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Tungsten 2024年第2期6卷 394-409页

作者： Yu-Lan Huang Bing Zhang Yu-Lian Li Li Wang le Dong Jian Li College of Ocean Food and Biological Engineering Jimei UniversityXiamen 361021China College of Oceanology and Food Science Quanzhou Normal UniversityQuanzhou 362000China

Due to its properties of mutagenic,teratogenic,and carcinogenic,the detection of furazolidone(FZD)in aquaculture is of great importance for food safety and human *** this study,molecularly imprinted fi lms modifi ed with carboxylated multi-walled carbon nanotube-phosphomolybdic acid composite were used to fabricate an electrochemical sensor for the determination of *** nanocomposites were characterized using infrared spectroscopy,scanning electron microscopy,energy-dispersive X-ray spectroscopy,and X-ray diff *** electrochemical characteristics of the modifi ed electrodes were examined using electrochemical impedance spectroscopy,cyclic voltammetry,and diff erential pulse *** sensor exhibited exceptional catalytic *** calibration curves were acquired in the concentration range of 6 nmol·L^(−1)to 0.6μmol·L^(−1),with a limit of detection of 3.38 nmol·L^(−1).Additionally,the sensor proved successful in recognizing FZD in shrimp samples with satisfactory recoveries and *** method provides a strategy to construct a molecularly imprinted electrochemical sensing platform using nanomaterials,which has great promise in the field of food safety.

关键词： Phosphomolybdate Furazolidone Polyoxometalates Carboxylated multi-walled carbon nanotube Molecularly imprinted polymers Electrochemical sensor

Stretchable and environment-resistant doubly crosslinked hydrogel for all-in-one supercapacitor and strain sensors

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Journal of Materiomics 2024年第6期10卷 1186-1195页

作者： Chunlin Liu le Jjiang Fenglin Zhao Qin Hu Yingge Zhang Xiaodan Sun Lianxin Peng School of Mechanical Engineering Chengdu UniversityChengdu 610106China Key Laboratory of Advanced Materials of Ministry of Education of China School of Materials Science and EngineeringTsinghua UniversityBeijing 100084China Key Laboratory of Coarse Cereal Processing of Ministry of Agriculture and Rural Affairs Chengdu UniversityChengdu 610106China

Despite their importance as components for flexible electronics,most stretchable hydrogels suffer from incomplete recovery after deformation,are prone to failure upon long-term repeated stretching,and cannot be exploited at subzero temperatures because of the freezing of their constituent ***-quently,strategies for circumventing these drawbacks are highly sought *** study describes the synthesis of a doubly(chemically and physically)crosslinked hydrogel from gelatin and methacrylic acid and demonstrates the suitability of this material for the fabrication of high-performance stretchable and environment-resistant supercapacitors and strain *** performance of this supercapacitor(areal capacitance=1,210.2 mF/cm^(2) at a current density of 1 mA/cm^(2),maximum energy density=158.8μW.h/cm^(-1),maximum power density=659.5μW/cm^(2))was superior to that of most of integrated super-capacitors reported to date and was hardly affected by stretchable,low temperatures,bending,ice-cold water and strong acid/alkali solutions or long-term ***,a strain sensor based on the above hydrogel was capable of accurately capturing human body motions when affixed to skin and recognising mouse movement(even in humid environments)after implantation into mouse *** work may pave the way to high-performance stretchable and environment-resistant wearable electronics.

关键词： Doubly crosslinked hydrogel Stretchable Environment-resistant All-in-one supercapacitor Strain sensor

Abnormal Innervation,Demyelination,and Degeneration of Spiral Ganglion Neurons as Well as Disruption of Heminodes are Involved in the Onset of Deafness in Cx26 Null Mice

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Neuroscience Bulletin 2024年第8期40卷 1093-1103页

作者： Yue Qiu le Xie Xiaohui Wang Kai Xu Xue Bai Sen Chen Yu Sun Department of Otorhinolaryngology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Department of Otolaryngology Nanchang UniversityNanchang 330006China

GJB2 gene mutations are the most common causes of autosomal recessive non-syndromic hereditary *** individuals suffering from severe to profound GJB2-related deafness,cochlear implants have emerged as the sole remedy for auditory *** previous studies have highlighted the crucial role of preserving cochlear neural components in achieving favorable outcomes after cochlear ***,we generated a conditional knockout mouse model(Cx26-CKO)in which Cx26 was completely deleted in the cochlear supporting cells driven by the Sox2 *** Cx26-CKO mice showed severe hearing loss and massive loss of hair cells and Deiter’s cells,which represented the extreme form of human deafness caused by GJB2 gene *** addition,multiple pathological changes in the peripheral auditory nervous system were found,including abnormal innervation,demyelination,and degeneration of spiral ganglion neurons as well as disruption of heminodes in Cx26-CKO *** findings provide invaluable insights into the deafness mechanism and the treatment for severe deafness in Cx26-null mice.

