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Health Emergency and Disaster Risk Management (Health-EDRM):Developing the Research Field within the Sendai Framework Paradigm

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International Journal of Disaster Risk Science 2017年第2期8卷 145-149页

作者： Sharon Tsoon Ting Lo Emily Ying Yang chan gloria kwong wai chan Virginia Murray Jonathan Abrahams Ali Ardalan Ryoma Kayano Johnny Chung wai Yau Collaborating Centre for Oxford University and CUHK for Disaster and Medical Humanitarian Response (CCOUC) The Jockey Club School of Public Health and Primary CareThe Chinese University of Hong Kong Nuffield Department of Medicine University of Oxford Franois-Xavier Bagnoud Center for Health & Human Rights Harvard University Public Health England The United Nations International Strategy for Disaster Reduction (UNISDR) Scientific and Technical Advisory Group Integrated Research on Disaster Risk (IRDR) Scientific Committee World Health Organization Tehran University of Medical Sciences World Health Organization Kobe Centre for Health Development Faculty of Medicine The Chinese University of Hong Kong

The intersection of health and disaster risk reduction(DRR) has emerged in recent years as a field of critical *** is recognized as an outcome and a goal of DRR,and the integration of both fields is essential to ensure the implementation of the Sendai Framework for Disaster Risk Reduction 2015–*** Emergency and Disaster Risk Management(Health-EDRM) has emerged as an umbrella field that encompasses emergency and disaster medicine,DRR,humanitarian response,community health resilience,and health systems *** September 2016,an international group of experts met in Hong Kong to assess the current status and potential of the Health-EDRM research field,a research area that these scholars characterized as underdeveloped and *** challenges identified include research overlap,lack ofstrategic research agenda,absence of consensus regarding terminology,and limited coordination between *** Sendai Framework provides a useful paradigm within which to shape the research field's strategic *** WHO Thematic Platform for Health-EDRM Research Group was established to coordinate activities,promote information-sharing,develop partnerships,and provide technical advice to strengthen the Health-EDRM research *** group will promote the generation of robust and scientific health research to support the meaningful implementation of the Sendai Framework.

关键词： Health disaster risk reduction Health emergency and disaster risk management Health-EDRM Sendai Framework

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Risk Perception and Knowledge in Fire Risk Reduction in a Dong Minority Rural Village in China: A Health-EDRM Education Intervention Study

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International Journal of Disaster Risk Science 2018年第3期9卷 306-318页

作者： Emily Ying Yang chan Holly Ching Yu Lam Phoebe Pui Wun Chung Zhe Huang Tony Ka Chun Yung Kelvin wai Kit Ling gloria kwong wai chan Cheuk Pong Chiu Collaborating Centre for Oxford University and CUHK for Disaster and Medical Humanitarian Response (CCOUC) The Chinese University of Hong Kong Nuffield Department of Medicine University of Oxford The Jockey Club School of Public Health and Primary Care The Chinese University of Hong Kong Franois-Xavier Bagnoud Center for Health and Human Rights Harvard University Integrated Research on Disaster Risk (IRDR) International Centre of Excellence–CCOUC (ICoE-CCOUC)

Fire is one of the major disasters in rural communities but evidence of the effectiveness of education interventions against fire risks is limited. This was a 2-year study assessed the effectiveness of face-to-face Health Emergency and Disaster Risk Management(HealthEDRM) education interventions for raising fire risk reduction knowledge in a fire-prone rural ethnic minority community. The study was conducted in various pre-set time points of an intervention-based project in a Dongbased community in Nanjiang Village, Guizhou Province in 2015 and 2016 to increase knowledge among the villagers about how to reduce general-and electrical-fire risks. Pre-and post-intervention questionnaires were used to evaluate the effectiveness of increasing fire risk-related knowledge through these interventions, immediately after the 2015 and 2016 interventions, and 17 months after the 2015 intervention. The knowledge of using fire blanket,recalling the correct emergency telephone number,unplugging unused electrical appliances, and not using water to extinguish electrical fires had immediately improved after the interventions. Subjects demonstrated a better understanding that fire blankets can fight a blaze if used appropriately, and that knowledge was sustained for 17 months. The interventions were effective in improving fire prevention and response knowledge. Targeted interventions should be organized according to communities' culture, the evolution of economic prosperity and lifestyle practices.

