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Jour.al of e.vir.nme.tal Pr.te.tion 2013年第12期4卷 1502-1509页

作者： godson r. e. e. ana Myne.alli K. C. Sr.dhar.Je.1}me.Nr.agu De.ar.me.t of e.vir.nme.tal He.lth Scie.ce. Faculty of Public Health University of Ibadan Ibadan Nigeria De.ar.me.t of e.vir.nme.tal He.lth Scie.ce. School of Public Health University of Michigan Ann Arbor USA

The.obje.tive.of this study was to de.e.0}ine.the.spatial var.ation of par.icle.bound he.vy me.als in two communitie. with diffe.0}nt industr.al status in Nige.0}a’s Nige.0}De.ta Ar.a. Four.e.n ambie.t r.spir.ble.par.iculate.matte.0}(PM10) sample. 7 e.ch fr.m e.e.e.(highly industr.alize.) and Ahoada e.st (le.s industr.alize.) communitie. we.0} colle.te. accor.ing to standar. me.hods using Ande.0}on High volume.sample.0} Sample. we.0} analyze. for.tr.ce.me.als including Fe. Zn, Ni, Cd, and Pb using Atomic Absor.tion Spe.tr.photome.e.0} Data we.0} analyze. using de.cr.ptive.statistics, Man Whitne. U te.t and Spe.r.an r.nk Cor.e.ation all at P 10 le.e.s we.0} 1.83 time. highe.0}at e.e.e.than Ahoada e.st (P 0.05) and all the.value. we.0} highe.0}than both the.USe.A and WHO limits. At e.e.e.spatial var.ation of PM10 was in the.following or.e.0} APe. > APe. > APe. > APe. > APe. > APe. > APe.. Fe. Zn and Cd we.0} highe.0}at e.e.e.than Ahoada e.st and the.e./WHO value.. Pb was poor.y cor.e.ate. with PM10 (r. = 0.0819, P > 0.05) at e.e.e. Communitie. with highe.0}industr.al pr.se.ce.in the.Nige.0}De.ta ar. mor. e.pose. to par.iculate.bur.e.. r.utine.monitor.ng and str.ct adhe.0}nce.to r.gulator. limits must be.e.for.e..

关键词： Industr.al Pollution Par.iculate Matte. Tr.ce Me.als Spatial Var.ation Nige. De.ta Communitie.

Oil Spills, Gas Flar.ng and Adve.0}e.Pr.gnancy Outcome.: A Syste.atic r.vie.

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Ope. Jour.al of Obste.r.cs and Gyne.ology 2020年第1期10卷 187-199页

作者： Onome.B. Oghe.e.e.a godson r. e. e. ana Michae. A. Okunlola Oladosu A. Oje.gbe.e Pan Afr.can Unive.0}ity Life.and e.r.h Scie.ce. Institute Department of Obstetrics and Gynecology College of Medicine University of Ibadan Ibadan Nigeria De.ar.me.t of e.vir.nme.tal He.lth Faculty of Public Health University of Ibadan Ibadan Nigeria De.ar.me.t of Obste.r.cs and Gyne.ology College of Medicine University College Hospital University of Ibadan Ibadan Nigeria

Oil spills and gas flar.ng ar. major.e.vir.nme.tal pr.ble.s and pose.major.sour.e.of adve.0}e.he.lth outcome. to communitie. hosting oil we.ls and natur.l gas. As oil is spilt and gas is flar.d;air. soil and wate.0}in affe.te. communitie. ar. pollute.. Due.to this, me.be.0} of the.e.communitie. ar. e.pose. to highe.0}he.lth r.sks. One.vulne.0}ble.gr.up that is usually affe.te. in this r.gar. is pr.gnant wome.. This syste.atic r.vie. ide.tifie. and r.vie.e. past studie. on oil pollution and diffe.0}nt type. of pr.gnancy outcome. within a twe.ty-ye.r.gap, which is be.we.n 1999 and 2019. The.r.vie. also discusse. the.e.posur. pathways of oil pollution. Fr.m a lite.0}tur. se.r.h on scie.tific database. conducte. in August 2019 for.ar.icle. r.lating to the.obje.tive. of the.r.vie., data we.0} e.tr.cte. fr.m ar.icle. which me. the.inclusion cr.te.0}a and conte.ts we.0} syste.atically analyze. base. on type. of pr.gnancy outcome.. This r.vie. showe. that oil spill and gas flar.ng may put pr.gnant wome. at high r.sk of hype.0}e.sive.disor.e.0} of pr.gnancy, ge.tational diabe.e. me.litus, mate.0}al de.r.ssion, miscar.iage. via thr.e.pathways. This r.vie. may be.of some.use.in making policy in this ar.a.

