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Animal Nutrition 2019年第3期5卷 297-306页

作者： Biagina Chiofalo giulia de vita Vittorio Lo Presti Salvatore Cucinotta Gabriella Gaglio Francesco Leone Ambra R.Di Rosa department of Veterinary Sciences University of Messina Polo Universitario Annunziata

Two different diets characterized by the absence of cereals or by the presence of conventional cereals were evaluated on the nutrient digestibility and faecal characteristics and faecal fermentative endproduct concentrations of 8 neutered adult Labrador retrievers housed at the Regional Centre Helen Keller(Messina,Italy)during the training work for the service guide for the ***(age = 17 ± 1 months,initial body weight [BW]= 26.3 ± 1 *** body condition score [BCS]= 4.5 ± 0.11)were divided into 2 homogeneous groups for sex(half males and half females).Dogs in the grain free(GF)group were fed a commercial diet characterized by the absence of grain cereals,and dogs in the control(CTR)group were fed a super-premium pet food characterized by conventional grains as the carbohydrate *** trial lasted 84 *** by a 7-d of adaption *** examination,*** faecal characteristics were *** statistical model included the effects of diet(GF ***),time(from d 0 to *** of the trial)and the interaction(diet x time).The high-protein,lowcarbohydrate dry diet(GF)offered higher apparent nutrient digestibility of protein(+10%;P =0.002)and fat(+7%;Pders consequent to stress coming from work and life in kennels,which cause in the Labrador retrievers an unusual weight loss.

关键词： Utility dog Grain free diet Nutrient digestibility Faecal quality Training work

Colorectal cancer screening from 45 years of age: Thesis, antithesis and synthesis

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World Journal of Gastroenterology 2019年第21期25卷 2565-2580页

作者： Alessandro Mannucci Raffaella Alessia Zuppardo Riccardo Rosati Milena Di Leo José Perea giulia Martina Cavestro Gastroenterology and Gastrointestinal Endoscopy Unit Division of Experimental OncologyVita-Salute San Raffaele UniversityIRCCS San Raffaele Scientific InstituteMilan 20132Italy department of Surgery Vita-Salute San Raffaele UniversityIRCCS San Raffaele Scientific InstituteMilan 20132Italy Digestive Endoscopy Unit Division of GastroenterologyHumanitas Research HospitalDepartment of Biomedical ScienceHumanitas UniversityMilan 20090Italy Surgery department “Fundación Jiménez Díaz” University HospitalMadrid 28040Spain Health Research Institute-Fundación Jiménez Díaz University Hospital Madrid 28040Spain

Colorectal cancer incidence and mortality in patients younger than 50 years are increasing, but screening before the age of 50 is not offered in Europe. Advancedstage diagnosis and mortality from colorectal cancer before 50 years of age are increasing. This is not a detection-bias effect;it is a real issue affecting the entire population. Three independent computational models indicate that screening from 45 years of age would yield a better balance of benefits and risks than the current start at 50 years of age. Experimental data support these predictions in a sex- and race-independent manner. Earlier screening is seemingly affordable, with minimal impediments to providing younger adults with colonoscopy. Indeed, the American Cancer Society has already started to recommend screening from 45 years of age in the United States. Implementing early screening is a societal and public health problem. The three independent computational models that suggested earlier screening were criticized for assuming perfect compliance. Guidelines and recommendations should be derived from well-collected and reproducible data, and not from mathematical predictions. In the era of personalized medicine, screening decisions might not be based solely on age, and sophisticated prediction software may better guide screening. Moreover, early screening might divert resources away from older individuals with greater biological risks. Finally, it is still unknown whether early colorectal cancer is part of a continuum of disease or a biologically distinct disease and, as such, it might not benefit from screening at all. The increase in early-onset colorectal cancer incidence and mortality demonstrates an obligation to take actions. Earlier screening would save lives, and starting at the age of 45 years may be a robust screening option.

关键词： Colonoscopy Guidelines Pros and cons Early onset Early-onset colorectal cancer

欧洲精神病学协会精神分裂症认知功能损害评估指引(全译)

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中华精神科杂志 2024年第9期

作者： vita Antonio Gaebel Wolfgang Mucci Armida Sachs Gabriele Erfurth Andreas Barlati Stefano Zanca Federico Giordano giulia Maria Glenth?j Louise Birkedal Nordentoft Merete Galderisi Silvana department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy department of Mental Health and Addiction Services, Spedali Civili Hospital, Brescia, Italy WHO Collaborating Centre on Quality Assurance and Empowerment in Mental Health deU-131, LVR-Klinikum Düsseldorf, Düsseldorf, Germany department of Psychiatry and Psychotherapy, Heinrich-Heine-University, Düsseldorf, Germany University of Campania"Luigi Vanvitelli", Naples, Italy Medical University of Vienna, Wien, Austria CORE-Copenhagen Research Centre for Mental Health, Copenhagen University Hospital, Copenhagen, denmark department of Psychology, Copenhagen University, Copenhagen, denmark

背景既往研究显示精神分裂症患者存在广泛的认知功能损害。神经认知功能损害和社会认知功能损害被认为是精神分裂症导致严重功能残疾的原因。尽管认知功能对精神分裂症预后起关键作用, 但无论是在科研研究中, 还是临床实践中, 相关评估...

