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Coronavirus disease 2019 (COVID-19) and prosthetic heart valve: An additional coagulative challenge

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World Journal of Emergency Medicine 2020年第4期11卷 258-259页

作者： Attilio Allione Jacopo Davide Giamello Sara Bernardi giulia Paglietta giulia Lucia Massimina Cavalot Luca Alessio Dutto Daniela Caruso Andrea Tortore Giuseppe Lauria Department of Emergency Medicine Santa Croce and Carle HospitalCuneoItaly School of Emergency Medicine University of TurinTurinItaly

Dear editor,A new infectious disease outbreak,caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),is now spreading all around the world.[1]One of the most critical understandings of the current pandemic of the coronavirus disease 2019(COVID-19)focuses on an imbalanced coagulation *** on the current evidence,we can divide the COVID-19-related hypercoagulable state into two categories[2]:patients without other pre-existing indications for anticoagulant therapy who develop a state of hypercoagulability linked to SARS-CoV-2 infection especially during the cytokine storm phase,and patients already on anticoagulation in whom we have to reevaluate their drug choices,dosages,and *** the same time,recent literature recommends the use of heparin in severe SARS-CoV-2 infection,both as thromboembolic prophylaxis and as an anticoagulant therapy,in light of possible anti-infl ammatory and antiviral mechanisms and less pharmacological interferences.[3]This indication should be adopted in all patients except for those with prosthetic heart valves,in whom vitamin K antagonists continue to remain the drug of choice.[4]In this subgroup of patients,strict monitoring of PT-INR is required to maintain the therapeutic *** purpose of this article is to underline the need for good quality evidence regarding the management of this high-risk category of the patient population.

关键词： dosage vitamin respiratory

Backward automatic calibration for three-dimensional landslide models

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Geoscience Frontiers 2021年第1期12卷 231-241页

作者： Giacomo Titti giulia Bossi Gordon G.D.Zhou Gianluca Marcato Alessandro Pasuto DICAM-UNIBO Department of CivilChemicalEnvironmental and Materials EngineeringAlma Mater Studiorum University of BolognaViale Risorgimento 2Bologna40136Italy IRPI-CNR Research Institute for Geo-Hydrological ProtectionNational Research CouncilC.so Stati Uniti4Padova35127Italy IMHE-CAS Key Laboratory of Mountain Hazards and Earth Surface Process/Institute of Mountain Hazards and EnvironmentChinese Academy of SciencesBlock 4Renminnanlu RoadChengdu610041China

Back-analysis is broadly used for approaching geotechnical problems when monitoring data are available and information about the soils properties is of poor *** landslide stability assessment back-analysis calibration is usually carried out by time consuming trial-and-error *** paper presents a new automatic Decision Support System that supports the selection of the soil parameters for three-dimensional models of landslides based on monitoring *** method considering a pool of possible solutions,generated through permutation of soil parameters,selects the best ten configurations that are more congruent with the measured *** reduces the operator biases while on the other hand allows the operator to control each step of the *** final selection of the preferred solution among the ten best-fitting solutions is carried out by an *** operator control is necessary as he may include in the final decision process all the qualitative elements that cannot be included in a qualitative analysis but nevertheless characterize a landslide dynamic as a whole epistemological subject,for example on the base of geomorphological evidence.A landslide located in Northeast Italy has been selected as example for showing the system *** proposed method is straightforward,scalable and robust and could be useful for researchers and practitioners.

关键词： Automatic landslide modelling FLAC3D~(TM) Back-analysis Optimization Decision Support System

Equilibrium Piezoelectric Potential Distribution in a Deformed ZnO Nanowire

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Nano Research 2009年第8期2卷 624-629页

作者： giulia Mantini Yifan Gao A.DʼAmico C.Falconi Zhong Lin Wang School of Materials Science and Engineering Georgia Institute of TechnologyAtlantaGeorgia 30332-0245USA Department of Electronic Engineering University of Tor VergataVia del Politecnico 100133 RomaItaly

The equilibrium piezoelectric potential distribution in a deformed ZnO semiconductive nanowire has been systematically investigated in order to reveal its dependence on the donor concentration,applied force,and geometric *** particular,the donor concentration markedly affects the magnitude and distribution of the electric *** a donor concentration of ND>1018 cm-3,the piezopotential is almost entirely *** the other parameters,a variation in the length of the nanowire does not signifi cantly affect the potential distribution.

