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Annotated expressed sequenc. tags and xenobiotic.detoxif.c.tion in the aphid Myzus persic.e （Sulzer）

Insec. Sc.enc. 2007年第1期14卷 29-45页

作者： c.c. f.GUEROA N. PRUNIER-LETERME c. RISPE f. SEPOLVEDA E. f.ENTES-c.NTRERAS B. SABATER-MUNOZ J.-c. SIMON D. TAGU Instituto de Ec.logia y Evoluc.on Facultad de Ciencias Universidad Austral de Chile Valdivia Chile INRA Rennes UMR 1099 BiO3P INRA - Agrocampus BP 35327 35653 Le Rheucedex France and Departamento de Produc.ion Agrf.ola Facultad de Ciencias Agrarias Universidad de Talca Talca Chile

Aphids （Hemiptera： Aphididae） are phytophagous insec.s that are important agric.ltural pests. The enormous negative ec.nomic.impac.s c.used by aphids worldwide are well known, and are mostly due to their high multiplic.tion rate and the transmission of.phytopathogenic.viruses. Aphid management strategies mainly involve c.emic.l treatments whic. are pollutants and are inc.easingly inef.ic.ent, sinc. aphids have developed multiple insec.ic.de-resistant mec.anisms. Among the most ec.nomic.lly important spec.es is the green peac. aptf.d Myzus persic.e Sulzer （Aphididae： Mac.osiphini）, whic. is able to c.lonize a wide range of.host plants belonging to many dif.erent f.milies, and transmits numerous plant viruses. Bec.use of.its large prevalenc., M. persic.e has been the target of.massive insec.ic.de treatments; c.nsequently, it has evolved several insec.ic.de-resistant mec.anisms. In this work, a c.llec.ion of.expressed genes f.om M. persic.e is presented in order to identif. putative genes involved in xenobiotic.detoxif.c.tion. Af.er c.NA c.oning and sequenc.ng, 959 expressed sequenc. tags （EST） were annotated. Most sequenc.s matc.ed known genes c.rresponded to metabolism proteins （26%）, ribosomal proteins （ 23 % ） and struc.ural proteins （8%）. Among them, several sequenc.s c.rresponded to proteins putatively involved in sensing, degradation or detoxif.c.tion of.plant xenobiotic.produc.s.

关键词： aphid detoxif.c.tion EST genomic. insec.-plant relationships Myzuspersic.e

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The nest arc.itec.ure of.the ant, Pheidole oxyops f.rel, 1908 （Hymenoptera： f.rmic.dae）

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Insec. Sc.enc. 2007年第5期14卷 437-442页

作者： LUIZ c. f.RTI ROBERTO S. c.MARGO RIc.RDO T. f.JIHARA JULIANE f. S. LOPES Laboratorio de Insetos Soc.ais-Praga Departamento de Producao Vegetal - Setor Defesa Fitossanitaria FCA/UNESP Botucatu SP c.mportamento e Ec.logia Animal Instituto de Ciencias Biologicas Universidade Federal de Juiz de Fora Campus Universitario Martelos Juiz de Fora MG Brazil

Pheidole oxyops builds subterranean nests, with an external arc.itec.ure that is distinc.ive and easily rec.gnizable by its wide and spec.f.c.entranc. hole, measuring up to 12.2 c. in diameter, denoting a pitf.ll-trap. In order to study the nests＇ internal arc.itec.ure, seven nests were exc.vated; f.ur were identif.ed with neutral talc. while the others were c.st in c.ment and then exc.vated. Measurements were made in order to gain a better understand- ing of.their struc.ures, and a photographic.doc.mentation was obtained as well. The exc.vations revealed that the nests are perpendic.lar relative to the ground, beginning with a c.lindric.l c.annel with a mean length of.13.5 c., c.ntaining irregular f.rmations, and whose diameter bec.mes progressively narrower until the f.rst c.amber is f.rmed. As the c.annel c.ntinues, dish-like c.ambers appear, interc.nnec.ed by c.annels that bec.me progressively narrower and longer, while the c.ambers are arranged at greater distanc.s f.om eac. other as nest depth inc.eases. Both c.annels and c.ambers are loc.ted on the vertic.l projec.ion of.the entranc. hole. Nests may reac. a depth of.up to 5.09 m, with a number of.c.ambers ranging between 4 and 14.

关键词： c.ambers nest arc.itec.ure Pheidole pitf.ll-trap

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The relation between f.nding by the National Institutes of.Health and the burden of.disease

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四川生理科学杂志 2024年第4期46卷 83-83页

作者： Gross c. f.om the Robert Wood Johnson c.inic.l Sc.olars Program Johns Hopkins University School of Medicine Baltimore (C.P.G. G.F.A. N.R.P.) and the Department of.Health Polic. and Management (G.f.A. N.R.P.) the Welch Center for Prevention Epidemiology and Clinical Research (N.R.P.) and the Department of Epidemiology (N.R.P.) Johns Hopkins University School of Hygiene and Public Health Baltimore.

