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Development.validat.on,and t.ansport.bilit. of several machine-learned,non-exercise-based VO_(2max)predict.on models for older adult.

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Journal of Sport.and Healt. Science 2024年第5期13卷 611-620页

作者： Benjamin t.Schumacher Michael J.LaMont. Andrea Z.LaCroix Eleanor M.Simonsick St.ven P.Hooker Humbert. Parada jr. John Bellet.iere Arun Kumar Herbert.Wert.eim School of Public Healt. and Human Longevit. Science University of California San DiegoLa JollaCA 92093USA Depart.ent.of Epidemiology and Environment.l Healt. School of Public Health and Health ProfessionsUniversity at BuffaloState University of New YorkBuffaloNY 14214USA t.anslat.onal Geront.logy Branch Intramural Research ProgramNational Institute on AgingNational Institutes of HealthBaltimoreMD 21225USA College of Healt. and Human Services San Diego State UniversitySan DiegoCA 92182USA Division of Epidemiology and Biost.t.st.cs School of Public HealthSan Diego State UniversitySan DiegoCA 92182USA Universit. of California San Diego Moores Cancer Cent.r La JollaCA 92093USA Comput.r Science and Engineering and Halicioglu Dat. Science Inst.t.t. University of California San DiegoLa JollaCA 92093USA

Background:t.ere exist.few maximal oxygen upt.ke(VO_(2max))non-exercise-based predict.on equat.ons,fewer using machine learning(ML),and none specifically for older *** direct.measurement.of VO_(2max)is infeasible in large epidemiologic cohort.st.dies,we sought.t. develop,validat.,compare,and assess t.e t.ansport.bilit. of several ML VO_(2max)predict.on ***:t.e Balt.more Longit.dinal St.dy of Aging(BLSA)part.cipant. wit. valid VO2_(max)t.st. were included(n=1080).Least.absolut. shrinkage and select.on operat.r,linear-and t.ee-boost.d ext.eme gradient.boost.ng,random forest.and support.vect.r machine(SVM)algorit.ms were t.ained t. predict.VO_(2max)*** developed t.ese algorit.ms for:(a)t.e overall BLSA,(b)by sex,(c)using all BLSA variables,and(d)variables common in aging ***,we quant.fied t.e associat.ons bet.een measured and predict.d VO_(2max)and ***:t.e age was 69.0±10.4 years(mean±SD)and t.e measured VO_(2max)was 21.6±5.9 mL/kg/*** absolut. shrinkage and select.on operat.r,linear-and t.ee-boost.d ext.eme gradient.boost.ng,random forest.and support.vect.r machine yielded root.mean squared errors of 3.4 mL/kg/min,3.6 mL/kg/min,3.4 mL/kg/min,3.6 mL/kg/min,and 3.5 mL/kg/min,*** quart.les of measured VO_(2max)showed an inverse gradient.in mort.lit. *** VO_(2max)variables yielded similar effect.est.mat.s but.were not.robust.t. ***:Measured VO_(2max)is a st.ong predict.r of *** ML can improve t.e accuracy of predict.on as compared t. simpler approaches but.est.mat.s of associat.on wit. mort.lit. remain sensit.ve t. *** st.dies should seek t. reproduce t.ese result. so t.at.VO_(2max),an import.nt.vit.l sign,can be more broadly st.died as a modifiable t.rget.for promot.ng funct.onal resiliency and healt.y aging.

关键词： Cardiorespirat.ry fit.ess Predict.on algorit.ms Epidemiology Mort.lit.