关键词： Spiral ganglion neurons Gjb2 Heminode Hearing loss

Progress on early diagnosing Alzheimer’s disease

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Frontiers of Medicine 2024年第3期18卷 446-464页

作者： Yixin Chen Murad Al-Nusaif Song Li Xiang Tan Huijia Yang Huaibin Cai Weidong le Liaoning Provincial Key Laboratory for Research on the Pathogenic Mechanisms of Neurological Diseases The First Affiliated Hospital of Dalian Medical UniversityDalian116021China Transgenic Section Laboratory of NeurogeneticsNational Institute on AgingNational Institutes of HealthBethesdaMD20892USA Institute of Neurology Sichuan Provincial People’s HospitalUniversity of Electronic Science and Technology of ChinaChinese Academy of Sciences Sichuan Translational Medicine Research HospitalChengdu610072China

Alzheimer’s disease(AD)is a progressive neurodegenerative disorder that affects both cognition and non-cognition *** disease follows a continuum,starting with preclinical stages,progressing to mild cognitive and behavioral impairment,ultimately leading to *** detection of AD is crucial for better diagnosis and more effective ***,the current AD diagnostic tests of biomarkers using cerebrospinal fluid and/or brain imaging are invasive or expensive,and mostly are still not able to detect early disease ***,there is an urgent need to develop new diagnostic techniques with higher sensitivity and specificity during the preclinical stages of *** non-cognitive manifestations,including behavioral abnormalities,sleep disturbances,sensory dysfunctions,and physical changes,have been observed in the preclinical AD stage before occurrence of notable cognitive *** research advances have identified several biofluid biomarkers as early indicators of *** review focuses on these non-cognitive changes and newly discovered biomarkers in AD,specifically addressing the preclinical stages of the ***,it is of importance to explore the potential for developing a predictive system or network to forecast disease onset and progression at the early stage of AD.

关键词： Alzheimer’s disease early diagnosis non-cognitive symptoms biomarkers

A new dust detection method for photovoltaic panel surface based on Pytorch and its economic benefit analysis

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Energy and AI 2024年第2期16卷 158-167页

作者： Yichuan Shao Can Zhang lei Xing Haijing Sun Qian Zhao le Zhang School of Intelligent Science&Engineering Shenyang UniversityShenyang 110044China School of Information Engineering Shenyang UniversityShenyang 110044China School of Chemistry and Chemical Engineering University of SurreyGU27XHUnited Kingdom School of Science Shenyang University of TechnologyShenyang 110044China

Dust accumulation on the surface of solar photovoltaic panels diminishes their power generation efficiency,leading to reduced energy *** monitoring and cleaning of solar photovoltaic panels is ***,developing optimal procedures for their upkeep is crucial for improving component efficiency,reducing maintenance costs,and conserving *** study introduces an improved Adam optimization algorithm designed specifically for detecting dust on the surface of solar photovoltaic *** the traditional Adam algorithm is the preferred choice for optimizing neural network models,it occasionally encounters problems such as local optima,overfitting,and not convergence due to inconsistent learning rates during the optimization *** mitigate these issues,the improved algorithm incorporates Warmup technology and cosine annealing strategies with traditional Adam algorithm,that allows for a gradual increase in the learning rate,ensuring stability in the preliminary phases of ***,the improved algorithm employs a cosine annealing strategy to dynamically tweak the learning *** not only counters the local optimization issues to some degree but also bolsters the generalization ability of the *** applied on the dust detection on the surface of solar photovoltaic panels,this improved algorithm exhibited superior convergence and training accuracy on the surface dust detection dataset of solar photovoltaic panels in comparison to the standard Adam ***,it displayed noteworthy improvements within three distinct neural network frameworks:ResNet-18,VGG-16,and MobileNetV2,thereby attesting to the effectiveness of the novel *** findings hold significant promise and potential applications in the field of surface dust detection of solar photovoltaic *** research results will create economic benefits for enterprises and individuals,and are an important strategic development direction for th