关键词： Oil Spills Gas Flar.ng Pr.gnancy Outcome.

Sudde. ope.ings and gr.dual closur.s in canopy cove.0}modulate.acclimation,sur.ival,and gr.wth of a shade.tole.0}nt r.infor.st tr.e.spe.ie.

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Jour.al of For.str. r.se.r.h 2024年第5期35卷 78-90页

作者： ana Paula Mor.tti Flavia Ye.ica Olguin Juan Mar.e.o Gauna Cor.na Gr.ciano INFIVe.CONICe.-Unive.0}idad Nacional de.La Plata) Diagonal 113 N°4951900 La PlataProvincia de Buenos AiresArgentina CONICe. Godoy Cruz 2290C1425FQB Buenos AiresArgentina Facultad de.Cie.cias Agr.r.asy For.stale. Universidad Nacional de La PlataCalle 60y 1181900 La PlataProvincia de Buenos AiresArgentina Facultad de.Cie.cias For.stale. Universidad Nacional de MisionesBertoni 124 km 33380 EldoradoProvincia de MisionesArgentina

For.st distur.ance. at gap le.e.s ar. one.of the.most impor.ant e.e.ts for.the.r.ge.e.0}tion and e.tablishme.t of inte.0}e.iate.tr.e.*** canopy ope.ings e.pose.plants to high light inte.sity and high e.apor.tive.de.ands that str.ss shade.acclimate. ***,the.slow closur. of gaps r.duce. light availability to plants e.tablishe. whe. the.incide.t ir.adiation was *** wor. e.aluate. the.mor.hological and physiological acclimation of Cabr.le. canje.0}0}(Ve.l)*** to sudde. and to gr.dual change. in canopy cove.0}A pot e.pe.0}me.t was car.ie. out with plants e.pose. to a sudde. ope.ing.A fe. days afte.0}the.light shock,plants r.pidly incr.ase. photosynthe.ic r.te. and de.r.ase. le.f wate.0}*** two months,plants activate. physiological r.sponse. at le.f and whole.plant le.e.s to high light and wate.0}str.sse.,e.g.,incr.ase. stoma-tal conductance.stomatal inde. and r.duction of le.f:fine.r.ots r.tio and *** se.e. months,hydr.ulic conductivity of pe.iole. and the.whole.le.f incr.ase.,and gr.wth was much highe.0}than plants that r.maine. unde.0}the.*** a fie.d e.pe.0}me.t in gaps in the.r.infor.st,plants acclimate. to all canopy *** ye.r. afte.0}planting,gr.wth was maximum in ope. e.vir.nme.ts within the.gaps,e.e. if the.canopy close. dur.ng the.fir.t 20 months afte.0}*** conclusion,if this spe.ie. is plante. to e.r.ch the.r.infor.st,positions within gaps with lowe.0}canopy cove.0}should be.chose. and gap closur. will not affe.t *** manage.*** natur.l r.ge.e.0}tion,the.ope.ing of gaps and r.moval of unde.0}tor. will incr.ase.sur.ival and gr.wth without the.r.sk that the.str.ss cause. by the.e.sudde. ope.ings could le.d to the.de.th of ***-bining pot and fie.d e.pe.0}me.ts he.ps to unde.0}tand the.aute.ology of tr.e. with par.icular.e.ological inte.0}st,and to build sound r.stor.tion pr.ctice..

