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Immortalized hippocampal astrocytes from 3xTg-AD mice,a new model to study disease-related astrocytic dysfunction:a comparative review

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Neural Regeneration Research 2023年第8期18卷 1672-1678页

作者： Laura Tapella giulia Dematteis Armando A Genazzani Massimiliano De Paola Dmitry Lim Department of Pharmaceutical Sciences Universitàdel Piemonte Orientale“Amedeo Avogadro”NovaraItaly Department of Neuroscience Mario Negri Institute for Pharmacological Research IRCCSMilanoItaly

Alzheimer's disease(AD)is characterized by complex etiology,long-lasting pathogenesis,and celltype-specific ***,there is no cure for AD,emphasizing the urgent need for a comprehensive understanding of cell-specific ***,principal homeostatic cells of the central nervous system,are key players in the pathogenesis of neurodegenerative diseases,including *** models greatly facilitate the investigation of cell-specific pathological alterations and the dissection of molecular mechanisms and ***-derived and immortalized astrocytic cell lines,alongside the emerging technology of adult induced pluripotent stem cells,are widely used to study cellular dysfunction in ***,no stable cell lines were available from genetic mouse AD ***,we established immortalized hippocampal astroglial cell lines from amyloid-βprecursor protein/presenilin-1/Tau triple-transgenic(3xTg)-AD mice(denominated as wild type(WT)-and 3Tg-iAstro cells)using retrovirus-mediated transduction of simian virus 40 large T-antigen and propagation without clonal selection,thereby maintaining natural heterogeneity of primary *** groups have successfully used 3Tg-iAstro cells for single-cell and omics approaches to study astrocytic AD-related alterations of calcium signaling,mitochondrial dysfunctions,disproteostasis,altered homeostatic and signaling support to neurons,and blood-brain barrier *** we provide a comparative overview of the most used models to study astrocytes in vitro,such as primary culture,tumor-derived cell lines,immortalized astroglial cell lines,and induced pluripotent stem cell-derived *** conclude that immortalized WT-and 3Tg-iAstro cells provide a noncompetitive but complementary,low-cost,easy-to-handle,and versatile cellular model for dissection of astrocyte-specific AD-related alterations and preclinical drug discovery.

关键词： Alzheimer's disease astrocytes immortalization astroglial Alzheimers's disease model blood-brain barrier calcium signaling central nervous system homeostasis disproteostasis endoplasmic reticulum-mitochondria contacts induced pluripotent stem cell-derived astrocytes protein synthesis

Efficient light harvesting from flexible perovskite solar cells under indoor white light-emitting diode illumination

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Nano Research 2017年第6期10卷 2130-2145页

作者： giulia Lucarelli Francesco Di Giacomo Valerio Zardetto Mariadriana creatore Thomas M. Brown Centre for Hybrid and Organic Solar Energy (CHOSE) Department of Electronic Engineering University of Rome Tor Vergata Via del Politecnico 100133 Rome Italy Hoist Centre/TNO - Solliance 5655AE Eindhoven the Netherlands Department of Applied Physics Eindhoven University of Technology P.O. Box 513 5600 MB Eindhoven the Netherlands

This is the first report of an investigation on flexible perovskite solar cells for artificial light harvesting by using a white light-emitting diode （LED） lamp as a light source at 200 and 400 Ix, values typically found in indoor environments. Flexible cells were developed using either low-temperature sol-gel or atomic- layer-deposited compact layers over conducting polyethylene terephthalate （PET） substrates, together with ultraviolet （UV）-irradiated nanoparticle TiO2 scaffolds, a CH3NHBPbI3xClx perovskite semiconductor, and a spiro-MeOTAD hole transport layer. By guaranteeing high-quality carrier blocking （via the 10-40 nm-thick com- pact layer） and injection （via the nanocrystalline scaffold and perovskite layers） behavior, maximum power conversion efficiencies （PCE） and power densities of 10.8% and 7.2 pW-cm-2, respectively, at 200 lx, and 12.1% and 16.0 -tW＇cm-2, respectively, at 400 lx were achieved. These values are the state-of-the-art, comparable to and even exceeding those of flexible dye-sensitized solar cells under LED lighting, and significantly greater than those for flexible amorphous silicon, which are currently the main flexible photovoltaic technologies commercially considered for indoor applications. Furthermore, there are significant margins of improvement for reaching the best levels of efficiency for rigid glass-based counterparts, which we found was a high of PCE -24% at 400 lx. With respect to rigid devices, flexibility brings the advantages of being low cost, lightweight, very thin, and COlfformal, which is especially important for seamless integration in indoor environments.