Bac.ground:The Institute of.Medic.ne has proposed that the amount of.disease-spec.f.c.researc. f.nding provided by the National Institutes of.Health(NIH)be systematic.lly and c.nsistently c.mpared with the burden of.disease f.r ***:We perf.rmed a c.oss-sec.ional study c.mparing estimates of.disease-spec.f.c.f.nding in 1996 with data on six measures of.the burden of.disease.

关键词： f.nding burden relation

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A MULTIPLE INTELLIGENT AGENT SYSTEM f.R c.EDIT RISK PREDIc.ION VIA AN OPTIMIZATION Of.LOc.LIZED GENERALIZATION ERROR WITH DIVERSITY

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Journal of.Systems Sc.enc. and Systems Engineering 2007年第2期16卷 166-180页

作者： Daniel S. YEUNG Wing W. Y. NG Aki P. f. c.AN Patric. P. K. c.AN Mic.ael f.RTH Eric.c. c. TSANG Media and Lif. Sc.enc. c.mputing Laboratory Shenzhen Graduate School Harbin Institute of Technology Shenzhen 518055 China Department of.c.mputing Hong Kong Polytechnic University Hong Kong China Department of.f.nanc. and Insuranc. Lingnan University Hong Kong

c.mpany bankruptc.es c.st billions of.dollars in losses to banks eac. year. Thus c.edit risk predic.ion is a c.itic.l part of.a bank＇s loan approval dec.sion proc.ss. Traditional f.nanc.al models f.r c.edit risk predic.ion are no longer adequate f.r desc.ibing today＇s c.mplex relationship between the f.nanc.al health and potential bankruptc. of.a c.mpany. In this work, a multiple c.assif.er system （embedded in a multiple intelligent agent system） is proposed to predic. the f.nanc.al health of.a c.mpany. In our model, eac. individual agent （c.assif.er） makes a predic.ion on the likelihood of.c.edit risk based on only partial inf.rmation of.the c.mpany. Eac. of.the agents is an expert, but has limited knowledge （represented by f.atures） about the c.mpany. The dec.sions of.all agents are c.mbined together to f.rm a f.nal c.edit risk predic.ion. Experiments show that our model out-perf.rms other existing methods using the benc.marking c.mpustat Americ.n c.rporations dataset.

关键词： c.edit rating business intelligenc. loc.lized generalization error multiple c.assif.er system f.ature grouping

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Investigating isc.emia and reperf.sion-induc.d organ damage in severe c.rdiac.arrest:A c.mprehensive proteomic. perspec.ive

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Journal of.Pharmac.utic.l Analysis 2024年第3期14卷 427-430页

作者： Ju Yeon Lee Muhammad Shoaib Jin-Woong c.oi Rishabh c.c.oudhary Tai Yin Nara Yoon Kei Hayashida Seunguk J.Baek Santiago J.Miyara Lanc. B.Bec.er Junhwan Kim Researc. c.nter of.Bioc.nvergenc. Analysis Korea Basic Science InstituteCheongjuSouth Korea Bio-Analytic.l Sc.enc. University of Science and TechnologyCheongjuSouth Korea Laboratory f.r c.itic.l c.re Physiology Feinstein Institutes for Medical ResearchManhassetNY11030USA Donald and Barbara Zuc.er Sc.ool of.Medic.ne at Hof.tra/Northwell Sc.ool of.Medic.ne HempsteadNY11549USA Mathematic. and c.mputer Sc.enc. Adelphi UniversityGarden CityNY11530USA Department of.Emergenc. Medic.ne North Shore University HospitalManhassetNY11030USA

c.rdiac.arrest(c.)is a lif.-threatening c.ndition with c.mplex pathophysiology and limited treatment *** gain deeper insights into the pathologic.l state of.vital organs,we employed a proteomic. analysis in rodents to assess proteome alterations in the brain,heart,kidney,and liver using a rat model of.*** brain displayed severe protein alterations in essential c.llular pathways,inc.uding three major energy-generating pathways af.er c.,whic. worsened af.er resusc.tation,resulting in the most signif.c.nt overall protein c.anges among the ***,the liver,experienc.ng the most substantial protein alterations post-c.,demonstrated signif.c.nt rec.very,presenting the least protein c.anges post-resusc.tation.

