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Adansonia digitata aqueous leaf extract ameliorates dexamethasone-induced testicular injury in male Wistar rats

Asian pacific Journal of Reproduction 2021年第3期10卷 113-120页

作者： Joseph Babatunde Dare Abdulfatai Olakunle Ojewale Olugbemi Tope Olaniyan John Adakole Adole gloria enevwo okotie Christopher Oloruntoba Akintayo Ayobami Dare Department of Anatomy Osun State UniversityCollege of Health SciencesOsogboOsunNigeria Department of Anatomy Bingham University KaruNasarawa StateNigeria Department of Anatomy Faculty of Basic Medical SciencesLagos State UniversityCollege of MedicineIkejaLagosNigeria Laboratory for Reproductive Biology and Developmental Programming Department of PhysiologyEdo UniversityUzairueIyamhoEdo StateNigeria Department of Physiology University of IbadanIbadanNigeria Department of Physiology Afe Babalola UniversityAdo-EkitiEkitiNigeria Department of Physiology Faculty of Basic Medical SciencesBingham UniversityKaruNasarawa StateNigeria

Objective:To evaluate the effects of aqueous leaf extract of Adansonia(A.)digitata L on dexamethasone-induced testicular damage in male Wistar ***:Twenty adult male Wistar rats weighing 170-190 g were divided into four ***Ⅰreceived 0.5 mL of phosphate buffer orally for 28 days and served as the normal control group;groupⅡreceived 10 mg/kg of dexamethasone(a synthetic glucocorticoid)intraperitoneally for 7 days and 0.5 mL of phosphate buffer orally for 21 days,groupⅢreceived 10 mg/kg of dexamethasone for 7 days and 800 mg/kg of *** extract orally for 21 days;groupⅣreceived 10 mg/kg of dexamethasone for 7 days and 300 mg/kg of vitamin-E orally for 21 *** was administered intra-peritoneally for 7 days and all administration lasted for 28 *** rats were sacrificed by anesthesia with diethyl ether and the testes of each animal were *** testis was homogenized in 0.25 M sucrose at 4℃for biochemical and histological ***:Administration of dexamethasone significantly decreased body weight,glucose-6-phosphate dehydrogenase(G6PDH),lactate dehydrogenase(LDH),superoxide dismutase(SOD),and glutathione peroxidase(GPx)(P<0.05),and significantly increased malondialdehyde(MDA)activities(P<0.05).The degeneration in the population of spermatogonia and vacuolation and abnormal widening of the interstitial spaces were observed in the rats treated with ***,administration of *** significantly increased SOD,GPx,G6PDH,and LDH levels,significantly decreased MDA activities and improved the histoarchitecture of the testis(P<0.05).Conclusions:*** may have an ameliorative effect on dexamethasone-induced testicular damage in Wistar rats because of its anti-inflammatory and antioxidant properties.

关键词： Adansonia digitata L Dexamethasone Vitamin E Testis Oxidative stress Wistar rats

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