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帕金森病患者跌倒的危险因素分析

广东医学 2011年第9期32卷 1117-1119页

作者：陈仰昆邓伟光肖卫民黄家星莫仲棠广东省东莞市人民医院神经内科 523000 香港中文大学精神科学系香港中文大学内科及药物治疗学系

目的回顾性研究帕金森病(PD)患者跌倒的危险因素。方法选择香港3所医院133例的神经科专科门诊PD患者纳入研究。收集患者的人口学及临床资料,并进行躯体功能、精神、智能及跌倒方面的评估。应用logistic多元回归分析研究PD患者跌倒的危... 详细信息

目的回顾性研究帕金森病(PD)患者跌倒的危险因素。方法选择香港3所医院133例的神经科专科门诊PD患者纳入研究。收集患者的人口学及临床资料,并进行躯体功能、精神、智能及跌倒方面的评估。应用logistic多元回归分析研究PD患者跌倒的危险因素。结果 44例(33.1%)患者在最近1年内有1次以上的跌倒,平均跌倒的次数为(1.9±0.7)次。logistic多元回归显示,婚姻状况(丧偶、离异或未婚)(OR=1.965,95%CI1.203～3.208,P=0.007)、Schwab和England日常生活能力评分低(OR=0.973,95%CI 0.955～0.991,P=0.003)及服用3种以上抗PD药物(OR=0.973,95%CI 0.955～0.991,P=0.026)是跌倒的独立危险因素。结论跌倒是PD患者一个很常见的问题。服用多种抗PD药物、日常生活能力及婚姻状况对跌倒均有明显的影响,提示在跌倒的预防与评估中,疾患内在因素和社会因素均需考虑。

关键词：帕金森病跌倒危险因素

Risk factors and natural history of breast cancer in younger Chinese women

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World Journal of Clinical Oncology 2014年第5期5卷 1097-1106页

作者： Winnie Yeo Hang-Mei Lee Amy chan Emily YY chan Miranda CM chan Keeng-wai chan Sharon WW chan Foon-Yiu Cheung Polly SY Cheung Peter HK Choi Josette SY Chor William WL Foo Wing-Hong Kwan Stephen CK Law Lawrence PK Li Janice WH Tsang Yuk Tung Lorna LS Wong Ting-Ting Wong Chun-Chung Yau Tsz-Kok Yau Benny CY Zee Department of Clinical Oncology Chinese University of Hong Kong Prince of Wales Hospital Hong Kong Breast Cancer Foundation Jockey Club School of Public Health and Primary Care Chinese University of Hong Kong Department of Surgery Kwong Wah Hospital Diagnostix Pathology Laboratories Ltd Canossa Hospital Kowloon East Cluster Breast Centre Department of Surgery United Christian Hospital Department of Clinical Oncology Pamela Youde Nethersole Eastern Hospital Private Clinical Oncologist Radiotherapy and Oncology Centre Hong Kong Baptist Hospital Comprehensive Oncology Centre Hong Kong Sanatorium and Hospital Hong Kong Adventist Oncology Center Hong Kong Adventist Hospital Department of Clinical Oncology University of Hong Kong Department of Clinical Oncology Tuen Mun Hospital Private Surgeon Department of Clinical Oncology Princess Margaret Hospital

AIM: To investigate the age differences in the risk factors, clinicopathological characteristics and patterns of treatment of female breast cancer patients. METHODS: Seven thousand one hundred and fiftytwo women with primary breast cancer from the Hong Kong Breast Cancer Registry were recruited after receiving patients' consent, they were asked to complete standardized questionnaires which captured their sociodemographic characteristics and risk factors associated with breast cancer development. Among them, clinicopathological data and patterns of treatment were further collected from medical records of 5523 patients with invasive breast cancers. Patients were divided into two groups according to the age at diagnosis: younger(< 40 years old) vs older patients(≥ 40 years old) for subsequent ***: Analysis on the sociodemographic characteristics and exposure to risk factors were performed on 7152 women with primary breast cancer and the results revealed that younger patients were more likely to have unhealthy lifestyles; these include a lack of exercise(85.4% vs 73.2%, P < 0.001), having high stress in life(46.1% vs 35.5%, P < 0.001), having dairy/meat-rich diets(20.2% vs 12.9%, P < 0.001),having alcohol drinking habit(7.7% vs 5.2%, P = 0.002). Younger patients were also more likely to have hormone-related risk factors including nulliparity(43.3% vs 17.8%, P < 0.001) and an early age at menarche(20.7% vs 13.2%, P < 0.001). Analyses on clinicopathological characteristics and patterns of treatment were performed on 5523 women diagnosed with invasive breast cancer. The invasive tumours in younger patients showed more aggressive pathological features such as having a higher percentage of grade 3 histology(45.7% vs 36.5%, P < 0.001), having a higher proportion of tumours with lymphovascular invasion(39.6% vs 33.2%, P = 0.003), and having multifocal disease(15.7% vs 10.3%, P < 0.001); they received different patterns of treatment than their older ***

