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Fat:A matter of disturbance for the immune system

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World Journal of Gastroenterology 2010年第38期16卷 476-4772页

作者： Alessandro Federico Elena D’Aiuto Francesco Borriello giusi Barra Antonietta Gerarda Gravina Marco Romano Raffaele De Palma Section of Gastroenterology Department of Clinical and Experimental MedicineSecond University of Naples Section of Clinical Immunology Department of Clinical and Experimental Medicine Second University of Naples

Obesity is increasingly being recognized as a risk factor for a number of benign and malignant gastrointestinal conditions. However, literature on the underlying pathophysiological mechanisms is sparse and ambiguous. There is compelling evidence that both overnutrition and undernutrition negatively interfere with the immune system. Overnutrition has been found to increase susceptibility to the development of inflammatory diseases, autoimmune diseases and cancer. In the regulation of immune and in? ammatory processes, white adipose tissue plays a critical role, not only as an energy store but also as an important endocrine organ. The obese state is characterised by a low-grade systemic in? ammation, mainly as a result of increased adipocytes as well as fat resident-and recruited-macrophage activity. In the past few years, various products of adipose tissue including adipokines and cytokines have been characterised and a number of pathways linking adipose tissue metabolism with the immune system have been identified. Activation of the innate immune system plays a major role in hepatic steatosis. Non-alcoholic fatty liver disease includes a wide spectrum of diseases, from pure steatosis to non-alcoholic steato-hepatitis in the absence of signif icant alcohol consumption. Although steatosis is considered a non-progressive disease, non-alcoholic steatohepatitis may deteriorate in advanced chronic liver diseases, cirrhosis, and hepatocellular carcinoma. An important parallel between obesityrelated pathology of adipose tissue and liver pertains to the emerging role of macrophages, and growing evidence suggests that Kupffer cells critically contribute to progression of non-alcoholic fatty liver disease. Moreover, a close link between specif ic immune activation and atherosclerosis has been well established, suggesting that fat can directly trigger immune responses. This review discusses the role of fat as "a matter of disturbance for the immune system" with a focus on hepat

关键词： Adipocytokine Adipose tissue Fat Immune system Kupffer cell Natural killer Steatosis

Inflammatory bowel diseases patients suffer from significant low levels and barriers to physical activity:The“BE-FIT-IBD”study

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World Journal of Gastroenterology 2023年第41期29卷 5668-5682页

作者： Antonietta Gerarda Gravina Raffaele Pellegrino Tommaso Durante Giovanna Palladino Rossella D’Onofrio Simone Mammone giusi Arboretto Salvatore Auletta Giuseppe Imperio Andrea Ventura Mario Romeo Alessandro Federico Department of Precision Medicine Hepatogastroenterology UnitUniversity of Campania Luigi VanvitelliNaples 80138Italy Mental Health Department S.Pio HospitalBenevento 82100Italy

BACKGROUND The place regular physical activity(PA)should occupy in managing patients with inflammatory bowel diseases(IBD)is *** To assess PA levels and barriers in a southern Italian IBD *** IBD patients with non-severe disease activity[assessed with partial Mayo score for ulcerative colitis(UC)and Harvey-Bradshaw index for Crohn’s disease]were approached to receive an anonymous online questionnaire to assess PA levels using the International Physical Activity Questionnaire(IPAQ)and to assess disease activity as patient-reported outcomes 2(PRO-2)and finally to assess habits,beliefs and barriers in conducting regular ***,anthropometric and demographic data of patients were also *** was expressed as continuous units of resting metabolic rate(Met)in min/*** PA groups were identified:Inactive(2500 Met min/wk)*** Included patients(219)showed overall PA levels of 834.5 Met min/wk,with a large proportion(94,42.9%)classified as inactive while only a minority(9,4.1%)as health-enhancing *** without dyslipidaemia(P0.05).Active patients expressed the need to discuss PA with their *** barriers(e.g.,diagnosis of IBD and fear of flare-ups after PA)are significantly more reported by inactive *** A significant rate of physical inactivity was recorded in this *** showed good *** should be an element of discussion in IBD visits assessed quickly with non-invasive questionnaires.