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Impact.on Soil Organic C and t.t.l Soil N from Cool- and Warm-Season Legumes Used in a Green Manure-Forage Cropping Syst.m

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Agricult.ral Sciences 2024年第3期15卷 333-357页

作者： Clark B. Neely Francis M. Rouquet.e jr. Crist.ne L.S. Morgan Frank M. Hons William L. Rooney Gerald R. Smit. Depart.ent.of Soil and Crop Science Washington State University Pullman WA USA t.xas A&M AgriLife Research Overton TX USA Chief Scient.fic Officer Soil Health Institute Morrisville NC USA Depart.ent.of Soil and Crop Science Texas A&M University College Station TX USA

Annual forage legumes are import.nt.component. of livest.ck product.on syst.ms in East.t.xas and t.e sout.east.rn US. Forage legumes cont.ibut. nit.ogen (N) t. cropping syst.ms t.rough biological N fixat.on, and t.eir seasonal biomass product.on can be managed t. complement.forage grasses. Our research object.ves were t. evaluat. bot. warm- and cool-season annual forage legumes as green manure for biomass, N cont.nt. abilit. t. enhance soil organic carbon (SOC) and soil N, and impact.on post.season forage grass crops. Nine warm-season forage legumes (WSL) were spring plant.d and incorporat.d as green manure in t.e fall. Forage rye (Secale cereale L.) was plant.d following t.e incorporat.on of WSL t.eat.ent.. Eight.cool-season forage legumes (CSL) were fall plant.d in previously fallow plot. and incorporat.d as green manure in lat. spring. Sorghum-sudangrass (Sorghum bicolor x Sorghum bicolor var. sudanense) was plant.d over all t.eat.ent. in early summer aft.r forage rye harvest.and incorporat.on of CSL t.eat.ent.. Sorghum-sudangrass was harvest.d in June, August.and Sept.mber, and t.eat.ent. were evaluat.d for dry mat.er and N concent.at.on. Soil cores were t.ken from each plot. split.int. dept.s of 0 t. 15, 15 t. 30 and 30 t. 60 cm, and soil C and N were measured using combust.on analysis. Nylon mesh bags cont.ining plant.samples were buried at.15 cm and used t. evaluat. decomposit.on rat. of above ground legume biomass, including change in C and N concent.at.ons. Mungbean (Vigna radiat. L. [Wilczek]) had t.e highest.shoot.biomass yield (6.24 t.DM ha-1) and cont.ibut.d t.e most.t.t.l N (167 kg∙ha-1) and t.t.l C (3043 kg∙ha-1) of t.e WSL t.st.d. Decomposit.on rat. of WSL biomass was rapid in t.e first.10 weeks and very slow aft.rward. Wint.r pea (Pisum sat.vum L. spp. sat.vum), arrow leaf clover (t.ifolium vesiculosum Savi.), and crimson clover (t.ifolium incarnat.m L.) were t.e most.product.ve CSL in t.is t.ial. Aust.ian wint.r pea

关键词： Annual Legumes Soil N Soil Organic C Green Manure Deer Browse Forage Cropping Syst.ms

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Legume Green Manure and Int.rcropping for High Biomass Sorghum Product.on

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Agricult.ral Sciences 2024年第6期15卷 605-621页

作者： Clark B. Neely Francis M. Rouquet.e jr. Crist.ne L. S. Morgan Frank M. Hons William L. Rooney Gerald R. Smit. Depart.ent.of Soil and Crop Science Washington State University Pullman WA USA t.xas A&M AgriLife Research Overton TX USA Soil Healt. Inst.t.t. Morrisville NC USA Depart.ent.of Soil and Crop Science Texas A&M University College Station TX USA

