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女子必修课:乳房自检的正确姿势

中国生殖健康 2018年第6期 8-10页

作者： gloria zhang 美国克利夫兰医学中心美国克利夫兰医学中心网站

自我检查不能替代乳腺癌筛查,不能比钼靶检查更早地发现乳腺癌。相关研究甚至不能证实乳房自检有明确的益处。但是,乳房自检很重要。乳腺癌筛查一般在40岁以后才开始,乳腺癌在年轻患者中虽然少见却并不罕见。我见过的最年轻的乳腺癌患... 详细信息

自我检查不能替代乳腺癌筛查,不能比钼靶检查更早地发现乳腺癌。相关研究甚至不能证实乳房自检有明确的益处。但是,乳房自检很重要。乳腺癌筛查一般在40岁以后才开始,乳腺癌在年轻患者中虽然少见却并不罕见。我见过的最年轻的乳腺癌患者只有27岁。另外,有个别患者癌症发展迅速,有一例乳腺癌患者做完常规筛查后6个月,还没到下一次筛查的时候就又复发了。

关键词：乳房自检乳房外观乳腺癌患者

Threat perception predicts cognitive behavioral therapy outcomes in anxious children

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Open Journal of Psychiatry 2013年第1期3卷 141-148页

作者： Katharina Manassis Kathryn M. Hum Trevor Changgun Lee gloria zhang Marc D. Lewis Behavioral Science Institute Radboud University Nijmegen The Netherlands Department of Human Development and Applied Psychology University of Toronto Toronto Canada Department of Psychiatry Hospital for Sick Children University of Toronto Toronto Canada

Objective: Anxiety disorders of childhood are prevalent, debilitating conditions that do not always respond to existing treatments. Attentional biases towards threatening stimuli have been reported in anxious children and hypothesized to interfere with treatment response. Therefore, we examined such biases in children with anxiety disorders in relation to cognitive behavioral therapy (CBT) outcomes. Method: Thirty-eight children diagnosed with anxiety disorders in a specialized clinic (21 girls and 17 boys;age = 10.50 ± 1.11 years) and 36 unaffected community controls (19 girls and 17 boys;age = 10.20 ± 1.07 years) participated. Participants completed standardized questionnaire measures of anxiety and a probe position task (PPT) with facial cues. This task often reveals a response slowing effect related to threatening faces in vulnerable individuals. Children with anxiety disorders repeated these measures after completing CBT. Results: Groups did not differ in performance on the PPT, but angry/calm incongruent difference scores were significantly associated with self-reports of social anxiety and state anxiety. When controlling for pre-CBT anxiety levels, incongruent difference scores involving angry faces predicted post-CBT anxiety disorders index scores on the Multidimensional Anxiety Scale for Children. PPT scores did not change significantly with CBT. Conclusions: Attentional bias towards threat on the PPT task may predict response to CBT and appears linked to social anxiety. Interventions to ameliorate this bias merit further study, as they might improve treatment outcomes for anxious, especially socially anxious, children.

关键词： Anxiety Disorder Children Threat Perception Emotion Cognitive Behavioral Therapy

Cathepsin D overexpression in the nervous system rescues lethality and Aβ42 accumulation of cathepsin D systemic knockout in vivo

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Acta Pharmaceutica Sinica B 2023年第10期13卷 4172-4184页

作者： Xiaosen Ouyang Willayat Y.Wani gloria A.Benavides Matthew J.Redmann Hai Vo Thomas van Groen Victor M.Darley-Usmar Jianhua zhang Department of Pathology University of Alabama at BirminghamBirminghamAL 35294USA Department of Cell Developmental and Integrative BiologyUniversity of Alabama at BirminghamBirminghamAL 35294USA Birmingham VA Medical Center University of Alabama at BirminghamBirminghamAL 35294USA

