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Lower limb suspension induces threshold-specific alterations of motor units properties that are reversed by active recovery

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Journal of Sport and Health Science 2024年第2期13卷 264-276页

作者： Giacomo Valli Fabio Sarto Andrea Casolo Alessandro del Vecchio Martino V.Franchi Marco V.Narici giuseppe de vito department of Biomedical Sciences University of PadovaPadova 35131Italy department Artificial Intelligence in Biomedical Engineering Friedrich-Alexander UniversityErlangen-Nurnberg 91052Germany

Purpose:This study aimed to non-invasively test the hypothesis that(a) short-term lower limb unloading would induce changes in the neural control of force production(based on motor units(MUs) properties) in the vastus lateralis muscle and(b) possible changes are reversed by active recovery(AR).Methods:Ten young males underwent 10 days of unilateral lower limb suspension(ULLS) followed by 21 days of *** ULLS,participants walked exclusively on crutches with the dominant leg suspended in a slightly flexed position(15°-20°) and with the contralateral foot raised by an elevated *** AR was based on resistance exercise(leg press and leg extension) and executed at 70% of each participant’s 1repetition maximum,3 times/*** voluntary isometric contraction(MVC) of knee extensors and MUs properties of the vastus lateralis muscle were measured at baseline,after ULLS,and after *** were identified using high-density electromyography during trapezoidal isometric contractions at 10%,25%,and 50% of the current MVC,and individual MUs were tracked across the 3 data collection ***:We identified 1428 unique MUs,and 270 of them(18.9%) were accurately *** ULLS,MVC decreased by 29.77%,MUs absolute recruitment/derecruitment thresholds were reduced at all contraction intensities(with changes between the 2 variables strongly correlated),while discharge rate was reduced at 10% and 25% but not at 50% *** MVC and MUs properties fully recovered to baseline levels after *** changes were observed in the pool of total as well as tracked ***:Our novel results demonstrate,non-invasively,that 10 days of ULLS affected neural control predominantly by altering the discharge rate of lower-threshold but not of higher-threshold MUs,suggesting a preferential impact of disuse on motoneurons with a lower depolarization ***,after 21 days of AR,the impaired MUs properties were fully restored to baseline levels,highlighting the plas

关键词： Disuse High-density EMG Muscle disuse Neural impairment Neuromuscular degeneration

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Zero Sequence Voltage and Current Control in Four-wire Grids-fed by Grid-forming Inverters

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CSEE Journal of Power and Energy Systems 2023年第6期9卷 2272-2279页

作者： Zixian Zhu Wei Chen vito giuseppe Monopoli the College of Electrical And Information Engineering Hunan UniversityChangshaChina the College of Electrical and Information Engineering Lanzhou University of TechnologyLanzhouChina the department of Electrical and Information Engineering Bari PolytechnicBariItaly

Low voltage three-phase four-wire AC distribution grids may experience high neutral current,mainly caused by asymmetrical distribution of single-phase loads in three *** neutral current will not only increase line losses but also result in neutral potential *** the LV AC distribution grid established by a grid-forming inverter(e.g.,uninterruptible power supply and solid-state-transformer),it also suffers from the same neutral current ***,this paper comparatively studies several neutral current control approaches and their impacts on grid voltage balance,which is required by grid ***,this paper proposes an optimal neutral current control approach,which can obtain maximum neutral current suppression with less impact on grid voltage *** correctness of the theoretical analysis is validated through both simulation and experimental results.

