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Next generation sequencing in oral disease diagnostics

World Journal of Stomatology 2018年第2期6卷 6-10页

作者： gokul sapna Sridharan gokul Department of periodontics Nair Hospital Dental College Oral Pathology and Microbiology YMT Dental College and Hospital

DNA sequencing is the method of identifying the precise order of DNA nucleotides within a molecule. The information of DNA sequencing is of prime requisite for basic biological research as well as in various clinical specialties.They can be used to determine the individual genetic sequence, larger genetic regions, chromosomes as well as to sequence RNA and proteins. Since the first DNA sequencing in 1970s, there has been tremendous advancements in the technologies aimed to determine the entire human genome. The need for rapid and accurate sequencing of human genome has resulted in the introduction of next generation sequencing(NGS) technology. NGS refers to the secondgeneration DNA sequencing technologies where millions of DNA can be sequenced simultaneously. Some of the next gen sequencing methods employed are Roche/454 life science, Illumina/Solexa, SOLiD system and HeliScope.Application of NGS in decoding the genomic database of various oral diseases may possess therapeutic and prognostic value. This presentation provides an overview of the basics of NGS and their potential applications in oral disease diagnostics.

关键词： DNA测序染色体口腔卫生治疗方法

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Pharmacogenomics in oral diseases

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World Journal of Stomatology 2013年第4期2卷 67-70页

作者： Sridharan gokul gokul sapna Oral Pathology and Microbiology YMT Dental College and HospitalKhargharNavi Mumbai-410210MaharashtraIndia Department of Periodontics Nair Hospital Dental CollegeMumbai-400008MaharashtraIndia

The availability of newer technologies for identification and characterization of the human genome has enabled our understanding of the genetic variations in a majority of human diseases.Human genomic sequence varies in less than 1%among the different population group and these differences known as gene polymorphisms are the primary reasons for differences in individuals’response to various drug therapy.Also understanding the genetic changes may enable implementation of targeted therapy,thus providing for effective treatment strategies and minimizing the adverse side effects.Pharmacogenomics is a recent development in the field of personalized medicine which focuses on the genetic determinants of drug response at the levels of entire human genome.It primarily deals with tailoring of drug therapy for every individual based on their genetic make-up and identifying new target in various diseases for drug therapy.While the application of pharmacogenomics in systemic illness is well researched,its role in oral diseases needs documentation.Identifying specific targets in periodontitis,head and neck cancer,infections and genetic disorders can be beneficial in discovery of new drugs.This editorial provides an overview of basics of pharmacoge-nomics,its current role in disease management and its potential role in various head and neck diseases.

关键词： Pharmacogenomics Oral Cancer Periodontal diseases Genomic variations Targeted drug therapy

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