The lysosome is responsible for protein and organelle degradation and homeostasis and the cathepsins play a key role in maintaining protein quality *** D(CTSD),is one such lysosomal protease,which when deficient in humans lead to neurolipofuscinosis(NCL)and is important in removing toxic protein *** studies demonstrated that CTSD germ-line knockout-CtsdKO(CDKO)resulted in accumulation of protein aggregates,decreased proteasomal activities,and postnatal lethality on Day 26±*** of wildtype CTSD,but not cathepsin B,L or mutant CTSD,decreased a-synuclein toxicity in worms and mammalian *** this study we generated a mouse line expressing human CTSD with a floxed STOP cassette between the ubiquitous CAG promoter and the *** crossing with Nestin-cre,the STOP cassette is deleted in NESTIN+cells to allow CTSD overexpression-CTSDtg(CDtg).The CDtg mice exhibited normal behavior and similar sensitivity to subchronic 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine(MPTP)induced *** breeding CDtg mice with CDKO mice,we found that over-expression of CTSD extended the lifespan of the CDKO mice,partially rescued proteasomal deficits and the accumulation of Aβ42 in the *** new transgenic mouse provides supports for the key role of CTSD in protecting against proteotoxicity and offers a new model to study the role of CTSD enhancement in vivo.

关键词： Cathepsin D transgenic mouse Mitochondrial bioenergetics Apoptosis Cathepsin D knockout mice Dopamine Autophagy Lysosome Life expectancy Behavior

西南天山前陆盆地侏罗纪-白垩纪盆山格局——来自碎屑锆石年代学的证据

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大地构造与成矿学 2017年第3期41卷 533-550页

作者：杨威郭召杰姜振学 gloria Heilbronn 张晨王思维中国石油大学(北京)油气资源与探测国家重点实验室北京102249 中国石油大学(北京)非常规天然气研究院北京102249 北京大学地球与空间科学学院北京100871 Géosciences Rennes Université Rennes 1 中国石油大学(北京)地球科学学院北京102249

目前对天山地区,特别是天山南缘中生代盆山格局认识尚存分歧。本文着眼于侏罗纪-白垩纪这一盆山演化关键阶段,利用碎屑锆石LA-ICP-MS U-Pb定年法对西南天山前陆盆地康苏剖面中侏罗统杨叶组、下白垩统克孜勒苏群沉积开展物源分析。发现... 详细信息

目前对天山地区,特别是天山南缘中生代盆山格局认识尚存分歧。本文着眼于侏罗纪-白垩纪这一盆山演化关键阶段,利用碎屑锆石LA-ICP-MS U-Pb定年法对西南天山前陆盆地康苏剖面中侏罗统杨叶组、下白垩统克孜勒苏群沉积开展物源分析。发现中侏罗统杨叶组碎屑锆石U-Pb年龄分布于369~2687 Ma间,基本分布在369~404 Ma(约占4%)、418~501 Ma(约占19%)和544~2687 Ma(约占77%)3个范围;下白垩统克孜勒苏群碎屑锆石U-Pb年龄分布于243~2820 Ma间,集中于253~414 Ma(约占35%)、423~489 Ma(约占27%)和668~2820 Ma(约占37%)3个范围。中侏罗统碎屑锆石年龄分布范围广,各年龄组分均较突显,反映中侏罗世西南天山前缘流域体系宽广,天山内各主要源区均得到沟通,物源范围广阔。下白垩统克孜勒苏群锆石年龄分布明显集中,反映早白垩世西南天山前缘源区范围有所缩小。西南天山前缘与库车前陆盆地的物源构成在中侏罗世存在一定差异,而在早白垩世呈现相似特征。包括西南天山前陆盆地在内的天山南缘或于早白垩世经历一期小规模构造反转,导致山-盆构造分异与抬升-剥蚀增强。

关键词：西南天山碎屑锆石U-Pb年龄物源盆山格局构造反转

The Cellulose Synthases Are Cargo of the TPLATE Adaptor Complex

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Molecular Plant 2018年第2期11卷 346-349页