关键词： LV AC grid neutral current reduction grid-forming inverter three-phase four-wire system

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Phrenic nerve displacement by intrapericardial balloon inflation during epicardial ablation of ventricular tachycardia: Four case reports

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World Journal of Cardiology 2020年第1期12卷 55-66页

作者： Sergio Conti vito Bonomo Antonio Taormina Umberto Giordano giuseppe Sgarito department of Cardiology ElectrophysiologyPalermo 90127Italy Faculty of Medicine University of Tor VergataRome 00133Italy department of Cardiology University of PalermoPalermo 90127Italy department of Cardiology University of MessinaMessina 98122Italy

BACKGROUND Phrenic nerve(PN)injury is one of the recognized possible complications following epicardial ablation of ventricular tachycardia(VT).High-output pacing is a widely used maneuver to establish a relationship between the PN and the ablation catheter *** absence of PN capture is usually considered an indication that it is safe to ablate,and that successful ablation may be performed at adjacent ***,PN capture may impact the procedural *** a few cases have been reported in the literature that avoid PN injury by using different *** SUMMARY Three patients with a previous history of myocarditis and one patient with ischemic cardiomyopathy underwent epicardial ablation for drug-refractory *** the procedure,transthoracic echocardiogram,coronary angiogram,and cardiac magnetic resonance imaging were performed on all *** general anesthesia,endo/epicardial three-dimensional anatomical and substrate maps of the left ventricle were *** radiofrequency delivery,the course of the PN was identified by provoking diaphragmatic stimulation with high-output pacing from the distal electrode of the ablation *** every case,a scar region with late potentials was mapped along the PN *** obtaining another epicardial access,a second introducer sheath was placed,and a vascular balloon catheter was inserted into the epicardial space and inflated with saline solution to separate the PN from the *** the absence of PN capture had been proven,radiofrequency was applied to aim for complete late potential elimination and avoid VT *** PN injury can occur as one of the complications following epicardial VT ablation procedures,and may prevent successful ablation of these *** displacement by using large balloon catheters into the epicardial space seems to be feasible and reproducible,avoid procedure-related morbidity,and improve ablation success when performed in selected cent

关键词： Catheter ablation Epicardial access Myocarditis Nonischemic cardiomyopathy Ventricular tachycardia Phrenic nerve Case series

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Growing pains: What do we know about etiology? A systematic review

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World Journal of Orthopedics 2019年第4期10卷 192-205页

作者： vito Pavone Andrea Vescio Fabiana Valenti Marco Sapienza giuseppe Sessa Gianluca Testa department of General Surgery and Medical Surgical Specialties Section of Orthopaedics and Traumatology University Hospital Policlinico-Vittorio Emanuele University of Catania

BACKGROUND Growing pains is the most common cause of musculoskeletal pain in early childhood and was first described in 1823 by French physician Marcel *** it has been researched extensively, the etiology is still *** theories have been proposed throughout the *** Analyze the available scientific literature to provide an update on the latest evidence on the *** According to the guidelines of the Preferred Reporting Items for Systematic Reviews and Meta-Analyses, the scientific literature on the etiology of growing pains was systematically reviewed using the following inclusion criteria: studies of any level of evidence reporting clinical or preclinical results and dealing with the etiology of growing pains. The medical electronic databases PubMed and Web of Science were searched by two independent authors on October 20, *** search string used was "(growing pains OR benign nocturnal limb pains OR musculoskeletal pains) AND(etiology OR pathogenesis) AND(pediatrics)".RESULTS A total of 32 articles were included. The etiology of growing pains still remains poorly understood. Many theories have been proposed, but none of them are decisive. A lower pain threshold has been found among patients suffering from growing pains in comparison to healthy controls. Furthermore, evidence suggests an association between growing pains and reduced bone strength in young patients, although this finding still remains controversial. Changes in the vascular perfusion pattern have also been studied. However, the etiology of growing pains does not seem related to a vascular component. The anatomical/mechanical theory has not been supported, but the role of vitamin D deficiency has been investigated many times. Strong recent evidence indicates a genetic susceptibility in the pathogenesis of growing pains. Furthermore,psychological factors also seem to play a strong role in the *** The scientific literature about the etiology of gro

关键词： Growing pains Benign nocturnal limb pains of childhood Recurrent limb pains of childhood Etiology Pathogenesis