关键词： Crohn’s disease Inflammatory bowel disease International Physical Activity Questionnaire Physical activity Ulcerative colitis

Hericium erinaceus,a medicinal fungus with a centuries-old history:Evidence in gastrointestinal diseases

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World Journal of Gastroenterology 2023年第20期29卷 3048-3065页

作者： Antonietta Gerarda Gravina Raffaele Pellegrino Salvatore Auletta Giovanna Palladino Giovanni Brandimarte Rossella D'Onofrio giusi Arboretto Giuseppe Imperio Andrea Ventura Marina Cipullo Marco Romano Alessandro Federico Department of Precision Medicine University of Campania“Luigi Vanvitelli”Naples 80138Italy Division of Internal Medicine and Gastroenterology Cristo Re HospitalRome 00167Italy

Hericium erinaceus is an edible and medicinal mushroom commonly used in traditional Chinese medicine for *** studies have highlighted its therapeutic potential for gastrointestinal disorders such as gastritis and inflammatory bowel *** addition,some components of this mushroom appear to possess strong antineoplastic capabilities against gastric and colorectal *** review aims to analyse all available evidence on the digestive therapeutic potential of this fungus as well as the possible underlying molecular mechanisms.

关键词： Hericium erinaceus Fungus Gastritis Inflammatory bowel diseases Gastric cancer Colorectal cancer

Marine natural product lepadin A as a novel inducer of immunogenic cell death via CD91-dependent pathway

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Natural Products and Bioprospecting 2023年第1期13卷 413-424页

作者： Dalila Carbone Carmela Gallo Genoveffa Nuzzo giusi Barra Mario Dell’Isola Mario Affuso Olimpia Follero Federica Albiani Clementina Sansone Emiliano Manzo Giuliana d’Ippolito Angelo Fontana Institute of Biomolecular Chemistry Consiglio Nazionale Delle RicercheVia Campi Flegrei 34Pozzuoli80078 NaplesItaly Department of Biology University of Naples“Federico II”Via Cupa Nuova Cinthia 2180126 NaplesItaly Stazione Zoologica Anton Dohrn Istituto Nazionale di BiologiaEcologia e Biotecnologie MarineUniversity of Naples“Federico II”Villa Comunale80121 NaplesItaly

Immunogenic Cell Death(ICD)represents a mechanism of enhancing T cell-driven response against tumor *** process is enabled by release of damage-associated molecular patterns(DAMPs)and cytokines by dying *** on molecular studies and clinical marker assessment,ICD can be a new target for cancer chemotherapy hitherto restricted to a few conventional anticancer *** view of the development of small molecules in targeted cancer therapy,we reported the preliminary evidence on the role of the natural product lepadin A(1)as a novel ICD *** we describe the ICD mechanism of lepadin A(1)by proving the translocation of the protein calreticulin(CRT)to the plasma membrane of human A2058 melanoma *** exposure is an ICD marker in clinical studies and was associated with the activation of the intrinsic apoptotic pathway in A2058 cells with lepadin A(1).After the treatment,the tumour cells acquired the ability to activate dendritic cells(DCs)with cytokine release and costimulatory molecule expression that is consistent with a phenotypic profile committed to priming T lymphocytes via a CD91-dependent *** effect of lepadin A(1)was dose-dependent and comparable to the response of the chemotherapy drug doxorubicin(2),a well-established ICD inducer.

关键词： Immunogenic cell death Natural products Anticancer Immunotherapy Drug discovery

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无干扰地均质化检测

实验与分析 2019年第2期 30-31,34页

作者： giusi Mondelli IMA Active公司意大利Ozzano市

红处线传感器配合滚筒式混合搅拌器实现工艺优化//固体物质的均质化与药品生产有着密切的关系,因为药物的有效成分要均匀的分布在药片之中。但怎样确定何时实现了完全均质化呢?怎样优化均质化检测过程呢?红外线传感器和统计学实验方法... 详细信息

红处线传感器配合滚筒式混合搅拌器实现工艺优化//固体物质的均质化与药品生产有着密切的关系,因为药物的有效成分要均匀的分布在药片之中。但怎样确定何时实现了完全均质化呢?怎样优化均质化检测过程呢?红外线传感器和统计学实验方法是最合适的选择。

关键词：检测过程均质化无干扰红外线传感器工艺优化药品生产固体物质有效成分

诗歌用大自然的词汇唤醒生活:两个二十世纪的女诗人——陈敬容(中国)和阿尔达·梅丽尼(Alda Merini,意大利)

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地方文化研究辑刊 2012年 132-139页

作者： giusi Tamburello—朱西意大利巴勒莫大学

中国女诗人陈敬容和意大利女诗人阿尔达·梅丽尼,尽管她们处在不同的国度,有着不同的文化,但诗歌中的元素却有许多的相同之处。这两位诗人用来描述大自然的诗句是非常相似的。两位诗人试图从中了解自己困境的根源,从而改变自己的命运,... 详细信息

中国女诗人陈敬容和意大利女诗人阿尔达·梅丽尼,尽管她们处在不同的国度,有着不同的文化,但诗歌中的元素却有许多的相同之处。这两位诗人用来描述大自然的诗句是非常相似的。两位诗人试图从中了解自己困境的根源,从而改变自己的命运,然而她们未能找到问题的答案和战胜困难的途径。但她们却没有放弃英勇反抗的精神,最终找到了一种补偿的方式。

