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Transarterial chemoembolization using 40 μm drug eluting beads for hepatocellular carcinoma

World Journal of Radiology 2017年第5期9卷 245-252页

作者： Giorgio Greco Tommaso Cascella Antonio Facciorusso Roberto Nani Rodolfo Lanocita Carlo Morosi Marta Vaiani giuseppina Calareso Francesca G Greco Antonio Ragnanese Marco A Bongini Alfonso V Marchianò Vincenzo Mazzaferro Carlo Spreafico Department of Radiology Interventional RadiologyNuclear Medicine and RadiotherapyNational Cancer Institute Gastroenterology Unit Ospedali Riuniti FoggiaUniversity of Foggia Radiology and Interv-entional Radiology Unit Hepato-biliary Surgery and Liver Transplantation Unit National Cancer Institute

AIM To assess the safety and efficacy of transarterial chemoembolization(TACE) of hepatocellular carcinoma(HCC) using a new generation of 40 μm drug eluting beads in patients not eligible for curative *** Drug eluting bead TACE(DEB-TACE) using a new generation of microspheres(embozene tandem,40 μm) preloaded with 100 mg of doxorubicin was performed on 48 early or intermediate HCC patients with *** to therapy was assessed with Response Evaluation Criteria in Solid Tumors(RECIST) and modified RECIST(m RECIST) guidelines applied to computed tomography or magnetic resonance *** out of the 48 treated patients treated progressed on to receive liver orthotopic transplantation(OLT).This allowed for histological analysis on the treated explanted *** DEB-TACE with 40 μm showed a good safety profile without major complications or 30-d *** objective response rate of treated tumors was 72.6% and 26.7% according to m RECIST and RECIST *** examination in 11 patients assigned to OLT showed a necrosis degree > 90% in 78.6% of *** overall time to progression was 13 mo(11-21).CONCLUSION DEB-TACE with 40 μm particles is an effective treatment for the treatment of HCC in early-intermediate patients(Barcelona Clinic Liver Cancer stage A/B) with a good safety profile and good results in term of objective response rate and necrosis.

关键词： Embozene tandem Drug eluting beads Drug eluting bead transarterial chemoembolization Transarterial chemoembolization Hepatocellular carcinoma

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The Italian ZECOMIX Platform: CO<sub>2</sub>Capture on Calcined Dolomite in Fluidized Bed Carbonator Unit

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Natural Resources 2014年第9期5卷 433-441页

作者： Silvera Scaccia Stefano Stendardo giuseppina Vanga Leandro Pagliari Stefano Cassani Mirko Nobili Giuseppe Messina Andrea Assettati Giuliano Guidarelli Salvatore Attanasi Caterino Stringola Andrea Grasso Ivano Cassani Antonio Calabró Pier Ugo Foscolo Department of Chemistry Chemical Engineering and Materials University of L’Aquila L’Aquila Italy Energy Efficiency UTEE-GRT ENEA-CCEI UMBRIA Perugia Italy Sustainable Combustion Laboratory (UTTEI-COMSO) C.R. ENEA Rome Italy

The Italian Zecomix platform is a gasification pilot-scale plant integrated CCS technology, whose flexibility allows operating each unit alone. For quantitative analysis of the gaseous species an analytical system based on commercially available instruments and sampling lines at various points of plant was properly designed. A Fourier Transform Infrared Spectrometric (FTIR) with portable low resolution and gas chromatographic tools were used. The fluidized bed calciner/ carbonator unit was fed with naturally occurring dolomite (about 300 kg) from quarry of Biella (Italy) and tested for CO2 capture. Carbonation reaction was conducted at around 700°C under simulated reformed synthesis gas containing 30% of CO2. Based on GC and FTIR results a CO2 retention better than 70% was achieved. The application of grain model establishing the carbonation reaction was kinetically controlled within 50 seconds and the reaction rate constant was comparable to that obtained at laboratory-scale level by thermogravimetric analyzer.