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Aetiology of Legg-Calvé-Perthes disease:A systematic review

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World Journal of Orthopedics 2019年第3期10卷 145-165页

作者： vito Pavone Emanuele Chisari Andrea Vescio Claudio Lizzio giuseppe Sessa Gianluca Testa department of General Surgery and Medical Surgical Specialties Section of Orthopaedics and TraumatologyUniversity Hospital Policlinico-Vittorio EmanueleUniversity of Catania

BACKGROUND Legg-Calvé-Perthes disease(LCPD) is a clinical condition affecting the femoral head of children during their growth. Its prevalence is set to be between 0.4/100000 to 29.0/100000 children less than 15 years of age with a peak of incidence in children aged from 4 years to 8 years. LCPD aetiology has been widely studied, but it is still poorly *** To analyse the available literature to document the up-to-date evidence on LCPD *** A systematic review of the literature was performed regarding LCPD aetiology,using the following inclusion criteria: studies of any level of evidence, reporting clinical or preclinical results and dealing with the aetiology or pathogenesis of LCPD. Two reviewers searched the PubMed and Science Direct databases from their date of inception to the 20th of May 2018 in accordance with the Preferred Reporting Items for Systemic Reviews and Meta-Analyses guidelines. To achieve the maximum sensitivity of the search strategy, we combined the terms: ‘‘Perthes disease OR LCPD OR children avascular femoral head necrosis" with "pathology OR aetiology OR biomechanics OR genetics" as either key words or MeSH *** We include 64 articles in this review. The available evidence on LCPD aetiology is still debated. Several hypotheses have been researched, but none of them was found decisive. While emerging evidence showed the role of environmental risk factors and evidence from twin studies did not support a major role for genetic factors, a congenital or acquired predisposition cannot be excluded in disease pathogenesis. One of the most supported theories involved mechanical induced ischemia that evolved into avascular necrosis of the femoral head in sensible *** The literature available on the aetiology of LCPD presents major limitations in terms of great heterogeneity and a lack of high-profile studies. Although a lot of studies focused on the genetic, biomechanical and radiological background of th

关键词： Legg-Calvé-Perthes disease Aetiology Pathogenesis Genetics Risk factors

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Harnessing the value of TCTP in breast cancer treatment resistance: an opportunity for personalized therapy

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Cancer Drug Resistance 2023年第3期6卷 447-467页

作者： Gianluca Santamaria Mario Cioce Antonia Rizzuto vito Michele Fazio giuseppe Viglietto Maria Lucibello department of Experimental and Clinical Medicine “Magna Graecia”University of CatanzaroCatanzaro 88100Italy department of Medicine Laboratory of Molecular Medicine and BiotechnologyUniversity Campus Bio-Medico of RomeRome 00128Italy Institute of Translational Pharmacology National Research Council of Italy(CNR)Rome 00133Italy department of Medical and Surgical Sciences “Magna Graecia”University of CatanzaroCatanzaro 88100Italy department of Biomedical Sciences Institute for Biomedical Research and InnovationNational Research Council of Italy(CNR)Catanzaro 88100Italy

Early identification of breast cancer (BC) patients at a high risk of progression may aid in therapeutic and prognostic aims. This is especially true for metastatic disease, which is responsible for most cancer-related deaths. Growing evidence indicates that the translationally controlled tumor protein (TCTP) may be a clinically relevant marker for identifying poorly differentiated aggressive BC tumors. TCTP is an intriguing protein with pleiotropic functions, which is involved in multiple signaling pathways. TCTP may also be involved in stress response, cell growth and proliferation-related processes, underlying its potential role in the initiation of metastatic growth. Thus, TCTP marks specific cancer cell sub-populations with pronounced stress adaptation, stem-like and immune-evasive properties. Therefore, we have shown that in vivo phospho-TCTP levels correlate with the response of BC cells to anti-HER2 agents. In this review, we discuss the clinical relevance of TCTP for personalized therapy, specific TCTP-targeting strategies, and currently available therapeutic agents. We propose TCTP as an actionable clinically relevant target that could potentially improve patient outcomes.

