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Emerging role of liquid biopsy in rat sarcoma virus mutated metastatic colorectal cancer:A case report

World Journal of Gastrointestinal Oncology 2024年第1期16卷 234-243页

作者： João Gramaça Isabel Gomes Fernandes Carolina Trabulo Joana Gonçalves Rita Gameiro dos Santos Adriano Baptista Idília pina Centro Hospitalar Barreiro Montijo Centro Hospitalar Barreiro MontijoSetúbalBarreiro 2830-003Portugal Medical Oncology Unit Centro Hospitalar Barreiro MontijoSetúbalBarreiro 2830-003Portugal

BACKGROUND In patients with metastatic colorectal cancer(mCRC),the treatment options are limited and have been proved to be affected by rat sarcoma virus(RAS)mutational *** RAS wild-type(wt)patients,the combination of antiepidermal growth factor receptor(EGFR)monoclonal antibodies with chemotherapy(CT)is more effective than CT *** the other hand,RAS-mutated patients are not eligible for treatment with anti-EGFR *** SUMMARY Eleven patients with initially RAS-mutated mCRC were followed from diagnosis to May *** the time of cell-free DNA determination,five patients had undergone one CT line,five patients had undergone two CT lines,and one patient had undergone three CT lines(all in combination with bevacizumab).At the second and third treatment lines[second line(2L),third line(3L)],patients with neo-RAS wt received a combination of CT and *** neo-RAS wt patients treated with anti-EGFR,our findings indicated an increase in progression-free survival for both 2L and 3L(14.5 mo,P=0.119 and 3.9 mo,P=0.882,respectively).Regarding 2L overall survival,we registered a slight increase in neo-RAS wt patients treated with anti-EGFR(33.6 mo vs 32.4 mo,P=0.385).At data cut-off,two patients were still alive:A RAS-mutated patient undergoing 3L treatment and a neo-RAS wt patient who received 2L treatment with anti-EGFR(ongoing).CONCLUSION Our case series demonstrated that monitoring RAS mutations in mCRC by liquid biopsy may provide an additional treatment line for neo-RAS wt patients.

关键词： Metastatic colorectal cancer Rat sarcoma virus mutational status Liquid biopsy Rat sarcoma virus wild-type Neo-rat sarcoma virus wild-type Anti-epidermal growth factor receptor therapy Case report

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High-refractive index acrylate polymers for applications in nanoimprint lithography

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Chinese Chemical Letters 2020年第1期31卷 256-260页

作者： Yunhui Tang Stefano Cabrini Jun Nie Carlos pina-Hernandez State Key Laboratory of Chemical Resource Engineering Beijing University of Chemical TechnologyBeijing 100029China The Molecular Foundry LBNLBerkeleyCA 94702United States aBeam Technologies Castro ValleyCA 94546United States

The development of polymeric optical materials with a higher refractive index,transparency in the visible spectrum region and easier processability is increasingly desirable for advanced optical applications such as microlenses,image sensors,and organic light-emitting *** acrylates have a low refractive index(around 1.50)which does not meet the high perfo rmance requirements of advanced optical *** this research,three novel acrylates were synthesized via a facile one-step approach and used to fabricate optical transparent *** of the polymers reveal good optical properties including high transparency(≥90%)in the visible spectrum region and high refractive index values(1.6363)at 550 ***,nanostructures of these acrylate polymers with various feature sizes including nanogratings and photonic crystals were successfully fabricated using nanoimprint *** results indicate that these acrylates can be used in a wide range of optical and optoelectronic devices where nanopatterned films with high refractive index and transparency are required.

关键词： High refractive index Acrylate Facile synthesis Nanostructure Nanoimprint lithography

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Intranasal delivery of nanostructured lipid carriers,solid lipid nanoparticles and nanoemulsions:A current overview of in vivo studies

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Acta Pharmaceutica Sinica B 2021年第4期11卷 925-940页

作者： Cláudia pina Costa Joao Nuno Moreira JoséManuel Sousa Lobo Ana Catarina Silva UCIBIO/REQUIMTE MedtechLaboratory of Pharmaceutical TechnologyDepartment of Drug SciencesFaculty of PharmacyUniversity of PortoPorto 4050-313Portugal CNC-Center for Neuroscience and Cell Biology Center for Innovative Biomedicine and Biotechnology(CIBB)University of CoimbraFaculty of Medicine(Pólo I)Coimbra 3004-504Portugal UC-University of Coimbra CIBBFaculty of PharmacyPólo Das Ciências da SaúdeCoimbra 3000-548Portugal FP-ENAS(UFP Energy Environment and Health Research Unit)CEBIMED(Biomedical Research Centre)Faculty of Health SciencesUniversity Fernando PessoaPorto 4249-004Portugal