Before t.e advent.of cheap, synt.et.c fert.lizers, legumes were commonly used as green manure crops for t.eir abilit. t. fix at.ospheric nit.ogen (N). A t.ree-year st.dy at.Overt.n, t. examined legume int.grat.on int. high-biomass sorghum (Sorghum bicolor L.) product.on syst.ms on a Lilbert.loamy fine sand recent.y cult.vat.d aft.r a fert.lized bermudagrass [Cynodon dact.lon (L.) Pers.] past.re. In t.is split.split.plot.design, ‘Dixie’ crimson clover (t.ifolium incarnat.m L.) and ‘Iron and Clay’ cowpea (Vigna unguiculat. L.) were int.grat.d int. a high-biomass sorghum product.on syst.m t. evaluat. impact. on N concent.at.on, C concent.at.on, and yield of high-biomass sorghum and t.eir impact. on soil t.t.l N and soil organic carbon (SOC). Main plot. were split.int. crimson clover green manure (CLGM) and wint.r fallow (FALL) followed by t.ree sub-plot. split.int. warm-season crop rot.t.ons: cowpea green manure (CPGM), cowpea-sorghum int.rcrop (CPSR), and sorghum monocrop (SORG). t.ree N fert.lizer t.eat.ent. (0, 45, 90 kg N∙ha−1) were randomized and applied as sub-sub plot.. t.e CLGM increased (P sorghum biomass yield (16.5 t.DM∙ha−1) 28% in year t.ree but.had no effect.in t.e first.t.o years. t.e CPSR t.eat.ent.reduced sorghum yield up t. 62% compared t. SORG;whereas CPGM increased sorghum yield 56% and 18% t.e t.o years following cowpea incorporat.on. Rat. of N fert.lizer had no effect.on sorghum biomass yield. Decrease in SOC and soil N over t.me indicat.d mineralizat.on of organic N and may explain why no N fert.lizer response was observed in sorghum biomass yield. Cowpea showed st.ong pot.nt.al as a green manure crop but.proved t. be t.o compet.t.ve for successful int.rcropping in high-biomass sorghum product.on syst.ms.

关键词： High-Biomass Sorghum Legumes Green Manure Int.rcrop Cowpea Crimson Clover Soil Organic Carbon Soil Nit.ogen

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Ca^(2+) binding t. t.e C_(2)E domain of ot.ferlin is required for hair cell exocyt.sis and hearing

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Prot.in & Cell 2024年第4期15卷 305-312页

作者： Han Chen Mehar Monga Qinghua Fang Loujin Slit.n Jakob Neef Shashank S.Chepurwar Regina Célia Mingroni Net.o Karina Lezirovit. Alfredo t.bit.,jr. Frit. Benseler Nils Brose Kat.rin Kusch Carolin Wichmann Nicola St.enzke Barbara Vona Julia Preobraschenski t.bias Moser Inst.t.t. for Audit.ry Neuroscience and InnerEarLab University Medical Center Göttingen37075 GöttingenGermany Collaborat.ve Research Cent.r 889 University of Göttingen37075 GöttingenGermany Audit.ry Neuroscience and Synapt.c Nanophysiology Group Max Planck Institute for Multidisciplinary Sciences37075 GöttingenGermany Göt.ingen Graduat. Cent.r for Neurosciences Biophysics and Molecular BiosciencesUniversity of Göttingen37075 GöttingenGermany Biochemist.y of Membrane Dynamics Group Institute for Auditory NeuroscienceUniversity Medical Center Göttingen37075 GöttingenGermany Molecular Archit.ct.re of Synapses Group Institute for Auditory Neuroscience and InnerEarLabUniversity Medical Center Göttingen37075 GöttingenGermany Cent.r for Biost.uct.ral Imaging of Neurodegenerat.on University Medical Center Göttingen37075 GöttingenGermany Audit.ry Syst.ms Physiology Group Institute for Auditory Neuroscience and InnerEarLabUniversity Medical Center Göttingen37075 GöttingenGermany Depart.ment. de Genét.ca e Biologia Evolut.va Centro de Pesquisas sobre o Genoma Humano e Células-TroncoInstituto de BiociênciasUniversidade de São PauloSão Paulo 05508-220Brazil Laborat.rio de Ot.rrinolaringologia/LIM32 Faculdade de MedicinaHospital das ClínicasUniversidade de São PauloSão PauloSP 05508-220Brazil DERDIC Pontifícia Universidade Católica de São PauloSão Paulo 05508-220Brazil Depart.ent.of Molecular Neurobiology Max Planck Institute for Multidisciplinary Sciences37075 GöttingenGermany Mult.scale Bioimaging Clust.r of Excellence(MBExC) University of Göttingen37075 GöttingenGermany Funct.onal Audit.ry Genomics Group Auditory Neuroscience and Optogenetics LaboratoryGerman Primate Center37077 GöttingenGermany Hearing Genomics Group Institute for Auditory Neuroscience and InnerEarLabUniversity Medical Center Göttingen37075 GöttingenGermany Inst.t.t. of Human Genet.cs University Medical Center Göttingen37075 GöttingenGermany

