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Activation of defense Response Pathways by OGs and Fig22 Elicitors in Arabidopsis Seedlings

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Molecular Plant 2008年第3期1卷 423-445页

作者： Carine denoux Roberta Galletti Nicole Mammarella Suresh Gopalan Danièle Werck giulia de lorenzo Simone Ferrari Frederick M. Ausubel Julia dewdney department of Genetics Harvard Medical School and Department of Molecular Biology Massachusetts General Hospital 185 Cambridge St Simches 7700Boston MA 02114 USA Institut de Biologie Moleculaire des Plantes CNRS Universite Louis Pasteur. Strasbourg France Dipartimento di Biologia Vegetale University di Roma 'La Sapienza' Piazzale Aldo Moro 5 00185 Rome. Italy

We carried out transcriptional profiling analysis in 10-d-old Arabidopsis thaliana seedlings treated with oligogalacturonides （OGs）, oligosaccharides derived from the plant cell wall, or the bacterial flagellin peptide Fig22, general elicitors of the basal defense response in plants. Although detected by different receptors, both OGs and Fig22 trigger a fast and transient response that is both similar and comprehensive, and characterized by activation of early stages of multiple defense signaling pathways, particularly JA-associated processes. However, the response to Fig22 is stronger in both the number of genes differentially expressed and the amplitude of change. The magnitude of induction of individual genes is in both cases dose-dependent, but, even at very high concentrations, OGs do not induce a response that is as comprehensive as that seen with Fig22. While high doses of either microbe-associated molecular pattern （MAMP） elicit a late response that includes activation of senescence processes, SA-dependent secretory pathway genes and PR1 expres- sion are substantially induced only by Fig22. These results suggest a lower threshold for activation of early responses than for sustained or SA-mediated late defenses. Expression patterns of amino-cyclopropane-carboxylate synthase genes also implicate ethylene biosynthesis in regulation of the late innate immune response.

关键词： Fig22 唇形科种子活化作用

Application of ultrasonography-elastography score to suspect porto-sinusoidal vascular disease in patients with portal vein thrombosis

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Hepatobiliary & Pancreatic Diseases International 2024年第1期23卷 20-24页

作者： Stefania Gioia Adriano de Santis giulia d’Amati Silvia Nardelli Alessandra Spagnoli Arianna Di Rocco lorenzo Ridola Oliviero Riggio department of Translational and Precision Medicine Sapienza University of RomeRomeItaly department of Radiological Oncologicaland Pathological SciencesSapienza University of RomeRomeItaly department of Public Health and Infectious Diseases Sapienza University of RomeRomeItaly

Background:Porto-sinusoidal vascular disease(PSVD)and portal vein thrombosis(PVT)are causes of portal hypertension characterized respectively by an intrahepatic and a pre-hepatic obstacle to the flow in the portal *** PVT may be a consequence of PSVD,in PVT patients at presentation,a pre-existing PSVD should be *** these patients the identification of an underlying PSVD would have relevant implication regarding follow-up and therapeutic management,but it could be *** this setting ultrasonography may be valuable in differential *** aim of the study was to use ultrasonography to identify parameters to discriminate between PSVD and“pure”PVT and then to suspect PVT secondary to a pre-existing ***:Fifty-three patients with histologically proven PSVD and forty-eight patients affected by chronic PVT were enrolled and submitted to abdominal ultrasonography with elastography by acoustic radiation force impulse(ARFI).Results:ARFI was higher and superior mesenteric vein(SMV)diameter was wider in PSVD patients than in PVT ***,a prognostic score was obtained as linear combinations of the two parameters with a good discrimination capacity between PSVD and PVT(the area under the curve=0.780;95%confidence interval:0.690-0.869).Conclusions:A score based on ARFI and SMV diameter may be useful to suspect an underlying PSVD in patients with PVT and to identify a subgroup of patients to be submitted to liver biopsy.