The management of the central nervous system(CNS)disorders is challenging,due to the need of drugs to cross the blood-brain barrier(BBB)and reach the *** the various strategies that have been studied to circumvent this challenge,the use of the intranasal route to transport drugs from the nose directly to the brain has been showing promising *** addition,the encapsulation of the drugs in lipid-based nanocarriers,such as solid lipid nanoparticles(SLNs),nanostructured lipid carriers(NLCs)or nanoemulsions(NEs),can improve nose-to-brain transport by increasing the bioavailability and site-specifc *** review provides the state-of-the-art of in vivo studies with lipid-based nanocarriers(SLNs,NLCs and NEs)for nose-to-brain *** on the literature available from the past two years,we present an insight into the different mechanisms that drugs can follow to reach the brain after intranasal *** results of pharmacokinetic and pharmacodynamics studies are reported and a critical analysis of the differences between the anatomy of the nasal cavity of the different animal species used in in vivo studies is carried *** the exact mechanism of drug transport from the nose to the brain is not fully understood and its effectiveness in humans is unclear,it appears that the intranasal route together with the use of NLCs,SLNs or NEs is advantageous for targeting drugs to the *** systems have been shown to be more effective for nose-to-brain delivery than other routes or formulations with non-encapsulated drugs,so they are expected to be approved by regulatory authorities in the coming years.

关键词： Nose-to-brain delivery Intranasal administration Nanostructured lipid carriers NLC Solid lipid nanoparticles SLN Nanoemulsions In vivo studies Pharmacokinetic Pharmacodynamics

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Prevalence and dietetic management of mild gastrointestinal disorders in milk-fed infants

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World Journal of Gastroenterology 2008年第2期14卷 248-254页

作者： D Infante pina X Badia Llach B Ario-Armengol V Villegas Iglesias Unit of Gastroenterology and Nutrition Children Hospital Vall d'Hebron Autonomous University Barcelona Spain Health Outcomes Research Europe Barcelona Spain CHIESI Espaa Barcelona Spain

AIM: To assess the prevalence of mild gastrointestinal disorders in milk-fed infants in paediatric practice, and to evaluate the effectiveness and satisfaction with dietetic ***: A cross-sectional epidemiological study was first carried out. A total of 285 paediatricians included 3487 children seen during a period of one week. In a second phase an observational, prospective and multicentre study was conducted and 2069 milk-fed infants with mild gastrointestinal disorders (colic, constipation, regurgitation and diarrhoea) were included. There was a baseline visit (start of treatment) and a final visit four weeks later. The effectiveness of the various Novalac formulas, as well as the satisfaction of the parents/tutors and paediatricians with the dietetic treatment were assessed at the final ***: The prevalence of mild gastrointestinal disorders was 27.8% of all paediatrician consultations (9.2%, 7.8%, 6.1% and 4.6% in relation to colic, constipation, regurgitation and diarrhoea, respectively). The several Novalac adapted milk formulas resolved 88.4% of the mild gastrointestinal disorders. Depending on the type of disorder, differences in response rate were observed. The highest effectiveness was recorded with respect to diarrhoea (92.6%), followed by constipation (91.6%), colic (87.6%) and regurgitation (81%). Overall, 91% of the paediatricians and 88.8% of the parents/tutors were satisfied or very satisfied with the Novalac adapted milk ***: Mild gastrointestinal disorders show a high prevalence in paediatric practice. The Novalac adapted milk formulas have been shown to be effective in treating mild gastrointestinal disorders in milk-fed infants in the context of routine clinical practice.

关键词： Mild gastrointestinal disorders Prevalence Adapted infant formulas Effectiveness Satisfaction

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Dynamics of a Non-Linear Stochastic Viscoelastic Equation with Multiplicative Noise

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Journal of Partial Differential Equations 2019年第4期32卷 304-325页

作者： CARABALLO Tomas pina Nicolas MUNOZ Jaime Departmento de Ecuaciones Diferenciales y Andlisis Numerico Universidad de SevillaSevillaEspaha Department of Mathematics University of Bio-BtoChile

The well-posedness and stability properties of a stochastic viscoelastic equation with multiplicative noise,Lipschitz and locally Lipschitz nonlinear terms are *** method of Lyapunov functions is used to investigate the asymptotic dynamics when zero is not a solution of the equation by using an appropriate cocycle and random dynamical *** stability of mild solutions is proved in both cases of Lipschitz and locally Lipschitz nonlinear ***,we investigate the existence of a non-trivial stationary solution which is exponentially stable,by using a general random fixed point theorem for general *** this case,the stationary solution is generated by the composition of random variable and Wiener *** addition,the theory of random dynamical system is used to construct another cocycle and prove the existence of a random fixed point exponentially attracting every path.