Dear Edit.r,Afferent.synapses of cochlear inner hair cells(IHCs)employ a unique molecular machinery(see ext.nded background in Supplement.ry Mat.rials).Ot.ferlin is a key player in t.is machinery and it. defect. cause human audit.ry synapt.pat.y(Moser and St.rr,2016).Ot.ferlin,a t.il-anchored(Vogl et.al.,2016)mult.-C_(2)-domain prot.in(Fig.1Ai)specific t. hair cells(Roux et.al.,2006),is a member of t.e ferlin prot.in family involved in membrane t.afficking and repair t.at.are of major disease relevance(Pangršičet.al.,2012),also see Supplement.ry *** is dist.ibut.d broadly wit.in IHCs(Fig.2Ai-Aiii;Pangrsic et.al.,2010;Roux et.al.,2006).

关键词： audit.ry hair

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Large int.st.nal dynamics differ bet.een fowl and swine:Anat.mical modificat.ons,microbial collaborat.on,and digest.ve advant.ges from fibrolyt.c enzymes

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Animal Nut.it.on 2022年第4期11卷 160-170页

作者： Edwin t.Moran jr. Michael R.Bedford Poult.y Science Depart.ent Auburn UniversityAL 36830-5416USA AB Vist. Woodstock CourtBlenheim RoadMarlboroughWiltshire SN84ANUK

t.e large int.st.nal syst.ms of fowl and swine recover nut.ient. from ileal indigest. by a st.at.gically different.*** wit. fowl ent.r a short.colon where ret.o-perist.lsis using urine from t.e urodeum carries small part.culat.s and solut.s int. bot. ceca while coarse mat.rials collect.in t.e *** repet.t.vely add fine and soluble mat.rials int. bot. ceca t. cont.nue ferment.t.on unt.l complexit. of t.e remainder exceeds microbial act.on,t.en cont.nt. apart.from faeces are ent.rely *** wit. swine init.ally ent.r a short.cecum followed by a lengt.y progression t.rough t. t.e rect.l *** out.pocket.ngs of circular muscle or haust.ae occur t.roughout.t.e lengt. of t.e pig's cecum and helicoidal *** pocket.carries cont.nt. acquired earlier in t.e *** collect. fines and solut.s int. haust.ae during t.eir progression t.rough t.e colon whereas coarse part.culat.s assemble in t.e *** cont.nt. cont.nually ferment.during movement.t. t.e dist.l colon wit. result.ng volat.le fat.y acids(VFA)and elect.olyt.s being *** loosely covers t.e lumen surface in caeca as well as helicoidal colon t.at.may capt.re microbes from act.ve int.st.nal cont.nt. as well as release ot.ers t. sust.in *** microbial communit. cont.nually modifies t. accommodat. fibre complexit. as *** st.rches(RS)and simple oligosaccharides rapidly ferment.t. yield VFA while encouraging but.ric acid in t.e cecum and ant.rior colon,whereas non-st.rch polysaccharides(NSP)complexit. requires ext.nded durat.ons t.rough t.e remaining colon t.at.enhance acet.c *** fibre event.ally result. in undue complexit. for ferment.t.on and consolidat.s at.t.rminat.on of t.e *** compact.pellet. are placed on core cont.nt. t. form faeces having a nodular ***,propionic,and but.ric acids represent.t.e bulk of VFA and are derived from non-digest.ble *** enzymes,when supplement.d

关键词： But.ric acid Endogenous prot.in Int.st.nal microbes Large int.st.ne Volat.le fat.y acids Xylanase

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Diet.ry free fat.y acids complex wit. amylose creat.ng anot.er form of resist.nt.st.rch: Gast.oint.st.nal format.on wit. fowl and swine

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Animal Nut.it.on 2021年第4期7卷 1124-1132页

作者： Edwin t.Moran jr. Poult.y Science Depart.ent Auburn UniversityAL36849-5416USA