关键词： flexible perovskite solar cells indoor light harvesting atomic layer deposition nanocrystalline scaffolds flexible photovoltaics energy harvesting

High risk of thrombosis recurrence in people with idiopathic or only locally caused non-cirrhotic splanchnic vein thrombosis: it is time for guidelines’ revision

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Hepatobiliary Surgery and Nutrition 2024年第4期13卷 699-702页

作者： Massimo Primignani giulia Tosetti Andrea Artoni Fondazione IRCCS Ca’Granda Ospedale Maggiore Policlinico–SC Gastroenterologia ed Epatologia MilanItaly Angelo Bianchi Bonomi Hemophilia and Thrombosis Center Fondazione IRCCS Ca'Granda Ospedale Maggiore PoliclinicoMilanItaly

Portal hypertension caused by non-cirrhotic(and non neoplastic)splanchnic vein thrombosis(NC-SVT)is responsible for 5–10%of portal hypertension cases in the western world(1).Chronic myeloproliferative neoplasms(MPN)or systemic prothrombotic disorders are in cause in about 40%of subjects,while in about 30%a local condition,such as recent abdominal surgery or infection/inflammation triggers the *** local condition,however,can only be the precipitating cause,since a thorough screening allows identifying the co-occurrence of systemic thrombophilia in about 30%of such ***,screening is mandatory even in cases where the cause of NC-SVT seems ***,about 30%of cases of NC-SVT remains unexplained and defined idiopathic(1).

关键词： Non-cirrhotic splanchnic vein thrombosis factor VIII thrombosis recurrence

Circulating and stool nucleic acid analysis for colorectal cancer diagnosis

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World Journal of Gastroenterology 2014年第4期20卷 957-967页

作者： giulia De Maio Claudia Rengucci Wainer Zoli Daniele Calistri Biosciences Laboratory Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori IRCCS

In recent years, the need to identify molecular markers characterized by high sensitivity and specificity in detecting and monitoring early and colorectal cancer lesions has increased. Up to now, none of the markers or panels of markers analyzed have met the rigorous standards required of a screening program. The important discovery of circulating nucleic acids in biological fluids has aroused intense scientific interest because of their usefulness in malignant and non malignant diseases. Over time, their yield and stability have been identified and compared with other “standard” biomarkers. The analysis of circulating DNA from blood and stool is a relatively simple and non-invasive procedure, representing a very attractive marker to detect genetic and epigenetic mutations and to monitor disease progression. A correlation between blood and stool biomarkers could also help to enhance currently available diagnostic approaches. However, various processing and analytic problems need to be resolved before such an approach can be applied in clinical practice.

关键词： Colorectal cancer Circulating DNA Circulating RNA Early diagnosis DNA integrity

Relation between skeletal muscle volume and prognosis in rectal cancer patients undergoing neoadjuvant therapy

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World Journal of Gastrointestinal Oncology 2022年第2期14卷 423-433页

作者： Paola De Nardi Alessandro Giani giulia Maggi Marco Braga Department of Gastrointestinal Surgery IRCCS San Raffaele Scientific InstituteMilano 20132Italy Department of Surgery School of MedicineUniversity of Milano-BicoccaMilan ItalyMonza 20900Italy Department of Oncologic Surgery Policlinico CasilinoRome 00169Italy Department of Surgery San Gerardo HospitalUniversity Milano BicoccaMonza 20900Italy

