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Regenerative medicine technology applied to gastroenterology:Current status and future perspectives

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World Journal of Gastroenterology 2012年第47期18卷 6874-6875页

作者： giuseppe Orlando Marie Curie Fellow Department of General SurgerySection of TransplantationWake Forest University School of MedicineWinston SalemNC 27157-1095United States

This special issue of World Journal of Gastroenterology has been conceived to illustrate to gastroenterology operators the role that regenerative medicine(RM) will have in the progress of gastrointestinal(GI) *** is a multidisciplinary field aiming to replace,regenerate or repair diseased tissues or *** past decade has been marked by numerous ground-breaking achievements that led experts in the field to manufacture functional substitutes of relatively simple *** progress is paving the ground for investigations that aims to the bioengineering and regeneration of more complex organs like livers,pancreas and *** this special issue,the reader will be introduced,hand-in-hand,to explore the field of RM and will be educated on the progress,pitfalls and promise of RM technologies as applied to GI medicine.

关键词： Regenerative medicine Gastroenterology

A new definition of soil to promote soil awareness,sustainability,security and governance

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International Soil and Water Conservation Research 2022年第1期10卷 99-108页

作者： Carmelo Dazzi giuseppe Lo Papa Department of Agricultural Food and Forest SciencesUniversity of PalermoItaly

In these last decades,the awareness that soil is a very important resource for humans has noticeably *** actions and initiatives to promote soil governance,aiming at sustainable soil manage-ment and soil security have been undertaken by several national and international institutions and in many *** of the changes of soil perception over the centuries allows highlighting a perfect harmony between the evolution of soil awareness and the level of knowledge and technology achieved by humans during their history and *** these many achievements,soils continue to be scarcely considered in politics and *** suggest some thoughts and reflections that could lead to an up-to-date and effective definition of soil that directly focuses the public attention on its economic *** our opinion,soil economic value could be the only aspect that truly attracts the attention of politicians and administrators,which could increase soil awareness and encourage soil sustainability,security and Sustainable Development Goals and finally promote soil governance.

关键词： Definition of soil Soil perception Soil governance Soil awareness Ecosystem services Soil security

CUBE, a Cable-driven Device for Limb Rehabilitation

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Journal of Bionic Engineering 2019年第3期16卷 492-502页

作者： Daniele Cafolla Matteo Russo giuseppe Carbone IRCCS Neuromed Via delFelettronica 86077 Pozzilli IS Italy University of Nottingham Advanced Manufacturing Building C47 Nottingham NG8 IBB UK DIMEG University of Calabria Via Bucci Cubo 46C 87036 Rende Italy CESTER Technical University of Cluj-Napoca MunciiAve. 103-105 400641 Cluj-Napoca Romania

In this paper, a novel cable-driven parallel robot, CUBE, is introduced for the assistance of patients in rehabilitation exercising of both upper and lower limbs. The system is characterized by a lightweight structure that is easy to set-up and operate, for both clinical and home usage for both pre-determined and customized exercises, with control over the position of the end-effector while locking its rotation around the horizontal axes. Its cable-driven design makes it inherently safe in human/robot interactions also due to the extremely low inertia. While a novel end-effector design makes the device wearable both on the upper and lower limbs without having to disassemble any part of the structure. The design is presented with its kinematic analysis. Then, the manufacturing through 3D?printing and commercial components of a first prototype is reported. Finally, the system is validated through motion tests along simple trajectories and two different spatial exercises.

关键词： cable-driven robots medical robots parallel robots rehabilitation devices

Scaling up of cluster beam deposition technology for catalysis application

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Frontiers of Chemical Science and Engineering 2021年第6期15卷 1360-1379页

作者： giuseppe Sanzone Jinlong Yin Hailin Sun Teer Coatings Ltd. DroitwichWorcestershire WR99ASUK Quantum Solid-State Physics Department of Physics and AstronomyB-3001 LeuvenBelgium

Many research works have demonstrated that the combination of atomically precise cluster deposition and theoretical calculations is able to address fundamental aspects of size-effects,cluster-support interactions,and reaction mechanisms of cluster *** the wet chemistry method has been widely used to synthesize nanoparticles,the gas-phase synthesis and size-selected strategy was the only method to prepare supported metal clusters with precise numbers of atoms for a long ***,the low throughput of the physical synthesis method has severely constrained its wider adoption for catalysis *** this review,we introduce the latest progress on three types of cluster source which have the most promising potential for scale-up,including sputtering gas aggregation source,pulsed microplasma cluster source,and matrix assembly cluster *** the sputtering gas aggregation source is leading ahead with a production rate of~20 mg·h^(-1),the pulsed microplasma source has the smallest physical dimensions which makes it possible to compact multiple such devices into a small volume for multiplied production *** matrix assembly source has the shortest development history,but already show an impressive deposition rate of~10 mg·h^(-1).At the end of the review,the possible routes for further throughput scale-up are envisaged.

关键词： nanoparticle cluster cluster beam deposition magnetron sputtering heterogeneous catalysis

An Empirical Study on the Impact of Automation on the Requirements Analysis Process

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Journal of Computer Science & Technology 2007年第3期22卷 338-347页

作者： giuseppe Lami Robert W.Ferguson Istituto di Scienza e Tecnologie dell'Informazione"Alessandro Faedo" 1-56124 Pisa Italy Software Engineering Institute Carnegie Mellon University 15213 PittsburghPAU.S.A.

