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Genetic Disposition: Susceptibility of Human Blood Groups and Abo Analysis to Malaria and Typhoid Infections

Advances in Infectious Diseases 2024年第3期14卷 497-510页

作者： Mbeh Ubana Eteng Ekpe Onot Okon Nyakno Akpan Essien Ugochukwu Iloh godwin oju igile Patrick Ubi Esukwu Richard Undigweundeye Ukpanukpong Ubong Edet Akpan Adaeze Bobchile-Agada Etim Esin Etim John ojuwu Ojowu Nnennaya Precious Akpa-Onyeabor Ayiku Audu Fanziya Mary Joan Obianuju Ngumah Mcvain Akpam Ugor Department of Biochemistry Faculty of Basic Medical Sciences College of Medical Sciences University of Calabar Calabar Nigeria Department of Biochemistry Faculty of Science Imo State University Owerri Nigeria Department of Biochemistry College of Biological Sciences Federal University of Agriculture Makurdi (JOSTRUM) Benue Nigeria School of Applied Sciences Department of Science Laboratory Technology Federal Polytechnic Wannue Benue State Benue Nigeria School of Applied Sciences and Technology College of Agriculture Science and Technology Lafia Nasarawa Nigeria Department of Biology Alvan Ikoku University of Education Owerri Nigeria

Background: Malaria and typhoid have remained major infectious tropical diseases. Clinically, whenever there is severe malaria, cough is always an associating symptom owing to typhoid infection arising from poor hygiene in respect to drinking water and food. There is a strong association between human blood group and disease. Residual malaria transmission, effect of climate change on malaria vector composition, environmental management targeted at malaria breeding control as an intervention strategy are areas of interest to WHO in malaria control in Sub-saharan Africa. A body of data is been built on susceptibility of human blood groups to malaria, HIV and HBV and presently malaria and typhoid. If climate change warrants a change in composition of vectors and as well resistance to ACT therapy, the susceptibility or vulnerability of the human blood group is also called to question. The link between susceptibility of human blood group to malaria and typhoid has not been previously investigated. Purpose: The present study assesses the genetic disposition (susceptibility of human blood groups and abo analysis) to malaria and typhoid infections. Patients and Methods: One hundred (100) patients were screened for malaria and typhoid infections in a tertiary health facility—His glory hospital Lagos, Nigeria. Blood samples were collected by venu-puncture from 53 females and 47 males adults aged between 15 – 47 years, who were infected either singly or coinfected with malaria and typhoid. Microscopic detection of P. falciparum, widal serological technique for salmonella antibody presence and genotypic determination were all done using standard WHO methods. Human material or data were analyzed or performed in accordance with the declaration of Helsinki (2000). Ethical clearance was obtained from the ethic and research committee of the Ministry of Health via the Faculty of the Basic Medical Sciences, University of Calabar (Ethical Certificate number CRS/MOH/HRP/2023/396). Resul

关键词： Malaria Plasmodium Falciparium Genotype Genetig Disposition

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