Fat.added t. poult.y and swine feeds oft.n cont.ins abundant.free fat.y acids(FFA)t.at.can impair digest.ble energy(DE).Placement.of t.e fat.y acid(FA)hydrocarbon chain in t.e helix core reformed from amylose creat.s a complex of bot. *** modificat.ons creat. a new st.uct.re t.rmed t.e V-helix t.at.becomes resist.nt.t.α-*** in grain nat.rally cont.in minimal amount. of t.ese complexes wit. more being generat.d during food manufact.ring when moist.re and heat.release amylose in t.e presence of FFA.A paucit. of FFA usually exist. in complet. feeds wit.out.sources of poorqualit. *** fat. and by-product.meals from rendering are prominent.in t.eir sat.rat.d FFA cont.nt.which favorably complex wit.in t.e helix.V-helix-FA complexes may arise during t.eir concurrent.encount.r of FFA t.get.er wit. amylose during feed manufact.re,part.cularly *** in t.e gast.oint.st.nal t.act.GIt.are speculat.d t. furt.er form complexes when present.t.get.er wit. *** amylose may be dissolved in t.e gast.ic and small int.st.nal milieu,FFA separat.ly coalesce int. hydrophobic fat.droplet. along wit. ot.er diet.ry *** of complexes is likely rest.ict.d unt.l FFA are released int. t.e aqueous phase during fat.***α-amylase may be prominent.V-helix-FA complexes being resist.nt.t. enzymic at.ack pass int. t.e large *** microbial cat.bolism of V-helices may generat. volat.le fat.y acids t.at.are absorbed by t.e mucosa;however,an inabilit. t. use FFA once released leads t. t.eir excret.on and basis for decreased *** microbial populat.ons wit. young animals usually lack t.e capacit. t. fully cat.bolize t.e V-helix,furt.er ext.nding t.e loss in DE.

关键词： Amylose Digest.ble energy Free fat.y acid Feed manufact.re

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Generalized Jackiw-t.it.lboim gravit. in presence of Block brane-like models

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Chinese Physics C 2022年第12期46卷 258-270页

作者： I.Andrade D.Bazeia A.S.Lobão jr. R.Menezes Depart.ment. de Física Universidade Federal da Paraíba58051-970 João PessoaPBBrazil Escola t.cnica de Saúde de Cajazeiras Universidade Federal de Campina Grande58900-000 CajazeirasPBBrazil Depart.ment. de Ciências Exat.s Universidade Federal da Paraíba58297-000 Rio TintoPBBrazil

We invest.gat. generalized Jackiw-t.it.lboim gravit.,coupling t.e dilat.n field wit. t.o scalar mat.er *** obt.in t.e equat.ons of mot.on for t.e fields and invest.gat. a linear pert.rbat.on of t.e solut.ons in *** st.dy t.o specific sit.at.ons t.at.allow for analyt.c solut.ons wit. t.pological behavior and check how t.e dilat.n field,t.e warp fact.r and t.e Ricci scalar *** part.cular,we show how t.e paramet.rs can be used t. modify t.e st.uct.re of t.e ***,t.e pert.rbat.ons are,in general,described by int.icat. coupled different.al equat.ons,but.in some specific cases,we can const.uct.t.e corresponding zero modes analyt.cally.

关键词： Dilat.n 2D gravit. Mult.field

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亚热带森林植物的叶片和根系功能性状部分耦合但具有不同的群落性状分布格局

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Journal of Plant.Ecology 2024年第1期17卷 94-110页

作者： Wenqi Luo Oscar J Valverde-Barrant.s Monique Weemst.a James F Cahill jr.Zi Wang Dong He Yongfa Chen Chengjin Chu Youshi Wang St.t. Key Laborat.ry of Biocont.ol School of Life Sciences/School of EcologySun Yat-sen UniversityGuangzhou 510275China Int.rnat.onal Cent.r for t.opical Bot.ny Department of Biological SciencesFlorida International UniversityMiamiFL 33199USA Depart.ent.of Biological Sciences University of AlbertaEdmontonABT6G 2E9Canada School of Ecology and t.e Environment Xinjiang UniversityUrumqi 830046China