背景既往研究显示精神分裂症患者存在广泛的认知功能损害。神经认知功能损害和社会认知功能损害被认为是精神分裂症导致严重功能残疾的原因。尽管认知功能对精神分裂症预后起关键作用, 但无论是在科研研究中, 还是临床实践中, 相关评估都非常不足。方法本文对科学文献进行系统综述, 详细阐述在科研研究和临床实践中对精神分裂症认知功能评估的若干推荐。结果专家共识和系统综述为精神分裂症认知功能的最佳评估提供了指导。基于遴选的证据, 本欧洲精神病学协会精神分裂症认识功能损害评估指引(下文简称指引)建议, 在精神分裂症的全病程以及精神病风险人群中进行神经认知功能和社会认知功能2个领域的全面且系统的评估。指引不仅建议使用知情者报告, 也建议使用自我报告和基于访谈的认知功能评估工具。指引还系统地回顾了首次发作精神病患者和精神病高危人群的评估现状。结论对证据的全面审查和推荐建议可能有助于推动这一领域的发展, 有利于进行更好的认知功能评估, 并避免与其他精神病理学维度重叠。该指导性文件的传播可促进涉及精神分裂症认知功能评估的相关指南的制定, 从而提高医疗质量并获得临床痊愈。

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Year-round multi-scale habitat selection by Crested Tit(Lophophanes cristatus)in lowland mixed forests(northern Italy)

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Avian Research 2022年第4期13卷 461-467页

作者： Alessandro Berlusconi Alessio Martinoli Lucas AWauters giulia Tesoro Stefania Martini Erminio Clerici Gualtiero Guenzani Gabriele Pozzi Diego Rubolini Michelangelo Morganti Adriano Martinoli Environment Analysis and Management Unit-Guido Tosi Research Group-department of Theoretical and Applied Sciences Universita degli Studi dell’InsubriaVia J.H.Dunant 321100VareseItaly CNR-IRSA National Research Council–Water Research Institute Via del Mulino 1920861BrugherioMBItaly Gruppo Insubrico di Ornitologia c/o Civico Museo Insubrico di Storia Naturale di Clivio e Induno OlonaVia Manzoni21050ClivioVAItaly Parco Pineta di Appiano Gentile e Tradate Via Alessandro Manzoni1122070Castelnuovo BozzenteCOItaly e Dipartimento di Scienze della Vita Biologia dei Sistemi Universita degli Studi di TorinoVia Accademia Albertina 1310123TurinItaly Conservation department LIPU-Birdlife Italia Via Udine 3/a43122ParmaItaly department of Environmental Science and Policy Universita degli Studi di MilanoVia Celoria 2620122MilanItaly

determining how animals respond to resource availability across spatial and temporal extents is crucial to understand ecological processes underpinning habitat ***,we used a multi-scale approach to study the year-round habitat selection of the Crested Tit(Lophophanes cristatus)in a semi-natural lowland woodland of northern Italy,analysing different habitat features at each *** performed Crested Tit censuses at three different spatial *** the macrohabitat scale,we used geolocalized observations of individuals to compute Manly's habitat selection index,based on a detailed land-use map of the study *** the microhabitat scale,the trees features were compared between presence and absence *** the foraging habitat scale,individual foraging birds and their specific position on trees were recorded using focal animal *** were performed during both the breeding(March to May)and wintering(december to January)*** the macrohabitat scale,the Crested Tits significantly selected pure and mixed pine forests and avoided woods of alien plant species,farmlands and urban *** the microhabitat scale,old pine woods with dense cover were selected,with no significant difference in the features of tree selection between the two phenological *** the foraging habitat scale,the species was observed spending more time foraging in the canopies than in the understorey,using mostly the portion of Scots Pine(Pinus sylvestris)canopies closer to the trunk in winter,while during the breeding period,the whole canopy was ***,breeding and wintering habitats largely overlapped in the Crested *** on our findings,lowland Crested Tits can be well defined as true habitat specialists:they are strictly related to some specific coniferous woodland ***,compared to other tit species,which normally show generalist habits during winter,the Crested Tit behaves as a habitat specialist also out of the breeding ***

