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Ebola:a review on the state of the art on prevention and treatment

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Asian Pacific Journal of Tropical Biomedicine 2014年第12期4卷 925-927页

作者： giuseppe la torre Vincenzo Nicosia Maurizio Cardi Department of Public Health and Infectious Diseases.Sapienza University of Rome SIMVIM-Italian Society of Travel and Migration Medicine Department of Surgery "Pietro Valdoni" Azienda Policlinico Umberto ISapienza University of Rome Emergency NGO Surgical Division

The aim of this paper is to highlight the current development in the research field for helping people just exposed to Ebola virus survive(treatment) and to prevent the disease when given at various times after exposure(vaccine).Concerning the treatment,recombinant anti-Ebola monoclonal antibodies and small interfering RNAs that block the expression of essential viral proteins,are the most promising way in stopping the disease when it has already reached the *** far as concerns the prevention field,two candidate vaccines have clinical-grade vials available for phase 1 pre-licensure clinical trials,and demonstrated to have a 100%efficacy in studies on non human ***-informed communities can reduce the main ways of spread the infection,by avoiding unprotected home-based care of people who are infected and also by completely modifying traditional burial practices that are way of diffusion of the contagion.

关键词： Ebola virus Treatment Vaccine Prevention

Hepatocellular carcinoma treated by conventional transarterial chemoembolization in field-practice:Serum sodium predicts survival

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World Journal of Gastroenterology 2014年第25期20卷 8158-8165页

作者： Marco Biolato Luca Miele Vittoria Vero Simona Racco Carmine Di Stasi Roberto Iezzi Andrea Zanché Maurizio Pompili Gian Ludovico Rapaccini giuseppe la torre Antonio Gasbarrini Antonio Grieco Department of Internal Medicine Policlinico Gemelli Hospital and Catholic University of the Sacred Heart Department of Radiology Policlinico Gemelli Hospital and Catholic University of the Sacred Heart Department of Public Health and Infectious Diseases Sapienza University

AIM: To assess the prognostic role of baseline clinical, biochemical and radiological characteristics of patients with hepatocellular carcinoma (HCC) treated with the first transarterial chemoembolization (TACE) proce... 详细信息

关键词： Liver cancer Sorafenib Hyponatremia Model for end-stage liver disease sodium Chemoembolization

Factors influencing response to ingenol mebutate therapy for actinic keratosis of face and scalp

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World Journal of Clinical Oncology 2017年第5期8卷 405-411页

作者： Nevena Skroza Ilaria Proietti Nicoletta Bernardini Veronica Balduzzi Alessandra Mambrin Anna Marchesiello Ersilia Tolino Sara Zuber giuseppe la torre Concetta Potenza Dermatology Unit "Daniele Innocenzi" Department of Medical and Surgical Sciences and BiotechnologiesSapienza University of Rome Department of Public Health and Infectious Diseases Sapienza University of Rome

AIM To determine factors independently influencing response to ingenol mebutate therapy and assess efficacy on clinical setting of non-hypertrophic non-hyperkeratotic actinic keratosis (AK).METHODS Consecutive patients affected by non-hypertrophic non-hyperkeratotic AKs of the face or scalp were enrolled to receive ingenol mebutate 0.015% gel on a selected skin area of 25 cm^2 for 3 consecutive *** skin reactions were calculated at each follow up visit using a validated composite *** was evaluated by the comparison of clinical and dermoscopic pictures before the treatment and at day 57,and classified as complete,partial and poor *** A number of 130 patients were enrolled,of which 101(77.7%) were treated on the face,while 29 (22.3%) on the *** great majority of our study population (n = 119,91.5%) reached at least a 75% clearance of AKs and,in particular,58 patients (44.6%) achieved a complete response while 61(46.9%) a partial *** backward multivariate analysis showed that facial localization,level of local skin reaction (LSR) at day 2,the highest LSR values and level of crusts at day 8 were factors independently associated with the achievement of a complete *** Ingenol mebutate 0.015% gel,when properly applied,is more effective on the face than on the scalp and efficacy is directly associated to LSR score.

