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Ampulla of Vater carcinoma: Molecular landscape and clinical implications

World Journal of Gastrointestinal Oncology 2018年第11期10卷 370-380页

作者： Antonio Pea giulio riva Riccardo Bernasconi Elisabetta Sereni Rita Teresa Lawlor Aldo Scarpa Claudio Luchini Department of Surgery University and Hospital Trust of Verona Department of Diagnostics and Public Health Section of Pathology University and Hospital Trust of Verona ARC-Net Research Center University and Hospital Trust of Verona

Ampulla of Vater is a peculiar anatomical structure, characterized by the crossroad of three distinct epithelia: Intestinal, ductal pancreatic and biliary. Adenocarcinomas arising in this area represent an opportunity to understand the comparative biology of all periampullary malignancies. These neoplasms can exhibit intestinal, pancreaticobiliary or mixed features, whereas the subclassification based on morphology and immunohistochemical features failed in demonstrating a robust prognostic reliability. In the last few years, the molecular landscape of this tumor entity has been uncovered, identifying alterations that may serve as prognostic and predictive biomarkers. In this review, the histological and genetic characteristics of ampullary carcinomas are discussed, taking into account the main clinical and therapeutic implications related to this tumor type as well.

关键词： Pancreatobiliary Intestinal Mixed ELF3 TP53 KRAS Ampullary Vater Histotype

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Histo-molecular oncogenesis of pancreatic cancer:From precancerous lesions to invasive ductal adenocarcinoma

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World Journal of Gastrointestinal Oncology 2018年第10期10卷 317-327页

作者： giulio riva Antonio Pea Camilla Pilati Giulia Fiadone Rita Teresa Lawlor Aldo Scarpa Claudio Luchini Department of Diagnostics and Public Health Section of PathologyUniversity and Hospital Trust of Verona Department of Surgery University and Hospital trust of Verona Personalized Medicine PharmacogenomicsTherapeutic Optimization Paris-Descartes University ARC-Net Research Center University and Hospital Trust of Verona

Pancreatic cancer is a lethal malignancy,whose precursor lesions are pancreatic intraepithelial neoplasm,intraductal papillary mucinous neoplasm,intraductal tubulopapillary neoplasm,and mucinous cystic *** better understand the biology of pancreatic cancer,it is fundamental to know its precursors and to study the mechanisms of *** of these precursors displays peculiar histological features,as well as specific molecular *** from such pre-invasive lesions,this review aims at summarizing the most important aspects of carcinogenesis of pancreatic cancer,with a specific focus on the recent advances and the future perspectives of the research on this lethal tumor type.

关键词： Oncogenesis Intraductal papillary mucinous neoplasm Mucinous cystic neoplasm Pancreatic ductal adenocarcinoma Pancreatic intraepithelial neoplasm KRAS Carcinogenesis Pancreatic cancer Intraductal tubulopapillary neoplasm

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