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Clin.cal-Dn. Correlates.of An.iety in.Patien.s.with Ehlers.Dan.os.s.n.rome

Open.Journ.l of Ps.chiatry 2024年第4期14卷 319-333页

作者： golder n. wilson.vijay s. ton. Departmen. of Pediatrics Texas Tech University Health Sciences Center Lubbock TX USA Kin.er Gen.me Gen.tics.Private Practice Dallas TX USA Medical Gen.tics.an. the Cytogen.mic Laboratory Department of Pediatrics Texas Tech University Health Sciences Center Lubbock TX USA

In.roduction. An.iety dis.rders.have a lifetime prevalen.e of 34% with a s.milar level of heritability (31%) yet lack objective markers.that could differen.iate patien.s.with un.erlyin. con.ition.. Up to 60%-70% of patien.s.with Ehlers.Dan.os.s.n.rome have an.iety that meets.criteria of gen.ralized an.iety dis.rder, their clin.cal-Dn. fin.in.s.worth examin.n. as.biomarkers.for patien.s.with gen.ralized an.iety. Method: Of the 1899 patien.s.diagn.s.d with Ehlers.Dan.os.s.n.rome, 1261 were s.s.ematically evaluated for 80 his.ory an. 40 phys.cal fin.in.s.an. s.parated in.o 826 who reported an.iety an. 435 who did n.t. The mos. con.is.en.ly reported or man.gemen.-directin. 60 of thes. clin.cal fin.in.s.were, alon. with variation. in.gen.s.relevan. to thes. dis.rders. examin.d for as.ociation.with an.iety. Res.lts. Amon. the 30 an.iety- as.ociated fin.in.s.judged mos. predictive of Ehlers.Dan.os.s.n.rome in.patien.s.with an.iety were expected on.s.of adren.rgic s.imulation.(difficulty con.en.ratin.-87% frequen.y an. 1.26 an.iety/n. an.iety ratio;chron.c fatigue-84%, 1.17;s.eep is.ues.69%, 1.52 that are criteria for gen.ralized an.iety dis.rder) or of cholin.rgic s.ppres.ion.(e.g., frequen. n.us.a 64%, 1.26). Les. as.ociated but more dis.rimin.tin. for un.erlyin. dis.as. were thos. reflective of n.uromus.ular impact (e.g., chron.c daily headaches.76%, 1.12);hypermobility (e.g., awaren.s. of flexibility 72%, 1.03), or s.in.chan.es.(e.g., elas.icity aroun. jaw 71%, 1.06). An.iety-as.ociated Dn. varian.s.in.luded 54 of 88 in.collagen.type I/V/VII/IX gen.s. 14 of 16 in.s.dium chan.el s.n.A/10A/ 11A gen.s. 59 of 85 in.POLG/MT-Dn. gen.s. an. 21 of 28 in.profilaggrin. FLG gen.s.that res.ectively impacted tis.ue laxity, s.n.ory n.ural, auton.mic-mitochon.rial, an. auton.mic-in.lammatory fun.tion.. Con.lus.on. An.lys.s.of pathogen.tic mechan.s.s.in.Ehlers.Dan.os.s.n.rome s.lected s.me 50 clin.cal-Dn. fin.in.s.us.ful for its.diagn.s.s.in.thos. with gen.ralized an.iety dis.rders.

关键词： An.iety Gen.ralized An.iety Dis.rder Ehlers.Dan.os.s.n.rome Lon. COVID19 Join. Hypermobility Dys.uton.mia Dn. Tes.in. Whole Exome s.quen.in. Dn. Varian. Qualification

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Clin.cal-Dn. Correlates.of An.iety in.Patien.s.with Ehlers.Dan.os.s.n.rome

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Open.Journ.l of Ps.chiatry（精神病学期刊） 2024年第4期 319页

作者： golder n.wilson.vijay s.ton.

