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Exploring conservative management for cervical intraepithelial neoplasia grade 2 in organised cervical cancer screening programmes:a multicentre study in Italy

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Family Medicine and Community Health 2024年第S2期12卷 1-7页

作者： Silvia Gori Helena Frayle Alessio Pagan Marika Soldà Cesare Romagnolo Egle Insacco Licia Laurino Mario Matteucci giuseppe Sordi Enrico Busato Manuel Zorzi Tiziano Maggino Annarosa Del Mistro CIN2 study Working Group Veneto Institute of Oncology IOV-IRCCS PadovaItaly Local Health Unit Marca Trevigiana TrevisoItaly Local Health Unit Serenissima VeneziaItaly Obstetrics and Gynecology Azienda Ospedale UniversitàPadovaItaly Local Health Unit Scaligera VeronaItaly Veneto Tumour Registry Azienda ZeroPadovaItaly 不详

Cervical intraepithelial neoplasia grade 2(CIN2)lesions may regress spontaneously,offering an alternative to immediate treatment,especially for women of childbearing age(15–45 years).We conducted a prospective multicentre study on conservative CIN2 management,with semiannual follow-up visits over 24 months,biomarkers’investigation and treatment for progression to CIN3+or CIN2 persistence for more than 12 ***,we assess women’s willingness to participate and adherence to the study *** study was set in population-based organised cervical cancer *** April 2019 to October 2021,640 CIN2 cases were diagnosed in women aged 25–64 participating in the screening *** to our predefined inclusion and exclusion criteria,228(35.6%)women were not eligible;93(22.6%)of the 412 eligible refused,and 319(77.4%)were *** for personal reasons(ie,desire to become pregnant,anxiety,difficulty in complying with the study protocol)and external barriers(ie,residence elsewhere and language problems)accounted for 71%and 17%,*** 9%expressed a preference for *** primary ineligibility factor was the upper age limit of 45 *** enrolment,12(4%)women without evidence of progression requested treatment,125(39%)were lost to follow-up(mostly after 6–12 months)and 182(57%)remained ***,40%of enrolees did not fully adhere to the protocol,whereas only 5%(20/412)of the eligible women desired *** study demonstrates a good acceptance of conservative management for CIN2 lesions by the women,supporting its implementation within cervical screening programmes.

关键词： cervical conservative centre

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钙钛矿晶格重构实现高亮度、卓越的颜色稳定性及低效率滚降的混合卤化物蓝色钙钛矿发光二极管（英文）

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Science China Materials 2024年第11期67卷 3553-3560页

作者：吴炯桦王仁杰张睿 giuseppe Portale Eduardo Solano 刘小可高峰 Department of Physics Chemistry and Biology(IFM)Link?ping University College of Physics and Information Engineering Institute of Micro-Nano Devices and Solar CellsFuzhou University Zernike Institute for Advanced Materials University of Groningen Experiments Division ALBA synchrotron Carrer de la Llum 2-2608290-Cerdanyola del Vallès

本文展示了一种简单、有效且通用的晶格重构方法,利用具有高古特曼供体数(DNs)的非极性溶剂来提高钙钛矿薄膜的质量.我们发现高DN非极性溶剂,例如乙酸乙酯,可以与钙钛矿前驱体相互作用.这种溶剂可以使钙钛矿晶格更加有序和“更坚硬”,... 详细信息

本文展示了一种简单、有效且通用的晶格重构方法,利用具有高古特曼供体数(DNs)的非极性溶剂来提高钙钛矿薄膜的质量.我们发现高DN非极性溶剂,例如乙酸乙酯,可以与钙钛矿前驱体相互作用.这种溶剂可以使钙钛矿晶格更加有序和“更坚硬”,并促使钙钛矿表面形成一种2D/3D的钙钛矿异质结构.晶格重构的钙钛矿薄膜表现出较低的缺陷密度并且其钙钛矿离子迁移受到了抑制.最终得到的混合卤化物蓝色钙钛矿发光二极管(PeLEDs)显示出极高的驱动电流密度和电压的耐受性,表现出高亮度和卓越的颜色稳定性.我们的工作深入研究了非极性溶剂与钙钛矿相互作用,并为进一步开发高性能的PeLEDs提供了启发.

