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中国药理学与毒理学杂志 2023年第7期37卷 547-548页

作者： WANG Muran LI Peijun LI Zewen Beatriz S.da silva ZHENG Wu XIANG Zhenghua HE Yan XU Tao Cristina CORdeIRO deNG Lu DAI Yuwei YE Mengqian LIN Zhiqing ZHOU Jianhong ZHOU Xuzhao YE Fenfen rodrigo A CUNHA CHEN Jiangfan GUO Wei Wenzhou Medical University University of Coimbra NavalMedicalUniversity

depressive disorder ranks as a major burden of disease worldwide, yet the current antidepressant medications are limited by frequent non-responsiveness and significant side effects. The lateral septum(LS) is thought to control of depression, however, the cellular and circuit substrates are largely unknown. Here, we identified a subpopulation of LS GABAergic adenosine A2A receptors(A2AR)-positive neurons mediating depressive symptoms via direct projects to the lateral habenula(LHb) and the dorsomedial hypothalamus(DMH). Activation of A2AR in the LS augmented the spiking frequency of A2AR-positive neurons leading to a decreased activation of surrounding neurons and the bi-directional manipulation of LS-A2AR activity demonstrated that LS-A2ARs are necessary and sufficient to trigger depressive phenotypes. Thus, the optogenetic modulation(stimulation or inhibition) of LS-A2AR-positive neuronal activity or LSA2AR-positive neurons projection terminals to the LHb or DMH, phenocopied depressive behaviors. Moreover,A2AR are upregulated in the LS in two male mouse models of repeated stress-induced depression. This identification that aberrantly increased A2AR signaling in the LS is a critical upstream regulator of repeated stress-induced depressive-like behaviors provides a neurophysiological and circuit-based justification of the antidepressant potential of A2AR antagonists, prompting their clinical translation.

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Numerical Evaluation of Strength in the Interface during Indentation Spherical Testing in Thin Films

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Materials Sciences and Applications 2014年第3期5卷 149-157页

作者： rodrigo Araújo Avelino Manuel da silva Dias Federal University of Sao Joao del-Rei(UFSJ) Sao Joao Del-ReiBrazil Federal University of Rio Grande do Norte(UFRN) NatalBrazil

The need for more components that are more resistant to wear and corrosion has promoted a growing interest in surface engineering. The search for improved tribological properties in materials contributes to the development of processes that extend the useful life of components and their applications in increasingly severe environments. In this respect, thin ceramic coatings have been used to enhance the tribological properties of components that operate under these conditions. However, new experimental assays are needed to assess the behaviour of these films and their surface as substrate. These experimental analyses require the use of sophisticated equipment and specialized personnel. On the other hand, with advances in computational mechanics, the application of numerical analysis to solve numerous technological problems has been increasingly frequent, owing to its low operational costs. This study aims to simulate an indentation assay with spherical penetrator in systems composed of thin ceramic film deposited on metallic substrate using a Finite Element commercial code. The main objective of this study was to evaluate the field behaviour of stresses in the contact region of the indenter with the sample, on the outline of the impression made by the penetrator and, primarily, on the film-substrate interface.

关键词： Finite Elements Indentation Test Thin Films

Acute Appendicitis after Liver Transplant: A Case Report and Review of the Literature

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Open Journal of Organ Transplant Surgery 2014年第4期4卷 29-32页

作者： Ronaldo de Oliveira Andrade rodrigo da silva Pires Raul évora silva Felipe Pedreira Tavares de Mello Cláudia Cristina Tavares de Sousa Samanta Teixeira Basto Eduardo de Souza Martins Fernandes department of Surgery and Liver Transplant Hospital Adventista Silvestre Rio de Janeiro Brazil

Acute appendicitis is rare in the postoperative period of liver transplantation;only 23 cases were described in the literature to date, including late and immediate postoperative. Our case reports a patient who was presented with acute appendicitis in the immediate post-transplant and died in the subsequent postoperative period. The article reviews the available literature and all cases known until now, commenting on incidence, casual factors, symptoms, diagnostic and management.

