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Diagnosis of pancreatic tumors by endoscopic ultrasound-guided fine-needle aspiration

World Journal of Gastroenterology 2007年第22期13卷 3112-3116页

作者： José Celso Ardengh César Vivian Lopes Luiz Felipe Pereira de Lima Juliano Rodrigues de Oliveira Filadélfi o Venco giulio cesare santo José Luiz Pimenta Módena Echoendoscopy and Pathology Units from 9 de Julho Hospital and Ribeiro Preto Medical School-USP So Paulo Brazil

AIM： To evaluate the diagnostic accuracy of endoscopic ultrasound-guided fine-needle aspiration （EUS-FNA） for pancreatic solid tumors larger or smaller than 3 cm, and cystic lesions.METHODS： From January/1997 to December/2006, 611 patients with pancreatic tumors were subjected to EUSFNA. The final diagnosis was obtained either by surgery （356 cases） or after a mean clinical follow-up of 11.8 mo in the remaining patients.RESULTS： There were 405 solid tumors, 189 cystic lesions and 17 mixed. Pancreatic specimens for cytological assessment were successfully obtained by EUS-FNA in 595 （97.4%） cases. There were 352 （57.6%） malignancies and 259 （42.4%） benign tumors. Among the malignancies, pancreatic adenocarcinomas accounted for 67% of the lesions. Overall, the sensitivity, specificity, positive and negative predictive values, and accuracy of EUS-FNA were, respectively, 78.4%, 99.2%, 99.3%, 77.2% and 87.2%. Specifically for solid tumors, the same parameters for neoplasms larger and smaller than 3 cm were, respectively, 78.8% ys 82.4%, 100% ys 98.4%, 100% vs 99%, 54.8% vs 74.1% and 83.1% vs 87.8%. For cystic lesions, the values were, respectively, 72.2%, 99.3%, 97.5%, 91% and 92.2%.CONCLUSION： EUS-FNA can be used to sample pancreatic tumors in most patients. Even though the negative predictive value is inadequate for large solid tumors, the results are rather good for small solid tumors, especially concerning the sensitivity, negative predictive value and diagnostic accuracy. Among all pancreatic lesions, EUS-FNA for cystic lesions can reveal the best negative predictive value and diagnostic accuracy, both higher than 90%.

关键词： Diagnosis Endoscopic ultrasound Fineneedle-aspiration biopsy Pancreas cancer Pancreatic disease Sampling

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Mesenteric and portal vein thrombosis associated with hyperhomocysteinemia and heterozygosity for factor V Leiden mutation

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World Journal of Gastroenterology 2005年第48期11卷 7700-7701页

作者： Giuseppe Famularo Giovanni Minisola giulio cesare Nicotra Claudio De Simone Department of Internal Medicine

A 79-year-old man was hospitalized because of worsening upper abdominal pain which started two days before admission and was continuously present. His personal and family historywas uneventful, he did not smoke and denied toxic habits or using any medications, including overthe-counter medications, herbal remedies or any vitamin supplements.

关键词： Portal Mesenteric Thrombosis hyperhomocysteinemia Factor V Leiden heterozygosity

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Artificial intelligence-aided colonoscopy:Recent developments and future perspectives

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世界胃肠病学杂志：英文版 2020年第47期26卷 7436-7443页

作者： giulio Antonelli Paraskevas Gkolfakis Georgios Tziatzios Ioannis S Papanikolaou Konstantinos Triantafyllou cesare Hassan Gastroenterology Unit Nuovo Regina Margherita HospitalRome 00153Italy Department of Translational and Precision Medicine “Sapienza”University of RomeRome 00185Italy Department of Gastroenterology Hepatopancreatology and Digestive Oncology Erasme University HospitalUniversite Libre de BruxellesBrussels 1070Belgium Hepatogastroenterology Unit Second Department of Internal Medicine-PropaedeuticMedical SchoolNational and Kapodistrian University of Athens“Attikon”University General HospitalAthens 12462Greece