关键词： color stability mixed halide perovskite low efficiency roll-off high brightness ion migration

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Laparoscopic central pancreatectomy with gastro-pancreatic anastomosis for symptomatic serous cystadenoma:A case report and literature review

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Laparoscopic, Endoscopic and Robotic Surgery 2024年第2期7卷 87-91页

作者： giuseppe Frazzetta Antonino Picciurro Angela Maffongelli Irene Vitale Francesco Vitale Daniela Scimeca Michele Amata Anna Calì Ambra Bonaccorso Barbara Scrivo Vincenzo Di Martino Elisabetta Conte Filippo Mocciaro Roberto Di Mitri Pierenrico Marchesa Oncologic Surgery Unit ARNAS Civico HospitalPalermo 90100Italy Gastroenterology Unit ARNAS Civico HospitalPalermo 90100Italy

Surgery for lesions of the proximal part of the pancreatic body or neck can be challenging,and when enucleation is not possible,central pancreatectomy is an *** central pancreatic resection is rarely described worldwide;it is considered a difficult procedure mainly because of the risk of double pancreatic fistula developing at two sites of ***,it seems to be an excellent alternative to distal pancreatectomy or pancreaticoduodenectomy,with the advantages of preserving functioning parenchyma and reducing endocrine and exocrine ***,patients with pancreatic lesions requiring central resection are often managed with the open approach in many hospitals due to the complexity of total laparoscopic central pancreatectomy,which requires advanced laparoscopic skills,expertise and ***,we report a case of a 29-year-old female who underwent total laparoscopic central pancreatic resection with gastro-pancreatic anastomosis for symptomatic serous *** discuss the details of case management and review the relevant literature.

关键词： Laparoscopic Pancreatic surgery Central pancreatectomy Cystadenoma

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Geophysical evidence of a large occurrence of mud volcanoes associated with gas plumbing system in the Ross Sea(Antarctica)

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Geoscience Frontiers 2024年第1期15卷 304-324页

作者： Martina Busetti Riccardo Geletti Dario Civile Chiara Sauli giuseppe Brancatelli Edy Forlin Daniela Accettella Lorenza Barro Savonuzzi Laura De Santis Aldo Vesnaver Andrea Cova National Institute of Oceanography and Applied Geophysics–OGS Borgo Grotta Gigante 42/c34010 SgonicoTriesteItaly

Seafloor and buried reliefs occur along continental margin of the Ross Sea(Antarctica).These features are several kilometres wide and tens of metres high,exhibiting cone or flat-top dome *** studies have proposed a volcanic or glacial origin for these formations,but these hypotheses do not account for all the available *** this study,we use morpho-bathymetric data,intermediate resolution multichannel seismic and high resolution chirp profiles,as well as magnetic lines to investigate these clusters of *** employing targeted processing techniques to enhance the geophysical characterization of the seafloor and buried reliefs,and to understand the underlying geological features,we propose that the reliefs are mud *** of these formations appear to be associated with a plumbing system,as indicated by acoustic anomalies linked to sediment containing *** formations are likely fed by clayey source rocks of Miocene ***,other reliefs might be the result of mud mobilisation caused by gravity instability and fluid overpressure.