关键词：陈敬容阿尔达·梅丽尼大自然唤醒生活

Psychological perspective of medication adherence in transplantation

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World Journal of Transplantation 2016年第4期6卷 736-742页

作者： Concetta De Pasquale Massimiliano Veroux Michele Fornaro Nunzia Sinagra giusi Basile Cecilia Gozzo Roberta Santini Alessandra Costa Maria Luisa Pistorio Vascular Surgery and Organ Transplant Unit Department of Medical Surgery Sciences and Advanced Technologies "GF Ingrassia" University of Catania

AIM To identify the risk factors and the post-transplant psychological symptoms that affect adherence to therapy in a population of kidney transplant recipients. METHODS The study examined the psychological variables likely responsible for the non-adherent behavior using a psychological-psychiatric assessment, evaluation of the perception of patients' health status, and an interview regarding the anti-rejection drug therapy assumption. The study included 74 kidney transplant recipients. RESULTS Individuals with a higher level of education and more years since transplantation showed better mental balance. Regarding gender, women appeared to be less adherent to therapy. Further, the years since transplantation adversely affected the proper pharmacological assumption. Adherence to therapy did not significantly change with the mental health index. CONCLUSION The biopsychosocial illness model provides a conceptualframe of reference in which biological, psychological, and social aspects take on the same importance in the adherence to treatment protocols. For effective management, it is necessary to understand the patients' personal experiences, their assumptions about the disease, health status perception, and mood, and to identify any "barriers" that could cause them to become noncompliant.

关键词： Transplantation Adherence Mental health Psychological assessment Psychiatric assessment

Magnetic resonance imaging:Is there a role in clinical management for acute ischemic colitis?

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World Journal of Gastroenterology 2013年第8期19卷 1256-1263页

作者： Maria Antonietta Mazzei Susanna Guerrini Nevada Cioffi Squitieri giusi Imbriaco Raffaele Chieca Serenella Civitelli Vinno Savelli Francesco Giuseppe Mazzei Luca Volterrani Department of Human Pathology and Oncology Section of Radiological SciencesUniversity of Siena53100 SienaItaly Oncologic Department UOC Gastroenterology and Digestive EndoscopyAzienda Ospedaliera Universitaria Senese53100 SienaItaly Division of Surgery Azienda Ospedaliera Universitaria SeneseUniversity of Siena53100 SienaItaly Department of Surgery and Bioengineering Section of SurgeryUniversity of Siena53100 SienaItaly Department of Diagnostic Imaging Azienda Ospedaliera Universitaria Senese53100 SienaItaly

AIM:To validate the utility of magnetic resonance imaging(MRI) for the clinical management of acute ischemic colitis(IC).METHODS:This is a magnetic resonance(MR) prospective evaluation of 7 patients who were proved to have acute IC on the basis of clinical,endoscopic and computed tomography(CT) findings and who were imaged in our institution between February 2011 and July *** mean age of the patients was 72.28 *** CTs were obtained using a 64-detector row configuration for all patients with un-enhanced and contrast-enhanced scans,in the late arterial phase(start delay 45-50 s) and in the portal venous phase(start delay 70-80 s).The MR examinations were performed using a 1.5T superconducting magnet,using Fast Imaging Employing Steady State Acquisition and T2-weighted fast-recovery fast-spin echo sequences in axial and coronal *** and MRI examinations were analysed for the presence of colonic abnormalities and associated ***:Segmental involvement was seen in 6 patients(85.71%),with a mean length of involvement of 412 mm(range 145.5-1000 mm).Wall thickness varied between 6 mm and 17.5 mm(mean 10.52 mm) upon CT examinations and from 5 to 15 mm(mean 8.8 mm) upon MR *** MRI appearance of the colonic wall varied over the time:TypeⅠappearance with a 3 layer sandwich sign was seen in 5 out of 12 examinations(41.66%),patients underwent MR within a mean of 36 h(ranging from 1 to 54 h) after the CT *** Ⅱ and Ⅲ appearance with a 2 layer sign,was seen in 4 examinations(33.33%),patients underwent MR within a mean of 420.5 h(ranging from 121 to 720 h) after the CT *** the remaining three MRI examinations,performed within a mean of 410 h(ranging from 99.5 to 720 h) the colonic wall appeared ***:MRI,only using precontrast images,may be used as a substitute for invasive procedures in diagnosis and follow-up of acute IC.

关键词： Ischemic colitis Magnetic resonance imaging Medical management Colon Computed tomography

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