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Robot-assisted trans-gastric drainage and debridement of walled-off pancreatic necrosis using the endoWrist stapler for the da Vinci Xi:A case report

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World Journal of Clinical Cases 2019年第12期7卷 1461-1466页

作者： Luca Morelli Niccolò Furbetta Desirée Gianardi Matteo Palmeri Gregorio Di Franco Matteo Bianchini Gianni Stefanini simone Guadagni Giulio Di Candio General Surgery Unit Department of Translational Research and New Technologies in Medicine and Surgery University of Pisa Pisa 56124 Italy endoCAS (Center for Computer Assisted Surgery) University of Pisa Pisa 56124 Italy

BACKGROUND Walled-off pancreatic necrosis (WOPN) is a late complication of acute pancreatitis. The management of a WOPN depends on its location and on patient's symptoms. Trans-gastric drainage and debridement of WOPN represents an important surgical treatment option for selected patients. The da Vinci surgical System has been developed to allow an easy, minimally invasive and fast surgery, also in challenging abdominal procedures. We present here a case of a WOPN treated with a robotic trans-gastric drainage using the da Vinci Xi. CASe SUMMARY A 63-year-old man with an episode of acute necrotizing pancreatitis was referred to our center. Six wk after the acute episode the patient developed a walled massive fluid collection, with an extensive pancreatic necrosis, causing obstruction of the gastrointestinal tract. The patient underwent a robotic transgastric drainage and debridement of the WOPN performed with the da Vinci Xi platform. Firstly, an anterior ideal gastrotomy was carried out, guided by intraoperative ultrasound (US)-scan using the TilePro? function. Then, through the gastrotomy, the best location for drainage on the posterior gastric wall was again US-guided identified. The anastomosis between the posterior gastric wall and the walled-off necrosis wall was carried out with the new endoWrist stapler with vascular cartridge. Debridement and washing of the cavity through the anastomosis were performed. Finally, the anterior gastrotomy was closed and the cholecystectomy was performed. The postoperative course was uneventful and a post-operative computed tomography-scan showed the collapse of the fluid collection. CONCLUSION In selected cases of WOPN the da Vinci Surgical System can be safely used as a valid surgical treatment option.

关键词： Case report da Vinci Xi endoWrist stapler Walled-off pancreatic necrosis TilePro Minimally-invasive surgery

Amine-rich carbon nitride nanoparticles:Synthesis,covalent functionalization with proteins and application in a fluorescence quenching assay

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Nano Research 2019年第8期12卷 1862-1870页

作者： Gabriele Capilli simone Cavalera Laura Anfossi Cristina Giovannoli Marco Minella Claudio Baggiani Claudio Minero Department of Chemistry and NIS Center of excellence University of Torino10125 TorinoItaly

Carbon nitride nanoparticles (CNNPs) have been employed as fluorescent sensing tools owing to their unique features, e.g. low cost production, high stability in water and high photoluminescence quantum yield. Here, an easy and versatile synthetic approach was exploited to design fluorescent nanoparticles with surface functionalities suitable for covalent binding to bioligands. High hydrophilic, brightly fluorescent CNNPs, rich of superficial amines, were obtained from the thermal condensation of urea and lysine (CNNP^Lys) and by tuning the precursor ratio and the heating time. Structure and size of the functionalized nanoparticles were characterized through infrared (IR) spectroscopy, transmission electron microscopy (TeM) and dynamic light scattering (DLS). Their optical properties were studied by ultraviolet-visible (UV-Vis) and fluorescence spectroscopy. The superficial primary amino groups, furnished by the lysine co-precursor, enabled for covalently linking CNNP^Lys to model proteins. The CNNP^Lys-protein conjugates excited under UV irradiation emit in the 400-450 nm visible range (quantum yield 24%). The applicability of CNNP^Lys as novel fluorescent probes was demonstrated by a fluorescence quenching assay, in which gold nanoparticles (GNPs) were attached to Staphylococcal protein A and employed to quench the CNNP^Lys fluorescence by Forster resonant energy transfer (FReT). The quenching occurred upon formation of the specific binding between the GNP-linked protein A and CNNP^Lys-tagged immunoglobulins, while the inhibition of the binding resulted in the recovery of CNNP^Lys luminescence. The synthetic strategy, based on combining a "conjugated polymer"-forming unit (urea) and a co-precursor able to provide the desired functional group (lysine), allows designing innovative materials for the development of new generation fluorescence biosensors in which easily functionalized fluorophores are needed.