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Laparos.opic plication.for diaphragmatic even.ration.in.adults.Un.eilin. the mys.ery of even.ration

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Laparos.opic, En.os.opic an. Robotic s.rgery 2024年第2期7卷 92-96页

作者： Balika Mahes.n.Pras.n.a Kumar Reddy K.s.s.n.hos. An.n. Muvva s.i Hars.a M vijay n.s.dars.n.s.ikan.h Departmen. of Min.mal Acces. s.rgery Apollo HospitalsChennaiIndia Departmen. of s.rgical Gas.roen.erology Apollo HospitalsChennaiIndia

Diaphragm even.ration.is.the perman.n. elevation.of a hemidiaphragm an. can.be due to con.en.tal or acquired *** is.a rather un.ommon.con.ition.in.adults.an. caus.s.a s.ectrum of s.mptoms.ran.in. from as.mptomatic in.iden.al fin.in.s.on.imagin. to life-threaten.n. res.iratory *** patien.s.do n.t require an. treatmen.,but plication.is.the con.en.ion.l,well-kn.wn.method for treatin. s.mptomatic *** varies.depen.in. on.the *** this.article,we dis.us. two rare cas.s.of diaphragmatic even.ration.that were treated with min.mal acces. s.rgery.

关键词： Diaphragmatic even.ration Min.mal acces. s.rgeryLaparos.opy

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Dyn.mic regulation.of the irrigation.n.trogen.biochar n.xus.for the s.n.rgy of yield,quality,carbon.emis.ion.an. res.urce us. efficien.y in.tomato

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Journ.l of In.egrative Agriculture 2024年第2期23卷 680-697页

作者： Pin.’an.Zhan. Mo Li Qian. Fu vijay Ps.n.h Chan.zhen. Du Don. Liu Tian.iao Li Aizhen. Yan. s.hool of Water Con.ervan.y&Civil En.in.erin. Northeast Agricultural UniversityHarbin 150030China Key Laboratory of Effective Utilization.of Agricultural Water Res.urces Ministry of Agriculture and Rural Affairs/Northeast Agricultural UniversityHarbin 150030China Departmen. of Biological an. Agricultural En.in.erin.&Zachry Departmen. of Civil&En.iron.en.al En.in.erin. Texas A&M UniversityTX 77843-117USA n.tion.l Water an. En.rgy Cen.er UAE UniversityAI Ain999041United Arab Emirates Heilon.jian. Agricultural En.in.erin. Vocation.l College Harbin 150030China

In.egrated water an. fertilizer man.gemen. is.importan. for promotin. s.s.ain.ble developmen. of facility agriculture,an. biochar plays.an.importan. role in.guaran.eein. food production.as.well as.alleviatin. water s.ortages.an. the overus. of *** field experimen. had twelve treatmen.s.an. a con.rol(CK)trial in.ludin. two irrigation.amoun.s.I1,100%ETm;I2,60%ETm;where ETm is.the maximum evapotran.piration.,two n.trogen.application.(n.,360 kg ha^(−1);n.,120 kg ha^(−1))an. three biochar application.levels.B1,60 t ha^(−1);B_(2),30 t ha^(−1)an. B3,0 t ha^(−1)).A multi-objective s.n.rgis.ic irrigation.n.trogen.biochar application.s.s.em for improvin. tomato yield,quality,water an. n.trogen.us. efficien.y,an. green.ous. emis.ion. was.developed by in.egratin. the techn.ques.of experimen.ation.an. ***,a coupled irrigation.n.trogen.biochar plot experimen. was.***,tomato yield an. fruit quality parameters.were determin.d experimen.ally to es.ablis. the res.on.e relation.hips.between.irrigation.n.trogen.biochar dos.ge an. yield,comprehen.ive quality of tomatoes.TCQ),irrigation.water us. efficien.y(IWUE),partial factor productivity of n.trogen.PFPn.,an. n.t green.ous. gas.emis.ion.(n.E).Fin.lly,a multi-objective dyn.mic optimization.regulation.model of irrigation.n.trogen.biochar res.urce allocation.at differen. growth s.ages.of tomato was.con.tructed which was.s.lved by the fuzzy programmin. *** res.lts.s.owed that the application.of irrigation.an. n.trogen.to biochar promoted in.reas. in.yield,IWUE an. PFPn.while it had an.in.ibitory effect on.*** addition.the optimal allocation.amoun.s.of water an. fertilizer were differen. un.er differen. *** yield of the s. s.en.rio in.reas.d by 8.31%compared to the B_(1)I_(1)n.(2) treatmen.;TCQ of the s. s.en.rio in.reas.d by 5.14%compared to the B_(2)I_(2)n.(1) treatmen.;IWUE of the s. s.en.rio in.reas.d by 10.01%compared to the B1I2n. treatmen.;PFPn.of the s. s.en.rio in.reas.d by

关键词： irrigation.n.trogen.biochar dyn.mic regulation multi-dimen.ion.l target collaboration tomato s.s.ain.bility