关键词： Ingenol mebutate Actinic keratosis Facial and scalp lesions Skin reactions Dermoscopic feature

Concentrations and sources of an emerging pollutant, decabromodiphenylethane (DBDPE), in sewage sludge for land application

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Journal of Environmental Sciences 2012年第3期24卷 558-563页

作者： De la torre A Concejero M A Martínez M A Persistent Organic Pollutant Group Environment Department CIEMAT Avd. Complutense 22 Madrid 28040 Spain

The presence of an emerging brominated flame retardant, decabromodiphenylethane （DBDPE）, has been confirmed in Spanish sewage sludge. Thirty one samples from different urban wastewater treatment plants （WWTPs） were analyzed for this brominated flame retardant. DBDPE was positively identified and quantified in all samples at lower concentrations （47.0 ± 29.7 ng/g dry weight （dw）; mean ± SD） than those obtained for decabromodiphenyl ether （BDE-209）（290 ± 236 ng/g dw; mean ± SD） in a previous study. Influence of the WWTP characteristics in the pollutant levels was evaluated. No significant correlations were obtained between DBDPE concentrations and the population or sewage sludge production rate associated with the plants, neither wastewater treatment method. Sources of DBDPE in the sludge were also evaluated. Data indicate a common origin for DBDPE and BDE-209, which may be related to leaching processes during the use and disposal of consumer products containing these chemicals. Nevertheless, DBDPE contents are not influenced by industrial activities, which suggests that the infusion of DBDPE commercial mixture is not a source of this chemical into the environment, and indicates that the use of DBDPE in the Spanish industry is still low compared to deca-BDE.

关键词： decabromodiphenylethane polybrominated diphenyl ethers wastewater treatment plants sewage sludge

Bird habitat preferences drive hemoparasite infection in the Neotropical region

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Integrative Zoology 2021年第5期16卷 755-768页

作者： Gabriel Massaccesi DE la torre Karla Magalhães CAMPIÃO Biological Interactions Departamento de ZoologiaUniversidade Federal do ParanáCuritibaBrazil Programa de Pós-graduação em Ecologia e Conservação Universidade Federal do ParanáCuritibaBrazil

The role that the environment plays in vector-borne parasite infection is one of the central factors for understanding disease *** assessed how Neotropical bird foraging strata and habitat preferences determine infection by parasites of the genera Haemoproteus,Plasmodium,Leucocytozoon,and Trypanosoma and filarioids,and tested for phylogenetic signal in these host-parasite *** performed extensive searches of the scientific literature and created a database of hemoparasite *** collected data on host body mass,foraging strata,habitat preference,and migratory status,and tested if host ecological traits predict each hemoparasite occurrence and prevalence using a phylogenetic Bayesian *** of Plasmodium tend to infect birds from tropical forests while birds from altitudinal environments are likely to be infected by species of *** probability of a bird being infected by filarioid or Trypanosoma is higher in lowland *** species that occur in anthropic environments and dry habitats of tropical latitudes are more susceptible to infection by species of *** foraging strata is also influential and bird species that forage in the mid-high and canopy strata are more prone to infection by species of Haemoproteus and *** also identified phylogenetic signal for host-parasite associations with the probability of infection of Neotropical birds by any hemoparasite being more similar among more closely related *** provided a useful framework to identify environments that correlate with hemoparasite infection,which is also helpful for detecting areas with potential suitability for hemoparasite infection due to land conversion and climate change.

关键词： habitat use haemosporidians host-parasite interaction migratory birds prevalence

The Role of the Solar Cycle in the Relationship Between the North Atlantic Oscillation and Northern Hemisphere Surface Temperatures

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Advances in Atmospheric Sciences 2007年第2期24卷 191-198页

作者： laura DE la torre Luis GIMENO Juan Antonio AEL Raquel NIETO Universidad de Vigo Facultad de Ciencias de Ourense 32004OurenseSpain

The North Atlantic Oscillation （NAO） is one of the leading modes of climate variability in the Northern Hemisphere. It has been shown that it clearly relates to changes in meteorological variables, such as surface temperature, at hemispherical scales. However, recent studies have revealed that the NAO spatial pattern also depends upon solar forcing. Therefore, its effects on meteorological variables must vary depending upon this factor. Moreover, it could be that the Sun affects climate through variability patterns, a hypothesis that is the focus of this study. We find that the relationship between the NAO/AO and hemispheric temperature varies depending upon solar activity. The results show a positive significant correlation only when solar activity is high. Also, the results support the idea that solar activity influences tropospheric climate fluctuations in the Northern Hemisphere via the fluctuations of the stratospheric polar vortex .