关键词： fluorescent probe carbon nitride nanoparticles quenching assay fluorescent materials g-C3N4 Forster resonant energy transfer (FReT)

An integrative Tai Chi program for patients with breast cancer undergoing cancer therapy:study protocol for a randomized controlled feasibility study

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Journal of Integrative Medicine 2018年第2期16卷 99-105页

作者： Lizhou Liu simone Petrich Blair McLaren Lyndell Kelly G.David Baxter Centre for Health Activity and Rehabilitation ResearchSchool of PhysiotherapyUniversity of Otago Department of Surgical Sciences Southern District Health Board Oncology Department Southern District Health Board

Background： Breast cancer patients experience various side effects during cancer therapy, often resulting in reduced quality of life and poor adherence to treatment. A limited range of proven interventions has been developed to target such side effects. While Tai Chi offers benefits for the health and well-being of breast cancer survivors, the effectiveness of Tai Chi across the treatment continuum has not been evalu- ated. Improved patient education and support has been suggested as a priority for breast cancer care. This pilot study assesses the feasibility of a randomized controlled trial （RCT） to evaluate the effectiveness of ＂an integrative Tai Chi＂（ANITA） program for breast cancer patients undergoing cancer therapy. Methods/design： This is a single-centre, two-arm feasibility RCT. Twenty-four patients with breast cancer who have undergone surgical treatment will be recruited from the Dunedin Hospital （New Zealand） over a 12-month period （from August 2017 to July 2018）. Subject to informed consent, patients will be ran- domized to receive standard cancer treatment alone or standard cancer treatment plus the ANITA pro- gram, consisting of peer support, health education, and Tai Chi Ruler exercise. The program runs alongside the patient＇s adjuvant cancer therapy, which may include chemotherapy, radiation therapy, antibody treatment, and/or antihormonal therapy. Analysis in this study will focus on process evaluation of participant recruitment, retention, treatment fidelity, acceptability of the program, and occurrence of adverse events. Clinical outcomes （i.e., fatigue, sleep quality, anxiety and depression and quality of life） will be assessed at baseline, and at 12 weeks and 24 weeks post-randomization. Discussion： Outcomes from this study will inform the feasibility and methodology for a future fully- powered RCT.

关键词： Tai Chi Breast cancer Feasibility study Randomized controlled trial Peer support Health education

Size-dependent structural and magnetic properties of chemically synthesized Co-Ni-Ga nanoparticles

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Nano Research 2017年第10期10卷 3421-3433页

作者： Changhai Wang Aleksandr A. Levin Julie Karel simone Fabbrici Jinfeng Qian Carlos e. ViolBarbosa Siham Ouardi Franca Albertini Walter Schnelle Jan Rohlicek Gerhard H. Fecher Claudia Felser Max Planck Institute for Chemical Physics of Solids D-01187 Dresden Germany Institute of Materials for electronics and Magnetism IMEM-CNRI-43124 Parma Italy MIST e-R Laboratory Via Gobetti 101 I-40129 Bologna Italy

Phase transitions and magnetic properties of shape-memory materials can be tailored by tuning the size of the constituent materials, such as nanoparticles. However, owing to the lack of suitable synthetic methods for size-controlled Heusler nanoparticles, there is no report on the size dependence of their properties and functionalities. In this contribution, we present the first chemical synthesis of size-selected Co-Ni-Ga Heusler nanoparticles. We also report the structure and magnetic properties of the biphasic Co-Ni-Ga nanoparticles with sizes in the range of 30-84 nm, prepared by a SBA-15 nanoporous silica- templated approach. The particle sizes could be readily tuned by controlling the loading and concentration of the precursors. The fractions and crystallite sizes of each phase of the Co-Ni-Ga nanoparticles are closely related to their particle size. enhanced magnetization and decreased coercivity are observed with increasing particle size. The Curie temperature （To） of the Co-Ni-Ga nanoparticles also depends on their size. The 84 nm-sized particles exhibit the highest Tc （≈ 1,174 K） among all known Heusler compounds. The very high Curie temperatures of the Co-Ni-Ga nanoparticles render them promising candidates for application in high-temperature shape memory alloy-based devices.