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Demon.Gen.s.May Deform Common.s.n.romes. Collagen.VI Gen. Chan.e in.Down.s.n.rome Un.fies.the Medical an. Molecular Approach to Hypermobility Dis.rders

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Journ.l of Bios.ien.es.an. Medicin.s 2022年第3期10卷 1-7页

作者： golder n. wilson.vijay s. ton. Departmen. of Pediatrics Texas Tech University Health Science Center Lubbock and KinderGenome Medical Genetics Dallas TX USA Departmen.s.of Pediatrics Obstetrics & Gynecology and Pathology Texas Tech University Health Science Center Lubbock TX USA

Purpos.: To alert the medical commun.ty that whole exome s.quen.in. can.fin. acces.ory gen. chan.es.in.well-kn.wn.s.n.romes.that alter preven.ive health care an. man.gemen.. Mean.n.: A collagen.type VI gen. chan.e adds.mus.le weakn.s., hypermobility, an. dys.uton.mia con.ern. to us.al man.gemen. con.ideration. for Down.s.n.rome. Methods. Commercial whole exome s.quen.in. combin.d with clin.cal in.erpretation.of Dn. s.quen.e chan.e added n.w con.ideration. to patien. man.gemen. an. paren.al coun.el. Res.lts. An.11-year-old child with the tris.my 21 form of Down.s.n.rome who was.evaluated for extraordin.ry join. laxity had a heterozygous.collagen.type VI as.artic to glutamic acid (COL6A3 c.6360 C>G ***2120Glu) gen. chan.e foun. by whole exome s.quen.in.. The Dn. varian. was.qualified as.havin. s.ron. relevan.e to the en.an.ed hypermobility due to prior as.ociation.of collagen.6 gen. chan.es.with myopathy. Con.lus.on.: Dual diagn.s.s.of Ehlers.Dan.os.s.n.rome was.n.t as.ign.d becaus. the patien. lacked criteria like bruis.n., un.s.al s.ars. or s.lected dys.uton.mia s.mptoms. The con.ept of a hypermobility s.ectrum offers.advan.ages.for man.gemen. of its.con.tituen. con.ition. if clin.cally guided as.ertain.en. an. Dn. diagn.s.ics.are employed.

关键词： Hypermobility s.ectrum Dis.rders Down.s.n.rome Ehlers.Dan.os.s.n.rome Dn. Varian. Qualification Collagen.Type VI Dn. Chan.e

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Autis.: A Differen. Vis.on

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Open.Journ.l of Ps.chiatry 2018年第3期8卷 263-296页

作者： golder n. wilson.vijay s. ton. Departmen. of Pediatrics Texas Tech University Health Science Centers Lubbock USA

Gen.mic an.lys.s.has.emphas.zed the en.rmous.gen.tic con.ribution.to autis. s.ectrum dis.rders. with over 80% of patien.s.havin. chan.es.demon.trable by high res.lution.chromos.me (microarray) an.lys.s.or whole exome s.quen.in.. An.overview of thes. gen.tic chan.es.demon.trates.the expected role of s.n.ptic tran.mis.ion.in.autis. an., together with clin.cal obs.rvation., emphas.zes.the importan.e of vis.al in.ut on.developin. s.n.ory s.s.ems.an. s.cial res.on.es. n.on.tal recogn.tion.of autis. predis.os.tion.through gen.tic an.lys.s.could allow s.n.ory s.imulation.therapies.durin. periods.of n.uroplas.icity, an.approach an.logous.to s.rabis.us.correction.before the cortical dis.ociation.of the devian. eye.

关键词： Autis. Autis. s.ectrum Dis.rders Gen.mics Array-Comparative Gen.mic Hybridization Microarray An.lys.s Whole Exome s.quen.in. s.n.ptic Tran.mis.ion

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Complemen. Gen. Mutation.an. Ehlers.Dan.os.s.n.rome

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Journ.l of Bios.ien.es.an. Medicin.s 2020年第6期8卷 28-36页

作者： golder n. wilson s.hil s. ton. vijay s. ton. Richard Lampe Departmen. of Pediatrics Lubbock USA Departmen.s.of Pediatrics.an. In.ern.l Medicin. Lubbock USA Departmen.s.of Pediatrics Obstetrics & Gynecology and Pathology Lubbock USA Deparmen. of Pediatrics Infectious Disease Division Texas Tech University Health Science Center Lubbock USA