关键词： Breast cancer metastasis TCTP stem cells therapy resistance biomarker

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Plate vs reverse shoulder arthroplasty for proximal humeral fractures:The psychological health influence the choice of device?

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World Journal of Orthopedics 2022年第3期13卷 297-306页

作者： giuseppe Maccagnano giuseppe Solarino vito Pesce Giovanni Vicenti Michele Coviello Vittorio Saverio Nappi Orazio Valerio Giannico Angela Notarnicola Biagio Moretti department of Clinical and Experimental Medicine Faculty of Medicine and SurgeryUniversity of FoggiaOrthopaedics UnitGeneral HospitalFoggia 71122Italy department of Basic Medical Science Neuroscience and Sensory OrgansFaculty of Medicine and SurgeryUniversity of BariOrthopaedics UnitGeneral HospitalBari 70124Italy Orthopaedics Unit Di Venere General HospitalBari 70124Italy department of Biomedical Sciences and Human Oncology University of Bari Aldo MoroBari 70124Italy

BACKGROUND Proximal humeral fractures represent the third most common observed osteoporotic fracture;the treatment in three and four-part proximal humeral fractures in patients over 65 years is still *** the treatments described in literature,open reduction and internal fixation(O.R.I.F)and reverse shoulder arthroplasty(RSA)are gaining an increasing *** To investigate the correct treatment for three and four-part proximal humeral fractures according to psychological *** It was conducted a prospective study with a series of 63 patients treated with O.R.I.F.(group A)and with RSA(group B)for three and four-part proximal humeral fractures according to Neer classification system.A conservative treatment group,as control,was finally *** independent observer performed clinical and a psychological evaluation at one(T0),six(T1)and twelve months(T2)*** Constant’s score and The Disabilities of the Arm,Shoulder and Hand(DASH score)were used for clinical evaluation,while General Anxiety Disorder-7(GAD-7)and Caregiver Strain Scale(CSS)were used for psychological *** At one month follow up in group A the mean values were DASH score 50.8,Constant score 36.1,GAD-7 score 5.4,CSS *** the group B,the average values at T0 were:DASH score 54.6,Constant score 32.0;GAD-7 score 6.4,CSS *** six months in group A the average values were DASH score 42.1,Constant score 47.3,GAD-7 score 4.3,CSS *** the group B,the average values at T1 were:DASH score 39.1,Constant score 43.2,GAD-7 score 5.7,CSS *** twelve months in the group A,the mean values were DASH score 32.8,Constant score 60.0,GAD-7 score 3.2,CSS *** the group B shown these mean values:DASH score 33.6,Constant score 52.9,GAD-7 score 4.3,CSS *** demonstrated a better clinical and psychological outcome at T2 in the group treated with osteosynthesis compared to the group treated with arthroplasty(Constant P=0.049,GAD-7 P=0.012 and CSS P=0.005

关键词： Proximal humerus fractures Open reduction and fixation Reverse shoulder arthroplasty Psychological health General Anxiety Disorder-7 scale Caregiver Strain scale

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Feasibility of cabazitaxel in octogenarian prostate cancer patients

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Current Urology 2023年第3期17卷 153-158页