关键词： Appendicitis Complications Early Postoperative Liver Transplantation

SARS-CoV-2 productively infects primary human immune system cells in vitro and in CoviD-19 patients

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Journal of Molecular Cell Biology 2022年第4期14卷 51-64页

作者： Marjorie C.Pontelli italo A.Castro Ronaldo B.Martins Leonardo La Serra Flavio P.Veras Daniele C.Nascimento Camila M.silva Ricardo S.Cardoso Roberta Rosales Rogério Gomes Thais M.Lima Juliano P.Souza Brenda C.Vitti Diego B.Caetite Mikhael H.F.de Lima Spencer D.Stumpf Cassandra E.Thompson Louis-Marie Bloyet Juliana E Toller-Kawahisa Marcela C.Giannini Leticia P.Bonjorno Marial.F.Lopes Sabrina S.Batah Li Siyuan rodrigo Luppino-Assad Sergio C.L.Almeida Fabiola R.Oliveira Maira N.Benatti Lorena L.F.Pontes rodrigo C.Santana Fernando C.Vilar Maria Auxiliadora-Martins Pei-Yong Shi Thiago M.Cunha rodrigo T.Calado JoséC.Alves-Filho Dario S.Zamboni Alexandre T.Fabro Paulo Louzada-Junior Rene D.R.Oliveira Sean P.J.Whelan Fernando Q.Cunha Eurico Arruda Virology Research Center Ribeirao Preto Medical SchoolUniversity of Sao Pauloibeirao PretoSao Paulo 14049-900.Brazil Center of Research in Inflammatory Diseases Ribeirao Preto Medical SchoolUniversity of Sao PauloRibeirao PretoSao Paulo 14049-900Brazil department of Celland Molecular Biology Ribeirao Preto Medical SchoolUniversityof Sao PauloRibeirao PretoSao Paulo 14049-900 Brazil Regional Blood Centerof Ribeirao Preto Ribeirao Preto Medical ScholUniversity of Sao PauloRibeirao PretoSao Paulo 14049-900Brazil department of Biochemistry&Molecular Biology the University of Texas Medical BranchGalvestonTX7755USA Divisions of Clinical lmmunology Infectious Diseases and Intensive Care UnitRibeirao Preto Medical Schooniversity of Sao PauloRibeirao PretoSao Paulo 14049-900Brazil department of Pathology Ribeirao Preto Medical Scholniversity of Sao PauloRibeirao PretoSao Paulo 14049-900Brazil department of Molecular Microbiology.Washington University in St.Louis Saint LouisMO 63110USA

The severe acute respiratory syndrome coronavirus 2(SARS-CovV-2)infection is associated with a hyperinflammatory state and lymphocytopenia,a hallmark that appears as both signature and prognosis of disease severity *** cytokine storm and a sustained inflammatory state are commonly associated with immune cell depletion,it is still unclear whether direct SARS-Cov-2 infection of immune cells could also play a role in this scenario by harboring viral *** found that monocytes,as well as both B and T lymphocytes,were susceptible to SARS-Cov-2 infection in vitro,accumulating double-stranded RNA consistent with viral RNA replication and ultimately leading to expressive T cell *** addition,flow cytometry and immunofluorescence analysis revealed that SARS-Cov-2 was frequently detected in monocytes and B lymphocytes from coronavirus disease 2019(CoVID-19)*** rates of SARS-Cov-2-infected monocytes in peripheral blood mononuclear cells from CoVID-19 patients increased over time from symptom onset,with SARS-CoV-2-positive monocytes,B cells,and CD4+T lymphocytes also detected in postmortem lung *** results indicated that SARS-CoV-2 infection of blood-circulating leukocytes in covID-19 patients might have important implications for disease pathogenesis and progression,immune dysfunction,and virus spread within the host.

关键词： SARS-CoV-2 CoVID-19 lymphocytopenia peripheral blood mononuclear cell(PBMC) lymphocytes monocytes apoptosis

Carcass image segmentation using CNN-based methods

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Information Processing in Agriculture 2021年第4期8卷 560-572页

作者： Diogo Nunes Goncalves Vanessa Aparecida de Moares Weber Julia Gindri Bragato Pistori rodrigo da Costa Gomes Anderson Vicoso de Araujo Marcelo Fontes Pereira Wesley Nunes Goncalves Hemerson Pistori Federal University of Mato Grosso do Sul Av.Costa e Silvas/nBairro UniversitarioCampo GrandeMS 79070-900Brazil INOVISAO Dom Bosco Catholic UniversityAvenida Tamandare6000CP 100Jardim SeminarioCampo GrandeMS 79117-900Brazil EMBRAPA Gado de Corte Av.Radio Maia830Vila PopularCampo GrandeMS 79106-550Brazil State University of Mato Grosso do Sul Av.Dom Antonio Barbosa4155Vila Santo AmaroCampo GrandeMS 79115-898Brazil

Carcass grading can be used as an important metric to determine meat ***,carcass grading is usually performed by a specialist,making it a subjective and errorprone *** increase the accuracy of such task,image-based systems have been proposed in the *** of the most important parts of an image-based system is the image segmentation,which aims to identify the regions of the carcass in the *** this paper,we propose the use of two recent image segmentation methods called Superpixel+CNN(Convolutional Neural Network)and *** evaluate both methods,we have also built a dataset of carcass images and their *** of approximately 96%of pixel accuracy show the robustness of the methods in carcass image *** novelty of this work is the proposal and comparison of recent deep learning methods that use CNN and superpixels in carcass *** this way,the methods can be used in carcass grading systems to increase the accuracy of the grading task.

