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Metabolic Syndrome and DNA Damage: The Interplay of Environmental and Lifestyle Factors in the Development of Metabolic Dysfunction

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Open Journal of Endocrine and Metabolic Diseases 2015年第7期5卷 65-76页

作者： giuseppe potrick stefani Giovana Baldissera Ramiro Barcos Nunes Thiago Gomes Heck Cláudia Ramos Rhoden Laboratory of Physiology Universidade Federal de Ciências da Saúde de Porto Alegre Porto Alegre Brazil Laboratory of Oxidative Stress and Atmospheric Pollution Universidade Federal de Ciências da Saúde de Porto Alegre Porto Alegre Brazil Laboratory of Toxicological Genetics Universidade Federal de Ciências da Saúde de Porto Alegre Porto Alegre Brazil Research Group in Physiology Regional University of Northwestern State’s Rio Grande do Sul (UNIJUI) Ijuí Brazil Postgraduate Program in Integral Attention to Health Regional University of Northwestern State’s Rio Grande do Sul (UNIJUI) Ijuí Brazil Department of Pharmacologic Sciences Universidade Federal de Ciências da Saúde de Porto Alegre Porto Alegre Brazil

The Metabolic Syndrome (MetS) is a complex condition which is characterized by increased risk factor for cardiovascular diseases, such as dyslipidemia, hypertension and central obesity, in addition to increased risk for type 2 diabetes mellitus (T2DM). All of these factors alone have a notable relationship with DNA damage. However, when the risks are combined, the extent for major outcomes being related to DNA damage (cancer), the consequence can be accelerated by the metabolic dysfunction. This article will illustrate the scientific evidence of the role of DNA damage in MetS, as well as discuss the interplay of major risks factors (air pollution, physical inactivity and dietary interventions) in genomic stability.

关键词： Metabolic Syndrome DNA Damage Diet Physical Activity Air Pollution

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