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International Journal of Ophthalmology(English edition) 2015年第5期8卷 945-949页

作者： Adem Turk Osman Melih Ceylan gokcen gokce Mehmet Borazan Mehmet Kola Department of Ophthalmology Faculty of MedicineKaradeniz Technical University Department of Ophthalmology Medical Park Hospital Department of Ophthalmology Kayseri Military Hospital Department of Ophthalmology Faculty of MedicineMevlana University

AIM: To compare the effectiveness of brimonidine/timolol fixed combination(BTFC) and dorzolamide/timolol fixed combination(DTFC) in the management of short-term intraocular pressure(IOP) increase after phacoemulsification surgery.·METHODS: Eighty eyes of 80 patients undergoing phacoemulsification and intraocular lens(IOL)implantation were randomly assigned into three *** 1 consisted of 28 eyes and represented the control group. Group 2 consisted of 25 eyes undergoing phacoemulsification surgery and BTFC was instilled at the end of surgery. Group 3 consisted of 27 eyes undergoing phacoemulsification surgery and DTFC was instilled at the end of surgery. IOP was measured preoperatively and 6, 24 h and 1wk postoperatively.·RESULTS: There was no statistically significant difference in preoperative baseline IOP among the three groups(P =0.84). However, IOP was significantly lower in groups 2 and 3 compared to the control group(P 25 mm Hg at 6h after surgery(P =0.008). However, IOP decreased and was >25 mm Hg in only one eye in each group at24 h after surgery.·CONCLUSION: BTFC and DTFC have similar effects in reducing increases in IOP after phacoemulsificationsurgery and can both be recommended for preventing IOP spikes after such surgery.

关键词： cataract brimonidine dorzolamide timolol intraocular pressure phacoemulsification postoperative complication

Fourier analysis of corneal Scheimpflug imaging:clinical use in keratoconus

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International Journal of Ophthalmology(English edition) 2021年第12期14卷 1963-1969页

作者： Dorukcan Akincioglu Gokhan Ozge Onder Ayyildiz gokcen gokce Umut Karaca Fatih Mehmet Mutlu Ataturk State Hospital Antalya 07040Turkey Department of Ophthalmology Gulhane School of MedicineUniversity of Health SciencesAnkara 06010Turkey Department of Ophthalmology Gülhane Training and Research HospitalAnkara 06010Turkey Memorial Hospital Kayseri 38010Turkey Department of Ophthalmology Suleyman Demirel UniversityIsparta 32040Turkey

AIM:To evaluate the clinical use of Fourier analysis of videokeratography data in the diagnosis and follow-up of keratoconus(KC).METHODS:We conducted a chart review of consecutive patients presented to our cornea clinic.A team of two experienced cornea specialists divided the patients into three groups:normal cornea,forme fruste KC(FFKC),and clinical *** exclusion criteria were a history of previous ocular surgery,any accompanying corneal pathology other than KC,high myopia(>6.00 diopters),amblyopia,pregnancy,breastfeeding,or any current autoimmune *** data of Fourier series harmonic analysis were evaluated for their diagnostic capacity using the receiver operating characteristic(ROC)curve.A binary logistic regression analysis was also conducted to construct a diagnostic model.A total of 259 eyes showed progression in the clinical KC group and underwent a combination of accelerated corneal collagen cross-linking and topographyguided customized treatment with an excimer ***:The study included 1262 eyes(618 normal,530 KC,and 114 FFKC)of 1262 *** observed that maximum decentration(MaxDec)was almost as good as maximum keratometry(Kmax)in detecting progressive *** area under the curve(AUC)was 0.95 for KC[95%confidence interval(CI):0.93-0.96]and 0.84 for FFKC(95%CI:0.79-0.88).Higher predictive accuracy was obtained using a model combining the spherical component,MaxDec,irregularity,and regular astigmatism in the center of the cornea(AUC:0.97;sensitivity:89%,and specificity:96%).CONCLUSION:Decentration,Kmax,and posterior radii of curvatures from a 3.0-mm optical zone centered on the thinnest point of the cornea provide the highest accuracy with low reproducibility of Kmax.