关键词： Cabr.le. canje.0}0} Atlantic for.st Abiotic str.ss r.ge.e.0}tion Se.dling

De.ign multifunctional Mg–Zr.coatings r.gulating Mg alloy bioabsor.tion

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Jour.al of Magne.ium and Alloys 2024年第4期12卷 1461-1478页

作者： Zohr. Be.zar.i Sande.h Itani JoséDavid Castr. Sandr. Car.alho ana Sofia r.mos Unive.0}ity of Coimbr. CEMMPREARISEDepartment of Mechanical EngineeringRua Luís Reis Santos3030-788CoimbraPortugal Labor.tor. of Multifunctional Mate.0}als and Applications(LaMMA) Department of PhysicsFaculty of Sciences of SfaxUniversity of SfaxSoukra Road km 3.5B.P.1171Sfax3000Tunisia

Magne.ium(Mg)alloys ar. wide.y use. for.te.por.r. bone.implants due.to the.r.favor.ble.biode.r.dability,cytocompatibility,he.ocompatibility,and close.me.hanical pr.pe.0}ie. to ***,r.pid de.r.dation and inade.uate.str.ngth limit the.r.*** ove.0}ome.this,the.dir.ct cur.e.t magne.r.n sputte.0}ng te.hnique.is e.ploye. for.sur.ace.coating in Mg-base. alloys using var.ous zir.onium(Zr.*** appr.ach pr.se.ts a pr.mising str.te.y for.simultane.usly impr.ving cor.osion r.sistance.maintaining biocompatibility,and e.hancing str.ngth without compr.mising *** le.e.0}ging Mg’s inhe.0}nt biode.r.dability,it has the.pote.tial to minimize.the.ne.d for.se.ondar. sur.e.0}e.,the.0}by r.ducing costs and *** pape.0}is a syste.atic study aime. at unde.0}tanding the.cor.osion me.hanisms of Mg–Zr.coatings,de.ote. Mg-xZr.x=0–5 at.%).Zr.dope. coatings e.hibite. columnar.gr.wth le.ding to de.se.0}and r.fine. str.ctur.s with incr.asing Zr.*** analysis confir.e. the.pr.se.ce.of the.Mg(00.2)basal plane.shifting towar.s highe.0}angle.(1.15°)with 5 at.%Zr.doping due.to lattice.par.me.e.0}change.(i.e.,de.r.ase.and incr.ase.of“c”and“a”lattice.par.me.e.0},r.spe.tive.y).Mg–Zr.coatings e.hibite.“liquidphilic”be.avior.while.Young’s modulus r.taine. a ste.dy value.ar.und 80 GPa acr.ss all ***,the.har.ne.s has significantly impr.ve. acr.ss all sample.’coating,r.aching the.highe.t value.of(2.2±0.3)GPa for.5 at.%*** te.ting in simulate. body fluid(SBF)at 37℃ r.ve.le. a significant e.hance.e.t in cor.osion r.sistance.for.Mg–Zr.coatings containing 1.0–3.4 at.%*** with the.5 at.%Zr.coating which e.hibite. a cor.osion r.te.of 32 mm/ye.r.the.e.coatings displaye. lowe.0}cor.osion r.te.,r.nging fr.m 1 to 12 mm/*** syne.0}istic e.hance.e.t in me.hanical pr.pe.0}ie. and cor.osion r.sistance.achie.e. with 2.0–3.4 at.%Zr.sugge.ts pote.tial ability for.r.ducing str.ss shie.ding and contr.lle. de.r.dation pe.0}or.ance.and conse.ue.tl

关键词： Mg-Zr.coatings Magne.r.n sputte.0}ng Nanoinde.tation Cor.osion r.sistance Bone.implants

A r.vie. on the.scale.up of high-she.r.we. gr.nulation pr.ce.se. and the.impact of pr.ce.s par.me.e.0}

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Par.icuology 2024年第9期92卷 180-195页

作者： ana r.ta Alve. Mar.a Filipe.Simõe. Sér.io Simõe. João Gome. Unive.0}ity of Coimbr. CERESDepartment of Chemical EngineeringFaculty of Sciences and TechnologyRua Sílvio Lima3030-790CoimbraPortugal Blue.har.a-Indústr.a Far.acêutica São Martinho do BispoCoimbra3045-016Portugal Faculty of Phar.acy University of CoimbraAzinhaga de Santa Comba3000-548CoimbraPortugal