关键词： Carcass grading Image segmentation Convolutional neural networks Superpixels

The Addition of Strength Training to Practice of High Intensity Group Gymnastics May Not Imply in Highest Levels of Strength and Quality of Life: A Cross-Sectional Study

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Health 2019年第7期11卷 896-904页

作者： Bruno Henrique da silva Bruno Allan Vieira rodrigo Sudatti delevatti Sogipa Faculty of Physical Education Porto Alegre Brazil Santa Catarina Federal University Florianópolis Brazil

The aim of the present study was to compare the levels of maximum strength, endurance muscular and quality of life among practitioners of group gymnastics (IG) of isolated form and practitioners of group gymnastics combinated with strength training (CG). This study is characterized as observational of comparative cross-sectional design. The sample was composted by young women, trained at least for three months, without health complications. Maximum strength (1RM) and endurance muscular (repetition at 60% 1RM) of the lower limbs were evaluated in knee extension exercise, unilaterally. Overall quality of life and in four domains was evaluated by the WHOQOL-bref. Data were described by mean and standard deviation values. Outcomes were compared by independent t-test, adopting a significance level (α) of 0.05. Thirty women were evaluated (isolated gymnastic (IG), n = 15;30.13 ± 7.24 years—combined gymnastic and strength (CG), n = 15;29.46 ± 8.18 years). Similarly values were found among groups for all outcomes (p > 0.05). The results suggest that the association of strength training with gymnastics training, possibly accumulating excessive training volume, may not increase the levels of maximum strength, endurance muscular and quality of life in young women.

关键词： Resistance Training Gymnastic Gym Exercise Training Quality of Life

Novel Protease from Aspergillus tamarii URM4634: Production and Characterization Using Inexpensive Agroindustrial Substrates by Solid-State Fermentation

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Advances in Enzyme Research 2016年第4期4卷 125-143页

作者： Osmar Soares da silva rodrigo Lira de Oliveira Cristina Maria Souza-Motta Ana Lúcia Figueiredo Porto Tatiana Souza Porto Northeast Biotechnology Network/RENORBIO Federal Rural University of Pernambuco (UFRPE) Recife Brazil Academic Unity of Garanhuns/UAG Federal Rural University of Pernambuco (UFRPE) Garanhuns Brazil department Mycology Federal University of Pernambuco (UFPE) Recife Brazil department of Morphology Physiology Animal/DMFA Federal Rural University of Pernambuco (UFRPE) Recife Brazil

This study reports the protease production from Aspergillus tamarii using agroindustrial residues as substrate for solid-state fermentation (SSF) and biochemical characterization. The highest protease production was obtained using wheat bran as substrate at 72 h fermentation with maximum proteolytic activity of 401.42 U/mL, collagenase of 243.0 U/mL and keratinase of 19.1 U/mL. The protease exhibited KM = 18.7 mg/mL and Vmax = 28.5 mg/mL/min. The optimal pH was 8.0 and stable in a wide pH range (5.0 - 11.0) during 24 h. The optimum temperature was 40°C. The proteolytic activity was inhibited by Cu2+ (33.98%) and Hg2+ (22.69%). The enzyme was also inhibited by PMSF (65.11%), indicating that is a Serine Protease. These properties suggest that alkaline protease from A. tamarii URM4634 is suitable for application in food industries and leather processing. Additionally, the present findings opened new vistas in the utilization of wheat bran and other effective agroindustrial wastes as substrates for SSF.

