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A Survey of the Homotopy Properties of Inclusion of Certain Types of Configuration Spaces into the Cartesian Product

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Chinese Annals of Mathematics,Series B 2017年第6期38卷 1223-1246页

作者： Daciberg lima GONCALVES John GUASCHI Departamento de Matematica IME-USPRua do Matao 1010CEP:05508-090Sao PauloSPBrazil Normandie Universite UNICAENLaboratoire de Mathematiques Nicolas Oresme UMR CNRS 6139CS 1403214032 Caen Cedex 5France

Let X be a topological *** this survey the authors consider several types of configuration spaces,namely,the classical(usual)configuration spaces F_n(X)and D_n(X),the orbit configuration spaces F_n^G(X)and F_n^G(X)/S_nwith respect to a free action of a group G on X,and the graph configuration spaces F_n~Γ(X)and F_n~Γ(X)/H,whereΓis a graph and H is a suitable subgroup of the symmetric group S_*** ordered configuration spaces F_n(X),F_n^G(X),F_n~Γ(X)are all subsets of the n-fold Cartesian product ∏_1~nX of X with itself,and satisfy F_n^G(X)?F_n(X)?F_n~Γ(X)?∏_1~*** A denotes one of these configuration spaces,the authors analyse the difference between A and ∏_1~nXfrom a topological and homotopical point of *** principal results known in the literature concern the usual configuration *** authors are particularly interested in the homomorphism on the level of the homotopy groups of the spaces induced by the inclusionι:A-→∏_1~nX,the homotopy type of the homotopy fibre I_ιof the mapιvia certain constructions on various spaces that depend on X,and the long exact sequence in homotopy of the fibration involving I_ιand arising from the inclusionι.In this respect,if X is either a surface without boundary,in particular if X is the 2-sphere or the real projective plane,or a space whose universal covering is contractible,or an orbit space S^k/Gof the k-dimensional sphere by a free action of a Lie group G,the authors present recent results obtained by themselves for the first case,and in collaboration with Golasi′nski for the second and third *** authors also briefly indicate some older results relative to the homotopy of these spaces that are related to the problems of *** order to motivate various questions,for the remaining types of configuration spaces,a few of their basic properties are described and proved.A list of open questions and problems is given at the end of the paper.

关键词： Configuration space Equivariant configuration space Fibration Homotopy fibre K(π,1)space Braid groups

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Combined Oxidative Phosphorylation Deficiency-20-Exome as a Diagnostic Implement

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Journal of Biosciences and Medicines 2024年第6期12卷 7-12页

作者： Paulo Roberto Matos-Neto Lucas Antonissen lima Verde Airton Ferreira da Ponte-Filho Luís Eduardo Oliveira Matos Amandha Espavier Trés Paulo Roberto Lacerda Leal Gerardo Cristino-Filho Regina Coeli de Carvalho Porto Carneiro Faculty of Medicine Federal University of Cear Sobral Cear Brazil Department of Neurosurgery Federal University of Cear Sobral Cear Brazil Department of Neuropediatrics Federal University of Cear Sobral Cear Brazil

Mitochondrial disorders are phenotypically varied, with serious clinical repercussions. Among them, there is the deficiency of combined oxidative phosphorylation of type 20, which occurs due to a defect in the VARS2 gene. This article presents a case of a 2-year-old female with progressive myoclonic epilepsy and psychomotor regression, with refractoriness to multiple anticonvulsants. The diagnosis was only made after the examination was carried out. Therefore, this article highlights the aspects of this rare disease and the importance of the exome for the diagnosis of rare conditions.

关键词： Oxidative Phosphorylation Epilepsy Exome Mitochondrial Defect VARS2

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Fixed points of n-valued maps on surfaces and the Wecken property a configuration space approach

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Science China Mathematics 2017年第9期60卷 1561-1574页

作者： GONCALVES Daciberg lima GUASCHI John Departamento de Matemdtica&IME Universidade de Sao PauloSdo Paulo 05508-090Brazil Laboratoire de Mathematiques Nicolas Oresme UMR CNRS 6139 UNICAENNormandie UniversiteCS 1403214032 Caen Cedex 5France

Abstract In this paper, we explore the fixed point theory of n-vaiued maps using configuration spaces and braid groups, focusing on two fundamental problems, the Wecken property, and the computation of the Nielsen number. We show that the projective plane （resp. the 2-sphere S2） has the Wecken property for n-valued maps for all n ∈N （resp. all n ≥ 3）. In the case n = 2 and S2, we prove a partial result about the Wecken property. We then describe the Nielsen number of a non-split n-valued map φ ： X → X of an orientable, compact manifold without boundary in terms of the Nielsen coincidence numbers of a certain finite covering q：）→ X with a subset of the coordinate maps of a lift of the n-valued split map → q ： →X.