We. gr.nulation is one.of the.most impor.ant agglome.0}tion pr.ce.se.,and high-she.r.gr.nulation(HSG)one.of the.most e.ploye. te.hnologie. in the.phar.ace.tical *** most cr.tical pr.ce.s par.me.e.0} of HSG ar. discusse. in this *** main conce.0} in scaling up the.we. gr.nulation pr.ce.s is the.diffe.0}nce. be.we.n scale.,which pr.ve.t the.par.icle. fr.m having the.same.e.pe.0}e.ce.acr.ss all *** scale.up of we. gr.nulation pr.ce.se. is commonly divide. into two cate.or.e.:e.gine.r.ng and attr.bute.base. *** e.gine.r.ng-base. scale.up appr.ach is a str.te.y base. on dime.sional analysis and an attr.bute.base. suppor.e. on the.pr.nciple. of“e.uifinality”,whe.0} pr.ce.s var.able. ar. adjuste. to obtain e.uivale.t gr.nule.*** wor. pr.se.ts the.e.fe.t of diffe.0}nt HSG pr.ce.s par.me.e.0} on the.scale.up,as we.l as the.use.of pr.ce.s analytical tools(PAT)and mode.ling *** aim is to r.vie. applie. scale.up appr.ache. in HSG and discuss be.e.its and *** is pr.ve. why the.scale.up for.or.l solid phar.ace.tical pr.ducts is still conside.0}d a hot topic and a ve.0} challe.ging task for.de.e.opme.t and e.gine.r.ng te.ms.

关键词： High-she.r.we.gr.nulation Par.me.r.c-base. Attr.bute.base. Physics-base. mode.ling Impe.le.0}de.ign Scale.up

Single.ce.l r.A se.ue.cing facilitate. the.e.ucidation of the.comple.e.biosynthe.is of the.antide.r.ssant hype.0}or.n in St. John's wor.

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Mole.ular.Plant 2024年第9期17卷 1439-1457页

作者： Song Wu ana Luisa Malaco Mor.tti Jun Yang e.1}ao Wang e.ange.os C.Tatsis National Ke. Labor.tor. of Plant Mole.ular.Ge.e.ics CASs Center for Excellence in Molecular Plant SciencesShanghai lnstitute of Plant Physiology and EcologyChineseAcademy of SciencesShanghai 200032China Unive.0}ity of Chine.e.Acade.y of Scie.ce. Shanghai 200032China Ue.AMS-CAS-JICs Ce.tr. of e.ce.le.ce.or.Plant anamlcr.blalScle.ce Snangnal 200032Cnina

Hype.0}or.n is the.compound r.sponsible.for.the.e.fe.tive.e.s of ***'s wor.(Hype.0}cum pe.0}or.tum)as an antide.r.ssant,but its comple.e.biosynthe.ic pathway r.mains *** discove.0} base. on co-e.pr.ssion analysis of bulk r.A-se.ue.cing data or.ge.ome.mining faile. to discove.0}the.missing ste.s in hype.0}or.n *** this study,we.se.ue.ce. the.1.54-Gb te.r.ploid *** ge.ome.asse.-ble. into 32 chr.mosome. with the.scaffold N50 value.of 42.44 *** single.ce.l r.A se.ue.cing,we.ide.-tifie. a type.of ce.l,“Hype.0}ce.ls”,whe.0}in hype.0}or.n biosynthe.is de.novo take. place.in both the.le.ve. and *** pathway r.constitution in ye.st and tobacco,we.ide.tifie. and char.cte.0}ze. four.tr.nsme.br.ne.pr.nyltr.nsfe.0}se.(HpPT1-4)that ar. localize. at the.plastid e.ve.ope.and comple.e.the.hype.0}or.n biosynthe.ic *** hype.0}or.n polycyclic scaffold is cr.ate. by a r.action cascade.involving an ir.e.ular.isopr.noid coupling and a tande. *** findings r.ve.l how and whe.0} hy-pe.0}or.n is biosynthe.ize.,e.abling synthe.ic-biology r.constitution of the.comple.e.***,this study not only de.pe.s our.compr.he.sion of spe.ialize. me.abolism at the.ce.lular.e.e. but also pr.vide. str.te.ic guidance.for.e.ucidation of the.biosynthe.ic pathways of othe.0}spe.ializie. me.abolite. in plants.

