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A Preliminary Study in the Effect of <i>Astragali radix</i>, a Qi-Invigorating Herb, on Mitochondria: Insights at Cellular Level and Mouse Tissues Level

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Chinese Medicine 2020年第3期11卷 113-125页

作者： Yu Chen Mengmei Li Zhongzhen Cai Yuming Chen Lin Wang Jie Teng Qian Feng Caixia Li glen rein Bruce Qing Tang Xuemei Bai ENNOVA Institute of Life Science and Technology ENN Group Langfang China Quantum Biology Research Laboratory Ridgway USA

Objectives: To explore the effects of Qi-invigorating herbs on mitochondrial function using cultured cells and animal organs. Methods: Using water extracts of Astragali radix, we investigated the effect of “Qi-invigoration” on M-1 renal cells and mouse organs in-vitro including total adenylate production (TAP), reactive oxygen species (ROS) levels, and mitochondrial membrane potential (MMP). We also examined the effect on antioxidant capacity by conducting an analysis of superoxide dismutase (SOD) and glutathione (GSH). Results: 1) Astragali radix increased mitochondrial TAP generation and decreased ROS levels in both mouse kidney tissues and M-1 renal cells. 2) Astragali radix also significantly increased MMP and GSH levels in M-1 cells, but in the kidney tissue, there was no significant change in MMP levels and a decrease in GSH levels. 3) Astragali radix stimulated TAP levels in the heart, spleen, lung, kidney and skeletal muscle tissue, which was accompanied by the reduction of ROS. 4) For the meridian organs that Astragali radix

关键词： Qi Astragali radix Mitochondria Total Adenylate Antioxidant Capacity

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The Effect of TCM Herbs on Mitochondrial Functions: The Linkage between Qi and Mitochondria

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Chinese Medicine 2020年第4期11卷 127-141页

作者： Yu Chen Qian Feng Mengmei Li Zhongzhen Cai Yuming Chen Lin Wang Jie Teng Yanjie Chen Wenjun Wang glen rein Bruce Qing Tang Xuemei Bai ENNOVA Institute of Life Science and Technology ENN Group Langfang China Quantum Biology Research Lab Ridgway USA

The linkage between Qi and mitochondria was investigated by exploring the effect of Traditional Chinese Medicine (TCM) Qi-invigorating herbs on mitochondrial function at the biochemical and molecular levels. Three Chinese herbs (Astragali radix, Herba cistanche, Panax ginseng) were used to treat cultured mouse kidney cells and the generation of adenosine triphosphate (ATP) was measured. The Qi-invigorating herb, Astragali radix, was selected for further study using additional biological and molecular parameters, including ATP, reactive oxygen species (ROS), mitochondrial membrane potential (MMP), mtDNA copies, superoxide dismutase (SOD), glutathione (GSH), cell growth, cell viability and transcriptomes. We also chose two concentrations of Astragali radix to study the hormetic effect. The results indicated that: 1) Qi-invigorating herbs have significant effects on the function of mitochondria, with ATP production and the antioxidant capacity being significantly enhanced, and ROS levels being reduced, allowing for a more optimal oxidation environment. The effect of the herbs followed a hormetic curve with a stimulating effect at lower doses but an inhibiting effect at high doses;2) The growth of the cells was not affected

关键词： Qi-Invigorating Herbs Qi Mitochondria Hormesis

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