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Advances in teleophthalmology and artificial intelligence for diabetic retinopathy screening:a narrative review

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Annals of Eye Science 2024年第2期9卷 24-37页

作者： Tanvi Chokshi Maria Jessica Cruz Jonathon Ross glenn Yiu Tschannen Eye Institute Department of OphthalmologyUniversity of CaliforniaDavis HealthSacramentoCAUSA Department of Research College of MedicineCalifornia Northstate UniversityElk GroveCAUSA

Background and Objective:Advances in teleophthalmology and artificial intelligence(AI)for diabetic retinal screening is of growing public health ***,only 30–40%of patients with diabetes adhere to recommended diabetes screening *** enhance early detection and reduce vision threatening complications,there has been a growing number of teleophthalmology programs and novel AI algorithms with the aim to improve eye care *** purpose of this review is to assess current literature on teleophthalmology and AI for use in diabetic retinopathy(DR)screening,and to discuss advances and barriers to these innovative ***:Literature review involving teleophthalmology and AI for DR screening,with focus on the past *** Content and Findings:Teleophthalmology has demonstrated the ability to increase DR screening rates,enable earlier eye care access,and reduce healthcare *** AI-based DR screening programs appear accurate and effective,but detection of other ocular pathologies is still under development and not yet approved in the United ***,technological,financial,and legal barriers limit widespread adoption and long-term sustainability of teleophthalmology ***:The use of teleophthalmology and AI algorithms expands eye care access and helps prevent vision loss from DR and potentially other sight threatening *** in the process utilized for arriving at a particular diagnosis or decision to refer,often referred to as the“black box”,remains a multifaceted issue within the field of telemedicine for developing trust and improving patient-centered outcomes.

关键词： Teleophthalmology artificial intelligence(AI) diabetic retinopathy(DR) screening public health

Antisense oligonucleotides provide optimism to the therapeutic landscape for tauopathies

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Neural Regeneration Research 2025年第3期20卷 803-804页

作者： glenn A.Harris Lauren R.Hirschfeld Rainwater Charitable Foundation Fort WorthTXUSA

Tauopathies are a group of neurodegenerative diseases characterized by abnormal metabolism of the misfolded tau protein. Tau is encoded by the microtubule-associated protein tau gene(MAPT) and can be classified as either 3-repeat(3R) or 4-repeat(4R) based on the number of repeat domains from alternative splicing of exon 10 of the MAPT gene.

关键词： tau metabolism diseases

Development of Cold-Chain for Postharvest Loss Reduction of Chinese Cabbage(Brassica campestris ***)

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Journal of Food Science and Engineering 2021年第1期11卷 9-22页

作者： Rathana Nai Buntong Borarin Tong Socheath Jessie LVipham glenn myoung Karen LeGrand Faculty of Agro-Industry Royal University of AgriculturePhnom Penh 12000-12401Cambodia Division of Research and Extension Royal University of AgriculturePhnom Penh 12000-12401Cambodia Mid-Campus Drive North Kansas State UniversityWeber HallManhattanKS 66506-8028United States Department of Food Science and Technology College of Agricultural and Environmental ScienceUniversity of California-Davis595 Hilgard LaneDavisCA 95616United States Science and Mathematics Division Department of BiologySierra College5100 Sierra College BoulevardRocklinCA 95677United States

Cold-chain is a well-known method for reducing postharvest losses and low-cost cooling technology has not previously been tested as part of postharvest handling in *** objective of this study was to measure postharvest loss,quality changes,and safety concerns of Chinese cabbage(Brassica campestris ***),during transportation using a cold-chain and compared to current farmers’employing ambient-chain *** quality and safety of Chinese cabbage were further evaluated by using ambient storage and Coolbot-powered cold chamber storage with and without modified atmosphere packaging(MAP).The samples were transported from farm sources in Battambang Province to a Phnom Penh specialty wholesale *** loss was evaluated by measuring weight loss and visual quality measurements,in addition to various physiochemical and nutritional quality *** addition,food safety was evaluated by quantifying total coliforms and Enterobacteriaceae,as well as the Salmonella spcies,and Escherichia *** results revealed that the cold-chain avoided postharvest loss,as indicated by produce weight gain of 14%on market arrival due to rehydration while inside the ice box during *** contrast,the traditional practice of ambient transport(28-31°C,62-78%relative humidity)resulted in very high postharvest loss,comprising 11%weight loss and 10%visual quality loss,for a total loss of 21%.Moreover,leaf yellowing found no marked influence on shelf life as L*,a*and b*values did not greatly differ with *** total soluble solids(TSS),titratable acidity(TA),pH and vitamin C content were not significantly affected during *** safety indicators(coliforms,Enterobacteriaceae,Salmonella and Escherichia coli)were lower in cold-chain storage than ambient-chain with lower counts of coliform bacteria,Enterobacteriaceae,and Salmonella *** traditionally handled *** coli was detected only in cold-chain *** had no effec

