检索结果-南通市图书馆

Biliary atresia and congenital disorders of the extrahepatic bile ducts

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastrointestinal Pharmacology and Therapeutics 2022年第4期13卷 33-46页

作者： Ali Islek gokhan tumgor Department of Pediatric Gastroenterology Cukurova University School of MedicineAdana 01320Turkey

Biliary atresia(BA)and choledochal cysts are diseases of the intrahepatic and extrahepatic biliary *** their exact etiopathogeneses are not known,they should be treated promptly due to the potential for irreversible parenchymal liver disease.A diagnosis of BA may be easy or complicated,but should not be *** is always treated surgically,and performing the surgery before the age of 2 mo greatly increases its effectiveness and extends the time until the need for liver transplantation *** the more common types of choledochal cysts require surgical treatment,some can be treated with endoscopic retrograde *** cysts may cause recurrent cholangitis and the potential for malignancy should not be ignored.

关键词： Bilier atresia Choledochal cyst Cholestasis Conjugated hyperbilirubinemia

Acute-on-chronic liver failure in children

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Hepatology 2021年第10期13卷 1289-1298页

作者： Ali Islek gokhan tumgor Department of Pediatric Gastroenterology Cukurova University School of MedicineAdana 01330Turkey

Although various complex definitions of acute-on-chronic liver failure(ACLF)have been suggested in relation to adult patients,there is currently no universal definition of the syndrome in pediatric *** simplified terms,ACLF is characterized by the acute deterioration of the liver functions due to the effects of a precipitating factor on the basis of a chronic liver *** events and underlying liver diseases are very different in children from those seen in ***,acute events and underlying chronic liver diseases vary among geographical regions,although it seems that the most common such diseases and acute events are autoimmune hepatitis,Wilson’s disease,and their *** is associated with a poor *** no scoring systems have been developed to predict the prognosis for children with ACLF,modified versions of the Asian Pacific Association for the Study of the liver’s acute-on-chronic liver failure scoring system and the Chronic Liver Failure-Sequential Organ Failure Assessment criteria can be used in children until specific and validated scoring systems are *** from liver transplantation,there is no proven treatment for ***,the early recognition of ACLF prior to the development of extrahepatic organ failure is important.

关键词： Liver failure Prognosis Prevalence Clinics Histopathology Scoring systems Treatment

Cirrhosis and hepatopulmonary syndrome

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2014年第10期20卷 2586-2594页

作者： gokhan tumgor Department of Pediatric Gastroenterology Cukurova University Medical Faculty 01380 Sar?cam AdanaTurkey

Hepatopulmonary syndrome(HPS)is characterized as a triad:liver disease,intrapulmonary vascular dilatation and arterial *** is reported to be present in 4%to 32%of adult patients with end-stage liver disease and in 9%-20%of *** pathogenesis of HPS has not been clearly *** hypertension causes impairment in the perfusion of the bowel and increases the enteral translocation of Gram(-)bacteria and *** stimulates the release of vasoactive mediators,such as tumor necrosis factor-alpha,heme oxygenase-derived carbon monoxide and nitric *** alterations have not been associated with this syndrome yet;however,cytokines and chemokines have been suggested to play a ***,it was reported that cumulated monocytes lead to the activation of vascular endothelial growth factor-dependent signaling pathways and pulmonary angiogenesis,which plays an important role in HPS *** present,the most effective and only radical treatment is a liver transplant(LT).Cirrhotic patients who are on the waiting list for an LT have a shorter survival period if they develop ***,it is suggested that all cirrhotic cases should be followed closely for HPS and they should have priority in the waiting list.

关键词： Cirrhosis Hepatopulmonary syndrome Pathophysiology

Inflammatory bowel disease in Turkish children

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Pediatrics 2015年第4期11卷 331-337页

作者： Murat Cakir Fatih Unal Gonul Dinler Masallah Baran Hasan Ali Yuksekkaya gokhan tumgor Erhun Kasirga Ayhan Gazi Kalayci Sema Aydogdu Department of Pediatric Gastroenterology Hepatology and Nutrition Faculty of MedicineKaradeniz Technical UniversityTrabzonTurkey Dortcelik Children Hospital BursaTurkey 19 Mayis University SamsunTurkey Tepecik Education and Research Hospital IzmirTurkey Necmettin Erbakan University KonyaTurkey Cukurova University AdanaTurkey Celal Bayar University ManisaTurkey Ege University IzmirTurkey

Background:This study was undertaken to evaluate demographics,clinical manifestations,laboratoryfi ndings and outcomes of children with inflammatory bowel disease(IBD)in ***:We analyzed the medical records of 127 children diagnosed with IBD(under 18 years old)between January 2004 and January 2012 in 8 pediatric gastroenterology ***:Of the 127 patients,90(70.9%)suffered from ulcerative colitis(UC),29(22.8%)from Crohn's disease(CD),and 8(6.3%)from IBD *** mean age of the 127 patients was 11.6±4.1 years,and 11.8%of the patients were below 5 years *** the patients,49.6%were male,and males were more predominant in patients with CD than in those with UC(72.4%vs.42.2%,P=0.008;a male/female ratio of 2.62 in CD,P=0.0016).Approximately one fifth of the patients had extra-intestinal manifestations and 13.3%of the patients had associated *** manifestations and associated diseases were more common in early onset disease[P=0.017,odds ratio(OR)=4.02;P=0.03,OR=4.1].Of the patients,15%had normal laboratory parameters including anemia,high platelet count,hypoalbuminemia,hypoferritinemia,and high sedimentation *** under receiver operation characteristics was used to predict pancolitis in patients with *** values of C-reactive protein,sedimentation rate and pediatric ulcerative colitis activity were 0.61(P=0.06),0.66(P=0.01)and 0.76(P=0.0001),***(4.4%)patients with UC underwent colectomy,andfi nally two(1.5%,95%confidence interval:0-3.7%)patients died from primary disease or ***:IBD is an increasing clinical entity in *** of IBD are similar to those in other populations,but prospective multicenter studies are needed to analyze the true incidence of IBD in Turkish children.

关键词： associated diseases Crohn's disease infl ammatory bowel disease outcome ulcerative colitis