作者： Clara Sanchez-Rodriguez Yanyun Shi Christopher Kesten Dongmei zhang gloria Sancho-Andres Alexander Ivakov Edwin R. Lampugnani Kamil Sklodowski Masaru Fujimoto Akihiko Nakano Antony Bacic Ian S. Wallace Takashi Ueda Daniel Van Damme Yihua Zhou Staffan Persson Max-Planck-lnstitute for Molecular Plant Physiology Am Muehlenberg 1 14476 Potsdam Germany Department of Biology ETH Zurich 8092 Zurich Switzerland State Key Laboratory of Plant Genomics Institute of Genetics and Developmental Biology Chinese Academy of Sciences Beijing 100101 China School of Biosciences University of Melbourne Parkvine 3010 VIC Australia ARC Centre of Excellence for Translational Photosynthesis Research School of Biology Australian National University GPO Box 475 Canberra ACT 2601 Australia Department of Biological Sciences Graduate School of Science The University of Tokyo Hongo Bunkyo-ku Tokyo 113-0033 Japan Live Cell Super-resolution Imaging Research Team RIKEN Center for Advances Photonics Hirosawa Wako Saitama 351-0198 Japan ARC Centre of Excellence in Plant Cell Walls School of Biosciences University of Melbourne Parkville 3010 VIC Australia Department of Biochemistry and Molecular Biology University of Nevada Reno NV 89557 USA Division of Cellular Dynamics National Institute for Basic Biology Okazaki Aichi 444-8585 Japan Department of Plant Biotechnology and Bioinformatics Ghent University 9052 Gent Belgium Center for Plant Systems Biology VIB Technologiepark 927 9052 Gent Belgium present address: Laboratory of Plant Molecular Genetics Graduate School of Agricultural and Life Sciences The University of Tokyo 1-1-1 Yayoi Bunkyo-ku Tokyo 113-8657 Japan

Dear Editor Clathrin-mediated endocytosis （CME） is an evolutionary conserved mechanism by which plasma membrane （PM）-based cargo proteins are recognized by adaptor protein complexes and internalized. Apart from the canonical adaptor complex, AP-2, plant cells rely on the TPLATE complex （TPC） to execute CME （Gadeyne et al., 2014）. FT160100218, DP110100410）, the Ministry of Education, Culture, Sports, Science, and Technology of Japan （24114003, 15H04382, and 17K19412）, the European Research Council （ERC grant 682436）, the IRRTF-RNC （no. 501892） and a USA National Science Foundation CAREER Award.

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A Dual-radiolabel Marker Quantifies Decrease in HT29 Xenograft Hypoxia Induced by Mild Temperature Hyperthermia

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International Journal of Medical Physics, Clinical Engineering and Radiation Oncology 2012年第2期1卷 32-39页

作者： Mutian zhang Xiao-Feng Li Makiko Suehiro Zhihong Zhao David Gagne John Pizzonia Zhigang zhang gloria Li C. Clifton Ling John L. Humm Department of Epidemiology & Biostatistics Memorial Sloan-Kettering Cancer Center New York USA Department of Medical Physics Memorial Sloan-Kettering Cancer Center New York USA Department of Radiation Oncology Memorial Sloan-Kettering Cancer Center New York USA Department of Radiation Oncology University of Nebraska Medical Center Omaha USA Life Sciences Group FUJIFILM Medical Systems USA Inc. Woodbridge USA Munroe-Meyer Institute University of Nebraska Medical Center Omaha USA

