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Adipose tissue and vascular inflammation in coronary artery disease

World Journal of Cardiology 2014年第7期6卷 539-554页

作者： Enrica Golia giuseppe limongelli Francesco Natale Fabio Fimiani Valeria Maddaloni Pina Elvira Russo Lucia Riegler Renatomaria Bianchi Mario Crisci Gaetano Di Palma Paolo Golino Maria Giovanna Russo Raffaele Calabrò Paolo Calabrò Division of Cardiology Cardio-thoracic and Respiratory Sciences DepartmentSecond University of NaplesAO Dei Colli-Monaldi Hospital

Obesity has become an important public health issue in Western and developing countries,with well known metabolic and cardiovascular *** the last decades,evidence have been growing about the active role of adipose tissue as an endocrine organ in determining these pathological *** a consequence of the expansion of fat depots,in obese subjects,adipose tissue cells develope a phenotypic modification,which turns into a change of the secretory *** produced by both adipocytes and adipose stromal cells are involved in the modulation of glucose and lipid handling,vascular biology and,moreover,participate to the systemic inflammatory response,which characterizes obesity and metabolic *** might represent an important pathophysiological link with atherosclerotic complications and cardiovascular events.A great number of adipocytokines have been described recently,linking inflammatory mileu and vascular *** understanding of these pathways is crucial not only from a pathophysiological point of view,but also to a better cardiovascular disease risk stratification and to the identification of possible therapeutic *** aim of this paper is to review the role of Adipocytokines as a possible link between obesity and vascular disease.

关键词： Adipocytokines Obesity Metabolic syndrome Coronary artery disease Inflammation

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