关键词： Co-Ni-Ga nanoparticles chemical synthesis size magnetic properties

Neurotrophic factors in Alzheimer＇s and Parkinson＇s diseases： implications for pathogenesis and therapy

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Neural Regeneration Research 2017年第4期12卷 549-557页

作者： Tuane Bazanella Sampaio Anne Suely Savall Maria eduarda Ziani Gutlerrez simone Proton Departamento de Farmacologia Centro de Ciencias BiologicasUniversidade Federal de Santa CatarinaFlorianopolisSCBrazil Universidade Federal do Pampa-Campus Uruguaiana UruguaianaRSBrazil

Neurotrophic factors comprise essential secreted proteins that have several functions in neural and non-neural tissues, mediating the development, survival and maintenance of peripheral and central nervous system. Therefore, neurotrophic factor issue has been extensively investigated into the context of neurodegenerative diseases. Alzheimer＇s disease and Parkinson＇s disease show changes in the regulation of specific neurotrophic factors and their receptors, which appear to be critical for neuronal degeneration. Indeed, neurotrophic factors prevent cell death in degenerative processes and can enhance the growth and function of affected neurons in these disorders. Based on recent reports, this review discusses the main findings related to the neurotrophic factor support – mainly brain-derived neurotrophic factor and glial cell line-derived neurotrophic factor – in the survival, proliferation and maturation of affected neurons in Alzheimer＇s disease and Parkinson＇s disease as well as their putative application as new therapeutic approach for these diseases management.

关键词： BDNF CDNF GDNF NGF neurodegenerative diseases treatment

Prediction of meat quality traits in the abattoir using portable near-infrared spectrometers:heritability of predicted traits and genetic correlations with laboratory-measured traits

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Journal of Animal Science and Biotechnology 2021年第3期12卷 1214-1225页

作者： simone Savoia Andrea Albera Alberto Brugiapaglia Liliana Di Stasio Alessio Cecchinato Giovanni Bittante Associazione Nazionale Allevatori Bovini di Razza Piemontese strada provinciale Trinita’32/A12061 CarrùCNItaly Department of Agronomy FoodNatural ResourcesAnimals and Environment(DAFNAE)University of Padova(Padua)viale dell’Università1635020 LegnaroPDItaly Department of Agricultural Forest and Food SciencesUniversity of TorinoVia L.Da Vinci 4410095 GrugliascoTOItaly

Background:The possibility of assessing meat quality traits over the meat chain is strongly limited,especially in the context of selective breeding which requires a large number of *** main objective of this study was to investigate the suitability of portable infrared spectrometers for phenotyping beef cattle aiming to genetically improving the quality of their *** quality traits(pH,color,water holding capacity,tenderness)were appraised on rib eye muscle samples of 1,327 Piemontese young bulls using traditional(i.e.,reference/gold standard)laboratory analyses;the same traits were also predicted from spectra acquired at the abattoir on the intact muscle surface of the same animals 1 d after *** parameters were estimated for both laboratory measures of meat quality traits and their spectra-based ***:The prediction performances of the calibration equations,assessed through external validation,were satisfactory for color traits(R^(2) from 0.52 to 0.80),low for pH and purge losses(R^(2) around 0.30),and very poor for cooking losses and tenderness(R^(2) below 0.20).except for lightness and purge losses,the heritability estimates of most of the predicted traits were lower than those of the measured traits while the genetic correlations between measured and predicted traits were high(average value 0.81).Conclusions:Results showed that NIRS predictions of color traits,pH,and purge losses could be used as indicator traits for the indirect genetic selection of the reference quality *** for cooking losses were less effective,while the NIR predictions of tenderness were affected by a relatively high uncertainty of ***,genetic selection of some meat quality traits,whose direct phenotyping is difficult,can benefit of the application of infrared spectrometers technology.

关键词： Genetic parameters Meat quality Near-infrared spectroscopy Piemontese

Alpine tundra species phenology is mostly driven by climate-related variables rather than by photoperiod

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Journal of Mountain Science 2020年第9期17卷 2081-2096页

作者： QUAGLIA elena RAVeTTO eNRI simone PeROTTI elisa PROBO Massimiliano LOMBARDI Giampiero LONATI Michele Department of Agricultural Forest and Food SciencesUniversity of TorinoLargo Paolo Braccini 210095Grugliasco(To)Italy Grazing Systems AgroscopeRoute de Duillier 501260NyonSwitzerland

