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Psycho-gastroenterological profile of an Italian population of children with disorders of gut-brain interaction:A case-control study

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World Journal of Clinical Pediatrics 2025年第1期14卷 69-77页

作者： Valentina Giorgio Ilaria Venezia Licia Pensabene Elisa Blasi Donato Rigante Paolo Mariotti giuseppe Stella Gaia Margiotta Giovanna Quatrale giuseppe Marano Marianna Mazza Antonio Gasbarrini Eleonora Gaetani Pediatric Unit Department of WomenChildren and Public Health SciencesFondazione Policlinico Universitario“A.Gemelli”IRCCSUniversitàCattolica del Sacro CuoreRome 00168Italy Child Neuropsychiatry Unit ASST Santi Paolo e CarloSan Paolo HospitalMilan 20142Italy Child Neuropsychiatry Unit Department of WomenChildren and Public Health SciencesFondazione Policlinico Universitario“A.Gemelli”IRCCSUniversitàCattolica del Sacro CuoreRome 00168Italy Department of Medical and Surgical Sciences Pediatric UnitUniversity Magna GraeciaCatanzaro 88100Italy Unit of Psychiatry Fondazione Policlinico Universitario“A.Gemelli”IRCCSRome 00168Italy Department of Neurosciences UniversitàCattolica del Sacro CuoreRome 00168Italy Department of Internal Medicine and Gastroenterology Fondazione Policlinico Universitario"A.Gemelli"IRCCSRome 00168Italy Department of Medical and Surgical Sciences Fondazione Policlinico Universitario"A.Gemelli"IRCCSUniversitàCattolica del Sacro CuoreRome 00168Italy

BACKGROUND Disorders of gut-brain interaction(DGBI)are common,but knowledge about their physiopathology is still poor,nor valid tools have been used to evaluate them in *** To develop a psycho-gastroenterological questionnaire(PGQ)to assess the psycho-gastroenterological profile and social characteristics of a pediatric population with and without *** One hundred and nineteen Italian children(age 11-18)were included:28 outpatient patients with DGBI(Rome IV criteria)and 91 healthy *** filled the PGQ,faces pain scale revised(FPS-R),Bristol stool chart,ga-strointestinal symptoms rating scale,state-trait anxiety inventory,Toronto alexithymia scale 20,perceived self-efficacy in the management of negative emotions and expression of positive emotions(APEN-G,APEP-G),irritable bowel syndrome-quality of life questionnaire,school performances,tobacco use,early life events,degree of *** Compared to controls,patients had more medical examinations(35%of them went to the doctor more than five times),a higher school performance(23%vs 13%,P<0.05),didn’t use tobacco(never vs 16%,P<0.05),had early life events(28%vs 1%P<0.05)and a higher percentage of pain classified as 4 in the FPS-R during the examination(14%vs 7%,P<0.05).CONCLUSION Pediatric outpatients with DGBI had a higher prevalence of early life events,a lower quality of life,more medical examinations rising health care costs,lower anxiety levels.

关键词： Disorders of gut-brain interaction Functional gastrointestinal disorders Psycho-gastroenterological profile Gut-brain axis Rome IV criteria Pediatric patients

Pancreatic cancer:Future challenges and new perspectives for an early diagnosis

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World Journal of Clinical Oncology 2025年第2期16卷 1-8页

作者： Silvia Cocca Giuseppina Pontillo Marinella Lupo Raffaele Lieto Margherita Marocchi Maria Marsico Emanuela Dell'Aquila Santi Mangiafico giuseppe Grande Rita Conigliaro Helga Bertani Gastroenterology and Endoscopy Unit Azienda Ospedaliero Universitaria Policlinico di ModenaModena 41121Italy Gastroenterology and Endoscopy Unit Presidio Ospedaliero San Giuseppe Moscati(AversaCE)–ASL CasertaCaserta 81100Italy Department of Clinical Medicine and Surgery University of Naples Federico IINaples 80131CampaniaItaly Department of Medical Oncology 1 IRCCS Regina Elena National Cancer InstituteRome 0144Italy Gastroenterology and Endoscopy Unit Azienda Ospedaliero Universitaria Policlinico“G Rodolico–San Marco”Catania 95123SiciliaItaly