关键词： Dong village Fire risk education Fire risk perception Fire risk reduction Health education Rural China Health-EDRM

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Surgical outcomes for unilateral superior oblique palsy in Chinese population: a retrospective study

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International Journal of Ophthalmology(English edition) 2015年第1期8卷 107-112页

作者： Gordon Shing Kin Yau Victor Tak Yau Tam Jacky wai Yip Lee Theo Tak kwong chan Can Yin Fun Yuen Department of Ophthalmology Caritas Medical Centre Department of Anatomy Faculty of MedicineUniversity of Hong Kong

AIM: To evaluate the outcome after surgery for unilateral superior oblique(SO) palsy in ***: The medical records of 39 patients that underwent surgery for unilateral SO palsy between January 2003 and December 2012 at Caritas Medical Centre, Hong Kong, were retrospectively reviewed. All surgeries were performed by a single surgeon. Pre-operative assessments for vertical deviation, cyclo-deviation, and Knapp’s classification were obtained to determine the nature and degree of surgical *** deviation was measured at 1wk; 1, 6mo and on last follow-up day post-operatively. Cyclo-deviation was measured on last follow-up day ***: During the 10 y period, 39 subjects were recruited. The most common etiology was congenital(94.9%). Knapp’s Type III(66.7%) and Type I(12.8%)classifications were the most common subtypes. To treat SO palsy, the most common surgical procedures were:isolated inferior oblique(IO) anteriorization(41.0%),isolated IO myectomy(10.3%), and isolated IO recession(10.3%). At 3.5 ±2.1y post-operatively, the vertical deviation was significantly reduced(15.1 ±6.2 PD versus0.5±1.4 PD, P <0.0001) without significant improvement in cyclo-deviation(P =0.5). Initial vertical deviation was correlated with cyclo-torsion(r =0.4, P =0.007). Those with over-correction had greater initial vertical deviation(19.4±7.2 PD versus 13.2±4.3 PD, P =0.003). After a single operation, 84.6% of subjects achieved a vertical deviation within ±3 PD.· CONCLUSION: The majority of subjects achieved corrected vertical deviation after a single surgery although there was no improvement in *** with over-correction of primary position deviation had greater preoperative vertical deviation and it may be related to simultaneous multiple muscle surgery.

关键词： superior oblique palsy vertical deviation surgery diplopia

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hale gas reservoir modeling and production evaluation considering complex gas transport mechanisms and dispersed distribution of kerogen

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Petroleum Science 2021年第1期18卷 195-218页

作者： Jie Zeng Jishan Liu wai Li Yee-kwong Leong Derek Elsworth Jianchun Guo School of Engineering The University of Western Australia35 Stirling HighwayPerthWA 6009Australia Department of Energy and Mineral Engineering G3 Center and Energy InstituteThe Pennsylvania State UniversityUniversity ParkPA 16802USA State Key Laboratory of Oil and Gas Reservoir Geology and Exploitation Southwest Petroleum UniversityChengdu 610500China

Stimulated shale reservoirs consist of kerogen,inorganic matter,secondary and hydraulic *** dispersed distribution of kerogen within matrices and complex gas flow mechanisms make production evaluation *** we establish an analytical method that addresses kerogen-inorganic matter gas transfer,dispersed kerogen distribution,and complex gas flow mechanisms to facilitate evaluating gas *** matrix element is defined as a kerogen core with an exterior inorganic *** most previous models,we merely use boundary conditions to describe kerogen-inorganic matter gas transfer without the instantaneous kerogen gas source *** is closer to real inter-porosity flow conditions between kerogen and inorganic *** diffusion,surface diffusion,adsorption/desorption,and slip corrected flow are involved in matrix gas ***-fracture coupling is realized by using a seven-region linear flow *** model is verified against a published model and field *** reveal that inorganic matrices serve as a major gas source especially at early *** provides limited contributions to production even under a pseudo-steady *** properties’influence starts from the late matrix-fracture inter-porosity flow regime,while inorganic matter properties control almost all flow regimes except the early-mid time fracture linear flow *** contribution of different linear flow regions is also documented.

关键词： Analytical solution Shale gas reservoir Well performance Kerogen and inorganic matter

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Multiparametric magnetic resonance imaging/transrectal ultrasound fusion prostate biopsy with semi-robotic navigation in the Chinese population： initial results

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Asian Journal of Andrology 2018年第1期20卷 93-94页

作者： wai Kit Ma Brian SH HO Andrew SH Lai Ka Cheong Lam Yun Sang chan Lawrance KC Yip Ada TL Ng James HL Tsu Ming kwong Yiu Division of Urology Department of Surgery The University of Hong Kong Queen Mary Hospital Hong Kong China Department of Diagnostic Radiology The University of Hong Kong Queen Mary Hospital Hong Kong China

Dear Editor, The current standard 12-core systematic transrectal ultrasound （TRUS）-guided biopsy in prostate cancer diagnosis has the disadvantages of overdetecting indolent tumors, while failing to identify clinically significant cancers in up to 35%.1 Advances in imaging techniques, notably the multiparametric magnetic resonance imaging （mpMRI）, allow clinically significant prostate cancers to be detected with more precise localization） Fusion of MRI and real-time TRUS enables targeted biopsy of suspicious lesions, overcoming human error, and inability of biopsy site tracking in cognitive fusion？ Multiple Western series have suggested a higher detection rate, higher specificity, and better risk stratification with fusion biopsy.