关键词： Hong Kong Breast Cancer Registry Breast cancer Younger Chinese women Sociodemographic characteristics Risk factors Clinicopathological characteristics Breast cancer treatment

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2009年香港法政大事记

中国法律（中英文版） 2010年第1期 44-48,107-112页

作者：刘惠怡黄林涧刘光汉《中国法律：中英文版》编辑部

刚划上句号的2009年，总括来说是香港抗击金融海啸的又一年，当中政经风云不定，政府施政面对重重挑战，另一边厢，历时9年的民事司法制度改革（Civil Justice Reform）开始实施，标志着香港民事司法制度发展的一个重要裹程碑。

关键词：香港大事记司法制度改革民事司法制度发展施政政府

Efficacy and safety of on demand tadalafil in the treatment of East and Southeast Asian men with erectile dysfunction:a randomized double-blind,parallel,placebo-controlled clinical study

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Asian Journal of Andrology 2006年第6期8卷 685-692页

作者： wai Chun Andrew Yip Han-Sun Chiang Jesus Benjamin Mendoza Hui-Meng Tan Man-Kay Li Wei Christine Wang Vladimir Kopernicky Department of Surgery Kwong Wah HospitalHong KongChina College of Medicine Fu Jen Catholic UniversityTaipei 24205TaiwanChina Department of Urology National Kidney and Transplant InstituteQuezon City 1100the Philippines Department of Urology Subang Jaya Medical CentreSelangor Darul Ehsan 47500Malaysia Department of Urology National University Hospital119074Singapore Lilly Research Laboratories Eli Lilly and CompanyIndianapolisIndiana 46285USA Lilly Area Medical Center Vienna 1030Austria

Aim： To assess the efficacy and safety of tadalafil in comparison to a placebo, when taken on demand for 12 weeks by East/Southeast Asian men with erectile dysfunction （ED）, Methods： This multicenter, randomized, double-blind, parallel group, placebo-controlled study was conducted at 17 centers across East and Southeast Asia between August 2002 and February 2003. Men more than 18 years of age with mild to severe ED of various etiologies were randomized to receive a placebo or 20 mg of tadalafil taken as needed （maximum once daily）. Efficacy assessments included the International Index of Erectile Function, the Sexual Encounter Profile diary and Global Assessment Questions. Results： Tadalafil significantly improved erectile function as compared to the placebo （P 〈 0.001）. At the endpoint, the patients receiving 20 mg of tadalafil reported a greater mean per patient percentage of successful intercourse attempts （Sexual Encounter Profile question 3： 70.9% compared to 33.5% in the placebo） and a greater proportion of improved erections （Global Assessment Question： 86.2% compared to 30.1%）. Most （≥3%） treatment emergent adverse events were mild or moderate. The most common treatment emergent adverse events were headache, back pain, dizziness and dyspepsia. Conclusion： Tadalafil was an effective and well-tolerated treatment for ED in East and Southeast Asian men.

关键词： tadalafil phosphodiesterase type 5 inhibitor erectile dysfunction efficacy safety Asian

香港食用植物中氰化物含量及加工过程对其含量的影响

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中国食品卫生杂志 2008年第5期20卷 428-431页

作者：邓绍平邝嘉萍钟伟祥肖颖食物环境卫生署、食物安全中心中国香港特别行政区食物环境卫生署食物安全中心食物研究化验所中国香港特别行政区北京大学医学部公共卫生学院北京100083

目的研究香港市场上常见的含氰甙食物及其制品的氰化物含量,以及烹调加工对其含量的影响。方法采用巴比妥酸-异烟酸比色法测定生成的总氢氰酸用来代表氰甙含量。结果苦杏仁(北杏)、竹笋、木薯及亚麻籽样本的氰化物含量范围为9.3～330mg/... 详细信息

目的研究香港市场上常见的含氰甙食物及其制品的氰化物含量,以及烹调加工对其含量的影响。方法采用巴比妥酸-异烟酸比色法测定生成的总氢氰酸用来代表氰甙含量。结果苦杏仁(北杏)、竹笋、木薯及亚麻籽样本的氰化物含量范围为9.3～330mg/kg;苦木薯的氰化物含量较甜木薯为高;氰化物含量在新鲜竹笋中分布不同,笋尖的氰化物含量最高(120mg/kg);竹笋和木薯制品中氰化物的含量较低,范围为从未检出到5.3mg/kg。把含有氰甙的食用植物切成小块后用沸水烹煮,可降低氰化物含量90%以上。干燥加热方法不能有效降低亚麻籽中的氰化物含量。结论食用植物中氰甙含量不同,沸水中烹煮,可有效释放氢氰酸,减低植物的氰化物含量。干燥加热方式仅能降低10%氰化物含量。