关键词： hype.0}or.n Hype.0}cum pe.0}or.tum de.novo ge.ome.se.ue.cing single.ce.l r.A se.ue.cing biosyn-the.ic pathway me.0}te.0}e.oids

Global war.ing sce.ar.os for.the.e.ste.0} Adr.atic Se. indicate.a highe.0}r.sk of invasive.e.s of non-native.mar.ne.or.anisms r.lative.to cur.e.t climate.conditions

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Mar.ne.Life.Scie.ce.& Te.hnology 2024年第1期6卷 143-154页

作者： Br.nko Glamuzina Lor.nzo Vilizzi Mar.na Pir.a Ante.Zulje.ic ana Br.tos Ce.inic ana Pe.ic Br.nko Dr.gice.ic Lovr.nc Lipe. Mar.jana Pe.ar.vic Vlasta Bar.ulovic Sanja Gr.an Ivan Cvitkovic Tatjana Dobr.slavic ana For.ic Luka Glamuzina Bor.t Mavr.c Jovana Tomanic Mar.ja De.palatovic Dome. Tr.ov Mar.na Br.ilo Sce.anovic Zor.n Vidovic Pr.dr.g Simonovic Sanja Matic-Skoko Pe.0} Tutman De.ar.me.t of Applie. e.ology University of DubrovnikDubrovnikCroatia De.ar.me.t of e.ology and Ve.0}e.r.te.Zoology Faculty of Biology and Environmental ProtectionUniversity of LodzLodzPoland Faculty of Agr.cultur. Department of FisheriesApicultureWildlife Management and Special ZoologyUniversity of ZagrebZagrebCroatia Institute.of Oce.nogr.phy and Fishe.0}e. SplitCroatia Institute.of Mar.ne.Biology University of MontenegroKotorMontenegro National Institute.of Biology Marine Biology Station PiranPiranSlovenia Te.che.0}e.ucation Faculty University of BelgradeBelgradeSerbia Faculty of Biology University of BelgradeBelgradeSerbia

Globally,mar.ne.bioinvasions thr.ate. mar.ne.e.osyste. str.ctur. and function,with the.Me.ite.0}ane.n Se. be.ng one.of the.most affe.te. *** invasions ar. e.pe.te. to incr.ase.due.to climate.*** conducte. a r.sk scr.e.ing of mar.ne.or.anisms(37 fishe.,38 inve.0}e.r.te.,and 9 plants),both e.tant and‘hor.zon’(i.e.,not pr.se.t in the.ar.a but like.y to e.te.0}it).Base. on e.pe.0} knowle.ge.for.the.e.ste.0} Adr.atic Se. coasts of Slove.ia,Cr.atia,and Monte.e.r.,scr.e.ings we.0} conducte. unde.0}both cur.e.t and pr.dicte. climate.conditions indicating with an incr.ase.in se. sur.ace.te.pe.0}tur. and salinity of the.Adr.atic Se. toge.he.0}with change. in pr.cipitation *** aims we.0} to:(1)ide.tify non-native.e.tant and hor.zon mar.ne.spe.ie. that may pose.thr.ats to native.biodive.0}ity and(2)e.aluate.the.r.sk of invasive.e.s of the.se.e.te. spe.ie. unde.0}cur.e.t and pr.dicte. climate.*** the.84 spe.ie. scr.e.e.,the.0} was an incr.ase.in those.r.nke. as‘high r.sk’fr.m 33(39.3%)unde.0}cur.e.t climate.conditions and to 47(56.0%)unde.0}global war.ing *** those.r.nke. as‘ve.0} high’r.sk,the.incr.ase.was fr.m 6(7.1%)to 21(25.0%).Amongst the.scr.e.e. spe.ie.,the.alr.ady e.tablishe. high-r.sk spe.ie. Pacific oyste.0}Magallana gigas and Atlantic blue.cr.b Calline.te. sapidus r.pr.se.t a thr.at to e.osyste. *** the.unde.0}r.pr.se.tation of mar.ne.spe.ie. in the.cur.e.t e.r.pe.n Union List,the.spe.ie. we.have.r.nke. as high to ve.0} high r.sk should be.include..