关键词： Stochastic viscoelastic exponential stability stabilization random dynamical systems attractors

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When do predatory mites (Phytoseiidae)attack? Understanding their diel and seasonal predation patterns

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Insect Science 2018年第6期25卷 1056-1064页

作者： Consuelo Perez-Sayas Ernestina Aguilar-Fenollosa Monica A.Hurtado Josep A.Jaques Tatiana pina Departament de Ciencies Agr&ries i del Medi Natural Universitat Jaume I (UJI)Unitat Associada d'Entomologia Agricola UJI-IVIACastello de la PlanaSpain Torres Hnos.y Sucs.S.A.U. Departamento de Calidad.Pol.Ind.AgricolaAlmenaraCastelloSpain

Predatory mites of the Phytoseiidae family are considered one of the most important groups of natural enemies used in biological *** behavioral patterns of arthropods can differ greatly daily and seasonally;however,there is a lack of literature related to Phytoseiidae diel and seasonal predation *** predatory activity of three phytoseiid species (two Tetranychidae-specialists,Phytoseiuluspersimilis and Neoseiulus californicus,and one omnivore,Euseius stipulatus)that occur naturally in Spanish citrus orchards was observed under laboratory conditions in winter and *** temperature and photoperiod of the climatic chamber where the mites were reared did not change during the *** study demonstrates that phytoseiids can exhibit diel and seasonal predatory patterns when feeding on Tetranychus urticae (Acari:Tetranychidae).Neoseiulus californicus was revealed to be a nocturnal predator in summer but diurnal in *** contrast,*** activity was maximal during the daytime,and *** showed no clear daily predation *** predatory patterns described in this study should be taken into account when designing laboratory studies and also in field samplings,especially when applying molecular techniques to unveil trophic relationships.

关键词： molecular techniques photoperiod phytoseiids predationbehavior Tetranychus urticae

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road to stemness in hepatocellular carcinoma

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World Journal of Gastroenterology 2017年第37期23卷 6750-6776页

作者： Teresita NJ Flores-Téllez Saúl Villa-Trevino Carolina pina-Vázquez Departam ento de Biología Celular Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional(CINVESTAV-IPN) Av.IPN No.2508 Col

Carcinogenic process has been proposed to relay on the capacity to induce local tissue damage and proliferative repair. Liver has a great regeneration capacity and currently, most studies point towards the dominant role of hepatocytes in regeneration at all levels of liver damage. The most frequent liver cancer is hepatocellular carcinoma(HCC). Historical findings originally led to the idea that the cell of origin of HCC might be a progenitor cell. However, current linage tracing studies put the progenitor hypothesis of HCC origin into question. In agreement with their dominant role in liver regeneration, mature hepatocytes are emerging as the cell of origin of HCC, although, the specific hepatocyte subpopulation of origin is yet to be determined. The relationship between the cancer cell of origin(CCO) and cancer-propagating cells, known as hepatic cancer stem cell(HCSC) is unknown. It has been challenging to identify the definitive phenotypic marker of HCSC, probably due to the existence of different cancer stem cells(CSC) subpopulations with different functions within HCC. There is a dynamic interconversion among different CSCs, and between CSC and non-CSCs. Because of that, CSC-state is currently defined as a description of a highly adaptable and dynamic intrinsic property of tumor cells, instead of a static subpopulation of a tumor. Altered conditions could trigger the gain of stemness, some of them include: EMT-MET, epigenetics, microenvironment and selective stimulus such as chemotherapy. This CSC heterogeneity and dynamism makes them out reach from therapeutic protocols directed to a single target. A further avenue of research in this line will be to uncover mechanisms that trigger this interconversion of cell populations within tumors and target it.

