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Effectiveness of Disinfection in Bacteriology Laboratories in Togo, 2021

Open Journal of Preventive Medicine 2023年第7期13卷 213-226页

作者： Wemboo Afiwa Halatoko Bawimodom Bidjada Ghislain Emmanuel Sopoh Pirenam Kpaïkpaï Fagdéba David Bara Kokou Akpanta Zoulkarneiri Issa Koffi Akolly Yao Adodo Sadji gnatoulma katawa Mounerou Salou Simplice Damintoti Karou Edgard Marius Ouendo Institut National d’Hygiène (INH) Lomé Togo Institut Régional de Santé Publique (IRSP) Département de Santé et Environnement Université d’Abomey Calavi (Bénin) Abomey-Calavi Benin Unité de Recherche en Immunologie et Immunomodulation (UR2IM)/Laboratoire de Microbiologie et de Contrô le de Qualité des Denrées Alimentaires (LAMICODA)/Ecole Supérieure des Techniques Biologiques et Alimentaires (ESTBA) Université de Lomé (UL) Lomé Togo Ecole Supérieure des Techniques Biologiques et Alimentaires (ESTBA) Université de Lomé Lomé Togo Faculté des Sciences de la Santé Université de Lomé Lomé Togo

Background: Laboratory personnel is at risk of biological contamination leading to laboratory-acquired infections (LAIs). The use of disinfection products is essential in the prevention of these infections. This work aimed to evaluate the effectiveness of antimicrobial agents used in disinfection in bacteriology laboratories in Togo. Methods: This was a cross-sectional study conducted from June to December 2021 in all bacteriology laboratories in Togo. Swabs taken before and after disinfection of surfaces and staff hands were immediately plated on agar media. Counting and identification of isolated colonies were done after 24 hours of incubation. The ANOVA test was used to compare calculated means, prevalence ratio (PR) and 95% confidence intervals (CI) to compare bacterial frequencies. Results: A total of 393 samples were taken, of which 41.2% were from hands. Before disinfection, surfaces were more contaminated than hands with respectively 40.4% and 29.6% (PR = 1.3;CI 95% = [0.9 - 1.9]). After surface disinfection with 0.5% of chlorine solution, bacterial elimination was total, but partial on hands washed with soap, with residual contamination of 3.7%. A total of 108 strains were isolated before disinfection of which Klebsiella spp. 38.9% and Staphylococcus spp. 25.0%;after disinfection 4 strains were isolated of which: Staphylococcus spp. 75.0% and Klebsiella spp. 25.0%. Conclusion: Surface disinfection was more effective than hand washing with soap and water. We recommend proper hand washing.

关键词： Effectiveness Antimicrobial Agents Disinfection Hands Surfaces

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CD4 T-Lymphocytes Count in HIV-<i>Toxoplasma gondii</i>Co-Infected Pregnant Women Undergoing a Prevention of Mother-to-Child Transmission Program

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Journal of Biosciences and Medicines 2018年第4期6卷 76-84页

作者： gnatoulma katawa Malewe Kolou Liza Koboyo Nadjir Essoham Ataba Gatigbene Bomboma Simplice Damintoti Karou Ecole Superieure des Techniques Biologiques et Alimentaires (ESTBA-UL) Universite de Lome Lomé Togo Laboratoire de Biologie Moleculaire et d’Immunologie (BIOLIM) Universite de Lome Lomé Togo

Toxoplasma gondii (T. gondii) is a parasite responsible of toxoplasmosis, a disease often asymptomatic but with serious consequences in pregnant women and immunocompromised subjects. Objective: This study aimed to investigate the impact of T. gondii infection on CD4+ T lymphocytes count in HIV-infected pregnant women. Methods: This was a cross-sectional study of pregnant women co-infected by HIV and T. gondii. The study was conducted from January to July 2016 at the Prevention of Mother-to-Child Transmission of HIV (PMTCT) sites in the Health District of Lacs in Togo. Diagnosis of HIV was performed by immuno-chromatographic methods with Determine TM HIV-1/2 and immuno-filtration with Tri-Dot HIV-1 and 2 kits. Presence of anti-toxoplasmic IgG and IgM antibodies was established via enzyme immunoassay using ELISA-BIOREX®kit. Flow cytometry was used to count CD4+ T lymphocytes. Results: Our study found that of the 4599 pregnant women, 111 (2.41%) were HIV-positive. Among them, 109 (98.20%) were infected by HIV-1 and 2 (1.98%) by HIV-2. Antibodies against T. gondii were detected in 5.36% (IgM), 25% (IgG) and 3.57% (both IgM and IgG) of HIV 56 infected women. There was no significant difference between CD4 cell count in HIV (+)/T. gondii IgM (-)/IgG (-) infected pregnant women (378.8 ± 222.8 cell//μl) compared to HIV (+)/T. gondii/IgM (+) (457.3 ± 183.3 cell//μl), HIV (+)/T. gondii IgG (+) (419.4 ± 287.3 cell//μl) and HIV (+)/T. gondii IgM/IgG (+) (480.5 ± 252.4 cell/μl). Conclusion: This study showed that intracellular parasite T. gondii did not alter CD4+ T lymphocytes count in HIV/T. gondii co-infected pregnant women.

关键词： HIV Toxoplasma gondii Co-Infection CD4+ T Lymphocytes Count

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Effectiveness of Disinfection in Bacteriology Laboratories in Togo, 2021

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Open Journal of Preventive Medicine（预防医学期刊） 2023年第7期

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