关键词： Ross Sea Antarctica Mud volcanoes Gas plumbing system Gas hydrate Bottom Simulating Reflector

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Unveiling hidden outcomes in malignant gastric outlet obstruction research–insights from a"Pancreas 2000"review

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World Journal of Gastrointestinal Endoscopy 2024年第8期16卷 451-461页

作者： Filipe Vilas-Boas Giacomo Emanuele Maria Rizzo Charles De Ponthaud Stuart Robinson Sebastien Gaujoux Gabriele Capurso giuseppe Vanella Bahadır Bozkırlı Department of Gastroenterology São João University HospitalPorto 4200Portugal Endoscopy Service Department of Diagnostic and Therapeutic ServicesScientific Institute for ResearchHospitalization and Healthcare-The Mediterranean Institute for Transplantation and Highly Specialized TherapiesPalermo 90127SiciliaItaly Department of Digestive Hepato-Biliary and Pancreatic Surgery and Liver TransplantationAP-HP Pitié-SalpêtriereSorbonne UniversitéParis 75013Île-de-FranceFrance Department of Hepatobiliary Pancreatic and Transplant SurgeryFreeman HospitalNewcastle NE77DNNewcastle upon TyneUnited Kingdom Division of Pancreato-Biliary Endoscopy and Endosonography Pancreas Translational and Clinical Research CenterIRCCS San Raffaele Scientific InstituteVita-Salute San Raffaele UniversityMilano 20132Italy Department of General Surgery HPB-UnitAcıbadem Maslak HospitalIstanbul 34398Türkiye

Malignant gastric outlet obstruction(mGOO)is a major condition affecting patients with periampullary tumors,including pancreatic *** current treatment options include surgical gastroenterostomy,endoscopic stenting and more recently EUS-guided *** studies comparing the outcomes of the three procedures focus on technical success,clinical success and ***“occult”outcomes relevant to the patient’s viewpoints and perspective may ultimately impact on cancer-related and overall survival,such as body mass composition,nutritional biomarkers,chemotherapy tolerance and patient-reported quality of *** aim of this review is to provide an overview of potential key outcomes that should be explored in future comparative research around mGOO treatment options.

关键词： Malignant gastric outlet obstruction Endoscopic ultrasound-guided gastroenterostomy Patient-reported outcomes Body composition Nutrition Quality of life

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Experimental Characterization of a Binary Actuated Parallel Manipulator

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Chinese Journal of Mechanical Engineering 2016年第3期29卷 445-453页

作者： CARBONE giuseppe Department of Engineering and Mathematics Sheffield Hallam UniversitySheffieldUnited Kingdom Laboratory of Robotics and Mechatronics University of Cassino and South LatiumCassino(Fr)Italy

This paper describes the BAPAMAN（Binary Actuated Parallel MANipulator） series of parallel manipulators that has been conceived at Laboratory of Robotics and Mechatronics（LARM）. Basic common characteristics of BAPAMAN series are described. In particular, it is outlined the use of a reduced number of active degrees of freedom, the use of design solutions with flexural joints and Shape Memory Alloy（SMA） actuators for achieving miniaturization, cost reduction and easy operation features. Given the peculiarities of BAPAMAN architecture, specific experimental tests have been proposed and carried out with the aim to validate the proposed design and to evaluate the practical operation performance and the characteristics of a built prototype, in particular, in terms of operation and workspace characteristics.

关键词： parallel manipulators binary actuation experimental characterization

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Arbitrary full-state hybrid projective synchronization for chaotic discrete-time systems via a scalar signal

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Chinese Physics B 2012年第6期21卷 94-99页

作者： giuseppe Grassi Dipartimento Ingegneria Innovazione Universitàdel Salento-73100 Lecce-Italy

In this paper we present a new projective synchronization scheme, where two chaotic （hyperchaotic） discrete-time systems synchronize for any arbitrary scaling matrix. Specifically, each drive system state synchronizes with a linear combination of response system states. The proposed observer-based approach presents some useful features： i） it enables exact synchronization to be achieved in finite time （i.e., dead-beat synchronization）; ii） it exploits a scalar synchronizing signal; iii） it can be applied to a wide class of discrete-time chaotic （hyperchaotic） systems; iv） it includes, as a particular case, most of the synchronization types defined so far. An example is reported, which shows in detail that exact synchronization is effectively achieved in finite time, using a scalar synchronizing signal only, for any arbitrary scaling matrix.

