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Host genetic factors affecting hepatitis B infection outcomes:Insights from genome-wide association studies

World Journal of Gastroenterology 2018年第30期24卷 3347-3360页

作者： Izzet Mehmet Akcay Seyma Katrinli Kamil Ozdil gizem dinler doganay Levent doganay Department of Molecular Biology and Genetics Istanbul Technical University Department of Gastroenterology and Hepatology Umraniye Teaching and Research Hospital

The clinical outcome of hepatitis B virus(HBV) infection depends on the success or failure of the immune responses to HBV,and varies widely among individuals,ranging from asymptomatic self-limited infection,inactive carrier state,chronic hepatitis,cirrhosis,hepatocellular carcinoma,to liver failure,depending on the success or failure of immune response to ***-wide association studies(GWAS) identified key genetic factors influencing the pathogenesis of HBV-related *** this review,we discuss GWAS for persistence of HBV infection,antibody response to hepatitis B vaccine,and HBV-related advanced liver *** persistence is associated with multiple genes with diverse roles in immune *** strongest associations are found within the classical human leukocyte antigen(HLA) genes,highlighting the central role of antigen presentation in the immune response to *** variants affect both epitope binding specificities and expression levels of HLA *** other susceptibility genes regulate the magnitude of adaptive immune responses,determining immunity vs *** persistence and nonresponse to vaccine share the same risk variants,implying overlapping genetic *** the other hand,the risk variants for HBV-related advanced liver diseases are largely different,suggesting different host-virus dynamics in acute vs chronic HBV *** findings of these GWAS are likely to pave the way for developing more effective preventive and therapeutic interventions by personalizing the management of HBV infection.

关键词： Genome-wide association studies Hepatitis B infection Hepatocellular carcinoma Cirrhosis Antigen presentation Immune response to hepatitis B virus

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Association of human leukocyte antigen DQB1 and DRB1 alleles with chronic hepatitis B

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World Journal of Gastroenterology 2014年第25期20卷 8179-8186页

作者： Levent doganay Arta Fejzullahu Seyma Katrinli Feruze Yilmaz Enc Oguzhan Ozturk Yasar Colak Celal Ulasoglu Ilyas Tuncer gizem dinler doganay Department of Gastroenterology Goz-tepe Teaching and Research HospitalMedeniyet University Department of Gastroen-terology Umraniye Teaching and Research Hospital Department of Molecular Biology and Genetics Istanbul Tech-nical University

AIM: To investigate the effect of human leukocyte antigen (HLA) DRB1 and DQB1 alleles on the inactive and advanced stages of chronic hepatitis B.

关键词： Chronic active hepatitis Cirrhosis Hepatitis B Human leukocyte antigen DQ Human leukocyte antigen DR

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