关键词： CANCER GUIDANCE SYSTEM

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A novel mitofusin 2 gene mutation causing Charcot-Marie-Tooth type 2A disease in a Chinese family

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Chinese Medical Journal 2010年第11期123卷 1466-1469页

作者： CHING Chor Kwan LAU Kwok kwong YU Kwok wai chan Yan Wo Albert MAK Miu Chloe Chemical Pathology Laboratory. Department of Pathology Princess Margaret hospital Hong Kong China Department of Medicine and Geriatrics Princess Margaret hospital Hong Kong China

Charcot-Marie-Tooth disease （CMT）, also known as hereditary motor and sensory neuropathies,comprises a genetically heterogeneous group of inherited peripheral neuropathies. Clinically it is characterized by progressive distal weakness, muscle atrophy, distal sensory loss and loss of deep tendon reflexes. Following electrophysiological criteria, CMT is divided into two main forms：

关键词： Charcot-Marie-Tooth type 2A mitofusin 2 gene Hong Kong

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Important role of cardiac spect imaging in patients undergoing percutaneous transluminal coronary angioplasty

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Chinese Medical Journal 1999年第3期 64-67页

作者： Babington Chun kuen Yung, wai kwong chan, Chiu Sun Yue, wai Chau Fan, Kwok Fai Leung Amy Siu ling Fung and James Chi sang chan Department of Radiology and Organ Imaging (Yung CK, Fan WC, chan CS) & Department of Medicine and Geriatrics (

Objective To examine the utilization and contribution of cardiac perfusion scans to patients undergoing percutaneous transluminal coronary angioplasty. Methods From July 1996 to January 1998, 34 patients underwent percutaneous transluminal coronary angioplasty and cardiac SPECT imaging was studied. Twenty five patients had pre procedure SPECT scans. The agreement between angioplasty strategies and SPECT findings of ischemia and hypokinesia was *** When radionuclide imaging was performed before revascularization procedures, 84% of the patients had intervention strategies guided by scan findings. Perfusion scan findings including extent and severity of ischemia, degree of hypokinesia directed the selection of target vessel for angioplasty in the patient subgroup with multi vessel disease. Post angioplasty radionuclide cardiac scans were performed only on symptomatic patients, demonstrating ischemia and hypokinesia in most of them, conceivably reflected the selection *** We recommend routine pre and post angioplasty radionuclide imaging with multigated scans for wall motion assessment for all patients receiving coronary intervention.

关键词： multigated SPECT angioplasty ischemia hypokinesia

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Investigation of the genetic etiology in male infertility with apparently balanced chromosomal structural rearrangements by genome sequencing

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Asian Journal of Andrology 2022年第3期24卷 248-254页

作者： Matthew Hoi Kin Chau Ying Li Peng Dai Mengmeng Shi Xiaofan Zhu Jacqueline Pui Wah Chung Yvonne K Kwok kwong wai Choy Xiangdong Kong Zirui Dong Department of Obstetrics and Gynaecology The Chinese University of Hong KongHong KongChina Shenzhen Research Institute The Chinese University of Hong KongShenzhen 518057China Hong Kong Hub of Paediatric Excellence The Chinese University of Hong KongHong KongChina Genetics and Prenatal Diagnosis Center The First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052China The Chinese University of Hong Kong-Baylor College of Medicine Joint Center for Medical Genetics Hong KongChina

Apparently balanced chromosomal structural rearrangements are known to cause male infertility and account for approximately 1%of azoospermia or severe ***,the underlying mechanisms of pathogenesis and etiologies are still largely ***,we investigated apparently balanced interchromosomal structural rearrangements in six cases with azoospermia/severe oligospermia to comprehensively identify and delineate cryptic structural rearrangements and the related copy number *** addition,high read-depth genome sequencing(GS)(30-fold)was performed to investigate point mutations causative of male ***-pair GS(4-fold)revealed additional structural rearrangements and/or copy number changes in 5 of 6 cases and detected a total of 48 ***,the breakpoints caused truncations of 30 RefSeq genes,five of which were associated with ***,the breakpoints disrupted 43 topological-associated *** disruptions or potential dysregulations of genes,which play potential roles in male germ cell development,apoptosis,and spermatogenesis,were found in all cases(n=6).In addition,high read-depth GS detected dual molecular findings in case MI6,involving a complex rearrangement and two point mutations in the gene ***,our study provided the molecular characteristics of apparently balanced interchromosomal structural rearrangements in patients with male *** demonstrated the complexity of chromosomal structural rearrangements,potential gene disruptions/dysregulation and single-gene mutations could be the contributing mechanisms underlie male infertility.