关键词： multivalued maps fixed points Wecken property Nielsen numbers braids configuration space

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Inhibition of BACE1, the β-secretase implicated in Alzheimer’s disease, by a chondroitin sulfate extract from Sardina pilchardus

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Neural Regeneration Research 2020年第8期15卷 1546-1553页

作者： Courtney J.Mycroft-West Anthony J.Devlin Lynsay C.Cooper Patricia Procter Gavin J.Miller David G.Fernig Marco Guerrini Scott E.Guimond Marcelo a.lima Edwin A.Yates Mark Andrew Skidmore Molecular&Structural Biosciences School of Life SciencesKeele UniversityHuxley BuildingKeeleStaffordshireST55BGUK Lennard-Jones Laboratory School of Chemical and Physical SciencesKeele UniversityKeeleStaffordshireST55BGUK Department of Biochemistry Institute of Integrative BiologyUniversity of LiverpoolCrown StreetLiverpoolL697ZBUK Istituto di Ricerche Chimiche e Biochimiche G.Ronzoni Via G.Colombo 8120133 MilanItaly School of Medicine KeeleStaffordshireST55BGUK

The pharmaceutical and anticoagulant agent heparin,a member of the glycosaminoglycan family of carbohydrates,has previously been identified as a potent inhibitor of a key Alzheimer’s disease drug target,the primary neuronalβ-secretase,β-site amyloid precursor protein cleaving enzyme 1(BACE1).The anticoagulant activity of heparin has,however,precluded the repurposing of this widely used pharmaceutical as an Alzheimer’s disease ***,a glycosaminoglycan extract,composed predominantly of 4-sulfated chondroitin sulfate,has been isolated from Sardina pilchardus,which possess the ability to inhibit BACE1(IC50[half maximal inhibitory concentration]=4.8μg/mL),while displaying highly attenuated anticoagulant activities(activated partial thromboplastin time EC50[median effective concentration]=403.8μg/mL,prothrombin time EC50=1.3 mg/mL).The marine-derived,chondroitin sulfate extract destabilizes BACE1,determined via differential scanning fluorimetry(ΔTm–5°C),to a similar extent as heparin,suggesting that BACE1 inhibition by glycosaminoglycans may occur through a common mode of action,which may assist in the screening of glycan-based BACE1 inhibitors for Alzheimer’s disease.

关键词： amyloid-β aspartyl protease carbohydrates galactosaminoglycans heparan sulfate heparin marine polysaccharide pilchards sardines therapeutics

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内蒙古边境牧区社会安全治理现代化:理论意涵、现实困境与路径选择

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内蒙古农业大学学报（社会科学版） 2024年第1期26卷 84-90页

作者：李俊清阿梨玛中央民族大学国家安全研究院北京100081 中央民族大学管理学院北京100081 呼和浩特民族学院公共管理学院内蒙古呼和浩特010051

围绕内蒙古边境牧区社会安全治理现代化展开研究,深入探讨其理论意涵,揭示治理主体多元协同化、治理制度完善规范化、治理措施动态有序化和治理工具智慧网络化等核心要素。同时,从现实出发,分析内蒙古边境牧区在应对草场纠纷、草原火灾... 详细信息

围绕内蒙古边境牧区社会安全治理现代化展开研究,深入探讨其理论意涵,揭示治理主体多元协同化、治理制度完善规范化、治理措施动态有序化和治理工具智慧网络化等核心要素。同时,从现实出发,分析内蒙古边境牧区在应对草场纠纷、草原火灾、动物疫情、非法信贷等社会安全问题时,所面临的理念滞后、制度缺失、主体协同不足和技术支撑薄弱等现实挑战。为破解这些难题,提出加强文化建设树立牧区新安全责任观、坚持制度导向实现重点治理与常态化预防相结合、推进主体协同构建牧区社会安全治理共同体,以及提供技术辅助提升社会安全治理效能等路径选择。

关键词：内蒙古边境牧区社会安全治理现代化

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Influence of wire spacing and plate spacing on electrostatic precipitation of nanoparticles: An approach involving electrostatic shielding and diffusion charging

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Particuology 2023年第9期80卷 127-139页

