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Impact of severe left ventricular dysfunction on mid-term mortality in elderly patients undergoing transcatheter aortic valve implantation

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Journal of Geriatric Cardiology 2016年第4期13卷 290-298页

作者： giuseppe ferrante Patrizia Presbitero Paolo Pagnotta Anna Sonia Petronio Nedy Brambilla Federico De Marco Claudia Fiorina Cristina Giannini Fabrizio D'Ascenzo Silvio Klugmann Marco L Rossi Federica Ettori Francesco Bedogni Luca Testa Department of Cardiovascular Medicine Humanitas Research Hospital Rozzano Italy Cardiothoracic and Vascular Department Azienda Ospedaliero-Universitaria Pisana Pisa Italy Department of Cardiology IRCCS Pol. S. Donato S. Donato Milanese Milan Italy Department of lnterventional Cardiology Niguarda Ca' Granda Hospital Milan Italy Cardiothoracic Department Spedali Civili di Brescia Brescia Italy Cardiothoracic Department Ospedale Molinette Torino Italy

Background Whether patients with reduced left ventricular function present worse outcome after transcatheter aortic valve implantation （TAVI） is controversial. The aim of this study was to assess the impact of baseline severe impairment of left ventricular ejection fraction （LVEF） on mortality after TAVI. Methods Six-hundred-forty-nine patients with aortic stenosis underwent TAVI with the CoreValve system （92.8%） or the Edwards SAPIEN valve system （7.2%）. Baseline LVEF was measured by the echocardiographic Simpson method. The impact of LVEF 〈 30% on mortality was assessed by Cox regression. Results Patients with LVEF 〈 30% （n = 63）, as compared to those with LVEF 〉 30% （n = 586）, had a higher prevalence of NHYA class 〉 2 （P 〈 0.001） and presented with a higher Euroscore （P 〈 0.001）. Procedural success was similar in both groups （98.4% vs. 97.2%, P = 1）. After a median follow-up of 436 days （25^-75th percentile, 357-737 days）, all-cause mortality [23.8% vs. 23.7%, P = 0.87, hazard ratios （HR）： 0.96, 95% confidence intervals （CI）： 0.56-1.63] and cardiac mortality （19.1% vs. 17.6%, P = 0.89, HR： 1.04, 95% CI： 0.57-1.90） were similar in patients with LVEF 〈 30% as compared to those with LVEF 〉 30%. Thirty-day all-cause mortality was not significantly different between the two groups （11.1% vs. 6.3%, P = 0.14, HR： 1.81, 95% CI： 0.814.06）. Patients with LVEF 〈 30% had a trend toward higher risk of 30-day cardiac mortality （11.1% vs. 5.3%; P = 0.06, HR： 2.16, 95% CI： 0.95-4.90）, which disappeared after multivariable adjustment （P = 0.22）. Conclusions Baseline severe impairment of LVEF is not a predictor of increased short-term and mid-term mortality after TAVI. Selected patients with severe impairment of left ventricular function should not be denied TAVI.

关键词： Left ventricular ejection fraction Mortality Transcatheter aortic valve implantation

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Non-linear self-driven spectral tuning of Extreme Ultraviolet Femtosecond Pulses in monoatomic materials

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Light(Science & Applications) 2021年第6期10卷 950-956页

作者： Carino ferrante Emiliano Principi Andrea Marini Giovanni Batignani giuseppe Fumero Alessandra Virga Laura Foglia Riccardo Mincigrucci Alberto Simoncig Carlo Spezzani Claudio Masciovecchio Tullio Scopigno Graphene Labs Istituto Italiano di TecnologiaVia Morego 3016163 GenovaItaly. Center for Life Nano Scie nee@Sapie nza Istituto Italia no di Tecno logiaViale Regina Elena 2911-00161 RomaItaly Dipartimento di Fisica Universita di Roma"La Sapienza"Piazzale Aldo Moro 500185 RomaItaly. Elettra-Sincrotrone Trieste S.C.p.ASS 14-km 163.5 34149 BasovizzaTriesteItaly Dipartimento di Scienze Fisiche e Chimiche Universita degli Studi dell'AquilaVia Vetoio67100 L'AquilaItaly

Self-action nonlinearity is a key aspect either as a foundational element or a detrimental factor of several optical spectroscopies and photonic *** generation,wavelength converters,and chirped pulse amplification are just a few *** recent advent of Free Electron Lasers(FEL)fostered building on nonlinearity to propose new concepts and extend optical wavelengths paradigms for extreme ultraviolet(EUV)and X-ray *** evidence for intrapulse dynamics,however,has been reported at such short wavelengths,where the light-matter interactions are ruled by the sharp absorption edges of core ***,we provide experimental evidence for self-phase modulation of femtosec ond FEL pulses,which we exploit for fine self-driven spectral tun ability by interaction with sub-micrometric foils of selected monoatomic *** the pulse wavelength across the absorption edge,the spectral profile changes from a non-linear spectral blue-shift to a red-shifted *** findings are rationalized account!ng for ultrafast ionization and delayed thermal response of highly excited electrons above and below threshold,respectively.

