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The Administration of Ocoxin Increases the Quality of Life of Patients with Advanced Epithelial or Metastatic Ovarian Cancer Undergoing Neoadjuvant Chemotherapy

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Journal of Cancer Therapy 2022年第9期13卷 561-584页

作者： Karen López Miguel Daniel Ricardo martínez Ávila Lliset Álvarez Pérez gisselle martínez rabasa Alejandro Linchenat Lambert Roberto Esperón Noa Lisandra Heredia Manzano Margarita De Quesada Amigó Rafael I. Reyes Velázquez Danay Corrales Otero Ramon Ropero Toirac Idelmis Curbelo Heredia Mircea Betancourt Cabeza Tania A. Agrelo Ramos Rosa María Muñoz Reyes Juan Jesús Lence Anta Rosalía Fuentes Sosa Karelia Silvera Candó Kirenia Silva Rodríguez Zaida Lastre Sosa Mayte Robaina García Eduardo Sanz David Marquez Department of Medical Oncology INOR La Habana Cuba Department of Gynaeco-Oncology INOR La Habana Cuba Department of Anatomical Pathology INOR La Habana Cuba Department of Imaging INOR La Habana Cuba Clinical Research Section INOR La Habana Cuba Department of Onco-Psychology INOR La Habana Cuba Clinical Laboratory Department INOR La Habana Cuba Clinical Trials Pharmacy Department INOR La Habana Cuba Department of Biostatistics CENCEC La Habana Cuba Scientific Department CATALYSIS Madrid Spain

Background: 70% of ovarian cancer cases are diagnosed at an advanced stage (III or IV) of the disease and, in turn, with a high prevalence of peritoneal carcinosis and ascites, which leads to progressive malnutrition in patients, with the consequent deterioration of their general condition. There is a very important relationship between nutritional status, quality of life, survival, and the ability to tolerate multidisciplinary treatment of peritoneal carcinosis. Methods: A phase II, open-label, single-center, non-randomised clinical trial was conducted that included 36 patients with advanced disease who were administered the nutritional supplement Ocoxin, 30 ml twice a day, beginning one week before chemotherapy (CT) based on carboplatin/paclitaxel, of which they receive three cycles with neoadjuvant intent. Ocoxin treatment was continued during chemotherapy and for three weeks after completion of the last cycle, as well as during any periods for which this treatment was discontinued due to toxicity. The effect of Ocoxin on the quality of life was assessed through the QLQ C30 and QLQ OV28 questionnaires from the start of treatment until the end of the follow-up period. In addition, the Karnofsky Index and nutritional parameters were assessed. Results: There were no significant differences between adverse events versus baseline values, except in leukocytes, lymphocytes, neutrophils, ALT, and AST. There was no deterioration of the QoL scales, except for those related to the effects of chemotherapy and alopecia. Conclusions: Ocoxin as an adjuvant to chemotherapy appears to improve better tolerance to chemotherapy, showed a good safety profile, and improved quality of life. For further information on Ocoxin neoadjuvant therapy benefits, a phase III clinical trial will be needed.

关键词： Chemotherapy Radiotherapy Ovarian Cancer Oncology Quality of Life Ad-juvant Therapy Supportive Care

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Forest Management Plans in Los Planes de La Palma, El Salvador

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Natural Resources 2015年第11期6卷 527-533页

作者： gisselle A. Mejia Blair Orr School of Forest Resources and Environmental Science Michigan Technological University Houghton MI USA

Fourteen farmers with small woodlots were interviewed about the forest management plans promoted by the government of El Salvador. As expected, farmers managed for many utilitarian products such as firewood and timber, but the farmers also expressed a strong set of environmental concerns revolved around the ecological value of their woodlots. Farmers generally approved of forest management plans as they saw how plans contributed to sustainable forestry on their woodlots. Farmers had concerns about specific silvicultural practices and about transportation of harvested timber.