关键词： Chinese cabbage postharvest practices postharvest loss Coolbot storage ice box packaging MAP food safety

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用微机电系统制造更好的手表

科技纵览 2024年第2期 10-11页

作者： glenn Zorpette 不详

新型手表电机技术试图超越智能手表。半个多世纪以来,一直是计时市场支柱的指针式石英手表终于要进行高技术改造了?法国贝桑松的初创公司SilMach正在大力推进这一进程。该公司表示,他们使用硅微机电系统(MEMS)生产了一种用于指针式手表... 详细信息

新型手表电机技术试图超越智能手表。半个多世纪以来,一直是计时市场支柱的指针式石英手表终于要进行高技术改造了?法国贝桑松的初创公司SilMach正在大力推进这一进程。该公司表示,他们使用硅微机电系统(MEMS)生产了一种用于指针式手表的全新手表电机,与目前手表中使用的标准步进电机相比,其尺寸缩小一半,效率大约是前者的3倍。

关键词：指针式初创公司智能手表电机技术步进电机贝桑松大力推进

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技术突破可实现无稀土电动汽车

科技纵览 2024年第5期 12-13页

作者： glenn Zorpette 不详

磁性材料有助于打破垄断。随着全球制造的电动汽车和卡车越来越多,围绕建造性能卓越、绿色的理想汽车的竞争正在展开。竞争目标是研制一种牵引电机,其功率、可靠性和重量至少与当今行业标准的稀土永磁同步电机一样,但不含稀土元素。钕... 详细信息

磁性材料有助于打破垄断。随着全球制造的电动汽车和卡车越来越多,围绕建造性能卓越、绿色的理想汽车的竞争正在展开。竞争目标是研制一种牵引电机,其功率、可靠性和重量至少与当今行业标准的稀土永磁同步电机一样,但不含稀土元素。钕和等稀土元素带来了高昂的环境成本和供应链风险,而中国对这些元素持有近乎垄断的份额。

关键词：供应链风险稀土永磁同步电机电动汽车行业标准全球制造牵引电机磁性材料稀土元素

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下一代功率晶体管

科技纵览 2024年第3期 7-9页

作者： glenn Zorpette 不详

过去十年里,半导体领域里最半导体SEMICONDUCTORS大的事件之一就是传统硅在电力电子领域黯然失色,碳化硅(SiC)禾和镓氮化物(GaN)占据了数十亿美元的市场份额。随着这些新材料在重要领域的应用,自然而然地出现了一个问题:下一代新的功率... 详细信息

过去十年里,半导体领域里最半导体SEMICONDUCTORS大的事件之一就是传统硅在电力电子领域黯然失色,碳化硅(SiC)禾和镓氮化物(GaN)占据了数十亿美元的市场份额。随着这些新材料在重要领域的应用,自然而然地出现了一个问题:下一代新的功率半导体会是什么材料?

关键词：功率晶体管功率半导体半导体领域电力电子氮化物市场份额 SEMICON 下一代

Testosterone and metabolic syndrome

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Asian Journal of Andrology 2015年第2期17卷 192-196,I0006页

作者： glenn R Cunningham Departments of Medicine and Molecular and Cellular Biology Baylor College of Medicine Baylor St. Luke's Medical Center 6624 Fannin Suite 1180 Houston TX 77030 USA.