关键词： tuning Femto spectral

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Experimental Characterization of a Binary Actuated Parallel Manipulator

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Chinese Journal of Mechanical Engineering 2016年第3期29卷 445-453页

作者： CARBONE giuseppe Department of Engineering and Mathematics Sheffield Hallam UniversitySheffieldUnited Kingdom Laboratory of Robotics and Mechatronics University of Cassino and South LatiumCassino(Fr)Italy

This paper describes the BAPAMAN（Binary Actuated Parallel MANipulator） series of parallel manipulators that has been conceived at Laboratory of Robotics and Mechatronics（LARM）. Basic common characteristics of BAPAMAN series are described. In particular, it is outlined the use of a reduced number of active degrees of freedom, the use of design solutions with flexural joints and Shape Memory Alloy（SMA） actuators for achieving miniaturization, cost reduction and easy operation features. Given the peculiarities of BAPAMAN architecture, specific experimental tests have been proposed and carried out with the aim to validate the proposed design and to evaluate the practical operation performance and the characteristics of a built prototype, in particular, in terms of operation and workspace characteristics.

关键词： parallel manipulators binary actuation experimental characterization

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Arbitrary full-state hybrid projective synchronization for chaotic discrete-time systems via a scalar signal

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Chinese Physics B 2012年第6期21卷 94-99页

作者： giuseppe Grassi Dipartimento Ingegneria Innovazione Universitàdel Salento-73100 Lecce-Italy

In this paper we present a new projective synchronization scheme, where two chaotic （hyperchaotic） discrete-time systems synchronize for any arbitrary scaling matrix. Specifically, each drive system state synchronizes with a linear combination of response system states. The proposed observer-based approach presents some useful features： i） it enables exact synchronization to be achieved in finite time （i.e., dead-beat synchronization）; ii） it exploits a scalar synchronizing signal; iii） it can be applied to a wide class of discrete-time chaotic （hyperchaotic） systems; iv） it includes, as a particular case, most of the synchronization types defined so far. An example is reported, which shows in detail that exact synchronization is effectively achieved in finite time, using a scalar synchronizing signal only, for any arbitrary scaling matrix.

关键词： chaos synchronization full-state hybrid projective synchronization observer-based syn-chronization chaotic discrete-time systems dead beat control attractor scaling

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Fuzzy-entropy based robust optimization criteria for tuned mass dampers

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Earthquake Engineering and Engineering Vibration 2010年第2期9卷 285-294页

作者： giuseppe Carlo Marano giuseppe Quaranta Sara Sgobba Department of Environmental Engineering and Sustainable Development Technical University of Bari Department of Structural Engineering and Geotechnics University of Rome "La Sapienza" Faculty of Engineering International University UNINETTUNO

Tuned mass dampers (TMD) are well known as one of the most widely adopted devices in vibration control passive strategies. In the past few decades,many methods have been developed to find the optimal parameters of a TMD installed on a structure and subjected to a random base excitation process,but most of them are usually based on an implicit assumption that all of the structural parameters are deterministic. However,in many real cases this simplification is unacceptable,so robust optimal design criteria becomes aviable alternative to better support engineers in the design process. In Robust Design Optimization (RDO) approaches,indeed the solution must be able to not only minimize the performance but also to limitits variation induced by uncertainty. Most of the currently available RDO methods are based on a probabilistic description of the model uncertainty,even if in many cases they are not able to explicitly include the influence of all the possible sources of uncertainties. Therefore,in this study,a fuzzy version of the robust TMD design optimization problem is proposed. The consistency of the fuzzy approach is studied with respect to the available non-probabilistic formulations reported in the literature and an application to an example of a robust design of a linear TMD subjected to base random vibrations in the presence of fuzzy uncertainties. The results show that the proposed fuzzy-based approach is able to give a set of optimal solutions both in terms of structural efficiency and sensitivity to mechanical and environmental uncertainties.

关键词： tuned mass damper random vibration robust design fuzzy variable expected value fuzzy entropy

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Bone alterations in inflammatory bowel diseases

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World Journal of Clinical Cases 2019年第15期7卷 1908-1925页

作者： Dolores Sgambato Francesca Gimigliano Cristiana De Musis Antimo Moretti giuseppe Toro Emanuele ferrante Agnese Miranda Domenico De Mauro Lorenzo Romano Giovanni Iolascon Marco Romano Departments of Precision Medicine and Polyspecialistic Internal Medicine University of Campania "Luigi Vanvitelli" and University HospitalNaples 80131Italy Department of Physical and Mental Health University of Campania“Luigi Vanvitelli”Naples 80131Italy Department of Medical and Surgical Specialties and Dentistry University of Campania“Luigi Vanvitelli”Naples 80131Italy Surgical Digestive Endoscopy Department of Clinical Medicine and SurgeryFederico Ⅱ UniversityNaples 80131Italy