关键词： ZECOMIX Experimental Platform Dolomite CO2 Capture Fluidized Bed GC and FTIR Kinetics

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中等传输距离下的无线功率传输链路第2部分:选择性工作方式

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南京信息工程大学学报（自然科学版） 2017年第1期9卷 73-81页

作者： Alessio De ANGELIS Marco DIONIGI Paolo CARBONE Mauro MONGIARDO 车文荃王清华 Franco MASTRI giuseppina MONTI DE University of Perugia 南京理工大学电子工程与光电技术学院南京210094 DEI School of Information TechnologyUniversity of Bologna DII University of Salento

对谐振感应式无线功率传输链路的3种不同的工作方式进行了讨论.第1种工作方式是输出恒定的电压或电流;第2种工作方式采用频率捷变操作,非常适合于不随耦合系数变化的应用场合;第3种工作方式实现负载独立工作并输出恒定的电压或电流.本... 详细信息

对谐振感应式无线功率传输链路的3种不同的工作方式进行了讨论.第1种工作方式是输出恒定的电压或电流;第2种工作方式采用频率捷变操作,非常适合于不随耦合系数变化的应用场合;第3种工作方式实现负载独立工作并输出恒定的电压或电流.本文讨论并提出了不同情况下的解决方案和相关公式.最后通过实验对提出的理论进行了验证.

关键词：无线功率传输链路电感耦合选择性工作耦合独立负载独立

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中等传输距离下的无线功率传输链路第1部分:实现工作状态最优化

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南京信息工程大学学报（自然科学版） 2017年第1期9卷 64-72页

中程无线功率传输(WPT)可以采用几种不同的方式实现,如通过电感或电容耦合、谐振或非谐振网络实现.本文主要研究了通过感应耦合谐振器实现的WPT链路,而且只着重研究了利用2个谐振器的链路(直接链路)并工作在主谐振频率下的情况.研究结... 详细信息

中程无线功率传输(WPT)可以采用几种不同的方式实现,如通过电感或电容耦合、谐振或非谐振网络实现.本文主要研究了通过感应耦合谐振器实现的WPT链路,而且只着重研究了利用2个谐振器的链路(直接链路)并工作在主谐振频率下的情况.研究结果表明,当工作在主谐振频率下,可以根据网络参数来对传输效率或负载功率进行优化.

关键词：中等传输距离无线功率传输链路电感耦合谐振/非谐振网络最优化

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Inhibition Mechanism in Concrete by Organic Substances： An Experimental and Theoretical Study

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材料科学与工程（中英文版） 2010年第10期4卷 66-77页

作者： Marco Ormellese Elmer Augusto Perez giuseppina Raffaini Fabio Ganazzoli Luciano Lazzari Department of Chemistry Materials and Chemical Engineering Politecnico di Milano Via Mancinelli Milano 7-20131 Italy

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Anaplastic thyroid carcinoma:A comprehensive review of current and future therapeutic options

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World Journal of Clinical Oncology 2011年第3期2卷 150-157页

作者： Francesco Perri Giuseppe Di Lorenzo giuseppina Della Vittoria Scarpati Carlo Buonerba Department of Skin Musculoskeletal System and Head-neckINT Foundation G.PascaleNapoli 80131Italy Department of Endocrinology and Medical Oncology Genitourinary Cancer SectionUniversity Federico IINapoli 80131Italy

Anaplastic thyroid carcinoma(ATC)is the rarest,but deadliest histologic type among thyroid malignancies,with a dismal median survival of 3-9 *** though ATC accounts for less than 2%of all thyroid tumors,it is responsible for 14%-39%of thyroid carcinoma-related *** clinically presents as a rapidly growing mass in the neck,associated with dyspnoea,dysphagia and vocal cord *** is usually locally advanced and often metastatic at initial *** operable diseases,the combination of radical surgery with adjuvant radiotherapy or chemotherapy,using agents such as doxorubicin and cisplatin,is the best treatment *** drugs for advanced/metastatic ATC are poorly *** the other hand,targeted agents might represent a viable therapeutic ***,combretastatin A4,sorafenib and imatinib have been tested in small clinical trials of ATC,with a promising disease control rate ranging from 33%to 75%.Other clinical trials of targeted therapy for thyroid carcinoma are currently *** agents that are under investigation include pazopanib,gefitinib and *** the very limited therapeutic armamentarium available at the present time,targeted therapy constitutes an exciting new horizon for *** future,biological agents will probably represent the standard of care for this aggressive malignancy,in the same fashion as it has recently occurred for other chemo-refractory tumors,such as kidney and hepatic cancer.

