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世界胃肠病学杂志:英文版 2023年第32期29卷 4851-4859页

作者： Fabian Fellipe Bueno Lemos Marcel Silva luz Samuel Luca Rocha Pinheiro Kádima Nayara Teixeira Fabrício Freire de Melo Instituto Multidisciplinar em Saúde Universidade Federal da BahiaVitória da Conquista 45029094Brazil Campus Toledo Universidade Federal do ParanáToledo 85919899Brazil

Marginal zone lymphomas rank as the third most prevalent form of non-Hodgkin B-cell lymphoma,trailing behind diffuse large B-cell lymphoma and follicular *** mucosa-associated lymphoid tissue lymphoma(GML)is a low-grade B-cell neoplasia frequently correlated with Helicobacter pylori(***)-induced chronic *** the other hand,a specific subset of individuals diagnosed with GML does not exhibit *** *** contrast to its ***-positive counterpart,it was previously believed that ***-negative GML was less likely to respond to antimicrobial *** this,surprisingly,increasing evidence supports that a considerable proportion of patients with ***-negative GML show complete histopathological remission after bacterial eradication ***,the precise mechanisms underlying this treatment responsiveness are not yet fully *** recent years,there has been growing interest in investigating the role of *** gastric helicobacters(NHPHs)in the pathogenesis of ***-negative ***,additional research is required to establish the causal relationship between NHPHs and *** this minireview,we examined the current understanding and proposed prospects on the involvement of NHPHs in ***-negative GML,as well as their potential response to bacterial eradication therapy.

关键词： Lymphoma B cell Marginal zone Gastric mucosa-associated lymphoid tissue lymphoma Helicobacter pylori Non-Helicobacter pylori gastric helicobacters Helicobacter heilmannii Helicobacter suis

Effects of the allelopathic plant Artemisia herba-alba Asso on the soil seed bank of a semi-arid plant community

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Journal of Plant Ecology 2017年第6期10卷 927-936页

作者： Antonio I.Arroyo Yolanda Pueyo Ramón Reiné Maria luz Giner Concepción L.Alados Instituto Pirenaico de Ecología(CSIC) Av.Montañana 1005P.O.Box 13.034Zaragoza 50080Spain Escuela Politécnica Superior(Universidad de Zaragoza) Ctra.Cuarte s/nHuesca 22071Spain

Aims Seed bank strongly influences composition and structure of above-ground *** attention has been paid to the role of allel-opathy driving soil seed bank dynamics,even though allelochemicals released by allelopathic plants might determine whether a species can or cannot germinate from the soil seed bank and,therefore,to co-exist in the neighborhood of the allelopathic ***,the effects of allelopathic plants on community organization through the effects of allelochemicals on soil seed bank remain largely *** this study,we assessed spatial heterogeneities in soil seed bank caused by the presence of allelopathic plants,and evaluated allelo-pathic effects on seed bank germination and seedling *** We examined the effects of the allelopathic shrub Artemisia herba-alba Asso on the spatial structure(in terms of species richness and seed density)of the soil seed bank of a semi-arid ecosystem in NE ***,we evaluated seed bank richness and density at three microsites:under the canopy of ***-alba individuals,under the canopy of Salsola vermiculata L.(a non-allelopathic shrub)individuals,and in bare *** addition,we assessed the effects of aqueous extract of ***-alba on soil seed bank germination(seed-ling emergence and emergence timing)and seedling *** Findings We found that seed bank richness and density were higher under shrub canopy than they were in bare ***-alba and *** microsites had similar seed bank ***,seed bank density was higher under ***-alba because of the high abundance of ***-alba *** extract reduced seedling emergence from the seed bank by 50%,and affected mortality of some emerged *** the other hand,aqueous extract did not influence the emergence timing of *** conclude that,although the presence of allelo-pathic plants does not cause relevant changes in seed bank struc-ture relative to similar non-allelopathi

关键词： allelopathic shrub aqueous extract Middle Ebro Valley seed bank inhibition seed bank density seedling emergence

The challenge of drug resistance in pancreatic ductal adenocarcinoma:a current overview

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Cancer Biology & Medicine 2019年第4期16卷 688-699页

作者： Francisco Quinonero Cristina Mesas Kevin Doello Laura Cabeza gloria Perazzoli Cristina Jimenez-Luna Ana Rosa Rama Consolación Melguizo Jose Prados Institute of Biopathology and Regenerative Medicine(IBIMER) Center of Biomedical Research(CIBM)University of Gran adaz Gran ada 18100Spain Department of An atomy and Embryology Faculty of Medici neUn iversity of Gran adaGranada 18071Spain Instituto Biosanitario de Granada(ibs.GRANADA) Granada 18014Spain Medical Oncology Service Virgen de las Nieves HospitalGranada 1812Spain Department of Oncology Ludwig Institute for Cancer ResearchUniversity of LausanneEpalinges 1066Switzerland Department of Health Scienee University of JaenJa6n 23071Spain