植物的生态过程依赖于叶片和根系的功能运行,但少有研究同时关注这两类性状在群落中的分布格局(Ct.)。本文测定了广东亚热带森林44种共生木本植物的16个叶片和根系性状,旨在检验类比的叶片和根系性状是否耦合,是否沿类似的功能性状谱变... 详细信息

植物的生态过程依赖于叶片和根系的功能运行,但少有研究同时关注这两类性状在群落中的分布格局(Ct.)。本文测定了广东亚热带森林44种共生木本植物的16个叶片和根系性状,旨在检验类比的叶片和根系性状是否耦合,是否沿类似的功能性状谱变异,是否表现出类似的Ct.,其Ct.和群落加权平均性状值(CWM)是否沿环境梯度表现出类似的响应。研究结果表明,叶片和根系性状变异的第一轴均呈显出由资源获取向资源保守变异的经济学谱,但叶片变异的第二轴主要由叶片碳含量表征,而根系变异的第二轴主要由反映菌根协作程度的根系粗细表征。类比的叶片和根系化学性状整体正相关,但形态性状的耦合程度较低。在群落水平上,叶片和根系性状第一轴的CWM均随海拔升高而变得更保守,而第二轴的变化则不一致。随土壤磷含量的降低或钾含量的升高,根系变得更细和在养分性状上更保守,而叶片性状无显著变化。当整合多维性状轴时,叶片性状呈发散格局,且随海拔、土壤磷和钾含量的增加呈收敛趋势;而根系性状呈收敛格局,但沿上述环境梯度呈发散趋势。该研究强调,叶片和根系性状与环境互作的差异可能导致不同的性状分布格局;植物可通过多样的地上和地下功能设计应对环境异质性。

关键词：性状维度群落构建叶片性状根系性状植物经济谱群落性状结构亚热带森林

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t.e Paleoarchean Nort.ern Mundo Novo Greenst.ne Belt.São Francisco Crat.n:Geochemist.y,U-Pb-Hf-O in zircon and pyrit.δ^(34)S-Δ^(33)S-Δ^(36)S signat.res

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Geoscience Front.ers 2022年第5期13卷 190-206页

作者： Guilherme S.t.les Farid Chemale jr. Janaína N.Ávila t.evor R.Ireland Unidade Acadêmica de Mineração e Geologia Universidade Federal de Campina GrandeCampina GrandeBrazil Programa de Pós-Graduação em Geologia Universidade de BrasíliaBrasíliaBrazil Programa de Pós-Graduação em Geologia Universidade do Vale do Rio dos SinosSão LeopoldoBrazil Research School of Eart. Sciences The Australian National UniversityCanberraACT 2601Australia Griffit. Cent.e for Social and Cult.ral Research Griffith UniversityNathanQueensland 4111Australia