Artificial intelligence(AI)systems,especially after the successful application of Convolutional Neural Networks,are revolutionizing modern *** Endoscopy has shown to be a fertile terrain for the development of AI systems aiming to aid endoscopists in various aspects of their daily *** detection can be one of the two main aspects in which AI can increase diagnostic yield and abilities of *** colonoscopy,it is well known that a substantial rate of missed neoplasia is still present,representing the major cause of interval *** addition,an extremely high variability in adenoma detection rate,the main key quality indicator in colonoscopy,has been extensively *** other domain in which AI is believed to have a considerable impact on everyday clinical practice is lesion characterization and aid in“optical diagnosis”.By predicting in vivo histology,such pathology costs may be averted by the implementation of two separate but synergistic strategies,namely the“leave-in-situ”strategy for<5 mm hyperplastic lesions in the rectosigmoid tract,and“resect and discard”for the other diminutive *** this opinion review we present current available evidence regarding the role of AI in improving lesions’detection and characterization during colonoscopy.

关键词： Artificial intelligence Colonoscopy Polyp Adenoma Detection Characterization

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The effect of humidity on the CO_2/N_2 separation performance of copolymers based on hard polyimide segments and soft polyether chains:Experimental and modeling

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Green Energy & Environment 2016年第3期1卷 201-210页

作者： Luca Olivieri Alberto Tena Maria Grazia De Angelis Antonio Hernández Giménez Angel E.Lozano giulio cesare Sarti Dipartimento di Ingegneria Civile Chimica Ambientale e dei Materiali Alma Mater Studiorum-Università di Bologna SMAP UA UVA-CSIC Universidad de Valladolid Facultad de Ciencias Real de Burgos s/n Helmholtz-Zentrum Geesthacht Institute of Polymer Research Instituto de Ciencia y Tecnología de Polímeros CSIC

In this work, we studied two copolymers formed by segments of a rubbery polyether（PPO or PEO） and of a glassy polyimide（BPDA-ODA or BKDA-ODA） suitable for gas separation and CO2 capture. Firstly, we assessed the absorption of water vapor in the materials, as a function of relative humidity（R.H.）, finding that the humidity uptake of the copolymers lies between that of the corresponding pure homopolymers ***, we studied the effect of humidity on CO2 and N2 permeability, as well as on CO2/N2 selectivity, up to R.H. of 75%. The permeability decreases with increasing humidity, while the ideal selectivity remains approximately constant in the entire range of water activity investigated. The humidity-induced decrease of permeability in the copolymers is much smaller than the one observed in polyimides such as Matrimid? confirming the positive effect of the polyether phase on the membrane ***, we modeled the humidity-induced decrease of gas solubility, diffusivity and, consequently, permeability, using a suitable approach that considers the free volume theory for diffusion and LF model for solubility. Such model allows estimating the extent of competition that the gases undergo with water during sorption in the membranes, as a function of the relative humidity, as well as the expected reduction of free volume by means of water molecules occupation and consequent reduction of diffusivity.

关键词： CO2 capture Humid gas permeation Transport properties in polymeric membranes Water vapor sorption Modeling

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Exploring the Potentialities of Automatic Extraction of University Webometric Information

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Journal of Data and Information Science 2020年第4期5卷 43-55页

作者： Gianpiero Bianchi Renato Bruni Cinzia Daraio Antonio Laureti Palma giulio Perani Francesco Scalfati ISTAT Italian National Institute of StatisticsVia Cesare Balbo 16Rome 00184Italy DIAG Sapienza University of RomeVia Ariosto 25Rome 00185Italy