关键词： Non-cirrhotic portal hypertension Porto-sinusoidal vascular disease Chronic portal vein thrombosis Liver stiffness Portal hypertension Acoustic radiation force impulse

This pain drives me crazy:Psychiatric symptoms in women with interstitial cystitis/bladder pain syndrome

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World Journal of Psychiatry 2024年第6期14卷 954-984页

作者： Marianna Mazza Stella Margoni Giuseppe Mandracchia Guglielmo Donofrio Alessia Fischetti Georgios D Kotzalidis Giuseppe Marano Alessio Simonetti delfina Janiri lorenzo Moccia Ilaria Marcelli Greta Sfratta Domenico de Berardis Ottavia Ferrara Evelina Bernardi Antonio Restaino Francesco Maria Lisci Antonio Maria D'Onofrio Caterina Brisi Flavia Grisoni Claudia Calderoni Michele Ciliberto Andrea Brugnami Sara Rossi Maria Chiara Spera Valeria de Masi Ester Maria Marzo Francesca Abate Gianluca Boggio Maria Benedetta Anesini Cecilia Falsini Anna Quintano Alberto Torresi Miriam Militenda Giovanni Bartolucci Marco Biscosi Sara Ruggiero Luca Lo Giudice giulia Mastroeni Elisabetta Benini Luca Di Benedetto Romina Caso Francesco Pesaresi Francesco Traccis Luca Onori Luca Chisari Leonardo Monacelli Mariateresa Acanfora Eleonora Gaetani Monia Marturano Sara Barbonetti Elettra Specogna Francesca Bardi Emanuela de Chiara Gianmarco Stella Andrea Zanzarri Flavio Tavoletta Arianna Crupi giulia Battisti Laura Monti Giovanni Camardese Daniela Chieffo Antonio Gasbarrini Giovanni Scambia Gabriele Sani department of Neurosciences Fondazione Policlinico Universitario A Gemelli IRCCSUniversita Cattolica del Sacro CuoreRome 00168Italy department of Psychiatry UniversitàCattolica del Sacro CuoreRome 00168Italy department of Neurosciences Section of PsychiatryFondazione Policlinico Universitario Agostino Gemelli IRCCSUniversitàCattolica del Sacro CuoreRome 00168Italy Mental Health NHSASL 4 TeramoTeramo 64100Italy Medical and Surgical Sciences UniversitàCattolica del Sacro CuoreRome 00168Italy Division of Gynecologic Oncology UniversitàCattolica del Sacro CuoreRome 00168Italy UOS Psicologia Clinica Governo ClinicoFondazione Policlinico Universitario Agostino Gemelli IRCCSRome 00168Italy CEMAD Digestive Disease Center Fondazione Policlinico Universitario A.Gemelli-IRCCSRome 00168Italy department of Woman and Child Health Catholic UniversityRome 00168Italy UOC Psichiatria Clinica e d’Urgenza Dipartimento di Scienze Dell’InvecchiamentoNeurologicheOrtopediche e Della Testa-colloFondazione Policlinico Universitario Agostino Gemelli IRCCSRome 00168Italy

BACKGROUND Interstitial cystitis/bladder pain syndrome(IC/BPS)is an at least 6-mo noninfectious bladder inflammation of unknown origin characterized by chronic suprapubic,abdominal,and/or pelvic *** the term cystitis suggests an inflammatory or infectious origin,no definite cause has been *** occurs in both sexes,but women are twice as much *** To systematically review evidence of psychiatric/psychological changes in persons with IC/*** Hypothesizing that particular psychological characteristics could underpin IC/BPS,we investigated in three databases the presence of psychiatric symptoms and/or disorders and/or psychological characteristics in patients with IC/BPS using the following strategy:("interstitial cystitis"OR"bladder pain syndrome")AND("mood disorder"OR depressive OR antidepressant OR depression OR depressed OR hyperthymic OR mania OR manic OR rapid cyclasterisk OR dysthymiasterisk OR dysphoriasterisk).RESULTS On September 27,2023,the PubMed search produced 223 articles,CINAHL 62,and the combined PsycLIT/PsycARTICLES/PsycINFO/Psychology and Behavioral Sciences Collection search *** on *** produced 14 studies,of which none had available *** were peer-reviewed articles reporting psychiatric/psychological symptoms in patients with IC/BPS,i.e.63 articles spanning from 2000 to October *** studies identified depression and anxiety problems in the IC/BPS population,along with sleep problems and the tendency to *** Psychotherapies targeting catastrophizing and life stress emotional awareness and expression reduced perceived pain in women with IC/*** concepts should be considered when implementing treatments aimed at reducing IC/BPS-related pain.