关键词： chaos synchronization full-state hybrid projective synchronization observer-based syn-chronization chaotic discrete-time systems dead beat control attractor scaling

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Fuzzy-entropy based robust optimization criteria for tuned mass dampers

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Earthquake Engineering and Engineering Vibration 2010年第2期9卷 285-294页

作者： giuseppe Carlo Marano giuseppe Quaranta Sara Sgobba Department of Environmental Engineering and Sustainable Development Technical University of Bari Department of Structural Engineering and Geotechnics University of Rome "La Sapienza" Faculty of Engineering International University UNINETTUNO

Tuned mass dampers (TMD) are well known as one of the most widely adopted devices in vibration control passive strategies. In the past few decades,many methods have been developed to find the optimal parameters of a TMD installed on a structure and subjected to a random base excitation process,but most of them are usually based on an implicit assumption that all of the structural parameters are deterministic. However,in many real cases this simplification is unacceptable,so robust optimal design criteria becomes aviable alternative to better support engineers in the design process. In Robust Design Optimization (RDO) approaches,indeed the solution must be able to not only minimize the performance but also to limitits variation induced by uncertainty. Most of the currently available RDO methods are based on a probabilistic description of the model uncertainty,even if in many cases they are not able to explicitly include the influence of all the possible sources of uncertainties. Therefore,in this study,a fuzzy version of the robust TMD design optimization problem is proposed. The consistency of the fuzzy approach is studied with respect to the available non-probabilistic formulations reported in the literature and an application to an example of a robust design of a linear TMD subjected to base random vibrations in the presence of fuzzy uncertainties. The results show that the proposed fuzzy-based approach is able to give a set of optimal solutions both in terms of structural efficiency and sensitivity to mechanical and environmental uncertainties.

关键词： tuned mass damper random vibration robust design fuzzy variable expected value fuzzy entropy

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Novel four-wing and eight-wing attractors using coupled chaotic Lorenz systems

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Chinese Physics B 2008年第9期17卷 3247-3251页

作者： giuseppe Grassi Dipartimento di Ingegneria dell’Innovazione Università del Salento

This paper presents the problem of generating four-wing （eight-wing） chaotic attractors. The adopted method consists in suitably coupling two （three） identical Lorenz systems. In analogy with the original Lorenz system, where the two wings of the butterfly attractor are located around the two equilibria with the unstable pair of complex-conjugate eigenvalues, this paper shows that the four wings （eight wings） of these novel attractors axe located around the four （eight） equilibria with two （three） pairs of unstable complex-conjugate eigenvalues.

关键词： chaotic attractors multi-wing attractor coupled Lorenz systems dynamical behaviours

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Reliability based multiobjective optimization for design of structures subject to random vibrations

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2008年第1期9卷 15-25页

作者： giuseppe Carlo MARANO Department of Environmental Engineering and Sustainable Development Technical University of Bari viale del Turismo 10-74100 Taranto Italy

Based on a multiobjective approach whose objective function (OF) vector collects stochastic reliability performance and structural cost indices, a structural optimization criterion for mechanical systems subject to random vibrations is presented for supporting engineer’s design. This criterion differs from the most commonly used conventional optimum design criterion for random vibrating structure, which is based on minimizing displacement or acceleration variance of main structure responses, without considering explicitly required performances against failure. The proposed criterion can properly take into account the design-reliability required performances, and it becomes a more efficient support for structural engineering decision making. The multiobjective optimum (MOO) design of a tuned mass damper (TMD) has been developed in a typical seismic design problem, to control structural vibration induced on a multi-storey building structure excited by nonstationary base acceleration random process. A numerical example for a three-storey building is developed and a sensitivity analysis is carried out. The results are shown in a useful manner for TMD design decision support.

关键词： Structural optimization Multiobjective optimization (MOO) Random vibration Tuned mass damper (TMD)

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