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Nanotechnology and pancreatic cancer management:State of the art and further perspectives

World Journal of Gastrointestinal Oncology 2021年第4期13卷 231-237页

作者： Damiano Caputo Daniela Pozzi Tommaso Farolfi Roberto Passa Roberto Coppola giulio caracciolo Department of General Surgery University Campus Bio-Medico di RomaRome 00128Italy Department of Molecular Medicine Sapienza University of RomeRome 00161Italy

Pancreatic ductal adenocarcinoma(PDAC)represents a leading cause of cancer death and is often diagnosticated too late to allow adequate *** of biomarkers have been discovered in lasts years but,to date,there is a lack of lowcost and non-invasive tools for PDAC early ***,drugs commonly used in PDAC treatment do not allow achieving long-term satisfying *** is gaining importance in both PDAC early detection and *** main implications of nanotechnology in cancer diagnosis lay in the ability that nanoparticles have on concentrate the alteration in human proteome caused by ***-enabled blood tests have been demonstrated to reach high rate of sensitivity(up to 85%)and specificity(up to 100%).In the field of cancer therapy nanoparticles can be used as nanocarriers able to reach specific tumour’s cells and selectively release the drug they contain into them.A literature review was carried out with the aim to assess the state of the art and highlight the future perspectives of nanotechnology in PDAC early detection and therapy.

关键词： Pancreatic ductal adenocarcinoma Biomarkers Nanotechnology Nanoparticles Protein corona Early detection

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Crossed Molecular Beams and Theoretical Studies of the O(~3P)+1,2-Butadiene Reaction:Dominant Formation of Propene+CO and Ethylidene+Ketene Molecular Channels

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Chinese Journal of Chemical Physics 2019年第1期32卷 113-122,I0002页

作者： Adriana caracciolo Gianmarco Vanuzzo Nadia Balucani Domenico Stranges Silvia Tanteri Carlo Cavallotti Piergiorgio Casavecchia Dipartimento di Chimica Biologia e Biotecnologie Universita degli Studi di Perugia Perugia 06123 Italy Dipartimento di Chimica Universita degli Studi La Sapienza Roma 00185 Italy Politecnico di Milano Dipartimento di Chimica Materiali e Ingegneria Chimica "Giulio Natta" Milano 20131 Italy

Detailed understanding of the mechanism of the combustion relevant multichannel reactions of O(3P) with unsaturated hydrocarbons (UHs) requires the identification of all primary reaction products, the determination of their branching ratios and assessment of intersystem crossing (ISC) between triplet and singlet potential energy surfaces (PESs). This can be best achieved combining crossed-molecular-beam (CMB) experiments with universal, soft ionization, mass-spectrometric detection and time-of-flight analysis to high-level ab initio electronic structure calculations of triplet/singlet PESs and RRKM/Master Equation computations of branching ratios (BRs) including ISC. This approach has been recently demonstrated to be successful for O(3P) reactions with the simplest UHs (alkynes, alkenes, dienes) containing two or three carbon atoms. Here, we extend the combined CMB/theoretical approach to the next member in the diene series containing four C atoms, namely 1,2-butadiene (methylallene) to explore how product distributions, branching ratios and ISC vary with increasing molecular complexity going from O(3P))+propadiene to O(3P)+1,2-butadiene. In particular, we focus on the most important, dominant molecular channels, those forming propene+CO (with branching ratio ∽0.5) and ethylidene+ketene (with branching ratio ∽0.15), that lead to chain termination, to be contrasted to radical forming channels (branching ratio ∽0.35) which lead to chain propagation in combustion systems.

关键词： Reactive scattering Crossed molecular beams O(3P) reaction dynamics O(3P)+diene reactions Soft electron ionization Intersystem crossing Ab initio quantum chemistry

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