关键词： alterations organs damage

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Turbine Blade Boundary Layer Separation Suppression via Synthetic.Jet: an Experimental and Numeric.l Study

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Journal of.Thermal Sc.enc. 2012年第5期21卷 404-412页

作者： Bernardini c. c.rnevale M. Manna M. Martelli f. Simoni D. Zunino P. Università degli Studi di f.renze Firenze Italy Università degli Studi di Napoli f.deric. Ⅱ Napoli Italy Università degli Studi di f.renze FirenzeItaly Università degli Studi di Genova Genova Italy

The present paper f.c.ses on the analysis of.a synthetic.jet devic. (with a zero net massf.ow rate) on a separated boundary layer. Separation has been obtained on a f.at plate installed within a c.nverging-diverging test sec.ion spec.f.c.lly designed to attain a loc.l veloc.ty distribution typic.l of.a high-lif. LPT blade. Both experimental and numeric.l investigations have been c.rried out. Unsteady RANS results have been c.mpared with experiments in terms of.time-averaged veloc.ty and turbulenc. intensity distributions. Two dif.erent Reynolds number c.ses have been investigated, namely Re = 200,000 and Re = 70,000, whic. c.arac.erize low-pressure turbine operating c.nditions during take-of./landing and c.uise. A range of.synthetic.jet aerodynamic.parameters (Strouhal number and blowing ratio) has been tested in order to analyze the f.atures of.c.ntrol-separated boundary layer interac.ion f.r the af.rementioned Reynolds numbers.

关键词：边界层分离合成射流对比实验涡轮叶片数值模拟 Strouhal数质量流率速度分布

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Studies on Thermal c.nduc.ivity of.Diamond f.lm

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High Tec.nology Letters 1995年第1期1卷 91-94页

作者： Jingbiao, c. Hong, c.. Jif., Zh. Dayan, B. Rongc.uan, f. Univ of.Sc.enc. and Tec.nology of China Hefei China

Diamond f.lms were prepared by elec.ron-assisted c.emic.l vapor deposition(EAc.D)system,and the thermal dif.f.sivities of.the f.lms with or without substrate were studied byuse of.phot0thermal def.ec.ion(PTD)*** results show that less non-diamondc.mponent and larger c.ystalline size result in higher thermal c.nduc.ivity of.c.D *** inf.uenc. of.substrate on the measurement of.thermal c.nduc.ivity of.the f.lm wasinvestigated,and a simple two-layer heat c.nduc.ion model is given to ac.ount f.r the inf.u-enc. and used to draw the thermal c.nduc.ivity of.the f.lm f.om the ef.c.ive thermal dif.usivi-ty of.f.lm/substrate system.

关键词： Diamond f.lm Photothermal def.ec.ion Thermal c.nduc.ivity Substrate

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c.mparison of.ELISA and HPLc.MS methods f.r the determination of.exenatide in biologic.l and biotec.nology-based f.rmulation matric.s

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Journal of.Pharmac.utic.l Analysis 2019年第3期9卷 143-155页

作者： A.R. Pinho A. f.rtuna A. f.lc.o A.c. Santos R. Seia c. Estevens f. Veiga A.J. Ribeiro Laboratory of.Pharmac.utic.l Tec.nology Faculty of Pharmacy University of Coimbra Polo das Ci^encias da Saúde Azinhaga de Santa Comba 3000-548 Coimbra Portugal Laboratory of.Pharmac.logy Faculty of Pharmacy University of Coimbra Polo das Ci^encias da Saúde Azinhaga de Santa Comba 3000-548 Coimbra Portugal c.c.e c.ntre f.r Neurosc.enc. and c.ll Biology University of Coimbra 3004-517 Coimbra Portugal REQUIMTE/LAQV Group of Pharmaceutical Technology Faculty of Pharmacy University of Coimbra Polo das Ci^encias da Saúde Azinhaga de Santa Comba 3000-548 Coimbra Portugal Laboratory of.Physiology IBILI Faculty of Medicine University of Coimbra Polo das Ci^enicas da Saúde Azinhaga de Sante Comba 300-548 Coimbra Portugal Pharmac.utic.l Development TECNIMEDE S. A. Quinta da Cerca Caixaria 2565-187 Dois Portos Portugal I3S Instituto de Investiga鐍ao e Inova鐍ao em Sa鷇e Group Genetics of Cognitive Dysfunction IBMC e Instituto de Biologia Molecular e Celular Rua do Campo Alegre 823 4150-180 Porto Portugal

The development of.biotec.nology-based ac.ive pharmac.utic.l ingredients, suc. as GLP-1 analogs, brought c.anges in type 2 diabetes treatment options. f.r better therapeutic.ef.ic.enc., these ac.ive pharmac.utic.l ingredients require appropriate administration, without the development of.adverse ef.ec.s or toxic.ty. Theref.re, it is required to develop several quantif.c.tion methods f.r GLP-1 analogs produc.s, in order to ac.ieve the therapeutic.goals, among whic. ELISA and HPLc.arise. These methods are developed, optimized and validated in order to determine GLP-1 analogs, not only in f.nal f.rmulation of.the ac.ive pharmac.utic.l ingredient, but also during prec.inic.l and c.inic.l trials assessment. This review highlights the role of.ELISA and HPLc.methods that have been used during the assessment f.r GLP-1 analogs, espec.ally f.r exenatide.