关键词： Nanogenerator ZnO nanowire

Clinical Significance of Apurinic/Apyrimidinic Endodeoxyribonuclease 1 and MicroRNA Axis in Hepatocellular Carcinoma

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Journal of Clinical and Translational Hepatology 2023年第6期11卷 1291-1307页

作者： Giovanna Mangiapane Devis Pascut Emiliano Dalla giulia Antoniali Monica Degrassi Lory Saveria Crocè Veronica De Sanctis Silvano Piazza giulia Canarutto Claudio Tiribelli Gianluca Tell Laboratory of Molecular Biology and DNA Repair Department of MedicineUniversity of UdineUdineItaly Fondazione Italiana Fegato-ONLUS Liver Cancer UnitTriesteItaly Department of Medical Sciences University of TriesteTriesteItaly Clinica Patologie Fegato Azienda Sanitaria Universitaria Giuliano Isontina(ASUGI)TriesteItaly NGS Core Facility Department CIBIOUniversity of TrentoTrentoItaly Computational Biology International Centre for Genetic Engineering and BiotechnologyICGEBTriesteItaly

Background and Aims:Identification of prognostic factors for hepatocellular carcinoma(HCC)opens new perspectives for *** and cellular onco-miRNAs are noncoding RNAs which can control the expression of genes involved in oncogenesis through post-transcriptional *** microRNAs(miRNAs)are considered novel prognostic and predictive factors in *** apurinic/apyrimidinic endodeoxyribonuclease 1(APE1)contributes to the quality control and processing of specific onco-miRNAs and is a negative prognostic factor in several *** present work aims to:a)define APE1 prognostic value in HCC;b)identify miRNAs regulated by APE1 and their relative target genes and c)study their prognostic ***:We used The Cancer Genome Atlas(commonly known as TCGA)data analysis to evaluate the expression of APE1 in *** identify differentially-expressed miRNAs(DEmiRNAs)upon APE1 depletion through specific small interfering RNA,we used NGS and nanostring approaches in the JHH-6 HCC tumor cell *** analyses were performed to identify signaling pathways involving APE1-regulated *** analysis was performed to identify miRNAs correlating with serum APE1 ***:APE1 is considerably overexpressed in HCC tissues compared to normal liver,according to the TCGA-liver HCC(known as LIHC)*** analyses showed that APE1-regulated miRNAs are implicated in signaling and metabolic pathways linked to cell proliferation,transformation,and angiogenesis,identifying Cyclin Dependent Kinase 6 and Lysosomal Associated Membrane Protein 2 as ***-33a-5p,miR-769,and miR-877 are related to lower overall survival in HCC *** array profiling,we identified eight circulating DE-miRNAs associated with APE1 overexpression.A training phase identified positive association between sAPE1 and miR-3180-3p and ***:APE1 regulates specific miRNAs having prognostic value in HCC.

关键词： APE1 miRNAs Prognostic factors Hepatocellular carcinoma

Helicobacter pylori infection and drugs malabsorption

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World Journal of Gastroenterology 2014年第30期20卷 10331-10337页

作者： Edith Lahner Camilla Virili Maria giulia Santaguida Bruno Annibale Marco Centanni Gastrointestinal Unit Department of Digestive and Liver Disease"Sapienza" University of Roma00189 RomaItaly Endocrinology Unit Department of Medico-Surgical Sciences and Biotechnologies"Sapienza" University of Roma04100 LatinaItaly