This editorial is a commentary on the case report by Furuya et al focusing on the challenging diagnosis of early pancreatic adenocarcinoma and new tools for an earlier ***,pancreatic cancer still has a poor prognosis,mainly due to late diagnosis in an advanced *** main precancerous routes have been identified as pathways to pancreatic adenocarcinoma:The first encompasses a large group of mucinous cystic lesions:intraductal papillary mucinous neoplasm and mucinous cystic neoplasm,and the second is pancreatic intraepithelial *** the last decade the focus of research has been to identify high-risk patients,using advanced imaging techniques(magnetic resonance cholangiopancreatography or endoscopic ultrasonography)which could be helpful in finding“indirect signs”of early stage pancreatic ***,the survival rate still remains poor,and alternative screening methods are under *** retrograde cholangiopancreatography followed by serial pancreatic juice aspiration cytology could be a promising tool for identifying precursor lesions such as intraductal papillary mucinous neoplasm,but confirming data are still needed to validate its *** a combination of cross-sectional imaging,endoscopic techniques(old and new ones)and genetic and biological biomarkers also in pancreatic juice)could be the best solution to reach an early *** could help to predict and follow the progression of early pancreatic ***,further studies are needed to validate their diagnostic reliability and to establish diagnostic algorithms to improve prognosis and survival in patients with pancreatic cancer.

关键词： Pancreatic cancer Endoscopic ultrasonography Endoscopic retrograde cholangiopancreatography Magnetic resonance cholangiopancreatography Serial pancreatic-juice aspiration cytologic examination

Experimental Characterization of a Binary Actuated Parallel Manipulator

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Chinese Journal of Mechanical Engineering 2016年第3期29卷 445-453页

作者： CARBONE giuseppe Department of Engineering and Mathematics Sheffield Hallam UniversitySheffieldUnited Kingdom Laboratory of Robotics and Mechatronics University of Cassino and South LatiumCassino(Fr)Italy

This paper describes the BAPAMAN（Binary Actuated Parallel MANipulator） series of parallel manipulators that has been conceived at Laboratory of Robotics and Mechatronics（LARM）. Basic common characteristics of BAPAMAN series are described. In particular, it is outlined the use of a reduced number of active degrees of freedom, the use of design solutions with flexural joints and Shape Memory Alloy（SMA） actuators for achieving miniaturization, cost reduction and easy operation features. Given the peculiarities of BAPAMAN architecture, specific experimental tests have been proposed and carried out with the aim to validate the proposed design and to evaluate the practical operation performance and the characteristics of a built prototype, in particular, in terms of operation and workspace characteristics.

关键词： parallel manipulators binary actuation experimental characterization

Arbitrary full-state hybrid projective synchronization for chaotic discrete-time systems via a scalar signal

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Chinese Physics B 2012年第6期21卷 94-99页

作者： giuseppe Grassi Dipartimento Ingegneria Innovazione Universitàdel Salento-73100 Lecce-Italy

In this paper we present a new projective synchronization scheme, where two chaotic （hyperchaotic） discrete-time systems synchronize for any arbitrary scaling matrix. Specifically, each drive system state synchronizes with a linear combination of response system states. The proposed observer-based approach presents some useful features： i） it enables exact synchronization to be achieved in finite time （i.e., dead-beat synchronization）; ii） it exploits a scalar synchronizing signal; iii） it can be applied to a wide class of discrete-time chaotic （hyperchaotic） systems; iv） it includes, as a particular case, most of the synchronization types defined so far. An example is reported, which shows in detail that exact synchronization is effectively achieved in finite time, using a scalar synchronizing signal only, for any arbitrary scaling matrix.

关键词： chaos synchronization full-state hybrid projective synchronization observer-based syn-chronization chaotic discrete-time systems dead beat control attractor scaling

Fuzzy-entropy based robust optimization criteria for tuned mass dampers

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Earthquake Engineering and Engineering Vibration 2010年第2期9卷 285-294页

作者： giuseppe Carlo Marano giuseppe Quaranta Sara Sgobba Department of Environmental Engineering and Sustainable Development Technical University of Bari Department of Structural Engineering and Geotechnics University of Rome "La Sapienza" Faculty of Engineering International University UNINETTUNO

Tuned mass dampers (TMD) are well known as one of the most widely adopted devices in vibration control passive strategies. In the past few decades,many methods have been developed to find the optimal parameters of a TMD installed on a structure and subjected to a random base excitation process,but most of them are usually based on an implicit assumption that all of the structural parameters are deterministic. However,in many real cases this simplification is unacceptable,so robust optimal design criteria becomes aviable alternative to better support engineers in the design process. In Robust Design Optimization (RDO) approaches,indeed the solution must be able to not only minimize the performance but also to limitits variation induced by uncertainty. Most of the currently available RDO methods are based on a probabilistic description of the model uncertainty,even if in many cases they are not able to explicitly include the influence of all the possible sources of uncertainties. Therefore,in this study,a fuzzy version of the robust TMD design optimization problem is proposed. The consistency of the fuzzy approach is studied with respect to the available non-probabilistic formulations reported in the literature and an application to an example of a robust design of a linear TMD subjected to base random vibrations in the presence of fuzzy uncertainties. The results show that the proposed fuzzy-based approach is able to give a set of optimal solutions both in terms of structural efficiency and sensitivity to mechanical and environmental uncertainties.