Controversies surround the usefulness of identifying patients with the metabolic syndrome （MetS）. Many of the components are accepted risk factors for cardiovascular disease （CVD）. Although the MetS as defined includes many men with insulin resistance, insulin resistance is not universal. The low total testosterone （TT） and sex hormone binding globulin （SHBG） levels in these men are best explained by the hyperinsulinism and increased inflammatory cytokines that accompany obesity and increased waist circumference. It is informative that low SHBG levels predict future development of the MetS. Evidence is strong relating low TT levels to CVD in men with and without the MetS; however, the relationship may not be causal. The recommendations of the International Diabetes Federation for managing the MetS include cardiovascular risk assessment, lifestyle changes in diet, exercise, weight reduction and treatment of individual components of the MetS. Unfortunately, it is uncommon to see patients with the MetS lose and maintain a 10% weight loss. Recent reports showing testosterone treatment induced dramatic changes in weight, waist circumference, insulin sensitivity, hemoglobin Alc levels and improvements in each of the components of the MetS are intriguing. While some observational studies have reported that testosterone replacement therapy increases cardiovascular events, the Food and Drug Administration in the United States has reviewed these reports and found them to be seriously flawed. Large, randomized, placebo-controlled trials are needed to provide more definitive data regarding the efficacy and safety of this treatment in middle and older men with the MetS and low TT levels.

关键词： cardiovascular risk metabolic syndrome sex hormone binding globulin testosterone testosterone replacement therapy

Improved properties and thermal stability of a titanium-stainless steel solid-state weld with a niobium interlayer

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Journal of Materials Science & Technology 2021年第20期79卷 191-204页

作者： Jianxiong Li Anupam Vivek glenn Daehn Department of Materials Science and Engineering The Ohio State University2041 College RoadColumbusOH43210USA

Stainless steel(SS)and titanium alloys can be welded in the solid-state by high speed oblique ***,the effect of a niobium(Nb)interlayer on weld strength and thermal stability is *** Ti/SS and Ti/Nb/SS welds were subjected to thermal exposure ranging from 300℃ to 950℃ for 1.5 *** exposure monotonically decreases the strength and toughness of the Ti/SS pair with a dramatic falloff in strength and change in failure mode from partial pullout failure to full interfacial fracture at 600℃.With the interlayer,toughness was increased versus baseline up to 700℃ thermal exposure and then intermetallic formation again caused falloff in *** for the production,properties and applications of these classes of welds are provided.

关键词： Impact spot welding Titanium alloy Stainless steel Nb interlayer Thermal exposure Phase transformation

Phylogeny of nucleus medianus of the posterior tubercle in ray-finned fishes

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Integrative Zoology 2009年第1期4卷 134-152页

作者： R.glenn NORTHCUTT Laboratory of Comparative Neurobiology Scripps Institution of Oceanographyand Department of NeurosciencesUniversity of CaliforniaLa JollaUSA

The brains of ray-finned fishes form a morphocline of increasing complexity,from cladistians through *** is particularly apparent in the posterior tubercle of the *** cladistians,the posterior tubercle consists of a periventricular nucleus and a migrated nucleus medianus that is fused across the *** more advanced ray-finned fishes,such as gars and bowfins,the posterior tubercle comprises numerous additional mi-grated nuclei,termed the preglomerular complex,in addition to a more well developed nucleus *** teleosts,the most derived ray-finned fishes,there is an even more elaborate preglomerular complex,but there is no recognizable nucleus *** an attempt to explain the variation in the posterior tubercle of the diencephalon in ray-finned fishes,the immunohistochemistry and connections of nucleus medianus were examined in cladistians,gars and *** each of these taxa,nucleus medianus exhibits large numbers of calretinin-positive neurons and has ascending projections that terminate in several divisions of the *** teleosts,such as goldfish,also exhibit numerous cell groups in the posterior tubercle that are rich in calretinin,none of these cell groups has connections that are comparable to those of nucleus medianus in non-teleost ray-finned *** is possible,therefore,that nucleus medianus was lost with the origin of teleosts.

关键词： bichirs evolution gars nucleus medianus posterior tubercle sturgeons.