Requirements analysis is an important phase in a software project. The analysis is often performed in an informal way by specialists who review documents looking for ambiguities, technical inconsistencies and incomplete parts. Automation is still far from being applied in requirements analyses, above all since natural languages are informal and thus difficult to treat automatically. There are only a few tools that can analyse texts. One of them, called QuARS, was developed by the Istituto di Scienza e Tecnologie dell＇Informazione and can analyse texts in terms of ambiguity. This paper describes how QuARS was used in a formal empirical experiment to assess the impact in terms of effectiveness and efficacy of the automation in the requirements review process of a software company.

关键词： requirements/specifications analysis requirements/specifications tools process metrics

The neural bases of vitality forms

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National Science Review 2020年第1期7卷 202-213页

作者： giuseppe Di Cesare Marzio Gerbella Giacomo Rizzolatti Cognitive Architecture for Collaborative Technologies Unit Italian Institute of Technology 2. Department of Medicine and Surgery Neuroscience Unit University of Parma Istituto di Neuroscienze Consiglio nazionale delle Ricerche

Unlike emotions, which are short-lasting events accompanied by viscero-motor responses, vitality forms are continuous internal states that modulate the motor behaviors of individuals and are devoid of the autonomic modifications that characterize real emotions. Despite the importance of vitality forms in social life, only recently have neurophysiological studies been devoted to this issue. The first part of this review describes f MRI experiments, showing that the dorso-central insula is activated during the execution, the perception and the imagination of arm actions endowed with different vitality forms as well as during the hearing and the production of speech conveying vitality forms. In the second part, we address the means by which the dorso-central insula modulates the networks for controlling action execution and how the sensory and interoceptive information is conveyed to this insular sector. Finally, we present behavioral data showing the importance of vitality forms in social interactions.

关键词： action observation social interactions emotions insula mirror mechanism

Zero Sequence Voltage and Current Control in Four-wire Grids-fed by Grid-forming Inverters

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CSEE Journal of Power and Energy Systems 2023年第6期9卷 2272-2279页

作者： Zixian Zhu Wei Chen Vito giuseppe Monopoli the College of Electrical And Information Engineering Hunan UniversityChangshaChina the College of Electrical and Information Engineering Lanzhou University of TechnologyLanzhouChina the Department of Electrical and Information Engineering Bari PolytechnicBariItaly

Low voltage three-phase four-wire AC distribution grids may experience high neutral current,mainly caused by asymmetrical distribution of single-phase loads in three *** neutral current will not only increase line losses but also result in neutral potential *** the LV AC distribution grid established by a grid-forming inverter(e.g.,uninterruptible power supply and solid-state-transformer),it also suffers from the same neutral current ***,this paper comparatively studies several neutral current control approaches and their impacts on grid voltage balance,which is required by grid ***,this paper proposes an optimal neutral current control approach,which can obtain maximum neutral current suppression with less impact on grid voltage *** correctness of the theoretical analysis is validated through both simulation and experimental results.

关键词： LV AC grid neutral current reduction grid-forming inverter three-phase four-wire system

Botulinum toxin for chronic anal fissure after biliopancreatic diversion for morbid obesity

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World Journal of Gastroenterology 2012年第10期18卷 1021-1027页

作者： Serafino Vanella giuseppe Brisinda Gaia Marniga Anna Crocco giuseppe Bianco Giorgio Maria Department of Surgery Catholic School of Medicine University Hospital "Agostino Gemelli"

AIM: To study the effect of botulinum toxin in patients with chronic anal fissure after biliopancreatic diversion (BPD) for severe obesity. METHODS: Fifty-nine symptomatic adults with chronic anal fissure developed after BPD were enrolled in an open label study. The outcome was evaluated clinically and by comparing the pressure of the anal sphincters before and after treatment. All data were analyzed in univariate and multivariate analysis. RESULTS: Two months after treatment, 65.4% of the patients had a healing scar. Only one patient had mild incontinence to flatus that lasted 3 wk after treatment, but this disappeared spontaneously. In the multivariate analysis of the data, two registered months after the treatment, sex (P = 0.01), baseline resting anal pressure (P = 0.02) and resting anal pressure 2 mo after treatment (P < 0.0001) were significantly related to healing ***: Botulinum toxin, despite worse results than in non-obese individuals, appears the best alternative to surgery for this group of patients with a high risk of incontinence.

关键词： Botulinum toxin Anal diseases Anal fis- sure Severe obesity Bariatric surgery Biliopancreatic diversion

Toxic hepatitis in occupational exposure to solvents

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World Journal of Gastroenterology 2012年第22期18卷 2756-2766页

作者： Giulia Malaguarnera Emanuela Cataudella Maria Giordano giuseppe Nunnari giuseppe Chisari Mariano Malaguarnera Research Centre "The Great Senescence" University of Catania Department of Infective Diseases Hospital "Garibaldi di Nesima" University of Catania Microbiology and Clinical Microbiology Department of Biomedical Science Hospital Policlinico University of Catania

The liver is the main organ responsible for the metabolism of drugs and toxic chemicals, and so is the primary target organ for many organic solvents. Work activities with hepatotoxins exposures are numerous and, moreover, organic solvents are used in various industrial processes. Organic solvents used in different industrial processes may be associated with hepatotoxicity. Several factors contribute to liver toxicity; among these are: species differences, nutritional condition, genetic factors, interaction with medications in use, alcohol abuse and interaction, and age. This review addresses the mechanisms of hepatotoxicity. The main pathogenic mechanisms responsible for functional and organic damage caused by solvents are: inflammation, dysfunction of cytochrome P450, mitochondrial dysfunction and oxidative stress. The health impact of exposure to solvents in the workplace remains an interesting and worrying question for professional health work.

关键词： Work activity Hepatotoxicity Hepatotoxin Occupational disease Inflammation