关键词： Fourier keratoconus Scheimpflug imaging tomography topography

Comment on survival analysis following early surgical success in intermittent exotropia surgery

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International Journal of Ophthalmology(English edition) 2016年第10期9卷 1532-1534页

作者： Onder Ayyildz Gokhan Ozge Cem Ozgonul gokcen gokce Fatih Mehmet Mutlu Department of Ophthalmology Gulhane Military Medical School Ankara 06010 Turkey Department of Ophthalmology Van Military Hospital Van65100 Turkey Department of Ophthalmology Kayseri Military HospitalKayseri 38100 Turkey

Dear Editor,We read the article by Lee et al with great *** would like to congratulate the authors for venturing into this area that assess the consecutive recurrence following early success of intermittent exotropia[X（T）]surgery and to determine the clinical factors that affect the ***,we would like to make the following *** the present study,it was discussed about the correlation of early postoperative overcorrection with long-term outcomes.

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Novel biomarkers for patients with idiopathic acute anterior uveitis:neutrophil to lymphocyte ratio and platelet to lymphocyte ratio

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International Journal of Ophthalmology(English edition) 2017年第2期10卷 262-266页

作者： Cem Ozgonul Erdim Sertoglu Onder Ayyildiz Tarkan Mumcuoglu Murat Kucukevcilioglu gokcen gokce Ali Hakan Durukan Kellogg Eye Center University of MichiganAnn ArborMI48105USA Department of Biochemistry Gulhane Military Medical AcademyHaydarpasa Training HospitalIstanbul 34512Turkey Department of Ophthalmology Gulhane Military Medical AcademyAnkara 06065Turkey

AIM： To assess the levels of the neutrophil to lymphocyte ratio（N/L） and the platelet to lymphocyte ratio（P/L） in patients with idiopathic acute anterior uveitis（AAU） and to compare with healthy ***： Thirty-six male patients with idiopathic AAU and 36 male healthy subjects were enrolled in this retrospective *** ophthalmological examination and complete blood count measurements results of all subjects were ***： There was a significant difference in N/L and P/L between idiopathic AAU and control groups（P=0.006,P=0.022）.Also,correlation analysis revealed a significant correlation between C-reactive protein（CRP） and N/L（P= 0.002;r=0.461）.CONCLUSION： Our study for the first time provides evidence of N/L and P/L may be useful biomarkers in patients with idiopathic AAU.N/L is correlated with CRP,so it can be a useful biomarker to predict the prognosis in idiopathic AAU.

关键词： C-reactive protein inflammation neutrophil lymphocyte platelet uveitis

单剂量0.15%酒石酸溴莫尼定对正常个体脉络膜厚度的影响（英文）

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国际眼科杂志 2017年第11期17卷 2000-2004页

作者： Suleyman Demircan gokcen gokce Mustafa Atas Ahmet Gulhan Burhan Baskan Gokmen Zararsiz 开塞利医疗研究医院眼科土耳其开塞利38010 开塞利军事医院眼科土耳其开塞利38010 埃尔吉耶斯大学生物统计学系土耳其开塞利38010

目的:通过使用频域相干光学断层深度增强成像测量正常个体脉络膜厚度(CT)以评估眼部使用0.15%酒石酸溴莫尼定对眼后节的潜在影响。方法:前瞻性、安慰剂对照干预性临床试验,包括32例32眼正常个体。第1d,受试者接受一滴无防腐剂人工泪液... 详细信息

目的:通过使用频域相干光学断层深度增强成像测量正常个体脉络膜厚度(CT)以评估眼部使用0.15%酒石酸溴莫尼定对眼后节的潜在影响。方法:前瞻性、安慰剂对照干预性临床试验,包括32例32眼正常个体。第1d,受试者接受一滴无防腐剂人工泪液作为安慰剂;第2d,接受一滴0.15%酒石酸溴莫尼定。收集每次用药前及用药后1、3和5h,眼压,眼灌注压(OPP)以及EDI-SD-OCT数据。结果:相较于最初测量结果,局部应用0.15%酒石酸溴莫尼定后,在下凹(P=0.001),颞凹1500μm处(P=0.003),鼻凹1500μm处(P=0.003)测得脉络膜厚度显著增加。整个研究过程中,安慰剂组脉络膜厚度未发生变化(P>0.05)。分别使用安慰剂和溴莫尼定后眼灌注压没有显著降低(P>0.05)。研究中未观察到不良反应。结论:与预期相悖,局部应用0.15%酒石酸溴莫尼定导致下凹、颞凹、鼻凹处脉络膜厚度增加。

关键词：溴莫尼定脉络膜厚度增强深度成像眼压光学相干断层扫描

土耳其人Duane眼球后退综合征的临床特点及手术疗效分析（英文）

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国际眼科杂志 2019年第5期19卷 714-718页

作者： Osman Melih Ceylan Adem Turk Gken Gkce ?nder Ayyildiz Fatih Mehmet Mutlu Halil Ibrahim Altinsoy Diskapi Yildirim Beyazit 培训及研究医院眼科土耳其安卡拉06110 Karadeniz 工业大学医学院眼科土耳其特拉布宗61080 开塞利纪念医院眼科土耳其开塞利38010 Gülhane 培训及研究医院眼科土耳其06010 土耳其伊斯坦布尔世界眼科医院 34337