关键词：植物,食用氰化物 β葡糖苷酶类比色法

The Hong Kong consensus recommendations on the diagnosis and management of pancreatic cystic lesions

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Hepatobiliary Surgery and Nutrition 2023年第5期12卷 715-735,I0019-I0020页

作者： Tan-To Cheung Yuk Tong Lee Raymond Shing-Yan Tang Wong Hoi She Kai Chi Cheng Chin Cheung Cheung Keith Wan Hang Chiu Kenneth Siu Ho Chok Wing Sun Chow Tak Wing Lai wai-Kay Seto Thomas Yau Department of Surgery Queen Mary HospitalThe University of Hong KongHong KongChina Gastroenterologist in private practice Hong KongChina Department of Medicine and Therapeutics The Chinese University of Hong KongHong KongChina Department of Surgery Kwong Wah HospitalHong KongChina Department of Surgery Tuen Mun HospitalHong KongChina Department of Radiology&Imaging Queen Elizabeth HospitalHong KongChina Department of Medicine The University of Hong KongHong KongChina Department of Surgery Princess Margaret HospitalHong KongChina Department of Medicine School of Clinical MedicineThe University of Hong KongHong KongChina State Key Laboratory of Liver Research The University of Hong KongHong KongChina

Background:The finding of pancreatic cystic lesions(PCL)on incidental imaging is becoming increasingly *** studies report a prevalence of 2.2-44.7%depending on the population,imaging modality and indication for imaging,and the prevalence increases with *** with PCL are at risk of developing pancreatic cancer,a disease with a poor *** publication summarizes recommendations for the diagnosis and management of PCL and post-operative pancreatic exocrine insufficiency(PEI)from a group of local ***:Clinical evidence was consolidated from narrative reviews and consensus statements formulated during two online meetings in March *** expert panel included gastroenterologists,hepatobiliary surgeons,oncologists,radiologists,and ***:Patients with PCL require careful investigation and follow-up due to the risk of malignant transformation of these *** should undergo clinical investigation and pancreas-specific imaging to classify lesions and understand the risk profile of the *** indicated,patients should undergo pancreatectomy to excise *** pancreatectomy,patients are at risk of PEI,leading to gastrointestinal dysfunction and ***,such patients should be monitored for symptoms of PEI,and promptly treated with pancreatic enzyme replacement therapy(PERT).Patients with poor response to PERT may require increases in dose,addition of a proton pump inhibitor,and/or further investigation,including tests for pancreatic *** are also at risk of new-onset diabetes mellitus after pancreatectomy;they should be screened and treated with insulin if ***:These statements are an accurate summary of our approach to the diagnosis and management of patients with PCL and will be of assistance to clinicians treating these patients in a similar clinical landscape.

关键词： Pancreatic cystic lesions pancreatic endocrine insufficiency pancreatic enzyme replacement therapy

Follow up of serial urea breath test results in patients after consumption of antibiotics for non-gastric infections

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World Journal of Gastroenterology 2002年第4期8卷 703-706页

作者： wai-Keung Leung Lawrence Cheung-Tsui Hung Carrie Ka-Li Kwok Rupert Wing-Loong Leong Daniel Kwok-Keung Ng Joseph Jao-Yiu Sung Department of Medicine & Therapeutics Prince of Wales Hospitalthe Chinese University of Hong KongShatinHong KongChina Department of Paediatrics Kwong Wah HospitalKowloonHong KongChina

AIM: The widespread use of antibacterial therapy hasbeen suggested to be the cause for the decline in theprevalence of Helicobacter pyloriinfection. This studyexamine the serial changes of urea breath test resultsin a group of hospitalized patients who were givenantibacterial therapy for non-gastric ***: Thirty-five hospitalized patients who weregiven antibacterial therapy for clinical infections,predominantly chest and urinary infections, werestudied. Most (91%) patients were given singleantibiotic of either a penicillin or cephalosporin *** 13C-urea breath tests were performed within 24hours of initiation of antibiotics, at one-week and atsix-week post-therapy. H. pylori infection wasdiagnosed when one or more urea breath tests ***: All 35 patients completed three serial ureabreath tests and 26 (74 %) were H. pylori-positive. Ten(38 %) H. pylori-infected patients had at least onenegative breath test results during the study *** medium delta 13C values were significantly lowerat baseline (8.8) than at one-week (20.3) and six-week(24.5) post-treatment in H. pylori-positive individuals(P=0.022). Clearance of H. pyloriat six-week was onlyseen in one patient who had received anti-helicobactertherapy from another ***: Our results suggested that one-third ofH. pylori-infected individuals had transient false-negative urea breath test results during treatment withantibacterial agent. However, clearance of H. pyloriinfection by regular antibiotic consumption is rare.