关键词： Interstitial cystitis/bladder pain syndrome Psychiatric symptoms Psychological symptoms Catastrophizing Anxiety depression

Five-year longitudinal evaluation of quality of life in a cohort of patients with differentiated thyroid carcinoma

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2011年第3期12卷 163-173页

作者： Massimo GIUSTI giulia MELLE Monica FENOCCHIO lorenzo MORTARA Francesca CECOLI Valeria CAORSI Diego FERONE Francesco MINUTO Elda RASORE department of Endocrine and Medical Sciences University of Genoa department of Psychiatric Sciences University of Genoa

Differentiated thyroid carcinoma(DTC) generally has a favorable *** disease,treatments,stress,and comorbidity can compromise health-related quality of life(QoL) and indirectly weigh upon the outcome. From 2004 to 2008,we evaluated QoL longitudinally in 128 DTC *** scheduled examinations,subjects were asked to undergo a semi-structured psychiatric interview and five rated *** same examination was conducted in 219 subjects after surgery for benign thyroid *** scores represent a better *** and control subjects were similar in terms of age,male/female ratio,concomitant psychopharmacological treatments,and frequency of psychiatric *** DTC subjects,Billewicz scale(BS) scores showed an increasing trend over time,especially among *** ad hoc thyroid questionnaire(TQ) scores were similar in both groups and did not change over time,but at the end of the study ad hoc TQ and BS were significantly *** hoc TQ scores were also related to age on entry to the *** both male and female DTC subjects,Hamilton's tests for anxiety(HAM-A) ,but not for depression(HAM-D),showed an improving *** the end of the study,HAM-A and HAM-D scores were comparable to those of the control ***-A and HAM-D were both positively correlated with the stage of cancer and the time between diagnosis and *** HAM-D correlated with age on entry to the *** symptom questionnaire(KSQ) item scores were higher in DTC subjects than in *** change over time in the items including anxiety,somatization,depression,and hostility was *** and hostility were more significantly reduced in DTC females than in DTC *** scores were significantly lower in DTC subjects than in controls at the end of the *** and depression were significantly related to staging on diagnosis and age on entry to the *** study confirms a wide variation of illness perception in DTC subjects

关键词： Thyroid cancer Outcome Psycholoqical evaluation Qualitv of life Loneitudinal study

Exerav as a Parameter for Buildina Enerav Assessment

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Journal of Civil Engineering and Architecture 2015年第6期9卷 741-748页

作者： lorenzo Leoncini Marta giulia Baldi department oflndustrial Engineering University of Florence Florence 50139 ltaly department of Civil and Environmental Engineering University of Florence Florence 50139 Italy

The energy and environmental impacts resulting from the buildings sector are one of the impending problems which address the international action. The main strategies implemented to answer to this problem are the energy efficiency improvement, the CO2 emissions reduction and the renewable energy share increase in the energy mix. The key subject discussed in this paper is the ＂building energy impact＂, aimed to leading the building sector towards the energy efficiency improvement. The paper＇s aim is to show that an energy assessment is not able to give a consistent evaluation of building energy use, and it could be misleading. Therefore, the paper proposes the exergy assessment as complementary evaluation method, in order to achieve a complete description of the concept ＂building＇s energy impact on the environment＂. In the first section, we describe the parameters currently used for the building energy assessment, focusing on the primary energy index and the CO2 emissions index. In the second section, we introduce the exergy as a complementary index. This index is a possible answer to the problems previously identified. Finally, in the third section, we present three test-cases, analyzed through transient simulation software TRNSYS. The purpose of the test-cases analysis is to show the difference between energy and exergy assessment.

关键词： Building energy assessment energy performance exergy performance indices.

Is porto sinusoidal vascular disease to be actively searched in patients with portal vein thrombosis?

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World Journal of Hepatology 2019年第8期11卷 613-618页

作者： Stefania Gioia Silvia Nardelli lorenzo Ridola giulia d’Amati Oliviero Riggio Dipartimento di Medicina Traslazionale e di Precisione “Sapienza” Università di Roma Roma 00185 Italy Dipartimento di Scienze Radiologiche Oncologiche e Anatomo Patologiche“Sapienza” Università di Roma Roma 00185 Italy