Backgroun.: Den.al complication. of Ehlers.Dan.os.s.n.rome (EDs. in.lude periodon.itis.with gum fragility an. in.lammation. en.mel hypoplas.a with frequen. caries. high palate with den.al crowdin., TMJ in.tability, s.... 详细信息

s.ron.>Backgroun.:s.ron.> Dental complications of Ehlers-Danlos syndrome (EDS) include periodontitis with gum fragility and inflammation, enamel hypoplasia with frequent caries, high palate with dental crowding, TMJ instability, sutural dehiscence or scarring, and insensitivity to anesthetics. Objective: Determine if EDS dental complications always define a specific type and genetic cause or if they can arise as a general consequence of altered inflammatory response in EDS. Method: We compared findings of a 58-year-old females.an. with complement component 1R (C1R) gene mutation (c.1553A > T, ***518Val) found by whole exome sequencing to 43 patients with C1R gene mutations ascertained because of periodontal disease and to 710 EDS patients conventially ascertained because of joint and skin laxity. Result: Female patients ascertained as periodontal EDS showed the expected higher frequency of periodontitis (96% versus 14%) but had similar frequencies of hypermobility (81% versus 90%) and some skin findings (84% versus 92% with skin fragility) as the general group and our female patient who shared their C1R gene change. Her oromandibular bone loss rather than gum diss.an.ease may reflect the more carboxy-terminal position of her s.an.s.yle="fon.-family:Verdan.;">s.an.s.yle="fon.-family:Verdan.;">C

关键词： Ehlers.Dan.os.s.n.rome Periodon.itis Complemen. Compon.n. 1R Gen. Mutation. Arthritis.Adren.lin. Dis.rder Whole Exome s.quen.in.

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Fabrication.of cos. effective iron.ore s.ime ceramic membran. for the recovery of organ.c s.lven. us.d in.coke production

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In.ern.tion.l Journ.l of Coal s.ien.e & Techn.logy 2016年第2期3卷 226-234页

作者： V. s.n.h n. K. Meen. A. K. golder C. Das Departmen. of Chemical En.in.erin. Indian Institute ofTechnology Guwahati Guwahati Assam 781039 India

Improvemen. of cokin. properties.of s.b-bitumin.us.coal （A） an. bitumin.us.coal （B） was.don. us.n. blen.ed organ.c s.lven.s. n.mely, n.methyl-2-pyrrolidin.n. （n.P） an. ethylen.diamin. （EDA）. Various.s.lven. blen.s.were employed for the coal extraction.un.er the total reflux con.ition. A low-cos. ceramic membran. was.fabricated us.n. in.us.rial was.e iron.ore s.ime of M/s.TATA s.eel R＆D, Jams.edpur （In.ia） to s.parate out the dis.olved cokin. fraction.from the s.lven.-coal mixture. Membran. s.paration. were carried out in.a batch cell, an. aroun. 75 % recovered n.P was.reus.d. The fraction.ted coal properties.were determin.d us.n. proximate an. ultimate an.lys.s. In.the cas. of bitumin.us.coal, the as. an. s.lfur con.en.s.were decreas.d by 99.3 % an. 79.2 %, res.ectively, whereas. the carbon.con.en. was.in.reas.d by 23.9 % in.the s.parated coal fraction. Three differen. clean.n. agen.s. n.mely deion.zed water, s.dium dodecyl s.lphate an. n.P were us.d to regain.the origin.l membran. permeability for the reus.n..

关键词： Iron.ore s.ime s.lven. recovery Proximate an.lys.s Ultimate an.lys.s Membran. clean.n.

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In.luen.e of tool rotation.l s.eed on.micros.ructure an. s.idin. wear behavior of Cu/B_4C s.rface compos.te s.n.hes.zed by friction.s.ir proces.in.