The study of plant phenology has frequently been used to link phenological events to various factors,such as temperature or *** the high-alpine environment,proper timing of the phenological cycle has always been crucial to overcome harsh conditions and potential extreme events(*** frosts)but little is known about the response dynamics of the vegetation,which could shape the alpine landscape in a future of changing *** tundra vegetation is composed by an array of species belonging to different phytosociological optima and with various survival strategies,and snowbed communities are a relevant expression of such an extreme-climate adapted *** set eight permanent plots with each one in a snowbed located on the Cimalegna plateau in Northwestern Italy and then we selected 10 most recurring species among our plots,all typical of the alpine tundra environment and classified in 3different pools:snowbed specialists,grassland species and rocky debris *** 3 years we registered the phenophases of each species during the whole growing season using an adaptation of the BBCH *** later focused on the three most biologically relevant phenophases,i.e.,flower buds visible,full flowering,and beginning of seed *** important season-related variables were chosen to investigate their relationship with the phenological cycle of the studied species:(i)the Day Of Year(DOY),the progressive number of days starting from the 1 st of January,used as a proxy of photoperiod,(ii)Days From Snow Melt(DFSM),selected to include the relevance of the snow dynamics,and(iii)Growing Degree Days(GDD),computed as a thermal *** analysis highlighted that phenological development correlated better with DFSM and GDD than with ***,models showed that DOY was always a worse predictor since it failed to overcome interannual variations,while DFSM and marginally GDD were better suited to predict the phenological development of most of the species,desp

关键词： Alpine plants Climate change Growing degree days Italian Alps Salix herbacea Snowbed vegetation

Changes in response properties of nociceptive dorsal horn neurons in a murine model of cancer pain

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生理学报 2008年第5期60卷 635-644页

作者： Donald A. simone Sergey G. Khasabov Darryl T. Hamamoto Department of Diagnostic and Biological Sciences School of Dentistry University of Minnesota 515 Delaware St. S.E.Minneapolis Minnesota 55455 USA

Pain associated with cancer that metastasizes to bone is often severe and debilitating.A better understanding of the neural mechanisms that mediate cancer pain is needed for the development of more effective *** this study,we used an established model of cancer pain to characterize changes in response properties of dorsal horn *** cells were implanted into and around the calcaneus bone in mice and extracellular electrophysiological recordings were made from wide dynamic range(WDR) and high threshold(HT) dorsal horn *** of WDR and HT neurons evoked by mechanical,heat,and cold stimuli applied to the plantar surface of the hind paw were compared between tumor bearing mice and control *** exhibited hyperalgesia to mechanical and heat stimuli applied to their tumor-bearing hind *** neurons in tumor-bearing mice exhibited an increase in spontaneous activity,and enhanced responses to mechanical,heat,and cold stimuli as compared to *** findings show that sensitization of WDR neurons,but not HT neurons,contributes to tumor-evoked hyperalgesia.

关键词：反应特征感觉神经元临床分析癌症

Grazing Management Plans improve pasture selection by cattle and forage quality in sub-alpine and alpine grasslands

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Journal of Mountain Science 2019年第9期16卷 2126-2135页

作者： Marco PITTAReLLO Massimiliano PROBO elisa PeROTTI Michele LONATI Giampiero LOMBARDI simone RAVeTTO eNRI Department of Agricultural Forest and Food Sciences University of Torino Grugliasco Italy Agroscope Grazing Systems 1260 Nyon 1 Switzerland

Over the last decades, the reduction of manpower for herd management has led to an increase of continuous grazing systems(CGS) in the Italian Alps, which allow cattle to roam freely. Under CGS, due to high selectivity, livestock exploit grasslands unevenly, over-and under-using specific areas at the same time with negative effects on their conservation. To counteract these effects, a specific policy and management tool(i.e. Grazing Management Plan) has been implemented by Piedmont Region since 2010. The Grazing Management Plans are based on the implementation of rotational grazing systems(RGS), with animal stocking rate adjusted to balance it with grassland carrying capacity. A case study was conducted on alpine summer pastures to test the 5-year effects produced by the implementation of a Grazing Management Plan in grasslands formerly managed under several years of CGS on 1) the selection for different vegetation communities by cattle, 2) the abundance of oligo-, meso-, and eutrophic plant species(defined according to Landolt N indicator value), and 3) forage yield, quality, and palatability. A total of 193 vegetation surveys were carried out in 2011 and repeated in 2016. Cows were tracked yearly with Global Positioning System collars to assess their grazing selectivity, and forage Pastoral Value(PV) was computed to evaluate forage yield, quality, and palatability. Five years after RGS implementation, cow selectivity significantly decreased and the preference for the different vegetation communities was more balanced than under CGS. The abundance of meso-and eutrophic species increased, whereas oligotrophic ones decreased. Moreover, the abundance of moderately to highly palatable plant species increased, whereas non-palatable plant species decreased, with a consequent significant enhancement of the PV. Our findings indicate that the implementation of Grazing Management Plans can be considered a sustainable and effective management tool for improving pasture selecti

关键词： Mountain GPS tracking Agricultural policies Livestock Pastoral Value Vegetation community