Purpose: In this project, we developed novel methods to quantify changes in tumor hypoxia following a mild tempera-ture hyperthermia (MTH) treatment in rat HT29 human colon adenocarcinoma xenograft. Materials and Methods: An exogenous hypoxia marker (IAZGP) was labeled with two radioisotopes of iodine (131I and 123I, respectively) to form two distinct tracers. The two tracers were injected into HT29-bearing nude rats 4-hour before and immediately following 41.5℃, 45-minute mild hyperthermia treatment. The distributions of the two hypoxia tracers were obtained by performing digital autoradiography on tumor sections, and image processing resulted in quantitative information at 50 μm pixel size. Results: Following the hyperthermia treatment, there was a remarkable decrease in hypoxia tracer binding. The average whole tumor hypoxia tracer targeted fraction in five animals changed from 30.3% ± 9.7% to 13.0% ± 5.3% after the hyperthermia treatment (P = 0.001). Detailed pixelby-pixel analysis of the image data revealed a decline in hypoxia tracer uptake after hyperthermia in most regions. However, there was concomitant emergence of some new regions of hypoxia identified by increased tracer uptake. In the control group, the overall hypoxia tracer targeted fraction remained almost constant, with some hypoxic tracer redistribution (putative acute hypoxia) observed. Conclusion: Reoxygenation occurred in the rat HT29 xenograft following MTH treatment. This was evident with preponderance of decreased hypoxia specific tracer uptake on tumor sections. Our methodology might be a useful tool in hypoxia study.

关键词： Digital Autoradiography IAZGP Imaging Plate Mild Temperature Hyperthermia Tumor Hypoxi

X射线诱导γH2AX焦点形成的定量分析及其致DNA双链断裂的动态变化

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中华放射肿瘤学杂志 2018年第3期27卷 303-308页

作者：董隽王成涛张纯任玉峰欧阳斌张天王振宇 gloria C.Li Fuqiu He 文碧秀中山大学附属第一医院放射治疗科广州510080 东莞市人民医院放射治疗科 523059 Department ofMedical Physics and Radiation Oncology Memorial Sloan-Kettering Cancer Center New York10021

目的比较DNA依赖蛋白激酶催化亚基（DNA-PKcs^＋/＋）和DNA-PKcs^-/-小鼠胚胎成纤维细胞（MEF） X射线诱导γH2AX焦点形成的定量分析,并对鼻咽癌SUNE-1细胞进行X射线致DNA DSB动态变化。方法采用蛋白印迹检测DNA-PKcs蛋白表达情况,细... 详细信息

目的比较DNA依赖蛋白激酶催化亚基（DNA-PKcs^＋/＋）和DNA-PKcs^-/-小鼠胚胎成纤维细胞（MEF） X射线诱导γH2AX焦点形成的定量分析,并对鼻咽癌SUNE-1细胞进行X射线致DNA DSB动态变化。方法采用蛋白印迹检测DNA-PKcs蛋白表达情况,细胞免疫荧光检测X射线5 Gy诱导的γH2AX焦点形成,通过ImageJ软件分析γH2AX焦点形成数量的差异。结果 DNA-PKcs在DNA-PKcs^-/-和DNA-PKcs^＋/＋ MEF细胞中分别表达缺失和正常。应用γH2AX焦点/细胞和γH2AX焦点/mm2分析方法动态分析X射线诱导的DNA-PKcs^＋/＋、DNA-PKcs^-/-MEF细胞和SUNE-1细胞DSB形成的总体趋势一致;照后 0.5~1.0 h大量γH2AX焦点形成,DNA-PKcs^＋/＋ MEF细胞于照后6.0 h完成修复,DNA-PKcs^-/-MEF和SUNE-1细胞X射线后于照后24.0 h完成修复。γH2AX焦点/细胞的峰值出现在照后1.0 h,γH2AX焦点/mm2的峰值则出现在照后0.5 h。对于DNA-PKcs^＋/＋和DNA-PKcs^-/-MEF细胞,γH2AX焦点/细胞在照后0.5、1.0、3.0、6.0、12.0 h的不同,而γH2AX焦点/mm2在照后3.0、6.0、12.0 h不同。结论利用细胞免疫荧光动态检测照后致γH2AX焦点/细胞或γH2AX焦点/mm2的分析方法为动态定量研究DSB损伤及修复提供了新的思路。