关键词： solar activity North Atlantic Oscillation Arctic Oscillation Northern Hemisphere surface temperature

Modelling of compacted graphite cast iron solidification-Discussion of microstructure parameters

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China Foundry 2020年第2期17卷 144-149页

作者： Jacques lacaze Urko de la torre Jon Sertucha Anna Regordosa Centre Inter-universitaire de Recherche et d’Ingénierie des Matériaux(CIRIMAT) Universitéde ToulouseToulouseFrance Fundación AZTERlaN DurangoSpain

A melt maintained for hours in a press pour unit allowed the following changes over time from spheroidal graphite to compacted graphite iron by casting thermal cups at regular time *** provided extensive experimental information for checking the possibility of simulating solidification of compacted graphite irons by means of a microstructure modelling *** solidification,compacted graphite develops very much as lamellar graphite but with much less *** this basis,a simulation of the thermal analysis records was developed which considers solidification proceeding in a pseudo binary Fe-C *** simulated curves were compared with the experimental ones obtained from three representative alloys that cover the whole microstructure change during the holding of the *** most relevant result is that the parameter describing branching capability of graphite is the most important for reproducing the minimum eutectic temperature and the recalescence which are so characteristic of the solidification of compacted graphite cast irons.

关键词： compacted graphite irons thermal analysis stable eutectic metastable eutectic simulation

Evaluation of Early Action Mechanisms in Peru Regarding Preparedness for El Nino

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International Journal of Disaster Risk Science 2019年第4期10卷 493-510页

作者： Julio Aguirre Daniel De la torre Ugarte Juan Bazo Paulo Quequezana Mauricio Collado Department of Economics Universidad del Pacifico15072 LimaPeru Red Cross Red Crescent Climate Centre 2502 KC The HagueThe Netherlands Centro de Investigacion de Riesgo Resiliencia y Cambio Climatico(CIRCA)Universidad Tecnologica del Peru(UTP)15046 LimaPeru

In this article,we provide an impact evaluation of an intervention in Peru regarding preparedness for El Nino impacts in Picsi District of Chiclayo Province in Peru’s northwestern coastal lambayeque *** effort involved the provision of special kits that reduce the potential damage to homes as a consequence of rainfall and floods associated with an El Nino-Southern Oscillation *** was collected in 2016 when this Forecast-based Financing early action was activated by an El Nino forecast,and after a coastal El Nino actually struck in *** dual database permits us to estimate the impact of the intervention on the damage level of homes by comparing those homes supported by the program with those homes not receiving pilot-program *** comparison is achieved by using propensity score matching techniques,which identify the most comparable homes to the ones that were supported by the *** main findings of the study suggest a positive impact of the program in terms of its effectiveness in mitigating the damage caused by the 2017 El Ni?*** results suggest a drop in the scale of house damage(less damage)by around 63%for a home that received the modular kit *** considering other specifications of the model,the decrease in the scale of house damage improves up to approximately 66%.

关键词： Early warning Early action El NinoSouthern Oscillation Forecast-based Financing Matching propensity score Perú Red Cross

The roles of anurans in antagonistic networks are explained by life-habit and body-size

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Integrative Zoology 2022年第4期17卷 530-542页

作者： Amanda Caroline DUDCZAK Gabriel Massaccesi DE la torre Lorena EUCLYDES Karla Magalhães CAMPIÃO Department of Zoology Federal University of ParanáCuritibaBrazil Postgraduate Program in Zoology Federal University of ParanáCuritibaBrazil Postgraduate Program in Ecology and Conservation Federal University of ParanáCuritibaBrazil

Interactions among living beings are the structuring basis of ecosystems,and studies of networks allow us to identify the patterns and consistency of such *** networks reflect the energy flow of communities,and identifying network structure and the biological aspects that influence its stability is crucial to understanding ecosystem *** used antagonistic anuran interactions-predator-prey and host-parasite-to assess structural patterns and to identify the key anuran species structuring these *** tested whether anuran body-size and life-habit are related to their roles in these *** collected individuals of 9 species of anurans from an area of the Atlantic Forest in Brazil and identified their prey and helminth *** used network(modularity,specialization,and nestedness)and centrality metrics(degree,closeness,and betweenness)to identify the role of anuran species in both *** then evaluated whether anuran body-size or life-habit were related to anuran centrality using generalized linear mixed *** networks formed specialized interactions in compartments composed by key species from different *** our networks,anurans with rheophilic and cryptozoic habit are central in predator-prey networks,and those with larger body size and arboreal and cryptozoic habit in the host-parasite *** study represents a step towards a better understanding of the influential factors that affect the structure of anuran antagonist networks,as well as to recognize the functioning roles of anuran species.

关键词： diet disease food web helminth infection network centrality