关键词： azoospermia balanced structural rearrangements genome sequencing male infertility severe oligospermia

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A cross-sectional study on compliance with topical glaucoma medication and its associated socioeconomic burden for a Chinese population

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International Journal of Ophthalmology(English edition) 2017年第2期10卷 293-299页

作者： Man-Hin Lui Jason Chun Ho Lam Yi Lee kwong Tak Siu Wong Pak Long Cheung Sherri Shun Yan Lai Pak Lun Yuen wai Yiu Lam Ho Yan chan Yiu Fai Wong Jimmy Shiu Ming Lai Kendrick Co Shih Li Ka Shing Faculty of Medicine the University of Hong KongPokfulamHong KongChina Department of Ophthalmology Li Ka Shing Faculty of Medicinethe University of Hong KongPokfulamHongKongChina Department of Ophthalmology Queen Mary HospitalPokfulamHong KongChina

AIM： To estimate the overall drug compliance for local Chinese glaucoma patients on long-term topical ***： This was a retrospective cross-sectional ***-seven primary glaucoma patients from the subspecialty clinic of a publicly-funded tertiary care hospital in Hong Kong completed a questionnaire on compliance with topical glaucoma medication,attitude towards glaucoma and therapy and vision related quality of *** was defined as reporting missing more than or equal to 10% of the prescribed topical glaucoma medication during the 2wk immediately prior to the *** between noncompliance and demographics,attitude,disease and treatment status was *** was estimated with quality of life and direct medical cost involved with *** logistic regression on noncompliance was performed on selected ***： Compliance was calculated as 75%（95% CI： 64%-87%） among 57 subjects（mean age 69 y,female 51%）.No statistical significant relationship was established between noncompliance and any single factors or ***（P=0.048） and forgetfulness（P=0.064） were found to be marginally significant predictive factors on noncompliance in multivariable logistic *** might be related（P=0.130） to poorer self-rated vision-associated quality of *** societal cost of noncompliance was estimated to be over 2510 life-years and US$ 3.7 million ***： The compliance of Chinese glaucoma patients in Hong Kong is comparable to other parts in the world,and carries detrimental impacts on individual and societal *** and forgetfulness are two possible independent predictors for noncompliance.

关键词： glaucoma eye drop compliance quality of life

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Prostate cancer detection upon transrectal ultrasound-guided biopsy in relation to digital rectal examination and prostate-specific antigen level： what to expect in the Chinese population？

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Asian Journal of Andrology 2015年第5期17卷 821-825,I0010页

作者： Jeremy YC Teoh Steffi KK Yuen James HL Tsu Charles KW Wong Brian SH Ho Ada TL Ng wai-Kit Ma Kwan-Lun Ho Ming-kwong Yiu Department of Surgery Division of Urology Queen Mary Hospital University of Hong Kong Hong Kong China

We investigated the prostate cancer detection rates upon transrectal ultrasound （TRUS）-guided biopsy in relation to digital rectal examination （DRE） and prostate-specific antigen （PSA）, and risk factors of prostate cancer detection in the Chinese population. Data from all consecutive Chinese men who underwent first TRUS-guided prostate biopsy from year 2000 to 2013 was retrieved from our database. The prostate cancer detection rates with reference to DRE finding and PSA level of 〈 4, 4-10, 10.1-20, 20.1-50 and 〉 50 ng ml^-1 were investigated. Multivariate logistic regression analyses were performed to investigate for potential risk factors of prostate cancer detection. A total of 2606 Chinese men were included. In patients with normal DRE, the cancer detection rates were 8.6%, 13.4%, 21.8%, 41.7% and 85.2% in patients with PSA 〈 4, 4-10, 10.1-20, 20.1-50 and 〉 50 ng ml^-1 respectively. In patients with abnormal DRE, the cancer detection rates were 12.4%, 30.2%, 52.7%, 80.6% and 96.4% in patients with PSA 〈 4, 4-10, 10.1-20, 20.1-50 and 〉 50 ng m1-1 respectively. Older age, smaller prostate volume, larger number of biopsy cores, presence of abnormal DRE finding and higher PSA level were associated with increased risk of prostate cancer detection upon multivariate logistic regression analyses （P 〈 0.001）. Chinese men appeared to have lower prostate cancer detection rates when compared to the Western population. Taking the different risk factors into account, an individualized approach to the decision of TRUS-guided biopsy can be adopted.

关键词： Chinese digital rectal examination prostate biopsy prostate cancer prostate-specific antigen

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