Porto sinusoidal vascular liver disease (PSVD) and portal vein thrombosis (PVT) are distinct vascular liver diseases characterized, respectively, by an intrahepatic and a prehepatic obstacle to the flow in the liver portal system. PVT may also occur as a complication of the natural history of PSVD, especially if a prothrombotic condition coexists. In other cases, it is associated to local and systemic pro-thrombotic conditions, even if its cause remains unknown in up to 25% despite an active search. In our opinion, the presence of PSVD should be suspected in patients with PVT especially in those with PVT “sine causa” and the active search of this condition should be included in their diagnostic work-out. However, sometimes the diagnosis of pre-existing PSVD is very hard. Biopsy cannot be fully discriminant as similar histological data have been described in both conditions. Liver stiffness may help as it has been shown to be higher in PSVD than in “pure” PVT, due to the presence of sclerosis in the portal venous radicles observable in PSVD patients. Nevertheless, comparing liver stiffness between PVT and PSVD has until now been restricted to very limited series of patients. In conclusion, even if it is still totally hypothetical, our point of view may have clinical consequences, especially when deciding to perform a liver biopsy in patients with a higher liver stiffness and suspending the anticoagulation in patients with PVT and no detectable prothrombotic factors.

关键词： Porto sinusoidal vascular liver disease Obliterative portal venopathy Portal vein thrombosis Anticoagulant therapy

Childhood stressful events, HPA axis and anxiety disorders

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World Journal of Psychiatry 2012年第1期2卷 13-25页

作者： Carlo Faravelli Carolina Lo Sauro Lucia Godini lorenzo Lelli Laura Benni Francesco Pietrini Lisa Lazzeretti Gabriela Alina Talamba giulia Fioravanti Valdo Ricca department of Psychology University of Florence Psychiatric Unit Department of Neuropsychiatric Sciences Florence University School of Medicine

Anxiety disorders are among the most common of all mental disorders and their pathogenesis is a major topic in psychiatry, both for prevention and treatment. Early stressful life events and alterations of hypothalamic pituitary adrenal(HPA) axis function seem to have a significant role in the onset of anxiety. Existing data appear to support the mediating effect of the HPA axis between childhood traumata and posttraumatic stress disorder. Findings on the HPA axis activity at baseline and after stimuli in panic disordered patients are inconclusive, even if stressful life events may have a triggering function in the development of this disorder. Data on the relationship between stress, HPA axis functioning and obsessive-compulsive disorder(OCD) are scarce and discordant, but an increased activity of the HPA axis is reported in OCD patients. Moreover, normal basal cortisol levels and hyperresponsiveness of the adrenal cortex during a psychosocial stressor are observed in social phobics. Finally,abnormal HPA axis activity has also been observed in generalized anxiety disordered patients. While several hypothesis have attempted to explain these findings over time, currently the most widely accepted theory is that early stressful life events may provoke alterations of the stress response and thus of the HPA axis, that can endure during adulthood, predisposing individuals to develop psychopathology. All theories are reviewed and the authors conclude that childhood life events and HPA abnormalities may be specifically and transnosographically related to all anxiety disorders, as well as, more broadly, to all psychiatric disorders.

关键词： Anxiety disorders Early stressful life events Childhood traumata Cortisol Hypothalamic pituitary adrenal axis Vulnerability Psychopathology

Olfactory swab sampling optimization for α-synuclein aggregate detection in patients with Parkinson’s disease

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Translational Neurodegeneration 2022年第1期11卷 390-400页

作者： Matilde Bongianni Mauro Catalan Daniela Perra Elena Fontana Francesco Janes Claudio Bertolotti Luca Sacchetto Stefano Capaldi Matteo Tagliapietra Paola Polverino Valentina Tommasini giulia Bellavita Elham Ataie Kachoie Roberto Baruca Andrea Bernardini Mariarosaria Valente Michele Fiorini Erika Bronzato Stefano Tamburin Laura Bertolasi lorenzo Brozzetti Maria Paola Cecchini Gianluigi Gigli Salvatore Monaco Paolo Manganotti Gianluigi Zanusso department of Neurosciences Biomedicineand Movement SciencesPoliclinico G.B.RossiUniversity of Verona37134 VeronaItaly Neurology Unit Department of MedicineSurgery and Health SciencesOspedale CattinaraUniversity of Trieste34128 TriesteItaly Neurology Unit University of Udine Academic Hospital33100 UdineItaly department of Surgical Sciences DentistryGynecology and PediatricsUniversity of Verona37134 VeronaItaly Biocrystallography Laboratory Department of BiotechnologyUniversity of Verona37134 VeronaItaly Otolaryngology Unit Department of MedicineSurgery and Health SciencesOspedale CattinaraUniversity of Trieste34128 TriesteItaly.