Purpose:The main objective of this work is to show the potentialities of recently developed approaches for automatic knowledge extraction directly from the universities’*** information automatically extracted can be potentially updated with a frequency higher than once per year,and be safe from manipulations or ***,this approach allows us flexibility in collecting indicators about the efficiency of universities’websites and their effectiveness in disseminating key *** new indicators can complement traditional indicators of scientific research(*** of articles and number of citations)and teaching(*** of students and graduates)by introducing further dimensions to allow new insights for“profiling”the analyzed ***/methodology/approach:Webometrics relies on web mining methods and techniques to perform quantitative analyses of the *** study implements an advanced application of the webometric approach,exploiting all the three categories of web mining:web content mining;web structure mining;web usage *** information to compute our indicators has been extracted from the universities’websites by using web scraping and text mining *** scraped information has been stored in a NoSQL DB according to a semistructured form to allow for retrieving information efficiently by text mining *** provides increased flexibility in the design of new indicators,opening the door to new types of *** data have also been collected by means of batch interrogations of search engines(Bing,***)or from a leading provider of Web analytics(SimilarWeb,http://***).The information extracted from the Web has been combined with the University structural information taken from the European Tertiary Education Register(https://***/#/home),a database collecting information on Higher Education Institutions(HEIs)at European *** the above was used to perfo

关键词： Development of data and information services Webometrics indicators Higher education institutions Automatic extraction Machine learning Optimization

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Impact of body mass index in elderly patients treated with laparoscopic liver resection for hepatocellular carcinoma

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World Journal of Gastrointestinal Surgery 2023年第1期15卷 72-81页

作者： Maria Conticchio Riccardo Inchingolo Antonella Delvecchio Francesca Ratti Maximiliano Gelli Massimiliano Ferdinando Anelli Alexis Laurent giulio cesare Vitali Paolo Magistri Giacomo Assirati Emanuele Felli Taiga Wakabayashi Patrick Pessaux Tullio Piardi Fabrizio di Benedetto Nicola de’Angelis Javier Briceño Antonio Rampoldi RenèAdam Daniel Cherqui Luca Antonio Aldrighetti Riccardo Memeo Unit of Hepato-Pancreatic-Biliary Surgery “F.Miulli”Regional General HospitalBari 70021Italy Interventional Radiology Unit “F.Miulli”Regional General HospitalBari 70021Italy Unit of Hepatobiliary Surgery San Raffaele HospitalMilano 20132Italy Departement de Chirurgie Viscérale Gustave Roussy Cancer Campus Grand ParisParis 94800France Unit of Oncologic and Pancreatic Surgery Hospital University Reina SofíaCordoba 14004Spain Assistance Publique-Hôpitaux de Paris Department of Digestive and Hepatobiliary SurgeryCentre Hospitalier Universitaire Henri MondorCréteilParis 94000France Service of Abdominal Surgery Poliambulanza FoundationBrescia 25124Italy Hepato-Pancreato-Biliary Surgery and Liver Transplantation Unit University of Modena and Reggio EmiliaModena 41121Italy Institut de Recherche Contre les Cancers de l’Appareil Digestif(IRCAD) Strasbourg 67000France Service de Chirurgie Viscérale et Digestive Nouvel Hôpital CivilStrasbourg 67000France Department of Surgery Hôpital Robert DebréReims 51092France Interventional Radiology Unit Niguarda HospitalMilan 20162Italy Department of Surgery Centre HepatobiliaireHopital Paul BrousseParis 94000France

BACKGROUND The impact of obesity on surgical outcomes in elderly patients candidate for liver surgery is still *** To evaluate the impact of high body mass index(BMI)on perioperative and oncological outcome in elderly patients(>70 years old)treated with laparoscopic liver resection for hepatocellular carcinoma(HCC).METHODS Retrospective multicenter study including 224 elderly patients(>70 years old)operated by laparoscopy for HCC(196 with a BMI<30 and 28 with BMI≥30),observed from January 2009 to January *** After propensity score matching,patients in two groups presented comparable results,in terms of operative time(median range:200 min vs 205 min,P=0.7 respectively in non-obese and obese patients),complications rate(22%vs 26%,P=1.0),length of hospital stay(median range:4.5 d vs 6.0 d,P=0.1).There are no significant differences in terms of short-and long-term postoperative *** The present study showed that BMI did not impact perioperative and oncologic outcomes in elderly patients treated by laparoscopic resection for HCC.