Pancreatic ductal adenocarcinoma(PDAC)has one of the highest mortality rates among all cancer *** delayed diagnosis precludes curative resection,thus most of the current therapies against PDAC are based on chemo-and ***,these strategies are insufficient to improve its poor *** the advances made in chemotherapy(***-paclitaxel and gemcitabine),many patients with PDAC are unable to benefit from them due to the rapid development of drug ***,more than 165 genes have been found to be implicated in drug resistance of pancreatic tumors,including different integrins,mucins,NF-κB,RAS and ***,drug resistance in PDAC is thought to be mediated by the modulation of miRNAs(***-21,miRNA-145 and miRNA-155),which regulate genes that participate in cell proliferation,invasion and ***,cancer stem cells are intimately related to drug resistance in PDAC due to their ability to overexpress ABC genes-involved in drug transport-,and enzymes such as aldehyde dehydrogenases-implicated in cellular drug metabolism-and poly(ADP-ribose)polymerases-involved in drug-induced DNA damage *** the mechanisms involved in drug resistance will contribute to the development of efficient therapeutic strategies and to improve the prognosis of patients with PDAC.

关键词： Pancreatic ductal adenocarcinoma chemotherapy drug resistance cancer stem cells therapeutic strategies

Memory and relaxation time of biological systems. an analysis of the effect of abortion legalization in italy

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Natural Science 2011年第8期3卷 694-701页

作者： Michele Caputo Fulvia gloria-Bottini 不详

When a population is affected by a new law there is a lag between the date of application of the law and the response of the population;moreover there is a relaxation time after which a steady state is reached. The time to maximum response and the relaxation time may be approximately estimated from the raw data but the mathematical modeling of the data allows a better estimate. The model, when tested on real data, may be used for future laws or, when appropriately adapted, for other biological systems also. In this note the memory based model is tested on the effects of the 1978 law which legalized the abortions in Italy finding the response and the relaxation time. It is shown that Italian population, after the abortion law, has required about 5 years to have the maximum effect and about 10 years to reach stability. The evolution of women life and the changes of the structure of society in Italy is also discussed.

关键词： Memory Abortion Mathematical Model Live-Born Infant Population Growth

Photooxidative stress activates a complex multigenic response integrating the phenylpropanoid pathway and ethylene,leading to lignin accumulation in apple(Malus domestica Borkh.)fruit

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Horticulture Research 2020年第1期7卷 2501-2513页

作者： Carolina A.Torres Constanza Azocar Patricio Ramos Ricardo Pérez-Díaz gloria Sepulveda María A.Moya-León Facultad de Ciencias Agrarias Universidad de TalcaTalcaChile Department of Horticulture Tree Fruit Research&Extension CenterWashington State UniversityWenatcheeWAUSA Universidad Andres Bello Facultad Ciencias BiologicasSantiagoChile Instituto de Ciencias Biológicas Universidad de TalcaTalcaChile Núcleo Cientifíco Multidisciplinario-DI Universidad de TalcaTalcaChile

Photooxidative stress,when combined with elevated temperatures,triggers various defense mechanisms leading to physiological,biochemical,and morphological changes in fruit ***,during sun damage,apple fruit undergo textural changes characterized by high flesh firmness compared to unexposed *** and Royal Gala apples were suddenly exposed to sunlight on the tree and then sampled for up to 29 *** wall components and lignin biosynthetic pathway analyses were carried out on the fruit *** harvest,Fuji apples with different sun exposure levels,such as exposed to direct sunlight(Exp),shaded(Non-Exp),and with severe sun damage(Sev),were also *** fruit suddenly exposed to sunlight,the expression levels of phenylpropanoid-related genes,phenylalanine ammonia lyase(MdPAL),chalcone synthase(MdCHS),and flavanone-3-hydroxylase(MdF3H),were upregulated in the skin and flesh of Exp and *** had little effect on the lignin-related genes caffeic acid Omethyltransferase 1(MdCOMT1)and cinnamyl alcohol dehydrogenase(MdCAD)in the skin;however,the expression of these genes was highly induced in the flesh of Exp and Sev in both *** deposition increased significantly in skin with sun injury(Sev);in flesh,this increase occurred late during the stress ***,the ethylene biosynthesis genes 1-aminocyclopropane-1-carboxylate synthase(MdACS)and 1-aminocyclopropane-1-carboxylate oxidase(MdACO)were highly expressed in the skin and flesh tissues but were more upregulated in Sev than in Exp during the time-course experiment,which paralleled the induction of the phenylpropanoid pathway and lignin *** harvest,flesh from Sev fruit exhibited higher firmness than that from Non-Exp and Exp fruit,although no differences were observed in the alcohol-insoluble residues(AIR)among *** fractionation of cell wall polymers revealed an increase in the uronic acid contents of the water-soluble pectin fraction(WSF)in Ex