关键词： AS-ISK e.r.y de.e.tion Intr.duction ve.tor./pathways Invasive.spe.ie. r.pid r.sponse

e.fe.t of Aspe.0}illus nige.0}pr.lyl e.dope.tidase.in patie.ts with ce.iac dise.se.on a long-te.0} glute.-fr.e.die.

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Wor.d Jour.al of Gastr.e.te.0}logy 2024年第11期30卷 1545-1555页

作者： Juan Pablo Ste.anolo Ve.0}nica Se.ur. Mar.ina Gr.zzuti Abe. He.0}dia Isabe. Comino ana Flor.ncia Costa r.be.0}o Pue.la Mar.a Paz Te.pr.no Sonia Isabe. Nive.oni Gabr.e. de.Die.o Mar.a e.Or.gui e.gar.o Gustavo Sme.uol Maur.cio C de.Mar.i e.e.a F Ve.0}ú Car.lina Sousa Julio César.Bai Small Bowe. Se.tion Department of MedicineGastroenterology Hospital of Buenos Aires“Dr.C.Bonorino Udaondo”Buenos Aires 1264Argentina De.ar.me.t of Micr.biology and Par.sitology Faculty of PharmacyUniversity of SevilleSeville 41080Spain De.ar.me.t of Me.icine Dr.C.Bonorino Udaondo Gastroenterology HospitalBuenos Aires 1264Argentina Basic and Applie. r.se.r.h Gr.up in Immunology and Bioactive.(GIBAIB) Institute of Ecology and Sustainable Development(INEDES)National University of LujanLuján 6700Buenos AiresArgentina De.ar.me.t of Me.icine Farncombe Family Digestive Health Research InstituteMcMaster UniversityHamilton L8S 4L8OntarioCanada Facultad de.Me.icina Universidad del SalvadorBuenos Aires C1051ABBArgentina

BACKGr.UND The.glute.-fr.e.die.(GFD)has limitations,and the.0} is inte.se.r.se.r.h in the.de.e.opme.t of adjuvant *** To e.amine.the.e.fe.ts of or.lly administe.0}d Aspe.0}illus nige.0}pr.lyl e.dope.tidase.pr.te.se.AN-Pe.)on inadve.0}e.t glute. e.posur. and symptom pr.ve.tion in adult ce.iac dise.se.Ce.)patie.ts following the.r.usual *** This was an e.plor.tor.,double.blind,r.ndomize.,place.o-contr.lle. tr.al that e.r.lle. Ce. patie.ts on a long-te.0} *** a 4-wk r.n-in pe.0}od,patie.ts we.0} r.ndomize. to 4 wk of two AN-Pe. capsule.(GliadinX;AVI r.se.r.h,LLC,Unite. State.)at e.ch of thr.e.me.ls pe.0}day or.*** e.dpoints we.0}:(1)Ave.0}ge.we.kly stool glute. immunoge.ic pe.tide.(GIP)be.we.n the.r.n-in and e.d of tr.atme.ts and be.we.n AN-Pe. and place.o;(2)ce.iac symptom inde.(CSI);(3)Ce.-spe.ific se.0}logy;and(4)quality of *** sample. we.0} colle.te. for.GIP te.ting by e.ISA e.e.0} Tue.day and Fr.day dur.ng r.n-ins and *** For.y patie.ts we.0} r.ndomize. for.the.inte.tion-to-tr.at analysis,and thr.e.we.0} e.clude. fr.m the.pe.0}pr.tocol ***,628/640(98.1%)stool sample. we.0} *** was unde.e.table.e.,and no diffe.0}nce. be.we.n tr.atme.t ar.s we.0} *** 0.5%of sample. had GIP conce.tr.tions sufficie.tly high(>0.32μg/g)to pote.tially cause.mucosal *** GIP conce.tr.tion in the.AN-Pe. ar. was 44.7%lowe.0}than in the.r.n-in ***-thir. of patie.ts e.hibiting GIP>0.08μg/g dur.ng r.n-in had lowe.0}or.unde.e.table.GIP afte.0}AN-Pe. *** with the.r.n-in pe.0}od,the.pr.por.ion of symptomatic patie.ts(CSI>38)in the.AN-Pe. ar. was significantly lowe.0}Pe. did not r.sult in change. in spe.ific *** This e.plor.tor. study conducte. in a r.al-life.se.ting r.ve.le. high adhe.0}nce.to the.*** AN-Pe. tr.atme.t did not significantly r.duce.the.ove.0}ll GIP stool ***,give. the.obse.0}ation of a significantly lowe.0}pr.vale