作者： Paolo Tralongo Sebastiano Bordonaro giuseppe Di Lorenzo Ugo de Giorgi NicolòBorsellino Gaetano Facchini Sabrina Rossetti giuseppe Fornarini vito Longo Antonino Carmelo Tralongo Francesca Caspani Massimiliano Spada Nicola Calvani Paolo Carlini Medical Oncology Unit RAO-Umberto I HospitalSiracusa96100Italy department of Medicine and Health Sciences‘Vincenzo Tiberio' University of MoliseCampobassoItaly Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori(IRST)IRCCS Meldola(FC)Italy Medical Oncology Unit Ospedale Buccheri La FerlaFatebenefratelliPalermoItaly Medical Oncology Unit Santa Maria delle Grazie di PozzuoliNapoliItaly departmental Unit of Clinical and Experimental Uro-Andrologic Oncology Istituto Nazionale TumoriIRCCSFondazione G.PascaleNapoliItaly Medical Oncology 1 IRCCSOspedale Policlinico San MartinoGenovaItaly Istituto Tumori Giovanni PaoloⅡI.R.C.C.S. BaOspedale di CircoloVareseItaly Medical Oncology Unit ASSTSETTE LAGHIOspedale di CircoloVareseItaly Medical Oncology Unit Fondazione Istituto G.Giglio di CefalùPalermoItaly Medical Oncology Division&Breast Unit Sen.A.Perrino HospitalBrindisiItaly Medical Oncology 1 Istituto Nazionale Tumori Regina ElenaRomaItaly

Background:To evaluate the effectiveness and safety of cabazitaxel in castration-resistant prostate cancer patients aged>80 years,we performed a retrospective study on a sample of patients from 11 Italian cancer *** and methods:Fifty-seven patients aged>80 years were treated with cabazitaxel after previous failure with docetaxel;39 completed a comprehensive geriatric assessment questionnaire(34 fit and 5 vulnerable)and 8 patients(14%)had an Eastern Cooperative Oncology Group performance status(PS)>2,while most had a PS of 0-1(86%).Cabazitaxel was administered at a dose of 25 mg/m^(2)in 30(52%)patients and 20 mg/m^(2)or adapted schedules in 27(48%)*** schedules were adopted mainly in patients>85 years(75%),with a PS>2(87.5%),and those classified as vulnerable(100%).Results:The duration of treatment was 4.8 months and was comparable in all subgroups;disease control rate was reported in 36 patients(63%);prostate-specific antigen response was recorded in 18 patients(31.5%).Median overall survival was 13.1 months regardless of age(85 years),but overall survival was reduced in vulnerable(7.2 months)and PS>2 patients(6.8 months).The most frequently documented grade 3-4 toxicities were neutropenia(14%)and diarrhea(10.5%).Six patients(10.5%)dropped out due to severe ***:Octogenarian patients can be treated with cabazitaxel with reduced doses or alternative schedules that are associated with less toxicity and fewer treatment *** geriatric assessment could facilitate more appropriate patient selection.

关键词： Cabazitaxel Cancer Octogenarian Prostate

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Impact of low-intensity extracorporeal shockwave therapy on vascular parameters and sexual function in patients with arteriogenic erectile dysfunction

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Asian Journal of Andrology 2024年第4期26卷 344-348页

作者： Matteo Rubino Anna Ricapito Marco Finati Ugo G Falagario Pasquale Annese vito Mancini Gian Maria Busetto Luigi Cormio giuseppe Carrieri Carlo Bettocchi Andrology Unit Department of Urology and Renal TransplantationUniversity of FoggiaFoggia 71122Italy department of Molecular Medicine and Surgery Karolinska InstitutetStockholm 17177Sweden department of Urology Bonomo Teaching HospitalUniversity of FoggiaAndria 76123Italy.