关键词： Cancer stem cell Liver progenitor cell Liver stem progenitor cell Stemness Plasticity Cancer cell of origin Cancer stem cells subpopulations

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The Rise and Fall of the Secular Trend in Body Height in Sardinia:An Age-Period-Cohort Analysis

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Biomedical and Environmental Sciences 2020年第3期33卷 183-190页

作者： Giovanni Mario PES Roberta SALIS Alessandra ERRIGO Marco SATURNO Stefano BIBBO’ Bianca Maria QUARTA COLOSSO Nunzio Pio LONGO Maria pina DORE Department of Medical Surgical and Experimental SciencesUniversity of SassariI-07100 SassariItaly

Objective Over the last century, a progressive rise in stature, known as the ‘secular trend’, was documented worldwide, and especially in Sardinia, it has reached a peak in Europe. However, this situation recently ceased in several populations. In this study, we tested the hypothesis that the stature secular trend has significantly leveled off in the Sardinian younger *** Height measurements were retrieved from a database of patients undergoing digestive endoscopy, spanning generations between 1920 and 1990. Sex-specific principal component regression models were fitted to decompose stature variation into the contribution of age, period, and birth *** A steady increase in stature was observed in generations born after 1920, with an upward surge in those born after 1950. However, a significant leveling off was observed among cohorts born after 1970 among both sexes, as mean heights stabilized at 171.1 cm with a standard error(SE) of 0.9 cm among men and a mean of 160.1 cm(SE = 0.9 cm) among *** Our findings support a significant slowdown in the secular trend of stature among the latest Sardinian generations. Several factors, including the consumption of low-quality food, lack of physical activity, and late motherhood, among others, may explain the decline in the secular trend.

关键词： Body height Secular trend Socioeconomic status Sardinia

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Interpretable discovery of semiconductors with machine learning

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npj Computational Materials 2023年第1期9卷 1150-1160页

作者： Hitarth Choubisa Petar Todorović Joao M.pina Darshan H.Parmar Ziliang Li Oleksandr Voznyy Isaac Tamblyn Edward H.Sargent Department of Electrical and Computer Engineering University of Toronto10 King’s College RoadTorontoON M5S 3G4Canada Department of Physical and Environmental Sciences University of TorontoScarboroughON M1C 1A4Canada Department of Physics University of OttawaOttawaON K1N 6N5Canada Vector Institute for Artificial Intelligence TorontoON M5G 1M1Canada

Machine learning models of material properties accelerate materials discovery,reproducing density functional theory calculated results at a fraction of the cost1–*** bridge the gap between theory and experiments,machine learning predictions need to be distilled in the form of interpretable chemical rules that can be used by *** we develop a framework to address this gap by combining evolutionary algorithm-powered search with machine-learning surrogate *** then couple the search results with supervised learning and statistical *** strategy enables the efficient search of a materials space while providing interpretable design *** demonstrate its effectiveness by developing rules for the design of direct bandgap materials,stable UV emitters,and IR perovskite ***,we conclusively show how DARWIN-generated rules are statistically more robust and applicable to a wide range of applications including the design of UV halide perovskites.

关键词： preta learning perovskite

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Exercise-induced anaphylaxis with an Ayurvedic drug as cofactor:A case report

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World Journal of Clinical Cases 2019年第5期7卷 623-627页

作者： Francesca Losa Margherita Deidda Davide Firinu Maria Luisa Di Martino Maria pina Barca Stefano Del Giacco Department of Medical Sciences and Public Health and Unit of Allergy and Clinical Immunology University Hospital "Duilio Casula" University of Cagliari

BACKGROUND The practice of Indian Ayurvedic medicine is spreading in Western countries and Shilajit is one of the most used drugs, for its antioxidant activities and immunomodulatory effects. Albeit Shilajit has showed a high degree of safety, it can act as cofactor of anaphylaxis, especially in condition at high risk, such as mast cell activation syndrome(MCAS). We reported this case to sensitize practitioners to investigate to the use of complementary and alternative medicine,in case of exercise-induced anaphylaxis(EIAn).CASE SUMMARY A 43-year-old woman, working as a dance teacher, developed urticaria after ingestion of rice, tuna and Shilajit, which did not respond to intramuscular corticosteroids. Subsequently, she developed dyspnoea and hypotension with loss of consciousness that arose 1 h after sexual activity. The patient did not refer personal history of atopy. Specific IgE for main food allergens resulted negative,with total IgE levels of 14 IU/L. Oral provocation test with Shilajit was not perfomed because the patient refused, but we performed prick-by-prick and patch test that resulted negative. Serum tryptase at the time of anaphylaxis was 20.6 μg/L that fell down to of 10.6 μg/L after therapy, but has remained at the high value after two days and during the follow-up. We performed an analysis of the c-KIT gene in peripheral blood, which was negative. We felt the diagnosis consistent with EIAn in a patient with a possible *** In Western countries the use of drugs from Ayurvedic medicine is more common than in the past. These substances can be cofactors of anaphylaxis in patients with risk factors.

关键词： Indian Ayurvedic medicine Anaphylaxis Exercise-induced anaphylaxis Mast cell activation syndrome Case report

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