Drug absorption represents an important factor affecting the efficacy of oral drug *** secretion and motility seem to be critical for drug absorption.A causal relationship between impaired absorption of orally administered drugs and Helicobacter pylori(***)infection has been *** have been reported between poor bioavailability of l-thyroxine and l-dopa and *** *** to the Maastricht Florence Consensus Report on the management of *** infection,*** treatment improves the bioavailability of both these drugs,whereas the direct clinical benefits to patients still await to be *** strong seems the association between *** infection and other drugs malabsorption,such as delavirdine and *** exact mechanisms forming the basis of the relationship between *** infection and impaired drugs absorption and/or bioavailability are not fully *** infection may trigger a chronic inflammation of the gastric mucosa,and impaired gastric acid secretion often *** reduction of acid secretion closely relates with the wideness and the severity of the damage and may affect drug *** minireview focuses on the evidence of *** infection associated with impaired drug absorption.

关键词： Drug malabsorption Helicobacter pylori gastritis Gastric hypoacidity Thyroxine treatment Thyroxine malabsorption Human immunodeficiency virus Delavirdine L-dopa Parkinson's disease Ketaconazole

Neuronal and peripheral damages induced by synthetic psychoactive substances: an update of recent findings from human and animal studies

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Neural Regeneration Research 2020年第5期15卷 802-816页

作者： giulia Costa Maria Antonietta De Luca Gessica Piras Jacopo Marongiu Liana Fattore Nicola Simola Department of Biomedical Sciences University of CagliariCagliariItaly National Institute of Neuroscience (INN) University of CagliariCagliariItaly National Research Council of Italy Institute of NeuroscienceCagliariItaly

Preclinical and clinical studies indicate that synthetic psychoactive substances,in addition to having abuse potential,may elicit toxic effects of varying severity at the peripheral and central ***,toxicity induced by synthetic psychoactive substances poses a serious harm for health,since recreational use of these substances is on the rise among young and adult *** present review summarizes recent findings on the peripheral and central toxicity elicited by “old” and “new” synthetic psychoactive substances in humans and experimental animals,focusing on amphetamine derivatives,hallucinogen and dissociative drugs and synthetic cannabinoids.

关键词： cannabinoids dissociatives hallucinogens ketamine MDMA methamphetamine methoxetamine neuroinflammation neurotoxicity NPS

18,X,Y aneuploidies and transmission electron microscopy studies in spermatozoa from five carriers of different reciprocal translocations

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Asian Journal of Andrology 2009年第3期11卷 325-332页

作者： Elena Moretti Nicola Antonio Pascarelli Valentina Giannerini Michela Geminiani Cecilia Anichini giulia Collodel Department of Biomedical Sciences Applied Biology Section University of Siena Siena 53100 Italy Department of Pediatrics Obstetrics and Reproductive Medicine University of Siena Siena 53100 Italy

We analysed ejaculated spermatozoa from five infertile men with different balanced reciprocal translocations to contribute to the study of meiotic segregation of chromosomes 18, X and Y and also to evaluate sperm morphology by transmission electron microscopy （TEM） analysis. Conventional lymphocyte karyotype analyses highlighted dif- ferent reciprocal balanced translocations： t（12; 13）, t（4;9）, t（X;8）, t（8; 10） and t（3; 16）. Semen analysis was performed by light and TEM. Fluorescence in situ hybridization was performed directly on sperm nuclei using centromeric probes for chromosomes 18, X and Y. The carriers of the balanced reciprocal translocations considered in the present study showed a very similar pattern of sperm pathologies： diffused presence of apoptosis and immaturity. All patients showed meiotic segregation derangements, highlighted by the presence of sperm diploidies and sex chromosome disomies particularly related to the failure of the first meiotic division. However, an increased incidence of chromosome 18 aneuploidy was detected in spermatozoa from t（X;8） and t（8;10） carriers. We have also reported values from sex chromosomes such as t（X;8）, although the X chromosome was involved in translocation. Since patients with reciprocal translocations and spermatogenetic impairment are candidates for intracytoplasmic sperm injection cycles, the study of sperm parameters, and particularly of the level of aneuploidy rates, would provide better information for couples at risk and would contribute to the data in the literature for a better understanding of the effects of chromosomal rearrangement on the whole meiotic process and, in particular, on chromosomes not involved in translocation.

