticulosis(6%vs 14%,P=0.048).CONCLUSION These findings suggest that post-operative abdominal adhesions inducing high colonic intraluminal pressures do not appear to be the mechanism for diverticula ***,inguinal hernia and diverticulosis may share similar connective tissue pathologies with no causative relationship between them.

关键词： Diverticulosis Diverticulitis General surgery Adhesions Risk factors Abdomen

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FEATURED REVIEW

Frontiers of History in China 2013年第1期8卷 131-136页

作者： Paul R. goldin University of Pennsylvania E-mail: prg@sas.upenn.edu

This welcome new collaborative volume tells a story that has not been investigated adequately： the rise and spread of literacy in ancient China. While there is a large bibliography of studies of the writing system itself, few scholars have addressed the question of literacy, that is, how writing was used in society,

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