关键词： stress involvement suddenly

Human biofield therapy does not affect tumor size but modulates immune responses in a mouse model for breast cancer

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Journal of Integrative Medicine 2016年第5期14卷 389-399页

作者： gloria Gronowicz Eric R.Secor Jr. John R.Flynn Liisa T.Kuhn Department of Surgery University of Connecticut Health Center Department of Immunology University of Connecticut Health Center Hartford Healthcare Hartford Hospital Department of Reconstructive Sciences University of Connecticut Health Center

OBJECTIVE： To assess the effect of human biofield therapy, an integrative medicine modality, on the development of tumors and metastasis, and immune function in a mouse breast cancer model. METHODS： Mice were injected with 66cl4 mammary carcinoma cells. In study one, mice received biofield therapy after cell injection. In study two, mice were treated by the biofield practitioner only prior to cell injection. Both studies had two control groups of mock biofield treatments and phosphate- buffered saline injection. Mice were weighed and tumor volume was determined. Blood samples were collected and 32 serum cytokine/chemokine markers were measured. Spleens/popliteal lymph nodes were isolated and dissociated for fluorescent-activated cell sorting （FACS） analysis of immune cells or metastasis assays in cell culture. RESULTS： No signifcant differences were found in weight, tumor size or metastasis. Significant effects were found in the immune responses in study one but no additional effects were found in study two. In study one, human biofield treatment significantly reduced percentage of CD4~CD441oCD25~ and percentage of CD8~ cells, elevated by cancer in the lymph nodes, to control levels determined by FACS analysis. In the spleen, only CD11b~ macrophages were increased with cancer, and human biofield therapy significantly reduced them. Of 11 cytokines elevated by cancer, only interferon-y, interleukin-1, monokine induced by interferon-y, interleukin-2 and macrophage inflammatory protein-2 were significantly reduced to control levels with human biofield therapy. CONCLUSION： Human biofield therapy had no significant effect on tumor size or metastasis but produced significant effects on immune responses apparent in the down-regulation of specific lymphocytes and serum cytokines in a mouse breast cancer model.

关键词： biological therapy breast cancer immune system integrative medicine cytokine energymedicine

Factors Associated with Renal Impairment in Patients on Tenofovir for Chronic Hepatitis B in Yaoundé (Cameroon)

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Effects of asymmetric dimethylarginine on renal arteries in portal hypertension and cirrhosis

Open Journal of Gastroenterology（肠胃病学期刊） 2024年第1期

作者： Antonin Wilson Ndjitoyap Ndam Sonia Charlsia Ewuo Shu Mahamat Maimouna Winnie Bekolo Nga Isabelle Dang Babagna Paul Talla Mathurin Kowo Firmin Ankouane Andoulo gloria Enow Ashuntantang

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World Journal of Gastroenterology 2016年第48期22卷 10545-10556页

作者： gloria Segarra Belén Cortina María Dolores Mauricio Susana Novella Paloma Lluch Javier Navarrete-Navarro Inmaculada Noguera Pascual Medina Department of Physiology University of Valencia and Institute of Health Research INCLIVAHospital Clínico Universitario Valencia Department of Gastroenterology and Hepatology and Institute of Health Research INCLIVA Hospital Clínico Universitario Valencia

AIM To evaluate the effects of asymmetric dimethylarginine(ADMA) in renal arteries from portal hypertensive and cirrhotic *** Rat renal arteries from Sham(n = 15), pre-hepatic portal hypertension(PPVL; n = 15) and bile duct ligation and excision-induced cirrhosis(BDL; n = 15) were precontracted with norepinephrine, and additional contractions were induced with ADMA(10-6-10-3 mol/L), an endogenous inhibitor of nitric oxide(NO) synthase. Concentration-response curves to acetylcholine(1 × 10-9^(-3) × 10^(-6) mol/L) were determined in precontractedrenal artery segments with norepinephrine in the absence and in the presence of ADMA. Kidneys were collected to determine the protein expression and activity of dimethylarginine dimethylaminohydrolase(DDAH), an enzyme that catabolizes ADMA. RESULTS In renal arteries precontracted with norepinephrine, ADMA caused endothelium-dependent contractions. The pD 2 values to ADMA were similar in the Sham and PPVL groups(4.20 ± 0.08 and 4.11 ± 0.09, P > 0.05, respectively), but were lower than those of the BDL group(4.79 ± 0.16, P < 0.05). Acetylcholine-induced endothelium-dependent relaxation that did not differ, in terms of p D2 and maximal relaxation, among the 3 groups studied. Treatment with ADMA(3 × 10^(-4) mol/L) inhibited acetylcholine-induced relaxation in the 3 groups, but the inhibition was higher(P < 0.05) in the BDL group compared with that for the Sham and PPVL groups. The m RNA and protein expression of DDAH-1 were similar in kidneys from the three groups. Conversely, DDAH-2 expression was increased(P < 0.05) in PPVL and further enhanced(P < 0.05) in the BDL group. However, renal DDAH activity was significantly decreased in the BDL group. CONCLUSION Cirrhosis increased the inhibitory effect of ADMA on basal- and induced-release of NO in renal arteries, and decreased DDAH activity in the kidney.