关键词： Woodlots Ecotourism Forest Law Chalatenango Sustainable Management

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与母亲“同居”的日子

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新东方英语（中英文版） 2012年第9期 56-58页

作者： gisselle Perez Sherry Zhang

自摆脱婴儿床后，我就一直和母亲同睡一张床，不是因为我是“长不大的孩子”，不是因为我不够自立，而是在我成长的那个拥挤的家里，我根本就找不到任何私人空间。如今，我快大学毕业了，也终于有了属于自己的房间和床，但独眠之初，我... 详细信息

自摆脱婴儿床后，我就一直和母亲同睡一张床，不是因为我是“长不大的孩子”，不是因为我不够自立，而是在我成长的那个拥挤的家里，我根本就找不到任何私人空间。如今，我快大学毕业了，也终于有了属于自己的房间和床，但独眠之初，我竟无法安睡了……

关键词：母亲同居私人空间大学毕业婴儿床

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Pregnancy and Klippel-Trenaunay Syndrome—A Case Report

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Case Reports in Clinical Medicine 2014年第7期3卷 429-432页

作者： María Jesús Cancelo Hidalgo gisselle Adriana González Segura Laura Yago Lisbona Estherde la Viuda García Department of Obstetrics and Gynecology University Hospital of Guadalajara Alcalá University Madrid Spain

Klippel-Trenaunay Syndrome (KTS) is a rare triad of congenital vascular malformations involving extensive Port wine stains, soft tissue or bone hypertrophy and underlying venous and/or lymphatic malformation affecting limb, pelvicor abdominal organs. Pregnancy is known to exacerbate KTS complications and can put women at increased obstetrical risk due to deep venous thrombosis and other thromboembolic events. We report a case of a pregnant woman with KTS with the personal antecedent of two episodes of pulmonary thromboembolism.

关键词： Klippel-Trenaunay Syndrome Pregnancy

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Association of Serum Antioxidant Enzymes and Nervous Tissue Markers in Hypertensive Patients

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World Journal of Cardiovascular Diseases 2014年第4期4卷 160-168页

作者： Marisol Pena-Sanchez Sergio Gonzalez-Garcia Gretel Riveron-Forment Otman Fernandez-Concepcion Olivia martinez-Bonne gisselle Lemus-Molina Isabel Fernandez-Almirall Maria de la Caridad Menendez-Sainz Alina Gonzalez-Quevedo Janis TEells Institute of Neurology and Neurosurgery HavanaCuba National Genetic Center HavanaCuba College of Health Sciences University of Wisconsin-MilwaukeeMilwaukeeUSA

Background and Purpose: Hypertension has serious effects on cerebral blood vessels. Oxidative stress seems to be implicated in blood pressure elevation, through increased reactive oxygen species and/or decreased antioxidant capacity. Recently blood markers indicating damage to the central nervous system were reported to be increased in hypertensive patients. However, it is unknown whether antioxidant capacity is related to these changes. This study was designed to explore if the concentration of blood markers for nervous tissue damage was associated to antioxidant capacity in hypertensive patients. Methods: Twenty hypertensive patients and 23 healthy controls were studied. They were paired by age, sex, ethnicity, or risk factors. Serum neuron specific enolase (NSE) and S100 calcium binding protein B (S100B) were measured as nervous tissue damage markers, as well as the activity of antioxidant enzymes (catalase, glutathione peroxidase, glutathione reductase and gamma-glutamyltransferase). Results: Serum neuronal specific enolase (NSE) and S100 calcium binding protein B (S100B) concentrations determined by immunoassay were significantly increased in patients vs. controls. The activities of antioxidant enzymes measured by spectrophotometry showed that plasmatic catalase and erythrocytic glutathione peroxidase were significantly increased in patients, but erythocytic catalase was decreased. Gamma-glutamyltransferase activity was significantly correlated with S100B in hypertensive patients, while erythrocytic catalase activity was decreased in subjects with higher NSE levels. Conclusion: This preliminary investigation suggested that antioxidant status might be modulated through changes in antioxidant enzymatic activity in hypertensive patients. The association of some of these changes with peripheral markers of damage to the central nervous system could indicate that the increased levels of these proteins in hypertension are partly related to oxidative stress.

关键词： Hypertension Gamma-glutamyltransferase Catalase Neuron Specific Enolase S100 Calcium Binding Protein B

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