Greenst.ne belt. cont.in several clues about.t.e evolut.onary hist.ry of primit.ve ***,we describe t.e volcano-sediment.ry rock associat.on exposed along t.e east.rn margin of t.e Gavião Block,named t.e Nort.ern Mundo Novo Greenst.ne Belt.N-MNGB),and present.dat. collect.d wit. different.t.chniques,including U–Pb–Hf–O isot.pes of zircon and mult.ple sulfur isot.pes(^(32)S,^(33)S,^(34)S,and ^(36)S)of pyrit. from t.is supracrust.l sequence.A pillowed met.basalt.sit.at.d in t.e upper sect.on of t.e N-MNGB is 3337±25 Ma old and has zircon wit. ε_(Hf)(t.=2.47 t.1.40,Hf model ages bet.een 3.75 Ga and 3.82 Ga,and δ^(18)O=+3.6‰t.+7.3‰.t.ese isot.pic dat.,t.get.er wit. compiled whole-rock t.ace element.dat.,suggest.t.at.t.e mafic met.volcanic rocks formed in a subduct.on-relat.d set.ing,likely a back-arc basin juxt.posed t. a cont.nent.l *** t.is cont.xt.t.e magma int.ract.d wit. older Eoarchean crust.l component. from t.e Gavião *** zircons from t.e overlying quart.it.s of t.e Jacobina Group are sourced from Paleoarchean rocks,in accordance wit. previous st.dies,yielding a maximum deposit.onal age of 3353±22 *** det.it.l zircons have ε_(Hf)(t.=5.40 t.0.84,Hf model ages bet.een 3.66 Ga and 4.30 Ga,and δ^(18)O=+4.8‰t.+6.4‰.t.e pyrit. mult.ple sulfur isot.pe invest.gat.on of t.e 3.3 Ga supracrust.l rocks from t.e N-MNGB enabled a furt.er underst.nding of Paleoarchean sulfur *** samples have diverse isot.pic composit.ons t.at.indicat. sulfur sourced from dist.nct.***,t.ey preserve t.e signal of t.e anoxic Archean at.osphere,expressed by MIF-S signat.res(Δ^(33)S bet.een1.3‰t.+1.4‰)and a Δ^(36)S/Δ^(33)S slope of0.81 t.at.is indist.nguishable from t.e so-called Archean array.A BIF sample has a magmat.c origin of sulfur,as indicat.d by t.e limit.d Δ^(34)S range(0 t.+2‰),Δ^(33)S~0‰,and Δ^(36)S~0‰.A carbonaceous schist.shows posit.ve Δ^(34)S(2.1‰–3.5‰)and elevat.d Δ^(33)S(1.2‰–1.4‰)values,wit. corresponding negat.ve Δ^(36)S

关键词： Nort.ern Mundo Novo Greenst.ne Belt Mult.ple sulfur isot.pes Geochronology Paleoarchean Gavião Block São Francisco Crat.n

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t.e Prevalence of Het.rozygous Familial Hypercholest.rolemia among Adult.Filipino Pat.ent. wit. Dyslipidemia at.Universidad de Sant. Isabel Healt. Services Depart.ent. An Observat.onal Descript.ve Prospect.ve St.dy

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World Journal of Cardiovascular Diseases 2023年第7期13卷 377-395页

作者： Suzanne U. Jao-Sanchez Ramon t. Caceres jr. Shayne S. Calleja-t.ledano Int.rnal Medicine Depart.ent Universidad de Santa Isabel Health Services Department Naga City Camarines Sur Philippines

Object.ves: It.is t. det.rmine t.e prevalence of familial hypercholest.rolemia (FH) among adult.Filipino pat.ent. wit. dyslipidemia at.Universidad de Sant. Isabel Healt. Services Depart.ent.in one year. Met.ods: An observat.onal descript.ve prospect.ve st.dy involves Filipino pat.ent., aged 19 years and older, wit. dyslipidemia. t.e Dut.h Lipid Net.ork (DLN) Crit.ria was used t. diagnose FH. Prevalence dat. and cat.gorical variables were expressed as percent.ges, while cont.nuous variables were report.d as mean and st.ndard deviat.ons. Result.: 529 pat.ent. were included in t.e st.dy. 302 were females, and 227 were males. 180 (34%) scored Unlikely, 100 (19%) scored Probable, 185 (35%) scored Possible, and 64 (12%) were classified under Definit. Familial Hypercholest.rolemia. Most.of t.e pat.ent. diagnosed wit. definit. FH did not.have diabet.s, cerebrovascular disease (CVD), and coronary art.ry disease (CAD). t.e diagnosis was not.affect.d by gender, BMI, smoking, and alcohol consumpt.on. Hypert.nsion was significant.y correlat.d t. t.e diagnosis of FH, as most.of t.em were already hypert.nsive at.diagnosis. It.was not.d t.at.hypert.nsion, diabet.s, CVD, and CAD were seen at.an earlier age among pat.ent. wit. definit. FH. Conclusion: t.e prevalence of het.rozygous FH at.12% among dyslipidemia pat.ent. and 1.3% among t.e general populat.on was described for t.e first.t.me in our region. t.is result.should raise t.e awareness of our healt.care providers t.at.FH, which is a major risk fact.r for premat.re CAD and CVD, exist., and early det.ct.on and management.are import.nt.

关键词： Prevalence Het.rozygous Familial Hypercholest.rolemia Adult Filipino

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