The prognostic role of body composition indexes,and specifically sarcopenia,has recently been explored in different cancer ***,conflicting results have been *** in cancer type,cancer stage or oncological treatments,as well as different methodology and definition of sarcopenia,could be accounted for different conclusions retrieved from *** focusing on colorectal cancer,it clearly appears that colon and rectal cancers are often treated as a single entity though they have different behaviors and ***,patients with advanced rectal cancer represent a peculiar group of patients that according to current guidelines are treated with neoadjuvant chemotherapy and radiotherapy followed by radical *** review was restricted to a homogeneous group of patients with advanced lower rectal cancer and the aim of exploring whether there is a correlation between skeletal muscle depletion and *** was searched for articles related to patients with advanced rectal cancer undergoing neoadjuvant chemo-radiotherapy(NCRT)followed by radical surgery,in whom muscle mass and/or change in muscle mass during neoadjuvant treatment were *** full-text articles were selected and included in the present *** main findings of our review were:(1)The majority of the studies defined sarcopenia as muscle mass alone over muscle strength or physical performance;(2)There was a great deal of heterogeneity in the definition and measures of sarcopenia,in the definition of cut-off values,and in the method to measure change in muscle mass;(3)There was not full agreement on the association between sarcopenia at baseline and/or after chemoradiotherapy and prognosis,and only few studies found a significance in the multivariate analysis;and(4)It seems that a loss in skeletal muscle mass during NCRT is associated with the worst outcomes in terms of disease-free *** conclusion,analysis of muscle mass might provid

关键词： Advanced rectal cancer Sarcopenia Neoadjuvant treatment Chemoradiotherapy Surgery Muscle mass change Prognosis Survival Review

Validity of studies suggesting preoperative chemotherapy for resectable thoracic esophageal cancer:A critical appraisal of randomized trials

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World Journal of Gastrointestinal Oncology 2020年第1期12卷 113-123页

作者： giulia Manzini Ursula Klotz Doris Henne-Bruns Michael Kremer Department of General and Visceral Surgery University of UlmUlm 89081Germany Department of General and Visceral Surgery Hospital of AarauAarau 5000Switzerland

BACKGROUND In 2015,Kidane published a Cochrane review and meta-analysis to summarise the impact of preoperative chemotherapy versus surgery alone on survival for resectable thoracic esophageal *** authors concluded that preoperative chemotherapy improved overall survival(OS).AIM The aim of this article was to assess the validity of the three most powerful studies included in the Cochrane review and the meta-analysis supporting the advantage of preoperative chemotherapy and to investigate the impact of an exclusion of these three studies on the result of the *** OS was selected as the endpoint of *** the ten included papers which analysed this endpoint,we identified the three publications with the highest weights influencing the final *** validity of these papers was analysed using the CONSORT checklist for randomized controlled *** performed a new meta-analysis without the three studies to assess their impact on the general result of the original *** The three analysed studies revealed several *** answers were found in up to one third of the items of the CONSORT *** information about sample-size calculation and power,unclear or inadequate randomisation,and missing blinded set-up were the most common *** the three criticized studies were excluded in the meta-analysis,preoperative chemotherapy showed no benefit in *** The three most powerful publications in the Cochrane review show substantial *** the exclusion of these studies from the meta-analysis,preoperative chemotherapy does not seem to result in an advantage in *** suggest a more critical appraisal regarding the validity of single studies.

关键词： Esophageal cancer Assessment of validity Meta-analysis CONSORT Overall survival

Persistent dysexecutive syndrome after pneumococcal meningitis complicated by recurrent ischemic strokes:A case report

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World Journal of Clinical Cases 2023年第22期11卷 5344-5350页

作者： Laura Abbruzzese giulia Martinelli giulia Salti Benedetta Basagni Alessio Damora Cristiano Scarselli giulia Peppoloni Aleksandra Podgorska giuliana Rosso Marco Bacci Alba Rosa Alfano MAURO MANCUSO CRT Tuscany Rehabilitation ClinicMontevarchiArezzo 52025Italy Physical and Rehabilitative Medicine Unit NHS ASL-Tuscany South EstGrosseto 58100Italy Department of Internal Medicine and Medical Specialties UOC GeriatricsSapienza University of RomeRome 00185Italy

Meningitis is a possible complication of pneumococcal infection concerning acute otitis media and *** might compromise cognitive function,both for the infection itself and the vascular events that sometimes follow the acute *** SUMMARY Here we describe the case of a 32-year-old female patient admitted to the emergency room due to extensive pneumococcal meningitis as a consequence of sinus *** presented with extensive laminar ischemic damage in the acute phase,resulting in severe cognitive and behavioural *** years of follow-up,through neuropsychological assessments and neuroradiological investigations,demonstrated the presence of subsequent vascular events,3 months and 2 years after *** The case is discussed in light of scientific knowledge of the long-term outcomes of this pathology in order to potentially improve diagnosis and promote better outcomes.