关键词： tuned mass damper random vibration robust design fuzzy variable expected value fuzzy entropy

Novel four-wing and eight-wing attractors using coupled chaotic Lorenz systems

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Chinese Physics B 2008年第9期17卷 3247-3251页

作者： giuseppe Grassi Dipartimento di Ingegneria dell’Innovazione Università del Salento

This paper presents the problem of generating four-wing （eight-wing） chaotic attractors. The adopted method consists in suitably coupling two （three） identical Lorenz systems. In analogy with the original Lorenz system, where the two wings of the butterfly attractor are located around the two equilibria with the unstable pair of complex-conjugate eigenvalues, this paper shows that the four wings （eight wings） of these novel attractors axe located around the four （eight） equilibria with two （three） pairs of unstable complex-conjugate eigenvalues.

关键词： chaotic attractors multi-wing attractor coupled Lorenz systems dynamical behaviours

Reliability based multiobjective optimization for design of structures subject to random vibrations

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2008年第1期9卷 15-25页

作者： giuseppe Carlo MARANO Department of Environmental Engineering and Sustainable Development Technical University of Bari viale del Turismo 10-74100 Taranto Italy

Based on a multiobjective approach whose objective function (OF) vector collects stochastic reliability performance and structural cost indices, a structural optimization criterion for mechanical systems subject to random vibrations is presented for supporting engineer’s design. This criterion differs from the most commonly used conventional optimum design criterion for random vibrating structure, which is based on minimizing displacement or acceleration variance of main structure responses, without considering explicitly required performances against failure. The proposed criterion can properly take into account the design-reliability required performances, and it becomes a more efficient support for structural engineering decision making. The multiobjective optimum (MOO) design of a tuned mass damper (TMD) has been developed in a typical seismic design problem, to control structural vibration induced on a multi-storey building structure excited by nonstationary base acceleration random process. A numerical example for a three-storey building is developed and a sensitivity analysis is carried out. The results are shown in a useful manner for TMD design decision support.

关键词： Structural optimization Multiobjective optimization (MOO) Random vibration Tuned mass damper (TMD)

Consequences of a two-time relativistic Bohmian model

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Communications in Theoretical Physics 2024年第7期76卷 63-73页

作者： giuseppe Raguni Departamento de Fisica Universidad de MurciaE-30071 MurciaSpain

Effects of a Bohmian type quantum-relativistic theory are *** model is obtained by introducing a new and independent time parameter whose relative motions are not directly observable and cause quantum uncertainties of the physical *** the usual de Broglie-Bohm theories,the Quantum Potential does not directly affect the observable motion,but determines the one that is relative to the new time *** turns out that the Zitterbewegung of a free particle,of which a more general law is obtained,is the key example of these hidden motions and,through it,it seems possible to give physical reality to the Feynman's paths.A relativistic revision of the uncertainty principle is also derived from the theory.

关键词： Quantum Mechanics Foundations de Broglie-Bohm theory Zitterbewegung uncertainty principle verification extra dimensions

Knowledge-Enhanced Conversational Agents

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Journal of Computer Science & Technology 2024年第3期39卷 585-609页

作者： Fabio Caffaro giuseppe Rizzo LINKS Foundation 10138 TurinItaly

Humanity has fantasized about artificial intelligence tools able to discuss with human beings fluently for *** efforts have been proposed ranging from ELIZA to the modern vocal *** the large interest in this research and innovation field,there is a lack of common understanding on the concept of conversational agents and general over expectations that hide the current limitations of existing *** work proposes a literature review on the subject with a focus on the most promising type of conversational agents that are powered on top of knowledge bases and that can offer the ground knowledge to hold conversation autonomously on different *** describe a conceptual architecture to define the knowledge-enhanced conversational agents and investigate different domains of *** conclude this work by listing some promising research pathways for future work.

关键词： conversational agent dialogue system knowledge enhancing artificial agent intelligent conversation