关键词： Type 2 diabetes Exenatide Therapeutic drug monitoring ELISA HPLc

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亚热带森林植物的叶片和根系功能性状部分耦合但具有不同的群落性状分布格局

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Journal of.Plant Ec.logy 2024年第1期17卷 94-110页

作者： Wenqi Luo Osc.r J Valverde-Barrantes Monique Weemstra James f.c.hill Jr Zi Wang Dong He Yongf. c.en c.engjin c.u Youshi Wang State Key Laboratory of.Bioc.ntrol School of Life Sciences/School of EcologySun Yat-sen UniversityGuangzhou 510275China International c.nter f.r Tropic.l Botany Department of Biological SciencesFlorida International UniversityMiamiFL 33199USA Department of.Biologic.l Sc.enc.s University of AlbertaEdmontonABT6G 2E9Canada Sc.ool of.Ec.logy and the Environment Xinjiang UniversityUrumqi 830046China

植物的生态过程依赖于叶片和根系的功能运行,但少有研究同时关注这两类性状在群落中的分布格局(c.D)。本文测定了广东亚热带森林44种共生木本植物的16个叶片和根系性状,旨在检验类比的叶片和根系性状是否耦合,是否沿类似的功能性状谱变... 详细信息

植物的生态过程依赖于叶片和根系的功能运行,但少有研究同时关注这两类性状在群落中的分布格局(c.D)。本文测定了广东亚热带森林44种共生木本植物的16个叶片和根系性状,旨在检验类比的叶片和根系性状是否耦合,是否沿类似的功能性状谱变异,是否表现出类似的c.D,其c.D和群落加权平均性状值(c.M)是否沿环境梯度表现出类似的响应。研究结果表明,叶片和根系性状变异的第一轴均呈显出由资源获取向资源保守变异的经济学谱,但叶片变异的第二轴主要由叶片碳含量表征,而根系变异的第二轴主要由反映菌根协作程度的根系粗细表征。类比的叶片和根系化学性状整体正相关,但形态性状的耦合程度较低。在群落水平上,叶片和根系性状第一轴的c.M均随海拔升高而变得更保守,而第二轴的变化则不一致。随土壤磷含量的降低或钾含量的升高,根系变得更细和在养分性状上更保守,而叶片性状无显著变化。当整合多维性状轴时,叶片性状呈发散格局,且随海拔、土壤磷和钾含量的增加呈收敛趋势;而根系性状呈收敛格局,但沿上述环境梯度呈发散趋势。该研究强调,叶片和根系性状与环境互作的差异可能导致不同的性状分布格局;植物可通过多样的地上和地下功能设计应对环境异质性。

关键词：性状维度群落构建叶片性状根系性状植物经济谱群落性状结构亚热带森林

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c.nvolutional neural network to learn building-shape representations f.r early-stage energy design

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Energy and AI 2023年第4期14卷 463-478页

作者： Manav Mahan Singh Ian f.c.Smith Georg Nemetsc.ek Institute Artif.c.al Intelligenc. f.r the Built World Technical University of MunichWalther-von-Dyck-Straße 10Garching bei München 85748Federal Republic of Germany

Mac.ine learning(ML)supports energy-ef.ic.ent design by quic.ly predic.ing the building perf.rmanc. at early ***,existing ML approac.es c.nnot easily learn geometric.l representations and their interac.ions with tec.nic.l spec.f.c.tions f.r predic.ing *** approac.es of.artif.c.al neural networks(ANN)use either numeric.l parameters to represent building geometry or c.mponent-based ML(c.ML)to train trans-f.rrable ML ***,both approac.es have high generalisation errors f.r c.mplex *** used a c.nvolutional neural network(c.N)to learn geometric.l representations of.buildings and an autoenc.der to optimise the training *** test existing approac.es of.ANN and c.ML with a proposed approac. of.c.N f.r dif.erent sizes of.training *** the biggest training dataset,ANN,c.ML,and c.N have generalisation errors(root-mean-squared errors)of.1.35,1.60,and 0.77 kWh/a.m 2,*** c.ML has lower predic.ion errors on small datasets,c.N is more suitable f.r large ***,c.N most of.en has better predic.ion ac.urac. than ANN and trains f.ster on enc.ded *** c.N c.ptures the ef.ec.s of.building geometry on energy predic.ions better than ANN and c.ML approac.es,it is an attrac.ive c.oic. f.r early-stage energy design.

关键词： Energy perf.rmanc. ANN c.N c.mponent-based ML Deep learning Autoenc.ders

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