作者： Felipe de Aquino lima Vádila Giovana Guerra Department of Chemical Engineering Federal University of São CarlosRodovia Washington LuísKm 235C.P.676CEP 13560-970São CarlosSPBrazil

Electrostatic precipitation is a process widely used as gas cleaning device,to removal particles from gas ***,in a conventional and well-sized precipitator,the collection efficiency decreases for ultrafine particles,making it difficult to employ this equipment for controlling nanoparticle *** paper investigates the influence of plate spacing(4 and 6.5 cm)and wire spacing(4,6,and 12 cm)on the electric current and nanoparticle collection efficiency,considering the effect of diffusion charging and electrostatic *** laboratory-scale dry wire-plate electrostatic precipitators with different plate spacings were tested for the collection of nanoparticles(6.15–241.4 nm)at three air velocities(1.9,2.9,and 3.9 cm/s).The results demonstrated the effectiveness of the equipment in removing nanoparticles(99.9%)under the highest electric *** values of the wire spacing led to increases in the current and the collection *** was associated with reduced electrostatic shielding,which is more evident in smaller ducts with a higher density of field *** is expected that the findings should improve knowledge on electrostatic precipitation of nanoparticles,enabling optimization of collection efficiency by considering the effects of geometric parameters.

关键词： Electrostatic precipitation Nanoparticles Collection efficiency Plate spacing Wire spacing

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Phase Correlation Based Iris Image Registration Model

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Journal of Computer Science & Technology 2005年第3期20卷 419-425页

作者： Jun-ZhouHuang Tie-NiuTan lima Yun-HongWang NationalLaboratoryofPatternRecognition InstituteofAutomationChineseAcademyofSciencesBeijing100080P.R.China NationalLaboratoryofPatternRecognition InstituteofAutomationChineseAcademyofSciencesBeijing100080P.R.China／／SchoolofComputingBeihangUniversityBeijing100083P.R.China

Iris recognition is one of the most reliable personal identification methods. In iris recognition systems, image registration is an important component. Accurately registering iris images leads to higher recognition rate for an iris recognition system. This paper proposes a phase correlation based method for iris image registration with sub-pixel accuracy. Compared with existing methods, it is insensitive to image intensity and can compensate to a certain extent the non-linear iris deformation caused by pupil movement. Experimental results show that the proposed algorithm has an encouraging performance.

关键词： phase correlation image registration iris recognition biometrics

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Muscle strength and its association with cardiometabolic variables in adolescents:does the expression of muscle strength values matter?

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World Journal of Pediatrics 2021年第6期17卷 597-608页

作者： Tiago Rodrigues de lima Xuemei Sui Luiz Rodrigo Augustemak de lima Diego Augusto Santos Silva Research Center in Kinanthropometry and Human Performance Federal University of Santa CatarinaTrinity University CampusFlorianopolisSC CEP 88010-970Brazil Department of Exercise Science Arnold School of Public HealthUniversity of South CarolinaColumbiaSCUSA Research Group On Biodynamics of Human Performance and Health Institute of Physical Education and SportFederal University of AlagoasMaceioBrazil

Background We investigate the association between different muscle strength(MS)indices with cardiometabolic variables in *** Cross-sectional study comprising 351 adolescents(male 44.4%,age 16.6±1.0 years)from *** was assessed by handgrip strength and analyzed in live difrerent ways:absolute MS and MS normalized for body weight,body mass index(BMI),height,and fat mass,*** variables investigated as outcomes were systolic and diastolic blood pressure(DBP),waist circumference(WC),high-sensitive C-reactive protein(hs-CRP),lipid and glucose metabolism *** linear regression models adjusted for confounding factors were *** Absolute MS and/or MS normalized for height was directly associated with WC[up to 32.8 *** error(SE)=4.7]and DBP(up to 8.8 mmHg,SE=0.8),and inversely associated with high-density lipoprotein cholesterol(up to-8.0 mg/***=14.1).MS normalized for body *** or fat inass was inversely associated with WC(up to-17.5 cm,SE=2.2).According tesex,MS normalized for fat mass was inversely associated with triglycerides(male:0.02 times lower,SE=0.01;female:0.05 times lower,SE=0.01)and homeostatic model assessment for insulin resistance(male:0.02 times lower,SE=0.01;female:0.06 times ***=0.01).and inversely associated with hs-CRP only among male(0.03 times lower,SE=0.01).Conclusion When normalized for body weight,BMI or fat mass,MS was superior to absolute MS or MS normalized for height in representing adequately cardiometabolic variables among adolescents.