关键词： Hepatocellular carcinoma Body mass index Laparoscopy Surgical resection Elderly patients Propensity score matching

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Peri-operative score for elderly patients with resectable hepatocellular carcinoma

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World Journal of Hepatology 2023年第12期15卷 1307-1314页

作者： Maria Conticchio Riccardo Inchingolo Antonella Delvecchio Francesca Ratti Maximiliano Gelli Massimiliano Ferdinando Anelli Alexis Laurent giulio cesare Vitali Paolo Magistri Giacomo Assirati Emanuele Felli Taiga Wakabayashi Patrick Pessaux Tullio Piardi Fabrizio di Benedetto Nicola de'Angelis Javier Briceño Antonio Rampoldi RenèAdam Daniel Cherqui Luca Antonio Aldrighetti Riccardo Memeo Unit of Hepato-Pancreatic-Biliary Surgery “F.Miulli”Regional General HospitalAcquaviva Delle Fonti 70021Italy Interventional Radiology Unit Department of Radiology“F.Miulli”Regional General HospitalAcquaviva Delle Fonti 75100Italy Hepatobiliary Surgery Division IRCSS San Raffaele Scientific InstituteMilan 20132Italy Hepatobiliary Surgery Division Vita-Salute San Raffaele UniversityMilan 20132Italy Département de Chirurgie Viscérale Gustave Roussy Cancer Campus Grand ParisParis 94800France Unit of Oncologic and Pancreatic Surgery Hospital University Reina SofíaCordoba 14004Spain Department of Digestive and Hepatobiliary Surgery Assistance Publique-Hôpitaux de ParisCréteil 94000France Service of Abdominal Surgery Poliambulanza FoundationBrescia 25124Italy Hepato-Pancreato-Biliary Surgery and Liver Transplantation Unit University of Modena and Reggio EmiliaModena 41121Italy Department of Surgery Institut de Recherche Contre les Cancers de l'Appareil Digestif(IRCAD)Strasbourg 67000France Service de Chirurgie Viscérale et Digestive Nouvel Hôpital CivilUnitéINSERM U1110Strasbourg 67000France Department of Surgery Hôpital Robert DebréReims 51092France Assistance Publique-Hôpitaux de Paris Centre Hospitalier Universitaire Henri MondorParis 94000France Unit of Hepatobiliary Surgery and Liver Transplantation Hospital University Reina SofíaCordoba 14004Spain Interventional Radiology Unit Niguarda HospitalMilan 20162Italy Department of Surgery Centre HepatobiliaireHopital Paul BrousseParis 94000France

BACKGROUND Liver resection is the mainstay for a curative treatment for patients with resectable hepatocellular carcinoma(HCC),also in elderly *** this,the evaluation of patient condition,liver function and extent of disease remains a demanding process with the aim to reduce postoperative morbidity and *** To identify new perioperative risk factors that could be associated with higher 90-and 180-d mortality in elderly patients eligible for liver resection for HCC considering traditional perioperative risk scores and to develop a risk *** A multicentric,retrospective study was performed by reviewing the medical records of patients aged 70 years or older who electively underwent liver resection for HCC;several independent variables correlated with death from all causes at 90 and 180 d were *** coefficients of Cox regression proportional-hazards model for sixmonth mortality were rounded to the nearest integer to assign risk factors'weights and derive the scoring *** Multivariate analysis found variables(American Society of Anesthesiology score,high rate of comorbidities,Mayo end stage liver disease score and size of biggest lesion)that had independent correlations with increased 90-and 180-d mortality.A clinical risk score was developed with survival *** This score can aid in stratifying this population in order to assess who can benefit from surgical treatment in terms of postoperative mortality.

关键词： Hepatocellular carcinoma Score Laparoscopy Surgical resection Elderly patients Multivariate analysis

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