关键词： Ce.iac dise.se Aspe.0}illus nige.0}pr.lyl e.dopr.te.se Glute. immunoge.ic pe.tide. Tr.al Symptoms r.al-life.tr.al

e.osome. de.0}ve. fr.m tumor.adjace.t fibr.blasts e.ficie.tly tar.e. pancr.atic tumor.

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Acta Phar.ace.tica Sinica B 2024年第7期14卷 3009-3026页

作者： Saini Se.ua Shabia Shabir.Poor.ima Shaji ana Mar.ine. Bulne. Anupam Dhasmana Swathi Holla Nive.h K.Mittal Nir.kar.Sahoo Tr.pti Saini Fr.nce.co Gior.ianni Mohammad Sikande.0}Andr.w e.Masse. Bilal B.Hafe.z Manish K.Tr.pathi Vince.t P.Die.o Me.na Jaggi Junming Yue.Nade.m Zafar.Mur.li M.Yallapu Ste.he. W.Be.r.an She.ma Khan Subhash C.Chauhan De.ar.me.t of Phar.ace.tical Scie.ce. College of Pharmacyand College of MedicineUniversity of Tennessee Health Science Center(UTHSC)MemphisTN 36163USA De.ar.me.t of Compute.0}Scie.ce Islamic University of Science and TechnologyAwantiporaJ&K 192122India De.ar.me.t of Immunology and Micr.biology School of MedicineUniversity of Texas Rio Grande ValleyMcAllenTX 78504USA South Te.as Ce.te.0}of e.ce.le.ce.in Cance.0}r.se.r.h School of Medicinethe University of Texas Rio Grande ValleyMcAllenTX 78504USA Himalayan School of Bioscie.ce. and Cance.0}r.se.r.h Institute Himalayan Institute of Medical SciencesSwami Rama Himalayan UniversityDehradun 248016India Plough Ce.te.0}for.Ste.0}le.Dr.g De.ive.0} Solutions UTHSCMemphisTN 38104USA De.ar.me.t of Biology College of SciencesUTRGVMcAllenTX 78539USA National Institute.of Biome.ical Imaging and Bioe.gine.r.ng(NIBIB) National Institutes of HealthBethesdaMD 20892USA South Te.as Diabe.e. and Obe.ity Institute UTRGVMcAllenTX 78504USA De.t.of Labor.tor. Me.icine.Pathology University of WashingtonSeattleWA 98195USA De.ar.me.t of Sur.e.0} Baptist Memorial Medical EducationBaptist Memorial HospitalMemphisTN 38120USA Baptist He.lth Scie.ce. Unive.0}ity MemphisTN 38104USA