关键词： Portal hypertension Cirrhosis Nitric oxide Asymmetric dimethylarginine Nitric oxide inhibitors Dimethylarginine dimethylaminohydrolase

Thoracic aorta thickness and histological changes with aging: an experimental rat model

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Journal of Geriatric Cardiology 2019年第7期16卷 580-584页

作者： Giulio Cesar Gequelim Djanira Aparecida da luz Veronez Gustavo Lenci Marques Camila Harumi Tabushi Ronaldo da Rocha Loures Bueno Master’s Degree Student in Postgraduate Program of Internal Medicine Federal University of Paraná(UFPR)Medical Resident in Cardiology in Hospital de Clínicas UFPRCuritiba-PRBrazil Department of Anatomy School of MedicineUFPRCuritiba-PRBrazil Master’s Degree in Internal Medicine Adjunct ProfessorDepartment of Internal MedicineSchool of MedicineUFPRCuritiba-PRBrazil Medical Student Department of Internal MedicineSchool of MedicineUFPRCuritiba-PRBrazil Department of Internal Medicine School of MedicineUFPRCuritiba-PRBrazil

The three main components of the media layer of the aorta are elastic fibers,collagen fibers and smooth muscle cells(SMC).[1]This layer’s elastic properties are major determinants of its biomechanics in health and disease states.[2,3]Age-related changes in such elastic properties are associated with altered hemodynamic parameters,such as systolic hypertension,[4,5]and end-organ damage,[6,7]and are thought to result from changes of its main components.

关键词： Aging Collagen Elastic fibers Smooth muscle cells

Disabling portosystemic encephalopathy in a non-cirrhotic patient: successful endovascular treatment of a giant inferior mesenteric-caval shunt via the left internal iliac vein

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World Journal of Gastroenterology 2017年第47期23卷 8426-8431页

作者： Luca de Martinis gloria Groppelli Riccardo Corti Lorenzo Paolo Moramarco Pietro Quaretti Pasquale De Cata Mario Rotondi Luca Chiovato Unit of Endocrinology and Internal Medicine University of PaviaICS Maugeri SPA SocietàBenefit Unit of Interventional Radiology Radiology DepartmentIRCCS Fondazione Policlinico San Matteo

Hepatic encephalopathy is suspected in non-cirrhotic cases of encephalopathy because the symptoms are accompanied by hyperammonaemia. Some cases have been misdiagnosed as psychiatric diseases and consequently patients hospitalized in psychiatric institutions or geriatric facilities. Therefore, the importance of accurate diagnosis of this disease should be strongly emphasized. A 68-year-old female patient presented to the Emergency Room with confusion, lethargy, nausea and vomiting. Examination disclosed normal vital signs. Neurological examination revealed a minimally responsive woman without apparent focal deficits and normal reflexes. She had no history of hematologic disorders or alcohol abuse. Her brain TC did not demonstrate any intracranial abnormalities and electroencephalography did not reveal any subclinical epileptiform discharges. Her ammonia level was > 400 mg/d L(reference range < 75 mg/d L) while hepatitis viral markers were negative. The patient was started on lactulose, rifaximin and low-protein *** the basis of the doppler ultrasound and abdomen computed tomography angiography findings, the decision was made to attempt portal venography which confirmed the presence of a giant portal-systemic venous shunt. Therefore, mechanic obliteration of shunt by interventional radiology was performed. As a consequence, mesenteric venous blood returned to hepatopetally flow into the liver, metabolic detoxification of ammonia increased and hepatic encephalopathy subsided. It is crucial that physicians immediately recognize the presence of non-cirrhotic encephalopathy, in view of the potential therapeutic resolution after accurate diagnosis and appropriate treatments.

关键词： Non-cirrhotic patient Portosystemic shunt Hyperammonaemia Interventional radiology Mechanical embolization Encephalopathy