关键词： Anaplastic thyroid cancer Targeted agents

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Locally advanced nasopharyngeal carcinoma:Current and emerging treatment strategies

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World Journal of Clinical Oncology 2011年第12期2卷 377-383页

作者： Francesco Perri Davide Bosso Carlo Buonerba Giuseppe Di Lorenzo giuseppina Della Vittoria Scarpati Oncology Division Division INT Fondazione“G.Pascale”80131 NaplesItaly Oncology and Rare Cancer Center FedericoⅡUniversity80131 NaplesItaly

Although nasopharyngeal carcinoma(NPC)is a widespread malignant tumor,it is particularly frequent in Southeast *** T1 tumors can be effectively controlled with exclusive radiotherapy,this treatment modality is insufficient for most NPC patients,who present with locally advanced disease at *** fact,for stages ranging from T2b N0 to T4 N3,definitive scientific evidence supports the use of concurrent platinum-based chemotherapy with standard external beam *** treatment approach has shown a statistically significant advantage in terms of overall survival,with respect to radiotherapy *** trials have also investigated the use of neoadjuvant and adjuvant chemotherapy in combination with radiotherapy or *** compounds,anthracyclines and taxanes are among the chemotherapy agents *** review focuses on the clinical results obtained in the field of adjuvant/concurrent/neoadjuvant chemotherapy for locally advanced NPC,for which exclusive concurrent chemo-radiotherapy currently represents the standard treatment approach.

关键词： Chemotherapy Nasopharyngeal carcinoma Radiotherapy Treatment

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Clinical and molecular spectrum of Wiedemann-Steiner syndrome, an emerging member of the chromatinopathy family

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World Journal of Medical Genetics 2020年第1期9卷 1-11页

作者： Paolo Fontana Francesco Fioravanti Passaretti Marianna Maioli giuseppina Cantalupo Francesca Scarano Fortunato Lonardo Medical Genetics Unit San Pio HospitalBenevento 82100Italy Department of Molecular Medicine and Medical Biotechnology University of Naples Federico IINapoli 80131Italy

Wiedemann-Steiner syndrome(OMIM#605130)is a rare congenital malformation syndrome characterized by hypertrichosis cubiti associated with short stature;consistent facial features,including long eyelashes,thick or arched eyebrows with a lateral flare,wide nasal bridge,and downslanting and vertically narrow palpebral fissures;mild to moderate intellectual disability;behavioral difficulties;and hypertrichosis on the *** is caused by heterozygous pathogenic variants in *** gene has an established role in histone methylation,which explains the overlap of Wiedemann-Steiner syndrome with other chromatinopathies,a heterogeneous group of syndromic conditions that share a common trigger:The disruption of one of the genes involved in chromatin modification,leading to dysfunction of the epigenetic machinery.

关键词： Chromatin Chromatin remodeling Chromatinopathies Wiedemann-Steiner syndrome Hairy elbows KMT2A

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加拿大如何惩治网络侵权

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中国改革 2013年第8期 104-106页

作者：朱塞平娜·达格斯蒂诺(giuseppina D’Agostino) Benjamin Ziva(译) 加拿大约克大学奥斯古德法学院不详

《版权现代化法案》正式确立了加拿大独有的“通知相通知”体制，与美国和中国的“通知和移除”制度不同，加拿大的互联网服务提供商并不删除内容。

关键词：加拿大网络侵权互联网服务提供商惩治现代化侵权者法案

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德国GMP国际建筑设计有限公司

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城市环境设计 2006年第2期 10-21页

作者：麦哈德·冯·格康施蒂芬·舒茨 Nicolas Pomrnke Clemens Kampermann Sophie v．Mansberg 夏琳李凌施蒂芬·瑞沃勒 Ralf Sieber giuseppina Orto

一、设计理念——水与石的结合峰顶海拔1134m的崂山及其四周的山峰位于山东半岛的东南部,这一地区面朝黄海, 是中国著名的风景名胜之一,自古以来享有中国第一海上名山的美誉。对于青岛这座城市而言,水是决定其特色和形象的最重要的元素... 详细信息

一、设计理念——水与石的结合峰顶海拔1134m的崂山及其四周的山峰位于山东半岛的东南部,这一地区面朝黄海, 是中国著名的风景名胜之一,自古以来享有中国第一海上名山的美誉。对于青岛这座城市而言,水是决定其特色和形象的最重要的元素,它与崂山诸峰一起,共同构成了环绕城市的独特景观。由于地处滨水地带这一独特的地理位置,诸峰常云雾缭绕,颇为神秘、壮

关键词：主入口音乐厅建筑物青岛大剧院多功能厅 GMP

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