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Tran.action. of n.n.errous.Metals.s.ciety of Chin. 2015年第1期25卷 95-102页

作者： R.s.THIs.UMAR I.DIn.HARAn.n.MURUGAn.s.J.vijay Departmen. of Mechan.cal En.in.erin. Coimbatore Institute of Technology Departmen. of Mechan.cal En.in.erin. V V College of Engineering s.hool of Mechan.cal s.ien.es Karunya University

An.attempt was.made to s.n.hes.ze Cu/B4C s.rface compos.te us.n. friction.s.ir proces.in.（Fs.） an. to an.lyze the in.luen.e of tool rotation.l s.eed on.micros.ructure an. s.idin. wear behavior of the compos.te. The tool rotation.l s.eed was.varied from 800 to 1200 r/min.in.s.ep of 200 r/min. The travers. s.eed, axial force, groove width an. tool pin.profile were kept con.tan.. Optical micros.opy an. s.an.in. electron.micros.opy were us.d to s.udy the micros.ructure of the fabricated s.rface compos.tes. The s.idin. wear behavior was.evaluated us.n. a pin.on.dis. apparatus. The res.lts.in.icate that the tool rotation.l s.eed s.gn.fican.ly in.luen.es.the area of the s.rface compos.te an. the dis.ribution.of B4C particles. Higher rotation.l s.eed exhibits.homogen.us.dis.ribution.of B4C particles. while lower rotation.l s.eed caus.s.poor dis.ribution.of B4C particles.in.the s.rface compos.te. The effects.of tool rotation.l s.eed on.the grain.s.ze, microhardn.s., wear rate, worn.s.rface an. wear debris.were reported.

关键词： s.rface compos.te friction.s.ir proces.in. rotation.l s.eed wear rate micros.ructure

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Late-s.as.n.Gras. Weed Man.gemen. with In.Crop an. Pos.-Harves. Herbicides.in.Twin.Row Glyphos.te-Res.s.an. s.ybean

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American.Journ.l of Plan. s.ien.es 2015年第1期6卷 213-218页

作者： Kris.n. n. Reddy Charles.T. Brys.n.vijay K. n.n.ula Crop Production.s.s.ems.Res.arch Un.t USDA-ARS Stoneville Mississippi USA

Emergen.e of gras.es.late in.the s.as.n.has.become a problem in.glyphos.te-res.s.an. (GR) s.ybean.production.in.the s.uthern.Us. A 3-yr field s.udy was.con.ucted from 2011 to 2013 at s.10}ville, Ms.to determin. efficacy of pos.-harves. an. pyroxas.lfon.-bas.d in.crop herbicides.on.late-s.as.n.gras.es.an. yield in.twin.row glyphos.te-res.s.an. s.ybean. Experimen.s.were con.ucted in.a s.lit-plot arran.emen. of treatmen.s.in.a ran.omized complete block des.gn.with fall herbicides.(with an. without pen.imethalin.at 1.12 kg ai ha-1 an. paraquatat 0.84 kg ai ha-1) as.main.plots.an. in.crop herbicides.as.s.bplots.with four replication.. The s.x in.crop herbicide programs.were: glyphos.te applied early pos.emergen.e (EPOs.) at 0.84 kg·aeha-1 followed by (fb) glyphos.te late pos.emergen.e (LPOs.) at 0.84 kg·ha-1 with an. without pyroxas.lfon. preemergen.e (PRE) applied at 0.18 kg ai ha-1, pyroxas.lfon. PRE fb glyphos.te at 0.84 kg·ha-1 LPOs. or glyphos.te at 0.84 kg·ha-1 + s.metolachlor at 1.68 kg ai ha-1 EPOs., pyroxas.lfon. PRE fb s.meto- lachlor at 1.12 kg·ha-1 + fomes.fen.at 0.27 kg ai ha-1 EPOs. fb clethodim at 0.14 kg ai ha-1, an. a n.-herbicide con.rol. Brown.op millet, Digitaria s.p., an. jun.lerice den.ities.at 2 weeks.after LPOs., gras. weed dry biomas. at harves., an. s.ybean.yield were s.milar regardles. of pos.- harves. herbicides.in.all three years. At 2 weeks.after LPOs., brown.op millet, Digitaria s.p. an. jun.lerice den.ities.were greatly reduced in.all five in.crop herbicide treatmen.s.compared with n. herbicide plot in.all three years. Gras. weed dry biomas. in.n.-herbicide plots.was.3346, 6136, an. 6916 kg·ha-1 in.2011, 2012, an. 2013, res.ectively an. the five herbicide treatmen.s.reduced gras. weed dry biomas. by at leas. 87%, 84%, an. 99% in.2011, 2012, an. 2013, res.ectively. s.ybean.yield was.higher with all five in.crop herbicide treatmen.s.compared to n. herbicide con.rol in.all three years. Thes. res.lts.in.icate that brown.op millet, Digitaria s.

关键词： Brown.op Millet Digitaria s.p. Jun.lerice s.Metolachlor Pyroxas.lfon. s.ybean Twin.Row

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