Previous published studies have shown an improvement of penile hemodynamic parameters after low-intensity extracorporeal shockwave therapy(Li-ESWT).However,the clinical significance of these findings remains unclear,and definitive selection criteria for Li-ESWT based on preexisting comorbidities have yet to be *** was an observational study of 113 patients with ED,evaluated between January 2019 and december 2021 in Andrology Unit at the department of Urology and Renal Transplantation,University of Foggia(Foggia,Italy).Penile dynamic Doppler was performed to evaluate vascular parameters and 5-item version of the International Index of Erectile Dysfunction(IIEF-5)questionnaire was administered to assess the severity of *** was repeated 1 month after *** with a peak systolic velocity(PSV)dered eligible for *** protocol consisted of 8 weekly sessions with 1500 strokes distributed in 5 different locations along the *** treatment,a significant mean(±standard deviation[s.d.])PSV increase of 5.0(±3.4)cm s−1 was recorded and 52/113(46.0%)patients reached a PSV>30 cm s−1 at posttherapeutic penile dynamic Doppler.A clinically significant IIEF-5 score improvement was observed in 7 patients,21 patients,and 2 patients with mild-to-moderate,moderate,and severe pretreatment ED,*** different outcomes were assessed based on smoking habits,previous pelvic surgery,or use of oral phosphodiesterase-5 inhibitor(Pde5i).On the other side,only 1(6.7%)in 15 patients with diabetes mellitus showed an IIEF-5 score improvement after *** treatment determined a significant increase in PSV and correlated IIEF-5 improvement in ED *** advantage seemed particularly evident for moderate ED and was not affected by smoking habits,previous pelvic surgery,and use of ***,diabetic patients did not benefit from the treatment.

关键词： arteriogenic erectile dysfunction International Index of Erectile Function low-intensity extracorporeal shockwave therapy peak systolic velocity

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Natural history of untreatable hepatocellular carcinoma:A retrospective cohort study

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World Journal of Hepatology 2012年第9期4卷 256-261页

作者： giuseppe Cabibbo Marcello Maida Chiara Genco Pietro Parisi Marco Peralta Michela Antonucci giuseppe Brancatelli Calogero Cammà Antonio Craxì vito Di Marco Section of Gastroenterology Department of Internal Medicine and Biomedical SpecialistUniversity of PalermoPalermo 90127Italy department of Biopathology and Biomedical Methodologies University of PalermoPalermo 90127Italy department of Oncology Division of General Surgery and OncologyUniversity of PalermoPalermo 90127Italy department of Radiology DIBIMEFUniversity of PalermoPalermo 90127Italy

AIM: To investigate the clinical course of untreatable hepatocellular carcinoma (HCC) identified at any stage and to identify factors associated with mortality. METHODS: From January 1999 to december 2010, 320 out of 825 consecutive patients with a diagnosis of HCC and not appropriate for curative or palliative treatments were followed and managed with supportive therapy. Cirrhosis was diagnosed by histological or clinical features and liver function was evaluated according to Child-Pugh score. The diagnosis of HCC was performed by Ultra-Sound guided biopsy or by multiphasic contrast-enhanced computed tomography or gadolinium-enhanced magnetic resonance imaging. Data were collected for each patient including all clinical, laboratory and imaging variables necessary for the outcome prediction staging systems considered. HCC staging was performed according Barcelona Clinic Liver Cancer (BCLC) and Cancer of the Liver Italian Program scores. Follow-up time was defined as the number of months from the diagnosis of HCC to death. Prognostic baseline variables were analyzed by multivariate Cox analysis to identify the independent predictors of survival. RESULTS: Seventy-five per cent of patients had hepatitis C. Ascites was present in 169 patients (53%), while hepatic encephalopathy was present in 49 patients (15%). The Child-Pugh score was class A in 105 patients (33%), class B in 142 patients (44%), and class C in 73 patients (23%). One hundred patients (31%) had macroscopic vascular invasion and/or extra-hepatic spread of the tumor. A single lesion > 10 cm was observed in 34 patients (11%), while multinodular HCC was present in 189 patients (59%). Thirty nine patients (12%) were BCLC early (A) stage, 55 (17%) were BCLC intermediate (B) stage, 124 (39%) were BCLC advanced (C) stage, and 102 (32%) were end-stage BCLC (D). At the time of this analysis (July 2011), 28 (9%) patients were still alive. Six (2%) patients who were lost during follow-up were censored at the last vi

关键词： Hepatocellular carcinoma Liver Cancer Survival Prognosis Natural history

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