关键词： Solar photovoltaic panels Dust detection Pytorch Adam improved algorithm Economic benefits

Mental retardation,seizures and language delay caused by new SETD1B mutations:Three case reports

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World Journal of Clinical Cases 2024年第2期12卷 383-391页

作者： le Ding Li-Wan Wei Tai-Song Li Jing Chen Department of Neurology Children’s Hospital of Nanjing Medical UniversityNanjing 210000Jiangsu ProvinceChina Chigene(Beijing)Translational Medical Research Center Co.Ltd.Beijing 101111China

BACKGROUND The SETD1B gene is instrumental in human intelligence and nerve *** in the SETD1B gene have been linked in recent studies to neurodevelopmental disorders,seizures,and language *** SUMMARY This study aimed to analyze the clinical manifestations and treatment of three patients suffering from mental retardation,epilepsy,and language delay resulting from a new mutation in the SETD1B *** individuals with these symptoms were selected,and their clinical symptoms,gene test results,and treatment were *** article discusses the impact of the SETD1B gene mutation on patients and outlines the treatment *** the three patients(two females and one male,aged 8,4,and 1,respectively),all exhibited psychomotor retardation,attention deficit,and hyperactivity disorder,and two had *** treatment with sodium tripolyvalproate halted the seizures in the affected child,although mental development remained somewhat *** exome sequencing revealed new mutations in the SETD1B gene for all patients,specifically with c.5473C>T(***1825trp),c.4120C>T(***1374*,593),c.14_15insC(***5Hisfs*33).CONCLUSION Possessing the SETD1B gene mutation may cause mental retardation accompanied by seizures and language *** the exact mechanism is not fully understood,interventions such as drug therapy,rehabilitation training,and family support can assist patients in managing their symptoms and enhancing their quality of ***,genetic testing supplies healthcare providers with more precise diagnostic and therapeutic guidance,informs families about genetic disease risks,and contributes to understanding disease pathogenesis and drug research and development.

关键词： Neurodevelopmental disorder Seizure SETD1B gene Whole-exome sequencing New mutation Case report

Divergent total synthesis of marine meroterpenoids(+)-dysidavarones A–C

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Chinese Chemical letters 2024年第3期35卷 234-238页

作者： Qunlong Zhang Yang Kuang le Chang Jingyi Kang Bingjian Wang Chuanke Chong Zhaoyong Lu State Key Laboratory of Medicinal Chemical Biology College of PharmacyNankai UniversityTianjin 300350China

Here,we report a concise and divergent enantioselective total synthesis of marine sesquiterpene quinone meroterpenoids(+)-dysidavarones A–C(1–3)using predysidavarone 6 as a key common *** highly strained and bridged eight-membered carbocycle of predysidavarone 6 was constructed by a one-pot intermolecular alkylation and intramolecular arylation of Wieland–Miescher ketone derivative 11 and benzyl bromide *** total synthesis of(+)-dysidavarones A–C(1–3)was achieved from predysidavarone 6 in a divergent manner by a late-stage introduction of the ethoxy group,which reveals the possible source of the ethoxy group within(+)-dysidavarones A–C(1–3)and provides a late-stage modifiable route for the synthesis of dysidavarone analogs for further anti-cancer activity evaluation.

关键词： Total synthesis Natural product Dysidavarones A–C Sesquiterpene quinone Meroterpenoid

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高庙子膨润土胶体释放影响因素试验研究

原子能科学技术 2024年第5期58卷 998-1006页

作者：李娜娜核工业北京地质研究院北京100029 国家原子能机构高放废物地质处置创新中心北京100029

高放废物处置库中缓冲回填材料膨润土与地下水相互作用时会释放出胶体,而胶体会直接影响放射性核素的迁移行为,因此,膨润土遇水释放胶体研究是处置库系统安全评价的重要内容之一。本文以高庙子膨润土为研究对象,通过室内试验,获得了离... 详细信息

高放废物处置库中缓冲回填材料膨润土与地下水相互作用时会释放出胶体,而胶体会直接影响放射性核素的迁移行为,因此,膨润土遇水释放胶体研究是处置库系统安全评价的重要内容之一。本文以高庙子膨润土为研究对象,通过室内试验,获得了离子种类、离子强度、pH、温度与浊度的关系曲线,并对这些因素影响胶体释放的机理进行了分析。结果表明:阳离子种类抑制膨润土释放胶体排序依次为Li^(+)