关键词： Abdominal C-reactive protein Hand strength Insulin resistance Obesity Triglycerides

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Antimicrobial and synergistic effects of lemongrass and geranium essential oils against Streptococcus mutans,Staphylococcus aureus,and Candida spp.

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World Journal of Critical Care Medicine 2024年第3期13卷 63-74页

作者： Patrícia Michelle Nagai de lima Thaís Cristine Pereira Lara Steffany de Carvalho Letícia Ferreira dos Santos Carlos Eduardo Rocha Oliveira Lucas de Paula Ramos Maria Cristina Marcucci Amjad Abu Hasna Luciane Dias de Oliveira Department of Biosciences and Oral Diagnosis Institute of Science and TechnologySão Paulo State UniversitySão Josédos Campos 12245000SPBrazil Anhembi Morumbi University School of MedicineSão Josédos Campos 12230-002SPBrazil Department of Restorative Dentistry Endodontics DivisionInstitute of Science and TechnologySão Paulo State UniversitySão Josédos Campos 12245000São PauloBrazil

BACKGROUND The oral cavity harbors more than 700 species of bacteria,which play crucial roles in the development of various oral diseases including caries,endodontic infection,periodontal infection,and diverse oral *** To investigate the antimicrobial action of Cymbopogon Schoenanthus and Pelargonium graveolens essential oils against Streptococcus mutans,Staphylococcus aureus,Candida albicans,***,and *** Minimum microbicidal concentration was determined following Clinical and Laboratory Standards Institute *** synergistic antimicrobial activity was evaluated using the Broth microdilution checkerboard method,and the antibiofilm activity was evaluated with the 3-[4,5-dimethylthiazol-2-yl]-2,5 diphenyl tetrazolium bromide *** were analyzed by one-way analysis of variance followed by the Tukey post-hoc test(P≤0.05).RESULTS *** and *** essential oils were as effective as 0.12%chlorhexidine against *** and *** monotypic biofilms after 24 *** 24 h *** essential oil at 0.25%was more effective than the nystatin group,and *** essential oil at 0.25%was as effective as the nystatin *** *** and *** essential oils are effective against ***,***,***,***,and *** at different concentrations after 5 min and 24 h.

关键词： Antifungal effect Lemongrass Geranium Candida albicans Candida dubliniensis Candida krusei Staphylococcus aureus Streptococcus mutans

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Efficient Incremental Maintenance of Frequent Patterns with FP-Tree

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Journal of Computer Science & Technology 2004年第6期19卷 876-884页

作者： Xiu-lima Yun-HaiTong Shi-WeiTang Dong-QingYang SchoolofElectronicsEngineeringandComputerScience PekingUniversityBeijing100871P.R.China NationalLaboratoryonMachinePerception PekingUniversityBeijing100871P.R.China

Mining frequent patterns has been studied popularly in data mining area. However, little work has been done on mining patterns when the database has an influx of fresh data constantly. In these dynamic scenarios, efficient maintenance of the discovered patterns is crucial. Most existing methods need to scan the entire database repeatedly, which is an obvious disadvantage. In this paper, an efficient incremental mining algorithm, Incremental-Mining (IM), is proposed for maintenance of the frequent patterns when incremental data come. Based on the frequent pattern tree (FP-tree) structure, IM gives a way to make the most of the things from the previous mining process, and requires scanning the original data once at most. Furthermore, IM can identify directly the differential set of frequent patterns, which may be more informative to users. Moreover, IM can deal with changing thresholds as well as changing data, thus provide a full maintenance scheme. IM has been implemented and the performance study shows it outperforms three other incremental algorithms: FUP, DB-tree and re-running frequent pattern growth (FP-growth). Keywords data mining - association rule mining - frequent pattern mining - incremental mining Supported by the National Basic Research 973 Program of China under Grant No.G1999032705.Xiu-Li Ma received the Ph.D. degree in computer science from Peking University in 2003. She is currently a postdoctoral researcher at National Lab on Machine Perception of Peking University. Her main research interests include data warehousing, data mining, intelligent online analysis, and sensor network.Yun-Hai Tong received the Ph.D. degree in computer software from Peking University in 2002. He is currently an assistant professor at School of Electronics Engineering and Computer Science of Peking University. His research interests include data warehousing, online analysis processing and data mining.Shi-Wei Tang received the B.S. degree in mathematics from Peki

关键词： data mining association rule mining frequent pattern mining incremental mining

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