Background: In patients with Parkinson’s disease (PD), real-time quaking-induced conversion (RT-QuIC) detection of pathological α-synuclein (α-syn) in olfactory mucosa (OM) is not as accurate as in other α-synucleinopathies. It is unknown whether these variable results might be related to a different distribution of pathological α-syn in OM. Thus, we investigated whether nasal swab (NS) performed in areas with a different coverage by olfactory neuroepithelium, such as agger nasi (AN) and middle turbinate (MT), might affect the detection of pathological α-syn. Methods: NS was performed in 66 patients with PD and 29 non-PD between September 2018 and April 2021. In 43 patients, cerebrospinal fluid (CSF) was also obtained and all samples were analyzed by RT-QuIC for α-syn. Results: In the first round, 72 OM samples were collected by NS, from AN (NSAN) or from MT (NSMT), and 35 resulted positive for α-syn RT-QuIC, including 27/32 (84%) from AN, 5/11 (45%) from MT, and 3/29 (10%) belonging to the non-PD patients. Furthermore, 23 additional PD patients underwent NS at both AN and MT, and RT-QuIC revealed α-syn positive in 18/23 (78%) NSAN samples and in 10/23 (44%) NSMT samples. Immunocytochemistry of NS prepara-tions showed a higher representation of olfactory neural cells in NSAN compared to NSMT. We also observed α-syn and phospho-α-syn deposits in NS from PD patients but not in controls. Finally, RT-QuIC was positive in 22/24 CSF samples from PD patients (92%) and in 1/19 non-PD. Conclusion: In PD patients, RT-QuIC sensitivity is significantly increased (from 45% to 84%) when NS is performed at AN, indicating that α-syn aggregates are preferentially detected in olfactory areas with higher concentration of olfactory neurons. Although RT-QuIC analysis of CSF showed a higher diagnostic accuracy compared to NS, due to the non-invasiveness, NS might be considered as an ancillary procedure for PD diagnosis.

关键词： Parkinson disease Alpha-synuclein Real-time quaking-induced conversion assay Olfactory mucosa Cerebrospinal fluid

Five-year longitudinal evaluation of quality of life in a cohort of patients with differentiated thyroid carcinoma

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2012年第9期 716-716页

作者： Massimo GIUSTI giulia MELLE Monica FENOCCHIO lorenzo MORTARA Francesca CECOLI Valeria CAORSI Diego FERONE Francesco MINUTO Elda RASORE

Differentiated thyroid carcinoma(DTC) generally has a favorable *** disease,treatments,stress,and comorbidity can compromise health-related quality of life(QoL) and indirectly weigh upon the *** 2004 to 2008,we evaluated QoL longitudinally in 128 DTC *** scheduled examinations,subjects were asked to undergo a semi-structured psychiatric interview and five rated *** same examination was conducted in 219 subjects after surgery for benign thyroid *** scores represent a better *** and control subjects were similar in terms of age,male/female ratio,concomitant psychopharmacological treatments,and frequency of psychiatric *** DTC subjects,Billewicz scale(BS) scores showed an increasing trend over time,especially among *** ad hoc thyroid questionnaire(TQ) scores were similar in both groups and did not change over time,but at the end of the study ad hoc TQ and BS were significantly *** hoc TQ scores were also related to age on entry to the *** both male and female DTC subjects,Hamilton's tests for anxiety(HAM-A),but not for depression(HAM-D),showed an improving *** the end of the study,HAM-A and HAM-D scores were comparable to those of the control ***-A and HAM-D were both positively correlated with the stage of cancer and the time between diagnosis and *** HAM-D correlated with age on entry to the *** symptom questionnaire(KSQ) item scores were higher in DTC subjects than in *** change over time in the items including anxiety,somatization,depression,and hostility was *** and hostility were more significantly reduced in DTC females than in DTC *** scores were significantly lower in DTC subjects than in controls at the end of the *** and depression were significantly related to staging on diagnosis and age on entry to the *** study confirms a wide variation of illness perception in DTC subjects,w

关键词： DTC Five-year longitudinal evaluation of quality of life in a cohort of patients with differentiated thyroid carcinoma