关键词： Protease Aspergillus tamarii Biochemical Characterization Solid-State Fermentation Agroindustrial Waste

Influence of Water Content on the Quality of Pigeonpea Seeds

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American Journal of Plant Sciences 2017年第10期8卷 2397-2406页

作者： Cristiane Fernandes Lisboa rodrigo Starnek Lopes de Araújo Itamar Rosa Teixeira José Hortêncio Mota Alessandro Guerra Da silva Marcos Eduardo Viana de Araújo deyner Damas Aguiar silva Edgar Estevam Franca Isneider Luiz silva Fernando Ribeiro Teles de Camargo department of Agricultural Engineering Sate University of Goiás Anápolís Brazil department of Agricultural University of Rio Verde Rio Verde Brazil department of Agricultural Federal University of Goiás Jataí Brazil

The species Cajanus cajan L. where pigeonpea is from presents a harvest potential in tropical regions for it is used as human and animal feed, besides being used as green fertilizer. However, the harvest area of this Fabaceae is still insignificant, due to especially the lack of quality seeds. In this context, it is possible to affirm that drying and store are portrayed as important steps for obtaining superior quality seeds. The aim of this study is to evaluate the physiologic quality of dwarf pigeonpea seeds, with different water content during storage. A factorial scheme 3 × 6 was adopted in the delimitation completely randomized, with four replications. Treatments were constituted by the combination of lots of seeds containing three different water contents (11%, 14% and 16%), submitted to a 10-month storage period, with evaluations every two months (0, 2, 4, 6, 8 and 10). Seeds were stocked in a bag type kraft under normal lab conditions, that is, no control. Physiologic quality of the seeds was evaluated through the following tests: Germination Pattern Test—GPT, first count of germination, accelerated aging and electric conductivity. It can be concluded that pigeonpea with hard seeds containing water content at 11% existing superior physiologic quality throughout the 10-month storage, under no controlled condition, certainly promoted by the less intense breathing from the reserves cumulated in the seed lot. Pigeonpea seeds storage with water content superior to 14% promotes a sharp decrease of physiologic quality, due to an increase in metabolic activity.

关键词： Cajanus cajan L. Physiologic deterioration Seed Quality Viability and Vigour

An Online mtDNA Tool for Identification of Neotropical Psittacid Species and Taxonomic Issues:A Study Case of the Amazona ochrocephala Complex

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Natural Resources 2014年第11期5卷 634-652页

作者： Anderson Vieira Chaves rodrigo Octavio de Paiva Queiroz-Filho Fabiano Augusto Assuncao silva Cristina Yumi Miyaki Fabricio Rodrigues dos Santos departamento de Biologia Geral Instituto de Ciencias Biologicas(ICB)Universidade Federal de Minas GeraisBelo HorizonteBrazil Policia Federal Belo HorizonteBrazil departamento de Genetica e Biologia Evolutiva Instituto de BiocienciasUniversidade de Sao PauloSao PauloBrazil

Parrots are among the most popular pets in the world and they are also some of the most illegally traded, particularly in Brazil. Some computational tools were recently developed by researchers based on molecular databases for taxonomy support, forensic identification and conservation purposes. In this study, the DNA Surveillance platform was used to build an online database tool for molecular identification of Brazilian Psittacids using DNA sequences of six mitochondrial genes. To illustrate possible taxonomic issues of the online tool due to interspecific hybridization or unresolved taxonomy, we focused on Amazona aestiva that is considered as one of the most common parrots in Brazil, commonly bred as pets, and considered to be part of a species complex with Amazona ochrocephala from South America. We provide three curated sequence databases, which allow the species identification of individuals or tissue samples of birds of the Psittacidae family using mitochondrial DNA markers, and a comprehensive description of a taxonomic issue involving the A. ochrocephala complex. The results obtained corroborate previous studies suggesting that these species are not reciprocally monophyletic, due to either an ancient hybridization in central Brazil, or, they maybe just are morpho-varieties of the same species. Alternatively, if A. aestiva and A. ochrocephala were considered as sister species, the data could be interpreted either as a result of secondary contact or incipient speciation. Beyond the use of mtDNA for species identification, the high mtDNA haplotype diversity observed in A. aestiva indicates its potential use in discrimination of lineages that could be an important auxiliary tool to certify the captive origin of legally commercialized parrots.

关键词： Amazona aestiva Illegal Trade of Birds Psittaciformes Phylogeography DNA-Surveillance

Environmental Low Energy Gamma Rays Measurements in Brazilian Tropics Region During 2016

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Journal of Environmental Science and Engineering(A) 2016年第11期5卷 559-565页

作者： Inaicio Malmonge Martin Anatoli Alexandrovitch Goussev Douglas Carlos Vilela Marcelo Pego Gomes Mauro Angelo Alves Alessandro de Abreu Matheus Carlos silva rodrigo Rezende Femandez de Carvalho Physics department Technological Institute of Aeronautics-ITA Sao Jose dos Campos SP 12228-900 Brazil Space Research Institute of the Russian Academy of Sciences IKI Moscow 117997 Russia