关键词： electron microscopy fluorescence in situ hybridization altered karyotype spermatozoa reciprocal translocation

The landscape of cognitive impairment in superoxide dismutase 1-amyotrophic lateral sclerosis

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Neural Regeneration Research 2023年第7期18卷 1427-1433页

作者： Ilaria Martinelli Elisabetta Zucchi Cecilia Simonini giulia Gianferrari Giovanna Zamboni Marcello Pinti Jessica Mandrioli Clinical and Experimental Medicine PhD Program University of Modena and Reggio EmiliaModenaItaly Department of Neurosciences Azienda Ospedaliero-Universitaria di ModenaModenaItaly Department of Biomedical Metabolic and Neural SciencesUniversity of Modena and Reggio EmiliaModenaItaly Department of Life Sciences University of Modena and Reggio EmiliaModenaItaly

Although mutations in the superoxide dismutase 1 gene account for only a minority of total amyotrophic lateral sclerosis cases,the discovery of this gene has been crucial for amyotrophic lateral sclerosis *** the identification of superoxide dismutase 1 in 1993,the field of amyotrophic lateral sclerosis genetics has considerably widened,improving our understanding of the diverse pathogenic basis of amyotrophic lateral *** this review,we focus on cognitive impairment in superoxide dismutase 1-amyotrophic lateral sclerosis *** has mostly reported that cognition remains intact in superoxide dismutase 1-amyotrophic lateral sclerosis patients,but recent reports highlight frontal lobe function frailty in patients carrying different superoxide dismutase 1-amyotrophic lateral sclerosis *** thoroughly reviewed all the various mutations reported in the literature to contribute to a comprehensive database of superoxide dismutase 1-amyotrophic lateral sclerosis genotype-phenotype *** a resource could ultimately improve our mechanistic understanding of amyotrophic lateral sclerosis,enabling a more robust assessment of how the amyotrophic lateral sclerosis phenotype responds to different variants across genes,which is important for the therapeutic strategy targeting genetic *** in superoxide dismutase 1-amyotrophic lateral sclerosis deserves further longitudinal research since this peculiar frailty in patients with similar mutations can be conditioned by external factors,including environment and other unidentified agents including modifier genes.

关键词： amyotrophic lateral sclerosis cognitive impairment genotype-phenotype correlation superoxide dismutase 1

DTFab:A Digital Twin based Approach for Optimal Reticle Management in Semiconductor Photolithography

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Journal of Systems Science and Systems Engineering 2023年第3期32卷 320-351页

作者： Chandrasekhar Komaralingam Sivasubramanian Robert Dodge Aditya Ramani David Bayba Mani Janakiram Eric Butcher Joseph Gonzales giulia Pedrielli School of Computing and Augmented Inteligence Arizona State UniversityTempeAZUSA Intel Corporation ChandlerAZUSA

Photolithography is among the key phases in chip *** is also among the most expensive with manufacturing equipment valued at the hundreds of millions of *** is paramount that the process is ran efficiently,guaranteeing high resource utilization and low product cycle times.A key element in the operation of a photolithography system is the effective management of the reticles that are responsible for the imprinting of the circuit path on the *** reticles means determining which are appropriate to mount on the very expensive scanners as a function of the product types being released to the *** the importance of the problem,several heuristic policies have been developed in the industry practice in an attempt to guarantee that the expensive tools are never ***,such policies have difficulties reacting to unforeseen events(e.g.,unplanned failures,unavailability of reticles).On the other hand,the technological advance of the semiconductor industry in sensing at system and process level should be harnessed to improve on these"expert policies".In this manuscript,we develop a system for the real time reticle management that not only is able to retrieve information from the real system,but also is able to embed commonly used policies to improve upon *** develop a new digital twin for the photolithography process that efficiently and accurately predicts the system performance,thus allowing our system to make predictions for future behaviors as a function of possible *** results demonstrate the validity of the developed model,and the feasibility of the overall approach demonstrating a statistically significant improvement of performance as compared to the current policy.

关键词： Semiconductor manufacturing reinforcement learning reticle management digital twin