关键词：高庙子膨润土胶体浊度离子强度温度酸碱性

Virtually coupled train set control subject to space-time separation:A distributed economic MPC approach with emergency braking configuration

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High-Speed Railway 2024年第3期2卷 143-152页

作者： Xiaolin Luo Tao Tang le Wang Hongjie Liu State Key Laboratory of Advanced Rail Autonomous Operation Beijing Jiaotong UniversityBeijing 100044China Department of Electrical and Computer Engineering University of CaliforniaRiversideCA 92521USA Beijing Zongheng Electro-Mechanical Technology Development Co. Ltd.Beijing 100081China School of Automation and Intelligence Beijing Jiaotong UniversityBeijing 100044China National Engineering Research Center of Rail Transportation Operation and Control System Beijing Jiaotong UniversityBeijing 100044China

The emerging virtual coupling technology aims to operate multiple train units in a Virtually Coupled Train Set(VCTS)at a minimal but safe *** guarantee collision avoidance,the safety distance should be calculated using the state-of-the-art space-time separation principle that separates the Emergency Braking(EB)trajectories of two successive units during the whole EB *** this case,the minimal safety distance is usually numerically calculated without an analytic ***,the constrained VCTS control problem is hard to address with space-time separation,which is still a gap in the existing *** solve this problem,we propose a Distributed Economic Model Predictive Control(DEMPC)approach with computation efficiency and theoretical ***,to alleviate the computation burden,we transform implicit safety constraints into explicitly linear ones,such that the optimal control problem in DEMPC is a quadratic programming problem that can be solved *** theoretical analysis,sufficient conditions are derived to guarantee the recursive feasibility and stability of DEMPC,employing compatibility constraints,tube techniques and terminal ingredient ***,we extend our approach with globally optimal and distributed online EB configuration methods to shorten the minimal distance among ***,experimental results demonstrate the performance and advantages of the proposed approaches.

关键词： Virtually coupled train set Space-time separation Economic model predictive control Distributed model predictive control Emergency braking configuration

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不同类型重构土壤水分运移特征

农业工程学报 2024年第3期40卷 94-102页

作者：郭拿拿黄明斌西北农林科技大学资源环境学院杨凌712100 西北农林科技大学水土保持研究所/黄土高原土壤侵蚀与旱地农业国家重点实验室杨凌712100

为探究不同类型重构土壤对水分再分布过程和土壤持水量的影响,该研究以砒砂岩、砂黄土和粗砂土为试验材料进行室内土柱试验,设置5种不同类型重构土壤(砒-粗、砂-粗、砒-砂-粗、砂-砒-粗、混-粗),测定各处理在入渗过程、排水过程以及蒸... 详细信息

为探究不同类型重构土壤对水分再分布过程和土壤持水量的影响,该研究以砒砂岩、砂黄土和粗砂土为试验材料进行室内土柱试验,设置5种不同类型重构土壤(砒-粗、砂-粗、砒-砂-粗、砂-砒-粗、混-粗),测定各处理在入渗过程、排水过程以及蒸发过程中土壤水分的动态变化;同时利用Hydrus-1D模型对不同类型重构土壤的入渗和蒸发过程进行模拟分析。结果表明,有砒砂岩层存在的重构土体对入渗过程有明显阻滞作用,且砒砂岩层越厚、位置越靠上阻滞效果越明显,土柱达到稳渗时稳渗率越低;蒸发过程中,砒-砂-粗处理累积蒸发量为52 mm,显著高于其他重构土壤(P<0.05),而砂-砒-粗处理土柱累积蒸发量最小(32.1 mm),蒸发结束时相对蒸发速率低至0.07;在蒸发过程中,上细下粗型层状重构土壤水分损失来自表层土壤和下层粗砂土。利用优化后的土壤水力参数和Hydrus-1D模型可以较好地模拟重构土壤水分运动过程。较低的均方根误差和高的决定系数证明模型能准确模拟各类型土柱的累积排水量、累积蒸发量和蒸发过程剖面含水量的动态变化。混-粗土柱的持水能力高于其他土柱,说明该重构类型可作为晋陕蒙地区土壤复垦的重构方案。

关键词：土壤入渗过程蒸发过程土壤持水量 Hydrus-1D模型模拟