关键词：非同源末端连接 DNA依赖蛋白激酶催化亚基 γH2AX焦点 SUNE-1细胞系

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饮食与胆囊癌关系的流行病学研究

肿瘤 2005年第4期25卷 351-356页

作者：张学宏高玉堂邓杰程家蓉刘恩菊邬恺孙璐 Asif Rashid gloria Gridley Ann W Hsing 上海市肿瘤研究所上海200032 美国M.D.Anderson癌症中心美国国立癌症研究所

目的探讨饮食因素与胆囊癌发病的关联,为采取预防措施提供科学依据。方法采用全人群病例对照研究,研究对象为1997年6月-2001年5月期间确诊的、年龄在35-74岁的上海市区368例胆囊癌新发病例以及按性别、年龄(5岁一组)频数配对的895例人... 详细信息

目的探讨饮食因素与胆囊癌发病的关联,为采取预防措施提供科学依据。方法采用全人群病例对照研究,研究对象为1997年6月-2001年5月期间确诊的、年龄在35-74岁的上海市区368例胆囊癌新发病例以及按性别、年龄(5岁一组)频数配对的895例人群对照。采用非条件logistic回归模型分析饮食各因素与胆囊癌的关系。结果女性中,与最低四分位数组相比,葱属类蔬菜年摄入次数最高四分位组的调整OR为0.55(95%CI:0.31-0.97;Ptrend=0.06);与不吃组比较,大蒜头和洋葱最高摄入组的调整OR分别为0.59(95%CI:0.34-0.99;Ptrend=0.03)和0.52(95%CI:0.30-0.91;Ptrend=0.01)。与最低四分位组比较,腌制品摄入其余各组调整OR在女性中依次为1.06、1.88、2.31,Ptrend<0.001;与不吃乳腐组比较,余三组的调整OR依次为1.19、1.47、***<0.01。男性结果与女性类似,腌制品和葱属类蔬菜摄入的各组OR都有不显著的升高和降低。结论新鲜蔬菜,尤其是葱属类蔬菜对胆囊癌的保护作用在女性比男性明显,而且以大蒜头、洋葱的保护作用较为显著。而腌制品摄入,尤其是乳腐,可能会增加胆囊癌的发病风险。

关键词：胆囊肿瘤流行病学研究膳食调查饮食习惯病例对照研究

饮茶与胆道癌胆石症关系的全人群病例对照研究

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中华肿瘤杂志 2005年第11期27卷 667-671页

作者：张学宏高玉堂 Asif Rashid 邓杰刘恩菊邬恺孙璐程家蓉 gloria Gridley Ann W Hsing 上海市肿瘤研究所 200032 美国M.D.Anderson癌症中心美国国立癌症研究所

目的探讨饮茶与胆道癌和胆石症的关系.方法采用全人群病例对照研究.研究对象为上海市区新发胆道癌患者627例,包括胆囊癌368例,肝外胆管癌191例和壶腹癌68例;按年龄(每5岁1组)频数配对的对照人群959人;同时收集胆石症患者1037例.采用非条... 详细信息

目的探讨饮茶与胆道癌和胆石症的关系.方法采用全人群病例对照研究.研究对象为上海市区新发胆道癌患者627例,包括胆囊癌368例,肝外胆管癌191例和壶腹癌68例;按年龄(每5岁1组)频数配对的对照人群959人;同时收集胆石症患者1037例.采用非条件Logistic回归模型,分析饮茶与胆道癌、胆石症的关系. 结果与不饮茶者比较,女性胆囊癌、肝外胆管癌和胆石症组中现仍饮茶者的调整OR分别为0.57(95%CI: 0.34～0.96)、0.53(95%CI: 0.27～1.03)和0.71(95%CI: 0.51～0.99),肝外胆管癌OR值随饮茶年龄的提前及饮茶年限的增加而降低,趋势检验达到显著性水平.男性胆囊癌、肝外胆管癌和胆石症组OR均＜1,但尚无统计学意义.结论饮茶对女性胆囊癌、肝外胆管癌可能具有保护作用,这一保护作用不依赖于胆石症而具有独立性.

关键词：胆道肿瘤胆石症饮茶病例对照研究