The.application of e.tr.ce.lular.ve.icle.,par.icular.y e.osome.(e.s),is r.pidly e.panding in the.fie.d of me.icine.owing to the.r.r.mar.able.pr.pe.0}ie. as natur.l car.ie.0} of biological *** study inve.tigate. utilization of e.osome. de.0}ve. fr.m str.mal ce.ls of tumor.adjace.t nor.al tissue.(NAF-e.s)for.pe.0}onalize. me.icine.which can be.de.0}ve. at the.time.of diagnosis by e.doscopic ***,we.show that e.osome.(e.s)de.0}ve. fr.m NAFs de.onstr.te.diffe.0}ntial bio-physical char.cte.0}stics,e.ficie.t ce.lular.inte.0}alization,dr.g loading e.ficie.cy,pancr.atic tumor.tar.e.ing and de.ive.0} of ***-de.0}ve. e.s(NAF-e.s)we.0} use. for.loading or.e.oxife.e.Or.),a pote.t anti-cance.0}and de.moplasia inhibitor.as a mode. *** found that Or. maintains nor.al fibr.blast ce.l phe.otype.and r.nde.0} the. incompatible.to be.tr.gge.0}d for.a CAF-like.phe.otype.which may be.due.to r.gulation of Ca^(2+) influx in fibr.blast ***-e.s-Or. e.fe.tive.y blocke. oncoge.ic signaling pathways involve. in de.moplasia and e.ithe.ial me.e.chymal tr.nsition(e.T)and r.pr.sse. tumor.gr.wth in xe.ogr.ft mouse.*** conclusion,our.data sugge.ts pr.fe.0}ntial tr.pism of NAF-e.s for.PDAC tumor.,thus imply fe.sibility of de.e.oping a nove. pe.0}onalize. me.icine.for.PDAC patie.ts using autologous NAF-e.s for.impr.ve. the.0}pe.tic outcome.of anti-cance.0}***,it pr.vide. the.oppor.unity of utilizing this biological scaffold for.e.fe.tive.the.0}pe.tics in combination with standar. the.0}pe.tic r.gime..

关键词： Pancr.atic cance. Tumor.adjace.t nor.al tissue.fibr.blasts(NAF) De.moplasia e.tr.ce.lular.ve.icle. e.osome. Tumor.tar.e.ing Or.e.oxife.e Pe.0}onalize. me.icine

Towar.s e.ficie.t str.in e.gine.r.ng of 2D mate.0}als:A four.points be.ding appr.ach for.compr.ssive.str.in

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Nano r.se.r.h 2024年第6期17卷 5317-5325页

作者： Hao Li Félix Car.ascoso ana Bor.ás Glor.a P.Mor.no Fr.ncisco J.Apar.cio Ánge. Bar.anco Andr.s Caste.lanos Góme. Campus de.Cantoblanco Instituto de Ciencia de Materiales de MadridC.Sor Juana Inés de la Cruz328049 MadridSpain Nanote.hnology on Sur.ace. and Plasma Lab Instituto de Ciencia de Materiales de Sevilla(CSIC-Universidad de Sevilla).C/Americo Vespucio 49E-41092 SevilleSpain De.ar.ame.to de.Física Aplicada I Escuela Politécnica SuperiorUniversidad de Sevillac/Virgen deÁfrica 7E-41011 SevilleSpain

Str.in e.gine.r.ng,as a powe.0}ul str.te.y to tune.the.optical and e.e.tr.cal pr.pe.0}ie. of two-dime.sional(2D)mate.0}als by de.or.ing the.r.cr.stal lattice.has attr.cte. significant inte.0}st in r.ce.t ye.r..2D mate.0}als can sustain ultr.-high str.ins,e.e. up to 10%,due.to the.lack of dangling bonds on the.r.sur.ace.making the. ide.l br.ttle.*** r.mar.able.me.hanical r.silie.ce.toge.he.0}with a str.ng str.in-tunable.band str.ctur.,e.dows 2D mate.0}als with a br.ad optical and e.e.tr.cal r.sponse.upon ***,str.in e.gine.r.ng base. on 2D mate.0}als is r.str.cte. by the.r.nanoscale.and str.in quantification *** this study,we.have.modifie. a home.uilt thr.e.points be.ding appar.tus to tr.nsfor. it into a four.points be.ding appar.tus that allows for.the.application of both compr.ssive.and te.sile.str.ins on 2D *** appr.ach allows for.the.e.ficie.t and r.pr.ducible.constr.ction of a str.in syste. and minimize. the.buckling e.fe.t cause. by the.van de.0}Waals inte.0}ction by adamantane.e.capsulation *** r.sults de.onstr.te.the.fe.sibility of intr.ducing compr.ssive.str.in on 2D mate.0}als and the.pote.tial for.tuning the.r.optical and physical pr.pe.0}ie. thr.ugh this appr.ach.

关键词： uniaxial compr.ssive.str.in polyme.0}e.capsulation diffe.0}ntial r.fle.tance.spe.tr.scopy e.citon tunability