关键词： Pneumococcal meningitis Stroke,Cognitive and behavioural functioning Long-term outcome Case report

Surveillance strategies following curative resection and nonoperative approach of rectal cancer:How and how long?Review of current recommendations

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World Journal of Gastrointestinal Surgery 2023年第2期15卷 177-192页

作者： Andrea Lauretta giulia Montori Gian Piero Guerrini Department of Surgical Oncology Centro di Riferimento Oncologico di Aviano IRCCSAviano 33081Italy Department of General Surgery Vittorio Veneto HospitalULSS 2 Marca TrevigianaVittorio Veneto 31029Italy Hepato-Pancreato-Biliary Surgical Oncology and Liver Transplantation Unit Policlinico-AUO ModenaModena 41124Italy

Different follow-up strategies are available for patients with rectal cancer following curative treatment.A combination of biochemical testing and imaging investigation,associated with physical examination are commonly ***,there is currently no consensus about the types of tests to perform,the timing of the testing,and even the need for follow-up at all has been *** aim of this study was to review the evidence of the impact of different followup tests and programs in patients with non-metastatic disease after definitive treatment of the primary.A literature review was performed of studies published on MEDLINE,EMBASE,the Cochrane Library and Web of Science up to November *** published guidelines from the most authoritative specialty societies were also *** to the follow-up strategies available,the office visit is not efficient but represents the only way to maintain direct contact with the patient and is recommended by all authoritative specialty *** colorectal cancer surveillance,carcinoembryonic antigen represents the only established tumor *** and chest computed tomography scan is recommended considering that the liver and lungs are the most common sites of *** local relapse in rectal cancer is higher than in colon cancer,endoscopic surveillance is *** follow-up regimens have been published but randomized comparisons and meta-analyses do not allow to determine whether intensive or less intensive follow-up had any significant influence on survival and recurrence detection *** available data do not allow the drawing of final conclusions on the ideal surveillance methods and the frequency with which they should be *** is very useful and urgent for clinicians to identify a cost-effective strategy that allows early identification of recurrence with a special focus for highrisk patients and patients undergoing a“watch and wait”approach.

关键词： Rectal cancer Follow-up Surveillance Recurrence Carcinoembryonic antigen Computed tomography

Perioperative chemotherapy for advanced gastric cancer - results from a tertiary-care hospital in Germany

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World Journal of Gastrointestinal Oncology 2020年第5期12卷 559-568页

作者： Katrin Bauer giulia Manzini Doris Henne-Bruns Peter Buechler Department for General VisceralThoracic and Paediatric SurgeryClinic of KemptenKempten 87439Germany Department of General and Visceral Surgery University Hospital of UlmUlm 89081Germany

BACKGROUND Neoadjuvant/perioperative chemotherapy is the recommended treatment for advanced stages of gastric cancer(>T2,N+)before tumour resection in many European ***,there is no consensus as to whether perioperative chemotherapy is as effective in distal as in proximal tumours,in addition to a relevant uncertainty concerning appropriate treatment modalities for elderly *** To investigate the role of perioperative chemotherapy in advanced gastric cancer in patients from a German tertiary clinic with respect to efficacy,localisation,and *** We performed a retrospective analysis of 158 patients from our clinic with adenocarcinoma of the stomach or the gastroesophageal junction who underwent resection between 2008 and *** data were evaluated particularly in relation to patient age,tumour site,and perioperative *** Administration of perioperative chemotherapy did not lead to a significant survival advantage in our study *** 5-year survival rates were 40%for patients who received perioperative chemotherapy and 29%for the group without perioperative chemotherapy(P=0.125).Our patients were on average distinctly older than patients in most of the published randomised controlled *** elder than 75 years received perioperative chemotherapy far less *** with a proximal tumour received perioperative chemotherapy much more *** This analysis reconfirms our previous data concerning the effectiveness of perioperative chemotherapy for advanced gastric *** is reasonable doubt that the quality of the existing randomized controlled trials is sufficient to generally justify perioperative chemotherapy in patients with advanced gastric cancer independent of tumour localization or age.

关键词： Gastric cancer Perioperative Chemotherapy Tumour localisation Age distribution Validity