目的:分析Duane眼球后退综合征(DRS)患者的临床特点及手术疗效。方法:评估94例DRS患者临床数据。记录完整的眼科数据,包括年龄、性别、侧位、DRS类型、偏角、异常头部姿势(AHP)、眼球后退、过冲及手术入路类型。结果:患者年龄为15.4±9... 详细信息

目的:分析Duane眼球后退综合征(DRS)患者的临床特点及手术疗效。方法:评估94例DRS患者临床数据。记录完整的眼科数据,包括年龄、性别、侧位、DRS类型、偏角、异常头部姿势(AHP)、眼球后退、过冲及手术入路类型。结果:患者年龄为15.4±9.18岁,其中78例男性,16例女性。单侧和双侧受累分别为87%和13%。在单侧DRS患者中,左眼占65%。94例患者中,59.5%的患者为I型,29.7%的患者为II型,8.5%的患者为III型,2.1%的患者为IV型。大多数患者(36,38%)为嗜热性,43例(96%)患者术前AHP出现10°以上。有40例(43%)患者出现过度调校,通常为II型。对45例(48%)患者进行手术治疗。共32例(78%)行水平直肌手术后获得了较好疗效,24例(53%)患者AHP改善。结论:侧直肌的Y分裂和后榫固定在有明显过校的情况下都有令人满意的结果。垂直直肌转位增强术在限制外展方面取得了最佳效果。

关键词： Duane眼球后退综合征斜视手术结果

Validation of the PAGE-B score to predict hepatocellular carcinoma risk in caucasian chronic hepatitis B patients on treatment

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World Journal of Gastroenterology 2022年第6期28卷 665-674页

作者： Pinar gokcen Fatih Guzelbulut Gupse Adali Ayca gokce Degirmenci Salturk Oguzhan Ozturk Ozgur Bahadir Emine Kanatsiz Mevlut Kiyak Kamil Ozdil Hamdi Levent Doganay Department of Gastroenterology Health Sciences UniversityUmraniye Teaching and Research HospitalIstanbul 34764Turkey Department of Gastroenterology Health Sciences UniversityHaydarpasa Numune Teaching and Research HospitalIstanbul 34668Turkey

BACKGROUND Several risk scores have been developed to predict hepatocellular carcinoma(HCC)risk in chronic hepatitis B(CHB)*** majority of risk scores are based on pretreatment variables that are no longer considered risk factors for HCC development due to the suppression of hepatitis B virus replication early in the course of potent antiviral treatment in most *** PAGE-B score,which is based on platelet levels,age and sex,has been shown to accurately predict HCC risk in CHB patients on antiviral treatment in various *** We aimed to evaluate the PAGE-B score in predicting HCC risk in Turkish CHB patients on antiviral *** In this study,we recruited 742 CHB patients who had been treated with tenofovir disoproxil fumarate or entecavir for≥1 *** groups were determined according to the PAGE-B scores as follows:≤9,low;10-17,moderate and≥18,*** cumulative HCC incidences in each risk group were computed using Kaplan-Meier analysis and were compared using the log-rank *** accuracy of the PAGE-B score in predicting HCC risk was evaluated using a timedependent area under the receiver operating characteristic(AUROC)curve at all study time *** and multivariate logistic regression analyses were used to assess the risk factors for HCC *** The mean follow-up time was 54.7±1.2 *** was diagnosed in 26 patients(3.5%).The cumulative HCC incidences at 1,3,5 and 10 years were 0%,0%,0%and 0.4%in the PAGE-B low-risk group;0%,1.2%,1.5%and 2.1%in the PAGE-B moderate-risk group;and 5%,11.7%,12.5%,and 15%in the PAGE-B high-risk group,respectively(log-rank P<0.001).The AUROCs of the PAGE-B score in the prediction of HCC development at 1,3,5 and 10 years were 0.977,0.903,0.903 and 0.865,*** the multivariable analysis,older age,male sex,lower platelet levels,presence of cirrhosis,and absence of alanine aminotransferase normalization at month 6 were associated with HCC development(all P<0.05).C

关键词： Chronic hepatitis B Hepatocellular carcinoma PAGE-B score Surveillance