关键词： Crested tit Functional response Habitat selection Multi-scale approach Scots pine

Outcome of endotherapy for pancreas divisum in patients with acute recurrent pancreatitis

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World Journal of Gastroenterology 2014年第46期20卷 17468-17475页

作者： Alberto Mariani Milena Di Leo Maria Chiara Petrone Paolo Giorgio Arcidiacono Antonella Giussani Raffaella Alessia Zuppardo giulia Martina Cavestro Pier Alberto Testoni Gastroenterology and Gastrointestinal Endoscopy Unit Division of Experimental OncologyIRCCS San Raffaele Scientific Institute - Vita Salute San Raffaele University20132 MilanItaly

AIM: To assess the rate of relapses of acute pancreatitis (AP), recurrent AP (RAP) and the evolution of endosonographic signs of chronic pancreatitis (CP) in patients with pancreas divisum (PDiv) and RAP.

关键词： Endoscopic retrograde cholangiopancreatography Magnetic resonance cholangiopancreatography with secretin stimulation Minor papilla endotherapy Pancreatic stenting Endoscopic ultrasonography

Dieulafoy Gastric Lesion: An Unusual Cause of Pediatric Hematemesis

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Open Journal of Pediatrics 2016年第1期6卷 120-123页

作者： giulia Maria Tronconi Lucia Cococcioni Maria Chiara Petrone Patrizia Corsin Martina Fomasi Pier Alberto Testoni Graziano Barera department of Pediatrics San Raffaele Scientific Institute Vita-Salute San Raffaele University Milan Italy Gastroenterology and Gastrointestinal Endoscopy Unit San Raffaele Scientific Institute Vita-Salute San Raffaele University Milan Italy

Dieulafoy lesion is a vascular anomaly predominantly found in the stomach, which represents a rare cause of gastrointestinal bleeding and life-threatening haemorrhages in pediatric age with few cases reported in the literature. We experienced a 7-year-old previously healthy boy with hematemesis endoscopically diagnosed and successfully treated for a Dieulafoy lesion in the stomach. This case report illustrates the initial diagnostic workup and the possible differential diagnosis in presence of an acute episode of hematemesis in children. It focuses on an uncommon cause of gastrointestinal bleeding that is probably underestimated because of missing diagnosis. Any unusual and acute case of upper gastrointestinal bleeding should raise the suspicion of Dieulafoy lesion also in children, especially in those who have a past medical history negative for peptic disease and varices due to portal hypertension: a promptly endoscopy can provide visual diagnostic criteria and ensure an adequate hemostasis that is generally the definitive treatment of the lesion.

关键词： Dielafoy Lesion Hematemesis Pediatric Endoscopy

Transoral incisionless fundoplication for gastro-esophageal reflux disease: Techniques and outcomes

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World Journal of Gastrointestinal Pharmacology and Therapeutics 2016年第2期7卷 179-189页

作者： Pier Alberto Testoni Giorgia Mazzoleni Sabrina Gloria giulia Testoni Division of Gastroenterology and Gastrointestinal Endoscopy Vita-Salute San Raffaele University San Raffaele Scientific Institute

Gastro-esophageal reflux disease(GERD)is a verycommon disorder that results primarily from the loss of an effective antireflux barrier,which forms a mechanical obstacle to the retrograde movement of gastric *** can be currently treated by medical therapy,surgical or endoscopic transoral *** therapy is the most common approach,though concerns have been increasingly raised in recent years about the potential side effects of continuous longterm medication,drug intolerance or unresponsiveness,and the need for high dosages for long periods to treat symptoms or prevent *** too may in some cases have consequences such as longlasting dysphagia,flatulence,inability to belch or vomit,diarrhea,or functional dyspepsia related to delayed gastric *** the last few years,transoral incisionless fundoplication(TIF)has proved an effective and promising therapeutic option as an alternative to medical and surgical *** review describes the steps of the TIF technique,using the Esophy X®device and the MUSETM *** and their management are described in detail,and the recent literature regarding the outcomes is *** reconfigures the tissue to obtain a full-thickness gastroesophageal valve from inside the stomach,by serosato-serosa plications which include the muscle *** date the procedure has achieved lasting improvement of GERD symptoms(up to six years),cessation or reduction of proton pump inhibitor medication in about 75%of patients,and improvement of functional findings,measured by either p H or impedance monitoring.

关键词： Gastro-esophageal reflux disease Transoral incisionless fundoplication Anterior fundoplication with ultrasonic surgical endostapler Esophy X MUSE Surgical fundoplication