Inflammatory bowel diseases(IBDs)are characterized by a multifactorial partially unknown etiology that involves genetic,immunological and environmental *** to 50%of IBD patients experience at least one extraintestinal manifestation;among them is the involvement of bone density which is referred to as metabolic bone disease(MBD),including osteopenia and *** alterations in IBDs population appear to have a multifactorial etiology:Decreased physical activity,inflammation-related bone resorption,multiple intestinal resections,dietary malabsorption of minerals and vitamin D deficiency,genetic factors,gut-bone immune signaling interaction,steroid treatment,microbiota and pathogenic micro-organisms interaction,and dietary malabsorption of minerals,that,all together or individually,may contribute to the alteration of bone mineral *** review aims to summarize the prevalence and pathophysiology of metabolic bone alterations in IBD subjects outlining the main risk factors of bone *** also want to underline the role of the screening and prophylaxis of bone alterations in Crohn’s disease and ulcerative colitis patients and the importance of treating appropriately MBD.

关键词： Inflammatory bowel diseases Bone alterations Bone mineral density Osteoporosis Osteopenia Ulcerative colitis Crohn’s disease

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Novel four-wing and eight-wing attractors using coupled chaotic Lorenz systems

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Chinese Physics B 2008年第9期17卷 3247-3251页

作者： giuseppe Grassi Dipartimento di Ingegneria dell’Innovazione Università del Salento

This paper presents the problem of generating four-wing （eight-wing） chaotic attractors. The adopted method consists in suitably coupling two （three） identical Lorenz systems. In analogy with the original Lorenz system, where the two wings of the butterfly attractor are located around the two equilibria with the unstable pair of complex-conjugate eigenvalues, this paper shows that the four wings （eight wings） of these novel attractors axe located around the four （eight） equilibria with two （three） pairs of unstable complex-conjugate eigenvalues.

关键词： chaotic attractors multi-wing attractor coupled Lorenz systems dynamical behaviours

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Reliability based multiobjective optimization for design of structures subject to random vibrations

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2008年第1期9卷 15-25页

作者： giuseppe Carlo MARANO Department of Environmental Engineering and Sustainable Development Technical University of Bari viale del Turismo 10-74100 Taranto Italy

Based on a multiobjective approach whose objective function (OF) vector collects stochastic reliability performance and structural cost indices, a structural optimization criterion for mechanical systems subject to random vibrations is presented for supporting engineer’s design. This criterion differs from the most commonly used conventional optimum design criterion for random vibrating structure, which is based on minimizing displacement or acceleration variance of main structure responses, without considering explicitly required performances against failure. The proposed criterion can properly take into account the design-reliability required performances, and it becomes a more efficient support for structural engineering decision making. The multiobjective optimum (MOO) design of a tuned mass damper (TMD) has been developed in a typical seismic design problem, to control structural vibration induced on a multi-storey building structure excited by nonstationary base acceleration random process. A numerical example for a three-storey building is developed and a sensitivity analysis is carried out. The results are shown in a useful manner for TMD design decision support.

关键词： Structural optimization Multiobjective optimization (MOO) Random vibration Tuned mass damper (TMD)

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Knowledge-Enhanced Conversational Agents

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Journal of Computer Science & Technology 2024年第3期39卷 585-609页

作者： Fabio Caffaro giuseppe Rizzo LINKS Foundation 10138 TurinItaly

Humanity has fantasized about artificial intelligence tools able to discuss with human beings fluently for *** efforts have been proposed ranging from ELIZA to the modern vocal *** the large interest in this research and innovation field,there is a lack of common understanding on the concept of conversational agents and general over expectations that hide the current limitations of existing *** work proposes a literature review on the subject with a focus on the most promising type of conversational agents that are powered on top of knowledge bases and that can offer the ground knowledge to hold conversation autonomously on different *** describe a conceptual architecture to define the knowledge-enhanced conversational agents and investigate different domains of *** conclude this work by listing some promising research pathways for future work.

关键词： conversational agent dialogue system knowledge enhancing artificial agent intelligent conversation

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Consequences of a two-time relativistic Bohmian model

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Communications in Theoretical Physics 2024年第7期76卷 63-73页

作者： giuseppe Raguni Departamento de Fisica Universidad de MurciaE-30071 MurciaSpain

Effects of a Bohmian type quantum-relativistic theory are *** model is obtained by introducing a new and independent time parameter whose relative motions are not directly observable and cause quantum uncertainties of the physical *** the usual de Broglie-Bohm theories,the Quantum Potential does not directly affect the observable motion,but determines the one that is relative to the new time *** turns out that the Zitterbewegung of a free particle,of which a more general law is obtained,is the key example of these hidden motions and,through it,it seems possible to give physical reality to the Feynman's paths.A relativistic revision of the uncertainty principle is also derived from the theory.

关键词： Quantum Mechanics Foundations de Broglie-Bohm theory Zitterbewegung uncertainty principle verification extra dimensions

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