关键词：抗生素 HP感染连续尿素呼吸试验耐药

Noninvasive prenatal testing for aneuploidy in twin and triplet pregnancies by maternal plasma DNA sequencing

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Noninvasive prenatal testing for aneuploidy in twin and trip...

第十四次全国医学遗传学学术会议

作者： LAI Yun-li CHEN Yun YI Shang ZHENG Hai-yang TANG Yan-qing LEI Ya-qin YI Sheng ZHANG Qin-le TIAN Xiao-xian LU Ying-chi QIN Hai-song HUANG Xiao-shan FU Chun-yun HU Xu-yun XIE Bo-bo SUN Wei-jia WEI Hong-wei CHOY kwong-wai The Maternal and Child Health Hospital of Guangxi Zhuang Autonomous Region The Chinese University of Hong Kong ShatinNT

OBJECTIVES:Cell-free DNA(cf-DNA)based non-invasive prenatal testing(NIPT)had large-scale validation data in singleton pregnancies;however,the clinical usage of NIPT in twin pregnancies remains unclear due to insufficient supporting *** objective of this study is to evaluate the efficacy of NIPT in detecting fetal chromosomal aneuploidies among twin and triplet ***:From May 2013 to November 2014,a cohort of 289 women,286 twins and 3 triplet pregnancies(gestation week 19±4)were recruited for chromosomal aneuploidies testing through ***-DNA was extracted from maternal blood *** DNA library was amplified using PCR approach and sequenced by massively parallel sequencing(MPS).NIPT identified"highrisk"or"positive"individuals were advised for karyotyping;And we performed follow-up to the rest NIPT"low risk"individuals before and after their ***:Two trisomy 21 and one trisomy 13 in twin pregnancies were correctly identified through MPS and confirmed their discordant fetal karyotype(one normal and the other trisomy)by *** 286 cases(50 were monozygotic,236 were unclear)of twin/tripletpregnancies with negative NIPT results were confirmed by postnatal *** to this study,the detection rate of NIPT in twin pregnancies for trisomy 21 and trisomy 13were both 100%.The sensitivity and specificity were 100%and 100%,*** is the first report for trisomy 13 in twin pregnancies using ***:MPS-based noninvasive prenatal assessment of fetal chromosomal aneuploidy through maternal blood had shown a satisfied performance in twin *** high detection rate and specificity toward trisomy 21 and 13,NIPT could reduce unnecessary invasive procedures for prenatal diagnosis in twin *** data is still required to fully investigate the clinical usage of NIPT in twin/triplet pregnancies.

关键词： noninvasive prenatal test twin pregnancies aneuploidy trisomy 21 trisomy 13

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氯胺酮相关性泌尿系统损害

中华泌尿外科杂志 2008年第7期26卷 489-492页

作者：吴芃朱秀群姚铭广郑少斌谭万龙文志卫韦安阳程煒吴威武南方医科大学南方医院泌尿外科广州510515 香港新界屯门医院外科香港九龙玛嘉烈医院外科

目的探讨滥用氯胺酮（K粉）所引发的泌尿系损害及其诊治方法。方法因吸食K粉导致泌尿系统损害患者20例。男14例，女6例。平均年龄22岁。吸食K粉1～4年。均有严重的尿频、尿急、尿痛和（或）血尿症状。尿培养阴性。B超提示双侧上尿路积... 详细信息

目的探讨滥用氯胺酮（K粉）所引发的泌尿系损害及其诊治方法。方法因吸食K粉导致泌尿系统损害患者20例。男14例，女6例。平均年龄22岁。吸食K粉1～4年。均有严重的尿频、尿急、尿痛和（或）血尿症状。尿培养阴性。B超提示双侧上尿路积水16例，14例行IVU及10例行CT检查均提示上尿路积水扩张、膀胱挛缩，1例肾乳头坏死，合并不同程度肝肾功能损害。治疗时要求患者戒断毒品并实验性用药。结果 6例活检病理提示膀胱黏膜炎性改变，在停止或减少滥用K粉后，12例症状逆转，戊聚硫钠及透明质酸钠治疗6例症状缓解。结论 K粉相关性泌尿系统损害可能是一种以下尿路刺激症状为主要表现的全尿路炎性损害，其发生机制及治疗方法有待进一步研究。

关键词：氯胺酮药物滥用泌尿系损害